Editorial Material
Biochemistry & Molecular Biology
Mert Erginkaya, M. Eugenia Chiappe
Summary: Processing visual motion cues is crucial for animals to interpret self-motion, the movement of others, and the environment's structure, regardless of being prey or predator. A recent study in Drosophila has identified multiple pathways that are likely to contribute to visual motion-dependent computations and behaviors.
Article
Engineering, Chemical
Wentao Zhang, Jianjun Liang, Longmiao Yuan, Ruijie Li, Leiping Shi, E. Zhengyang, Jiayu Song, Yaqiong Dong, Ping Li, Qiaohui Fan
Summary: This study investigated the photocatalytic oxidation and sequestration behaviors of As(III) on beta-FeOOH/GO heteroaggregates. The results showed that the beta-FeOOH phase enhanced the sorption of As(III) and promoted its photocatalytic oxidation.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Neurosciences
Yongfa Zhang, Fei Wang, Jie Sui
Summary: Recent research supports a fundamental self hypothesis, suggesting that the self is a baseline function of the brain that regulates cognitive processing and behavior. Understanding this hypothesis can help identify the emergence of self-biased behaviors and predict the influence of brain signals at rest on such behaviors.
Article
Biology
Liliana Sokol, Anne Cuypers, Anh-Co K. Truong, Ann Bouche, Katleen Brepoels, Joris Souffreau, Katerina Rohlenova, Stefan Vinckier, Luc Schoonjans, Guy Eelen, Mieke Dewerchin, Laura P. M. H. de Rooij, Peter Carmeliet
Summary: Translation of academic results into clinical practice is a significant challenge. In this study, the authors addressed this challenge by prioritizing and validating potential target genes from single-cell RNA-sequencing data. They focused on tip endothelial cell markers and identified four candidates that showed tip EC characteristics. This study highlights the importance of targeted assessment and prioritization of candidate genes for successful translation into clinical practice.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biochemical Research Methods
Aastha Khatiwada, Bethany J. Wolf, Ayse Selen Yilmaz, Paula S. Ramos, Maciej Pietrzak, Andrew Lawson, Kelly J. Hunt, Hang J. Kim, Dongjun Chung
Summary: This study proposes a method called GPA-Tree, which improves association mapping and enhances understanding of the underlying genetic architecture and mechanisms of complex traits. Through simulation and application to GWAS data on a specific disease (SLE), the study demonstrates the superiority of GPA-Tree in detecting risk-associated SNPs and identifying true combinations of functional annotations.
Article
Endocrinology & Metabolism
Wei Xuan Tan, Xueling Sim, Chin Meng Khoo, Adrian K. K. Teo
Summary: This Perspective article examines the tools and platforms that can be used to prioritize candidate genes associated with an increased risk of type 2 diabetes mellitus (T2DM) for functional validation. Despite the identification of numerous genetic variants associated with T2DM, translating these findings into potential drug targets has been limited. The article discusses the potential of different approaches, such as sequencing data with increased sample size and ethnic diversity, single-cell omics data, and glycaemic trait associations, to strengthen gene functionalization workflows and expedite our understanding of T2DM genetic mechanisms.
NATURE REVIEWS ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Ruth Chia, Sara Saez-Atienzar, Natalie Murphy, Adriano Chio, Cornelis Blauwendraat, Ricardo H. Roda, Pentti J. Tienari, Henry J. Kaminski, Roberta Ricciardi, Melania Guida, Anna De Rosa, Loredana Petrucci, Amelia Evoli, Carlo Provenzano, Daniel B. Drachman, Bryan J. Traynor
Summary: This study identified genetic risk loci associated with myasthenia gravis through a genome-wide association study and demonstrated different genetic risk factors between early-onset and late-onset cases. Genetic correlation analysis also revealed a genetic link between myasthenia gravis and other autoimmune diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Aina Colomer-Vilaplana, Jesus Murga-Moreno, Aleix Canalda-Baltrons, Clara Inserte, Daniel Soto, Marta Coronado-Zamora, Antonio Barbadilla, Sonia Casillas
Summary: This study introduces PopHumanVar, an interactive online application designed to facilitate the exploration and thorough analysis of candidate genomic regions to identify variants potentially responsible for recent selective sweeps. It integrates functional and population genomics data, providing useful summary reports and gathering information from various databases to accurately estimate selection statistics and known causal variants. PopHumanVar successfully identifies causal variants in frequently reported candidate selection regions, such as EDAR, ACKR1 (DARC), and LCT/MCM6 in different populations.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Chemistry, Physical
Basudev Baral, Lekha Paramanik, Kulamani Parida
Summary: Efficient interfacial exciton transfer and separation are found to enhance photo-activity efficiency in a semiconductor ternary hybrid photocatalyst. The material shows promising performance in detoxification and oxygen evolution, indicating potential applications in energy and environmental fields.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Mingming Qi, Bei Zhang, Lihong Jiang, Saijuan Xu, Chang Dong, Yi-Ling Du, Zhan Zhou, Lei Huang, Zhinan Xu, Jiazhang Lian
Summary: The PCR & Go system is a rapid construction tool for integrating multiple gene pathways into the chromosome of Saccharomyces cerevisiae, enabling efficient functional expression. By combining with the CRISPR/Cas9 system and a gRNA plasmid library, different numbers of gene pathways can be integrated and assembled into the yeast genome with high efficiency.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maliheh Najari Beidokhti, Alexander C. Bertalovitz, Weizhen Ji, Jorge McCormack, Lauren Jeffries, Emily Sempou, Mustafa K. Khokha, Thomas V. McDonald, Saquib A. Lakhani
Summary: Next-generation sequencing platforms are increasingly used in clinical genetic settings to improve diagnostic accuracy in families with suspected heritable diseases. A functional testing approach was described in this study to identify potential genetic variants associated with long QT syndrome in a family, leading to precise diagnosis and personalized clinical management. Functional characterization was found to be a valuable adjunct to in silico analyses of whole exome sequencing results.
MOLECULAR GENETICS AND GENOMICS
(2021)
Article
Thermodynamics
Radhika Wazalwar, Ashok M. Raichur
Summary: The addition of graphene oxide (GO) and p-Phenylenediamine functionalized graphene oxide (fGO) to tetra-functional epoxy resulted in lower activation energy for curing behavior, indicating a more efficient curing process compared to neat epoxy. This was attributed to the amine groups on the surface of the filler, acting as a secondary hardener that triggered the epoxy ring opening reaction.
THERMOCHIMICA ACTA
(2021)
Article
Chemistry, Physical
Ruojue Lin, Shengfang Lu, Ao Yang, Weifeng Shen, Jingzheng Ren
Summary: Hydrogen is gaining more attention for its low environmental impact and high energy density, but the sustainability priorities of different production pathways have not been determined. This study aims to develop a framework to assist in the sustainability-oriented selection of hydrogen production pathways, addressing the difficulty of hybrid information from different sources with a new method.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2021)
Review
Ecology
Steven L. Chown, Melodie A. McGeoch
Summary: This article provides a theory-based examination and empirical review of functional trait-based ecology in relation to animal invasions. Despite the increase in empirical research in this field, interspecific comparisons and assemblage studies are still relatively rare. Broad environmental tolerances, life history traits, and phenotypic plasticity mediate the success of animal invasions at different stages, while introduction effort remains a crucial factor.
ANNUAL REVIEW OF ECOLOGY EVOLUTION AND SYSTEMATICS
(2023)
Article
Clinical Neurology
Elisa Musto, Vivian W. Y. Liao, Katrine M. Johannesen, Christina D. Fenger, Damien Lederer, Kavitha Kothur, Katrina Fisk, Bruce Bennetts, Pascal Vrielynck, Delphine Delaby, Berten Ceulemans, Sarah Weckhuysen, Peter Sparber, Arjan Bouman, Simone Ardern-Holmes, Christopher Troedson, Domenica I. Battaglia, Himanshu Goel, Timothy Feyma, Somayeh Bakhtiari, Linda Tjoa, Martin Boxill, Nina Demina, Olga Shchagina, Elena Dadali, Michael Kruer, Gaetano Cantalupo, Ilaria Contaldo, Tilman Polster, Bertrand Isidor, Stefania M. Bova, Walid Fazeli, Leen Wouters, Maria J. Miranda, Francesca Darra, Elisa Pede, Diana Le Duc, Rami Abou Jamra, Sebastien Kury, Jacopo Proietti, Niamh Mcsweeney, Elly Brokamp, Peter Ian Andrews, Marie Gouray Garcia, Mary Chebib, Rikke S. Moller, Philip K. Ahring, Elena Gardella
Summary: By analyzing the functional effects and structural positions of GABRA1 variants, we were able to assign individuals into different clinical subgroups and establish correlations between genotypes and phenotypes. Variants with loss-of-function effects generally exhibited milder phenotypes, while variants with gain-of-function effects were associated with more severe neurodevelopmental disorders. These findings enhance our understanding of the pathomechanism of GABRA1-related disorders and provide a foundation for precision medicine treatments.
ANNALS OF NEUROLOGY
(2023)
Article
Nanoscience & Nanotechnology
Lei Wang, Chengli Yao, Jun Shen, Yunpeng Zhang, Gang Liu, Xinyuan Wu, Guojun Zhang
Summary: Eutectic high entropy alloys (EHEAs) are an important branch of high entropy alloy field due to their excellent mechanical properties and superior castability. This paper proposed a new method to design EHEAs by determining the formation of single-phase solid solution, successfully designing three EHEAs with microstructures composed of eutectic dendrites, and discussing the deformation mechanism of B2 phase compared to BCC phase.
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2022)
Article
Materials Science, Multidisciplinary
Lei Wang, Luhan Gao, Jun Shen, Yunpeng Zhang, Gang Liu, Pengkang Zhao, Guojun Zhang
Summary: In this study, a NiAl-33Cr-4.5Ta near-eutectic alloy was successfully designed and verified, showing well-aligned microstructure and mechanical properties. The directionally solidified (DS) alloy exhibited high fracture toughness and tensile ductility at room temperature. Fracture behavior was analyzed through crack propagation and fracture surface examination.
METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE
(2022)
Article
Nanoscience & Nanotechnology
Lei Wang, Xinyuan Wu, Haijun Su, Bo Deng, Gang Liu, Zhenhua Han, Yanning Su, Yuandong Huang, Yunpeng Zhang, Jun Shen, Guojun Zhang
Summary: A novel L1(2) nanoparticles-strengthened (CoFeNi)84Ti8V8 medium entropy alloy with excellent mechanical properties has been fabricated. The alloy exhibits high yield strength, ultimate tensile strength, and good ductility compared to the single-phase alloy, mainly due to the precipitation strengthening of L1(2) nanoparticles.
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2022)
Article
Geosciences, Multidisciplinary
Yan Tang, An Yin, Xi Xu, Kaixuan An, Yunpeng Zhang
Summary: Through provenance analysis of samples from the Songpan-Ganzi basin, this study concludes that the basin had a stable and locally sourced sediment system, with different sub-basins receiving sediments from different areas, which is consistent with the remnant ocean model.
Article
Materials Science, Multidisciplinary
Lin Qin, Yunfei Xie, Z. Z. Zhu, Yihang Tu, Jiawei Long, Chong Gao, Yunpeng Zhang, J. W. Cai, Tao Liu, En Li
Summary: Spin pumping induced inverse spin Hall effect (SP-ISHE) measurement is a commonly used technique for searching materials with strong charge-to-spin conversion efficiency. However, obtaining reliable quantitative ISHE voltage (VISHE) remains challenging in current experimental setups. To address this issue, we propose a new measurement approach using an air-substrate micro-strip waveguide device, which offers both convenient sample wiring and reliable measurement of VISHE.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2022)
Article
Engineering, Multidisciplinary
Yihang Tu, Ji Li, Jiawei Long, Lin Qin, Yunpeng Zhang, Yang Qiu, Meng Ge, Hu Zheng, En Li
Summary: This paper presents the application of microwave thermography in defect detection of absorbing coatings. The measurement principle of microwave thermography is studied by theoretical analysis and simulation, and an improved morphological edge detection algorithm based on dual-threshold segmentation is proposed to get defect features.
MEASUREMENT SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Congxue Hu, Tengyue Li, Yingqi Xu, Xinxin Zhang, Feng Li, Jing Bai, Jing Chen, Wenqi Jiang, Kaiyue Yang, Qi Ou, Xia Li, Peng Wang, Yunpeng Zhang
Summary: CellMarker 2.0 is an updated database that provides experimentally supported markers of various cell types in different tissues of human and mouse. It also offers web tools for analyzing single cell sequencing data.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Hongying Zhao, Xiangzhe Yin, Haotian Xu, Kailai Liu, Wangyang Liu, Lixia Wang, Caiyu Zhang, Lin Bo, Xicheng Lan, Shihua Lin, Ke Feng, Shangwei Ning, Yunpeng Zhang, Li Wang
Summary: The updated LncTarD 2.0 database is a comprehensive resource for studying the regulatory mechanisms of lncRNA in human diseases, and provides various tools for analysis and visualization.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Qiuyan Guo, Peng Wang, Qian Liu, Yangyang Hao, Yue Gao, Yue Qi, Rongji Xu, Hongyan Chen, Mengyu Xin, Xiaoting Wu, Rui Sun, Hui Zhi, Yunpeng Zhang, Shangwei Ning, Xia Li
Summary: Understanding the multilevel interplay contributing to cell development trajectories is crucial for precision medicine and therapeutic exploration in tumor development. The CellTracer database provides gene expression profiles and development trajectories of different cell populations, allowing users to explore significant alterations and crosstalk among genes, biological contexts, cell characteristics, and clinical treatments.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Tiantongfei Jiang, Weiwei Zhou, Qi Sheng, Jiaxin Yu, Yunjin Xie, Na Ding, Yunpeng Zhang, Juan Xu, Yongsheng Li
Summary: Single-cell transcriptome analysis using ImmCluster tool provides valuable insights into cellular heterogeneity and immune cell clustering in cancer microenvironments. It integrates large datasets from healthy tissues and tumor samples, and provides various analytic modules and online tools for exploring immune cell annotations.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Engineering, Electrical & Electronic
Chengyong Yu, Man Qiao, Chong Gao, Yunpeng Zhang, Yong Gao, Hu Zheng, En Li
Summary: This article proposes a novel measurement method using parallel-plate dielectric resonator (PPDR) to determine the complex permittivity of low-loss dielectric materials over a wide frequency range. The method utilizes coaxial probes placed symmetrically in the center of the PPDR to selectively excite TM0np resonant modes. By operating within specific frequency ranges, dielectric constants of cylindrical or disk-shaped samples can be accurately measured from less than 20 up to 110 GHz using high-order TM0np modes. The effectiveness of the PPDR method is verified through rigorous analysis, numerical validation, and experimental measurements on well-known materials.
IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES
(2023)
Article
Food Science & Technology
Peng Xu, Wenbin Sun, Kang Xu, Yunpeng Zhang, Qian Tan, Yiren Qing, Ranbing Yang
Summary: This study establishes a fast, non-destructive, and effective approach for defect detection in maize seeds based on hyperspectral imaging (HSI) technology combined with deep learning. The proposed CNN-FES model can effectively capture important feature information in the spectral data using a subset of 24 feature wavelengths. The designed CNN-ATM model achieves comparable classification performance with three commonly used machine learning methods and achieves high classification accuracy on both the training and test sets.
Article
Materials Science, Multidisciplinary
Shuangjun Ma, Long Wang, Yun Peng Zhang, Nan Zou, Mouhamadou A. Diop
Summary: Most of the existing studies depict microwaves as an effective heating technique for alumina sintering, but the limitations of experimental devices have hindered the identification of its effects. This study aims to directly compare the sintering behavior of alumina in microwave and standard heating, considering the electromagnetic and radiation interactions with aluminum oxides. The results show that microwave effects accelerate the densification process, especially in the initial and intermediate stages, but prevent achieving higher final density compared to standard sintering.
METALS AND MATERIALS INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Nannan Chen, Yunpeng Zhang, Emmanuel J. Rivera-Rodriguez, Albert D. Yu, Michael Hobin, Michael Rosbash, Leslie C. Griffith
Summary: It is found that many glutamatergic and GABAergic neurons also transcribe cholinergic genes but fail to accumulate cholinergic effector proteins in Drosophila. The suppression of cholinergic signaling is posttranscriptionally regulated by the microRNA miR-190. This posttranscriptional restriction provides a mechanism for reversible tuning of neuronal output.
Article
Engineering, Electrical & Electronic
Chong Gao, Liyan Dai, Yong Gao, Yunpeng Zhang, Chengyong Yu, En Li, Hu Zheng, Zhuoyue Zhang
Summary: This letter proposes an improved cylindrical cavity for high-sensitivity detection. The cavity is characterized by symmetric double ridges inside, which compress the electric field and significantly improve the detection sensitivity. By optimizing the ridge parameters, considering the compromise between detection sensitivity, quality factor, and fabrication technique, the cavity design is determined. The proposed cavity shows higher sensitivity per unit volume (0.32%) compared to related research works.
IEEE MICROWAVE AND WIRELESS TECHNOLOGY LETTERS
(2023)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.
