Illegitimate V(D)J recombination involving nonantigen receptor loci in lymphoid malignancy

The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia

(2011) A. Gutierrez et al.   BLOOD

Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL

(2010) R. Jeannet et al.   BLOOD

Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1

(2010) T. D. Ashworth et al.   BLOOD

Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia

(2010) Maddalena Paganin et al.   BLOOD REVIEWS

The In Vivo Pattern of Binding of RAG1 and RAG2 to Antigen Receptor Loci

(2010) Yanhong Ji et al.   CELL

An Early T Cell Lineage Commitment Checkpoint Dependent on the Transcription Factor Bcl11b

(2010) L. Li et al.   SCIENCE

An Essential Developmental Checkpoint for Production of the T Cell Lineage

(2010) T. Ikawa et al.   SCIENCE

Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: on behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute Leukemia Working Party (GIMEMA AL WP)

(2009) I. Iacobucci et al.   BLOOD

IKZF1(Ikaros) Deletions inBCR-ABL1–Positive Acute Lymphoblastic Leukemia Are Associated With Short Disease-Free Survival and High Rate of Cumulative Incidence of Relapse: A GIMEMA AL WP Report

(2009) Giovanni Martinelli et al.   JOURNAL OF CLINICAL ONCOLOGY

Deletion ofIKZF1and Prognosis in Acute Lymphoblastic Leukemia

(2009) Charles G. Mullighan et al.   NEW ENGLAND JOURNAL OF MEDICINE

The role of NOTCH1 signaling in T-ALL

(2009) A. A. Ferrando   Hematology-American Society of Hematology Education Program

Notch Signaling in Leukemia

(2008) Jon C. Aster et al.   Annual Review of Pathology-Mechanisms of Disease

Failure of CDKN2A/B (INK4A/B-ARF)-mediated tumor suppression and resistance to targeted therapy in acute lymphoblastic leukemia induced by BCR-ABL

(2008) C. G. Mullighan et al.   GENES & DEVELOPMENT

V(D)J Recombinase Binding and Cleavage of Cryptic Recombination Signal Sequences Identified from Lymphoid Malignancies

(2008) Ming Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras–initiated leukemia

(2008) Mark Y. Chiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Rag-dependent and Rag-independent mechanisms of Notch1 rearrangement in thymic lymphomas of Atm−/− and scid mice

(2008) Hideo Tsuji et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros

(2008) Charles G. Mullighan et al.   NATURE