Article
Endocrinology & Metabolism
Kento Ikegawa, Yukihiro Hasegawa
Summary: This study demonstrated the involvement of the adrenal glands in the production of 11KT in prepubertal children through three observational studies.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Matthias K. Auer, James M. Hawley, Christian Lottspeich, Martin Bidlingmaier, Andrea Sappl, Hanna F. Nowotny, Lea Tschaidse, Marcus Treitl, Martin Reincke, Brian G. Keevil, Nicole Reisch
Summary: This study confirms that 11 β-hydroxyandrostenedione (11-OHA4) and 11-ketotestosterone (11-KT) are not biosynthesized by the human ovary. The testosterone/11-KT ratio as well as 11-OHA4 could help to identify predominant adrenal androgen excess and distinguish neoplastic and non-neoplastic ovarian androgen source.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Marianna Minnetti, Dario De Alcubierre, Ilaria Bonaventura, Riccardo Pofi, Valeria Hasenmajer, Maria Grazia Tarsitano, Daniele Gianfrilli, Eleonora Poggiogalle, Andrea M. Isidori
Summary: Licorice consumption can affect the reproductive system. However, its role needs to be further explored, especially due to the great variability of bioactive compounds used in existing studies.
Article
Endocrinology & Metabolism
Takashi Yazawa, Hiroyuki Inaba, Yoshitaka Imamichi, Toshio Sekiguchi, Junsuke Uwada, Mohammad Sayful Islam, Makoto Orisaka, Daisuke Mikami, Takanori Ida, Takahiro Sato, Yoshimichi Miyashiro, Satoru Takahashi, Md. Rafiqul Islam Khan, Nobuo Suzuki, Akihiro Umezawa, Takeshi Kitano
Summary: This study compared the presence and production of DHT and 11KDHT in Japanese eels and humans. The results suggest that in teleosts, DHT and 11KDHT may be important 5 alpha-reduced androgens produced in the gonads, while in healthy humans, DHT is the only major 5 alpha-reduced androgens.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Food Science & Technology
Xiang Hu, Xusheng Li, Pan Deng, Yulin Zhang, Ruijing Liu, Dongbao Cai, Qingjie Xu, Xinwei Jiang, Jianxia Sun, Weibin Bai
Summary: Androgen is a crucial steroid hormone in the reproductive system and body homeostasis. Flavonoids, a commonly found family of natural polyphenols, have received significant attention due to their widespread consumption and estrogen-like effects. Studies have shown that flavonoids can interfere with androgen synthesis and metabolism, and have a beneficial effect on androgen disorders.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Environmental Sciences
Jinshan Wang, Shizhen Jin, Wenshuang Fu, Yufeng Liang, Yani Yang, Xiaohong Xu
Summary: The study found that pubertal exposure to BPA may affect the actions of both androgens and estrogens in the brain, inhibit the AVP system of social circuits, resulting in impaired social recognition in adult male mice.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Behavioral Sciences
Nya Love, Doris Preininger, Matthew J. Fuxjager
Summary: Many animals use forms of gesture and dance to communicate with conspecifics in the breeding season. This study focuses on the hormone basis of visual signal behavior in Bornean rocks frogs. The results indicate that the aggregation of males at breeding waterfalls leads to higher testosterone levels, which may be caused by social cues related to sexual competition. The study also finds that testosterone levels positively predict the number of waving gestures while competing with rivals, but do not predict differences in male calling behavior.
HORMONES AND BEHAVIOR
(2023)
Article
Environmental Sciences
Maria C. Escalante-Rojas, Carlos E. Tolussi, Aline D. Gomes, Marcela Munoz-Penuela, Gabriela Brambila-Souza, Giovana S. Branco, Renata G. Moreira
Summary: Water contaminants in polluted reservoirs can impact the reproductive physiology of Astyanax fasciatus and Hoplias malabaricus males, potentially affecting the endocrine system and physiological adjustments. The biomarkers analyzed in polluted reservoirs show changes in gonadal steroid concentrations, suggesting the presence of endocrine disrupting compounds. Despite physiological changes, both species are able to maintain testicular function for reproduction in highly polluted environments.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Agriculture, Dairy & Animal Science
Lindsey J. Broadus, Brian Lee, Maja M. Makagon
Summary: This study compared the effects of rearing male ducklings with and without physical access to female ducklings on their reproductive behavior, physiology, and overall flock fertility. The results showed that auditory and visual exposure to female ducklings was sufficient to promote reproductive behavior and physiology in male ducklings, leading to high fertility within the flock.
Review
Endocrinology & Metabolism
Nathalie Sumien, J. Thomas Cunningham, Delaney L. Davis, Rachel Engelland, Oluwadarasimi Fadeyibi, George E. Farmer, Steve Mabry, Paapa Mensah-Kane, Oanh T. P. Trinh, Philip H. Vann, E. Nicole Wilson, Rebecca L. Cunningham
Summary: Neurodegenerative diseases have significant impacts on the elderly population, influenced by factors such as gender, age, and oxidative stress. Sex hormone receptors play a role in cell health, with menopausal women potentially facing higher levels of oxidative stress. Understanding these signaling pathways may offer therapeutic targets for neurodegenerative diseases.
Review
Endocrinology & Metabolism
Nathalie Sumien, J. Thomas Cunningham, Delaney L. Davis, Rachel Engelland, Oluwadarasimi Fadeyibi, George E. Farmer, Steve Mabry, Paapa Mensah-Kane, Oanh T. P. Trinh, Philip H. Vann, E. Nicole Wilson, Rebecca L. Cunningham
Summary: Neurodegenerative diseases have severe impacts on cognitive and motor function, with age and longevity being the main risk factors and sex also playing an important role. Sex hormone receptors play a crucial role in cell health, with oxidative stress associated with aging influencing this health status. Understanding these signaling cascades could lead to therapeutic targets for neurodegenerative diseases.
Review
Immunology
Robert G. Lahita
Summary: Autoimmune diseases show a tendency to be more prevalent in one biological sex compared to the other, with females dominating most autoimmune diseases. The reasons behind this predilection involve a combination of genetic, epigenetic, and hormonal factors.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
David J. Handelsman, Elliot R. Cooper, Alison K. Heather
Summary: Recent studies have shown that 11oxygenated androgens may play a potential role in human reproductive function. The concentrations of 11keto androgens in women and children are comparable to testosterone, while 11hydroxy androgens have minimal or no androgenic bioactivity. These findings are important for understanding the role of androgens in different populations.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Maria Santa Rocca, Giovanni Minervini, Cinzia Vinanzi, Alberto Bottacin, Federica Lia, Carlo Foresta, Maria Pennuto, Alberto Ferlin
Summary: This study evaluated the frequency and type of androgen receptor (AR) gene variants in a large cohort of infertile males. The study found that patients with AR gene variants had lower sperm count, higher testosterone concentration, and higher androgen sensitivity index compared to patients without variants. Two novel potentially pathogenic AR variants were identified. Based on these findings, AR sequencing is suggested as a routine genetic test in cases of idiopathic oligozoospermia with high testosterone levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Geriatrics & Gerontology
Jose V. V. Isola, Gabriel B. Veiga, Camila R. C. de Brito, Joao A. Alvarado-Rincon, Driele N. Garcia, Bianka M. Zanini, Jessica D. Hense, Arnaldo D. Vieira, Michael Garratt, Bernardo G. Gasperin, Augusto Schneider, Michael B. Stout
Summary: Chronic treatment with 17 alpha-E2 does not adversely affect reproductive fitness in male mice and does not extend lifespan or curtail disease parameters through tradeoff effects with reproduction.
Article
Biochemistry & Molecular Biology
Bridget M. Nugent, Kelly A. Stiver, Hans A. Hofmann, Suzanne H. Alonzo
Article
Neurosciences
Rayna M. Harris, Hsin-Yi Kao, Juan Marcos Alarcon, Hans A. Hofmann, Andre A. Fenton
Article
Multidisciplinary Sciences
Adam J. Northcutt, Daniel R. Kick, Adriane G. Otopalik, Benjamin M. Goetz, Rayna M. Harris, Joseph M. Santin, Hans A. Hofmann, Eve Marder, David J. Schulz
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Multidisciplinary Sciences
Guillermo Eastman, Guillermo Valino, Santiago Radio, Rebecca L. Young, Laura Quintana, Harold H. Zakon, Hans A. Hofmann, Jose Sotelo-Silveira, Ana Silva
SCIENTIFIC REPORTS
(2020)
Review
Biology
Ross S. DeAngelis, Hans A. Hofmann
JOURNAL OF EXPERIMENTAL BIOLOGY
(2020)
Article
Biochemical Research Methods
Alexander Nederbragt, Rayna Michelle Harris, Alison Presmanes Hill, Greg Wilson
PLOS COMPUTATIONAL BIOLOGY
(2020)
Article
Marine & Freshwater Biology
Keith W. Whitaker, Marcos Alvarez, Thomas Preuss, Molly E. Cummings, Hans A. Hofmann
Summary: The study found that in African cichlid fish, yellow dominant males exhibit higher spectral contrast when signaling to predators and conspecifics compared to blue dominant males. Different male phenotypes show distinct anti-predatory responses, with subordinate males shoaling for protection, and the more conspicuous yellow dominant males executing more escape responses. This suggests a novel mechanism where enhanced conspicuousness in certain male phenotypes is balanced by plastic changes in behavior.
Article
Behavioral Sciences
Kelly J. Wallace, Hans A. Hofmann
Summary: A study on male and female Astatotilapia burtoni in cognitive tasks revealed that both sexes prefer familiar objects in a novel object recognition task, but the timing of this preference varies between the sexes. Females excelled in learning the spatial task, showing longer decision latencies and quicker error correction, suggesting a potential speed-accuracy tradeoff.
Article
Neurosciences
Kelly J. Wallace, Hans A. Hofmann
Summary: Understanding animal decision-making involves dissecting and reconstructing processes across different biological levels and considering the decision-making environment. Although there have been foundational breakthroughs, our understanding of decision-making in social contexts is incomplete, requiring integration of novel approaches and perspectives. Social neuroscience and cognitive ecology have provided orthogonal perspectives on social decision-making, and integrating these fields is crucial for developing comprehensive and testable theories of the brain.
CURRENT OPINION IN NEUROBIOLOGY
(2021)
Editorial Material
Endocrinology & Metabolism
Chelsea A. Weitekamp, Hans A. Hofmann
Article
Evolutionary Biology
Megan E. Chan, Pranav S. Bhamidipati, Heather J. Goldsby, Arend Hintze, Hans A. Hofmann, Rebecca L. Young
Summary: Studies have shown that genes and entire pathways are often conserved, reused, and elaborated in the evolution of diversity. Observations in embryology suggest similarities in certain stages of vertebrate embryogenesis across species. Genes exhibiting conservation patterns through embryogenesis, including early conservation, hourglass, and late conservation, are significantly enriched in both microarray and RNA-seq data sets.
GENOME BIOLOGY AND EVOLUTION
(2021)
Article
Biology
Kelly J. Wallace, Kavyaa D. Choudhary, Layla A. Kutty, Don H. Le, Matthew T. Lee, Karleen Wu, Hans A. Hofmann
Summary: This study assessed male Astatotilapia burtoni fish in cognitive tasks before and after a community perturbation. The researchers found that ascending males underwent physiological changes and showed preference for novel object recognition during the perturbation, and differed in social competence from non-ascenders. Principal component analysis also identified specific cognitive and physiological attributes that predispose certain individuals to ascend in social status.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Neurosciences
Benjamin L. Clites, Hans A. Hofmann, Jonathan T. Pierce
Summary: The urgent need for medical treatments of alcohol use disorders has driven the search for new molecular targets. This article provides an evolutionary perspective on the molecular and genetic basis of alcohol consumption, highlighting the adaptive evolution of alcohol metabolic enzymes. By considering the natural selection of diverse species, novel conserved molecular targets of alcohol may be discovered.
NEUROSCIENCE INSIGHTS
(2023)
Meeting Abstract
Zoology
R. M. Butler, T. K. Solomon-Lane, H. A. Hofmann
INTEGRATIVE AND COMPARATIVE BIOLOGY
(2019)
Article
Endocrinology & Metabolism
Xiaomeng Li, Charles Brighton Ndandala, Qi Zhou, Chunyan Huang, Guangli Li, Huapu Chen
Summary: This study investigated the role of estrogen receptors (ERs) in vitellogenesis (Vtgs) regulation in pompano fish. The findings suggest that E2 may regulate the expression of different subtypes of vtg through ERs, displaying a compensatory expression effect on the regulation of ers and vtgs. This provides a theoretical basis for further research on reproductive endocrinology in pompano fish.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Norio Kansaku, Takeshi Ohkubo
Summary: Endocrine changes during bird reproduction, particularly the relationship between prolactin and incubation behavior, were investigated. The study monitored the physiological status and incubation behavior of Silkie hens over 1-2 years. The results showed that most mature hens exhibited incubation behavior multiple times, and there was a noticeable increase in nest occupancy 7-10 days before incubation onset. Protein analysis revealed that secreted prolactin during the reproductive cycle contains various isoforms, suggesting post-translational modifications like glycosylation and phosphorylation.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Minghui Li, Lina Sun, Linyan Zhou, Deshou Wang
Summary: This article summarizes the importance of the Nile tilapia as an excellent animal model for studying reproductive endocrinology in fish, with a focus on the crucial role of estrogen in female development.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Breanna N. Harris, Carolyn M. Bauer, James A. Carr, Caitlin R. Gabor, Jennifer L. Grindstaff, Caleigh Guoynes, Jennifer J. Heppner, Cris C. Ledon-Rettig, Patricia C. Lopes, Sharon E. Lynn, Carla B. Madelaire, Lorin A. Neuman-Lee, Maria G. Palacios, Paul Soto, Jennifer Terry
Summary: The COVID-19 pandemic had a significant impact on academics, particularly on those with minoritized identities or who were early career, caregivers, or had intersecting identities. The pandemic altered the impact factors of academia, including scholarly products, and affected the way individuals could respond. It is predicted that the pandemic will have long-term impacts on the population dynamics, composition, and landscape of the academic ecosystem. The number of journal submissions decreased, especially among women authors, and the pandemic heavily impacted women authors from Asia and the Middle East.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)