Article
Neurosciences
Zijue Wang, Hongmei Duan, Fei Hao, Peng Hao, Wen Zhao, Yudan Gao, Yiming Gu, Jianren Song, Xiaoguang Li, Zhaoyang Yang
Summary: An implanted NT3-chitosan scaffold can recruit neural stem cells to the lesion region and lead to the formation of functional neural circuits, promoting recovery after spinal cord injury. The scaffold facilitates the maturation of spinal neurons and the reestablishment of neural circuits, allowing for the recovery of neuromuscular function. This finding highlights the importance of the NT3-chitosan scaffold in promoting functional recovery after paraplegia.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Neurosciences
Ken Muramatsu, Naoko Niimi, Masako Ikutomo, Satoshi Shimo, Toru Tamaki, Masatoshi Niwa, Kazunori Sango
Summary: Complex motor skills training has been found to improve motor disorders in diabetic patients. Electrophysiological and immunohistochemical analysis showed that this training can induce plastic changes in the rubrospinal tract, compensating for the disruption caused by diabetes in the corticospinal tract and improving motor function.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Neurosciences
Boli Chen, Fuxiang Li, Bin Jia, Kwok-Fai So, Ji-An Wei, Yuchu Liu, Yibo Qu, Libing Zhou
Summary: This study investigated the impact of inactivating Celsr3 in the brainstem, revealing a reduction in rubrospinal and corticospinal axons in Celsr3 cKO animals. The mutant mice exhibited increased branching of dopaminergic fibers and decreased spinal motoneurons, neuromuscular junctions, and electromyographic signal amplitude. They also showed impaired motor coordination and response to heavy mechanical stimulation.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Shuang Jin, Xiangfeng Chen, Hanyu Zheng, Wanxiong Cai, Xurong Lin, Xiangxing Kong, Yingchun Ni, Jingjia Ye, Xiaodan Li, Luoan Shen, Binjie Guo, Zeinab Abdelrahman, Songlin Zhou, Susu Mao, Yaxian Wang, Chun Yao, Xiaosong Gu, Bin Yu, Zhiping Wang, Xuhua Wang
Summary: The limited regrowth capacity of corticospinal axons after cortical stroke hinders functional recovery. In this study, we identified ubiquitination factor E4B (UBE4B) as a regulator of axonal regrowth in retinal ganglion cells and corticospinal neurons. UBE4B represses axonal regrowth through the cooperative activation of p53 and mTOR pathways. Overexpression of UbV.E4B, a competitive inhibitor of UBE4B, promotes corticospinal axon sprouting and facilitates recovery of corticospinal tract-dependent function in a cortical stroke model.
Article
Neurosciences
Audra A. Kramer, Greta M. Olson, Advaita Chakraborty, Murray G. Blackmore
Summary: Forced expression of the transcription factor KLF6 enhanced axon sprouting in adult CST neurons after spinal injuries, but this effect required an injury stimulus and showed significant growth enhancement within four weeks. However, treatment with KLF6 did not lead to significant improvements in forelimb function, despite robust cross-midline sprouting by CST axons. Additional interventions or further optimization may be needed to translate the improvements in axon growth into functional gains.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Neurosciences
Frances S. Hausmann, John M. Barrett, Megan E. Martin, Huiqing Zhan, Gordon M. G. Shepherd
Summary: This study used MAPseq to investigate the diversity of brainstem branching patterns of the pyramidal tract projections from the forelimb-related areas of the motor cortex. The results showed high yet systematic diversity in PT axons at the level of brainstem projection patterns. The projections from M1 and M2 were qualitatively similar, but with quantitative differences in subclasses and clusters.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Clinical Neurology
Andrea Tedeschi, Molly J. E. Larson, Antonia Zouridakis, Lujia Mo, Arman Bordbar, Julia M. Myers, Hannah Y. Qin, Haven I. Rodocker, Fan Fan, John J. Lannutti, Craig A. McElroy, Shahid M. Nimjee, Juan Peng, W. David Arnold, Lawrence D. F. Moon, Wenjing Sun
Summary: The daily administration of gabapentin promotes structural and functional cortical plasticity in adult mice after a stroke. Gabapentin increases neuroplasticity and reduces maladaptive plasticity, leading to functional recovery. The findings suggest that repurposing gabapentinoids could be a promising treatment strategy for stroke repair.
Review
Neurosciences
Alisha Vartak, Divya Goyal, Hemant Kumar
Summary: Guidance molecules are essential for neural development, particularly in guiding axons to their target regions during spinal cord development. Defects in these molecules' expression or function can lead to abnormalities in axonal pathfinding, growth cone navigation, axonal branching, and synapse formation, affecting neuronal circuit construction and function after central nervous system traumas such as spinal cord injury (SCI).
Article
Neurosciences
Hisham Sharif, Heather Alexander, Anika Azam, John H. Martin
Summary: The study found that dual epidural motor cortex intermittent theta burst stimulation (iTBS) and cathodal transcutaneous spinal direct stimulation (tsDCS) enhance the efficacy of rehabilitation in improving motor function after spinal cord injury (SCI). Stimulation+rehabilitation group showed increased corticospinal tract axon length caudal to the injury, reduced proprioceptive afferent terminal labeling in the intermediate zone, and a negative correlation between afferent fiber terminal labeling and motor recovery.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Behavioral Sciences
Matthew Crowley, Alayna Lilak, Joseph P. Garner, Corinna Darian-Smith
Summary: The study compared behavioral data from two established spinal injury models in monkeys and found that the extent of corticospinal terminal sprouting does not directly correlate with behavioral recovery.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Cell Biology
Yansheng Liu, Jia-Xin Xie, Fang Niu, Zhexi Xu, Pengju Tan, Caihong Shen, Hongkun Gao, Song Liu, Zhengwen Ma, Kwok-Fai So, Wutian Wu, Chen Chen, Sujuan Gao, Xiao-Ming Xu, Hui Zhu
Summary: The study demonstrates that combining surgical intervention and long-term weight-bearing walking training in spinal cord injury (SCI) subjects can promote continued and significant neurological recovery, which is significant for patients who generally show little clinical recovery within the first year after injury and are often permanently disabled.
NEURAL REGENERATION RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Muyul Park, Yejin Cho, Dae Hyun Kim, Hyun Seok Choi, Dong-Hyun Kim, Deog Young Kim
Summary: MWI was used to monitor myelin content changes during rehabilitation in stroke patients, showing significant changes in MWF in the CST. Robot-assisted rehabilitation resulted in a significantly larger MWF change compared to conventional rehabilitation.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Review
Biochemistry & Molecular Biology
Narjes Shahsavani, Hardeep Kataria, Soheila Karimi-Abdolrezaee
Summary: White matter degeneration is a significant pathophysiological event in the central nervous system, characterized by demyelination, oligodendrocyte loss, axonal degeneration, and parenchymal changes. Various causes such as trauma, neurotoxic exposure, insufficient blood flow, neuroinflammation, and developmental neuropathies can lead to white matter degeneration, sharing similar pathological features. Research has identified numerous cellular and molecular mechanisms involved in axon and oligodendrocyte degeneration, with efforts made to develop neuroprotective and neuroregenerative approaches, although progress in this area remains limited due to the complex and multifactorial nature of the degeneration processes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Review
Cell Biology
Hajime Takase, Robert W. Regenhardt
Summary: Acute central nervous system injuries, particularly involving the motor tract, can lead to disability and have significant social and economic impacts. Understanding the pathophysiology of injury and subsequent motor tract reorganization is crucial for developing therapies to enhance recovery after such injuries, including targeted rehabilitation and novel pharmacotherapies. Experimental data suggest a promising future with potential advances in neurotechnologies and alignment of preclinical studies with human clinical trials.
NEURAL REGENERATION RESEARCH
(2021)
Article
Medicine, Research & Experimental
Linglong Xiao, Huaping Zheng, Jing Li, Meiqin Zeng, Dian He, Jianhao Liang, Kaijian Sun, Yunhao Luo, Feng Li, Baohong Ping, Wen Yuan, Hongwei Zhou, Qinghua Wang, Haitao Sun
Summary: This study investigated the effects of selective NLRP3 inflammasome inhibitor MCC950 on gut microbiota and corticospinal tract (CST) injury after intracerebral hemorrhage (ICH). The results showed that MCC950 modulated gut microbiota, alleviated CST injury located in the cervical enlargement of the spinal cord, and ameliorated neurological deficits after ICH.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Editorial Material
Cell & Tissue Engineering
Armin Blesch
Article
Cell & Tissue Engineering
Beatrice Sandner, Mareva Ciatipis, Melanie Motsch, Irina Soljanik, Norbert Weidner, Armin Blesch
CELL TRANSPLANTATION
(2016)
Article
Neurosciences
Andrew S. Jack, Caitlin Hurd, Juan Forero, Andrew Nataraj, Keith Fenrich, Armin Blesch, Karim Fouad
JOURNAL OF NEUROSCIENCE RESEARCH
(2018)
Review
Anesthesiology
Timo A. Nees, Nanna B. Finnerup, Armin Blesch, Norbert Weidner
Article
Multidisciplinary Sciences
Wenhui Xiong, Xingjie Ping, Matthew S. Ripsch, Grace Santa Cruz Chavez, Heidi Elise Hannon, Kewen Jiang, Chunhui Bao, Vaishnavi Jadhav, Lifang Chen, Zhi Chai, Cungen Ma, Huangan Wu, Jianqiao Feng, Armin Blesch, Fletcher A. White, Xiaoming Jin
SCIENTIFIC REPORTS
(2017)
Article
Neurosciences
Ioana Goganau, Beatrice Sandner, Norbert Weidner, Karim Fouad, Armin Blesch
EXPERIMENTAL NEUROLOGY
(2018)
Article
Neurosciences
Beatrice Sandner, Radhika Puttagunta, Melanie Motsch, Frank Bradke, Joerg Ruschel, Armin Blesch, Norbert Weidner
EXPERIMENTAL NEUROLOGY
(2018)
Article
Critical Care Medicine
Christopher Sliwinski, Timo A. Nees, Radhika Puttagunta, Norbert Weidner, Armin Blesch
JOURNAL OF NEUROTRAUMA
(2018)
Editorial Material
Cell Biology
Shengwen Liu, Armin Blesch
NEURAL REGENERATION RESEARCH
(2018)
Article
Cell & Tissue Engineering
Thomas Schackel, Prateek Kumar, Manuel Guenther, Shengwen Liu, Manuel Brunner, Beatrice Sandner, Radhika Puttagunta, Rainer Mueller, Norbert Weidner, Armin Blesch
TISSUE ENGINEERING PART A
(2019)
Article
Biochemistry & Molecular Biology
Karin Loew, Kornelia Hardes, Chiara Fedeli, Nabil G. Seidah, Daniel B. Constam, Antonella Pasquato, Torsten Steinmetzer, Alexandre Roulin, Stefan Kunz
Article
Multidisciplinary Sciences
Karin Loew, Anne-Lyse Ducrest, Luis M. San-Jose, Celine Simon, Vera Uva, Nabil G. Seidah, Antonella Pasquato, Stefan Kunz, Alexandre Roulin
Article
Biochemistry & Molecular Biology
Karin Low, Alexandre Roulin, Stefan Kunz
Review
Cell Biology
Camila Marques de Freria, Erna Van Niekerk, Armin Blesch, Paul Lu
Summary: Spinal cord injury leads to irreversible functional impairment due to neuronal loss and disruption of connections, but neural stem cell therapy shows promising potential in promoting axonal regeneration and forming new connections. This therapy has implications for improving motor systems, including the corticospinal tract, and restoring sensory feedback in SCI patients.
Article
Engineering, Biomedical
Shengwen Liu, Beatrice Sandner, Thomas Schackel, LaShae Nicholson, Abdelwahed Chtarto, Liliane Tenenbaum, Radhika Puttagunta, Rainer Mueller, Norbert Weidner, Armin Blesch
ACTA BIOMATERIALIA
(2017)