Article
Zoology
Zoe Holbrook, Tim P. Bean, Sharon A. Lynch, Chris Hauton
Summary: The decline of European flat oysters not only affects the coastal economies and marine environment of Europe, but also poses challenges in restoring their habitat. The importance of disease-resistant, tolerant, and resilient oysters in restoration efforts is discussed, highlighting the need for collaboration among experts to establish consensus on definitions and applications. Failure to act now may lead to the spread of disease to new locations and populations in the future, underscoring the significance of robust definitions in marine management regulations.
JOURNAL OF INVERTEBRATE PATHOLOGY
(2021)
Article
Engineering, Marine
Drazen Oraic, Relja Beck, Zeljko Pavlinec, Ivana Giovanna Zupicic, Ljupka Maltar, Tihana Miskic, Zaklin Acinger-Rogic, Snjezana Zrncic
Summary: The annual production of European flat oysters in Croatia is about 50 to 65 tons and has a long tradition. A national surveillance program detected the presence of Bonamia spp. parasite since 2016, with no mortalities reported, calling for further molecular and epidemiological studies.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2021)
Article
Immunology
Nicolas Merou, Cyrielle Lecadet, Martin Ubertini, Stephane Pouvreau, Isabelle Arzul
Summary: This study investigated the dynamics of M. refringens and B. ostreae in Rade of Brest, France. M. refringens was found to be present in flat oysters and all sampled environmental compartments, indicating its wider environmental distribution. In contrast, B. ostreae had low prevalence in flat oysters and was rarely detected in planktonic and benthic compartments. Planktonic and benthic compartments play a key role in the transmission and overwintering of M. refringens.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Fisheries
Pauline Kamermans, Ainhoa Blanco, Pim van Dalen, Marc Engelsma, Nienke Bakker, Pascalle Jacobs, Marco Dubbeldam, Ines M. Sambade, Manuel Vera, Paulino Martinez
Summary: This study collected infected flat oysters (Ostrea edulis) with the pathogenic parasite Bonamia ostreae in the Dutch Delta area and successfully selected individuals with Bonamia resistance to produce Bonamia-free larvae. The results showed that it is possible to screen for individuals with resistance to Bonamia during the hatchery production of flat oysters. Evaluation: 8 points.
AQUATIC LIVING RESOURCES
(2023)
Article
Environmental Sciences
Sebastian Hernandis, Fiz da Costa, Angel Hernandez-Contreras, Marina Albentosa
Summary: The Mar Menor lagoon in Spain has experienced severe eutrophication, leading to a decline in the population of flat oysters and loss of their habitats not only in the lagoon but also in European seas. The Mar Menor Oyster Initiative aims to understand the nutrient extraction capability of flat oysters and develop tools for restoration and bioextraction. The RemediOS project, part of the initiative, focuses on obtaining oyster seed from local broodstock for population restoration. This study presents the results of the first attempt at reproducing Mar Menor local broodstock in captivity.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Ecology
Per Bergstrom, Linnea Thorngren, Mats Lindegarth
Summary: Human activities are increasingly affecting marine coastal areas, resulting in changes in species and habitat distributions. Understanding these patterns and their causes and consequences is crucial for the conservation and restoration of these evolving habitats.
ECOLOGY AND EVOLUTION
(2022)
Article
Immunology
Germain Chevignon, Aurelie Dotto-Maurel, Delphine Serpin, Bruno Chollet, Isabelle Arzul
Summary: The flat oyster Ostrea edulis has been declining in many areas of the NE Atlantic due to over-exploitation and diseases like bonamiosis caused by the intracellular protozoan parasite Bonamia ostreae. We obtained the first transcriptome of B. ostreae, which will greatly contribute to understanding its biology and developing new diagnostic tools.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Environmental Sciences
Erica C. N. Chapman, Ana Rodriguez-Perez, Tristan Hugh-Jones, Cass Bromley, Mark A. James, Karen Diele, William G. Sanderson
Summary: This study investigated temporal and spatial abundance patterns of European oyster larvae in Loch Ryan, Scotland, UK, finding that temperature is the most significant seasonal predictor of larval abundance, peaking at 617 degree-days. Additionally, oyster larval abundance did not significantly vary between habitats but was significantly higher in the mid and near-surface part of the water column.
MARINE POLLUTION BULLETIN
(2021)
Article
Evolutionary Biology
Ines Martinez Sambade, Adrian Casanova, Andres Blanco, Manu K. Gundappa, Tim P. Bean, Daniel J. Macqueen, Ross D. Houston, Antonio Villalba, Manuel Vera, Pauline Kamermans, Paulino Martinez
Summary: This study used a flat oyster SNP array to validate outlier loci associated with Bonamia ostreae in European flat oysters. The results showed that there were differences in genetic diversity and differentiation between outlier loci and neutral markers, with outlier loci mainly located on chromosome 8 of the flat oyster genome. Genes in this genomic region may be associated with resilience mechanisms to the parasite.
EVOLUTIONARY APPLICATIONS
(2022)
Article
Genetics & Heredity
Carolina Penaloza, Agustin Barria, Athina Papadopoulou, Chantelle Hooper, Joanne Preston, Matthew Green, Luke Helmer, Jacob Kean-Hammerson, Jennifer C. Nascimento-Schulze, Diana Minardi, Manu Kumar Gundappa, Daniel J. Macqueen, John Hamilton, Ross D. Houston, Tim P. Bean
Summary: The study evaluated the potential of genomic selection for improving growth traits in European flat oyster populations. The heritability of growth traits was low to moderate, and a polygenic architecture was observed. Genomic prediction accuracies using low-density SNP panels were high.
FRONTIERS IN GENETICS
(2022)
Article
Multidisciplinary Sciences
Sarah Hayer, Dirk Brandis, Alexander Immel, Julian Susat, Montserrat Torres-Oliva, Christine Ewers-Saucedo, Ben Krause-Kyora
Summary: The research successfully depicted the historical population structure of the European flat oyster Ostrea edulis, identifying four haplogroups with one having a patchy distribution from the North Sea to the Atlantic coast of France, while the other three are restricted to narrow geographic ranges. The phylogenetic reconstruction suggested the signatures of glacial refugia and postglacial expansion, showing a temporally stable population genetic pattern over the past 150 years despite large-scale translocations. The discovery of an autochthonous population in the German and Danish Wadden Sea in the late nineteenth century, where O. edulis is extinct today, hints at a connection between the genetic background of O. edulis in the Wadden Sea and its absence until today.
SCIENTIFIC REPORTS
(2021)
Article
Evolutionary Biology
Sylvie Lapegue, Celine Reisser, Estelle Harrang, Serge Heurtebise, Nicolas Bierne
Summary: Oyster reefs have suffered the greatest losses among all marine ecosystems. Efforts have been made to restore these ecosystems, and a recent study focused on the genetic differentiation among oyster populations in Europe. The study detected genetic differentiation between Atlantic and Mediterranean populations, identified potential aquaculture-related translocations, and found a parallel pattern of differentiation between certain populations. This information will be useful for the selection of animals for translocation and restocking.
EVOLUTIONARY APPLICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Xinchun Li, Yitian Bai, Zhen Dong, Chengxun Xu, Shikai Liu, Hong Yu, Lingfeng Kong, Qi Li
Summary: The European flat oyster (Ostrea edulis), an endangered and economically important species, has been found to possess a high-quality chromosome-level genome assembly. The genome contains a large number of protein-coding genes and repeat sequences, and shows evidence of population shaping by breeding habit and historical climatic change. The genome also exhibits unique features, such as a novel Hox gene cluster rearrangement, which makes it valuable for evolutionary studies. Additionally, the genome expansion of O. edulis contributes to its adaptation to various ecological factors. This chromosome-level assembly provides valuable insights and resources for genetic research, evolutionary studies, and conservation efforts of O. edulis.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS
(2023)
Article
Environmental Sciences
Oscar G. Bos, Stephanie Duarte-Pedrosa, Karin Didderen, Joost H. Bergsma, Sonia Heye, Pauline Kamermans
Summary: The study found that European flat oysters performed well in pilot projects in the Dutch North Sea, demonstrating good growth and reproductive capabilities. Translocated oysters showed a strong growth rate and were able to adapt to their new environment. No Bonamia virus was found in the pilot projects, indicating that the Dutch North Sea is still Bonamia-free.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Ecology
Marine Potet, Aurelie Fabien, Samuel Chaudemanche, Nassim Sebaibi, Theo Guillet, Sonia Gachelin, Helene Cochet, Mohamed Boutouil, Stephane Pouvreau
Summary: The European flat oyster, an important ecosystem engineer, has been disappearing from European coasts due to overexploitation, habitat degradation and disease. Conservation and restoration programs have been implemented to protect and manage the remaining populations. Studies have shown that microscale surface texture of concrete has a greater impact on larval settlement in artificial reef-building than concrete formulation.
ECOLOGICAL ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Maurine Hammel, Alexis Simon, Christine Arbiol, Antonio Villalba, Erika A. V. Burioli, Jean-Francois Pepin, Jean-Baptiste Lamy, Abdellah Benabdelmouna, Ismael Bernard, Maryline Houssin, Guillaume M. Charriere, Delphine Destoumieux-Garzon, John J. Welch, Michael J. Metzger, Nicolas Bierne
Summary: Transmissible cancers are parasitic malignant cell lineages that can infect new hosts from the same or related species. Two lineages of transmissible neoplasia, MtrBTN1 and MtrBTN2, have been identified in Mytilus mussels, both originating from a Mytilus trossulus founder individual.
Article
Fisheries
Nuria R. de la Ballina, Antonio Villalba, Asuncion Cao
Summary: Recovery of wild populations of the European flat oyster Ostrea edulis is crucial for ecosystem health and species conservation, given the decline of native oyster populations in European waters. This study aimed to explore differential functions between two main types of haemocytes in O. edulis and enrich the knowledge of its immune system through proteome comparison using mass spectrometry. The results revealed distinct protein profiles and signaling pathways relevant to immune response, specialization in phagocytosis processes, and differences in apoptotic and oxidative response between granulocytes and hyalinocytes.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Review
Immunology
Nuria R. de la Ballina, Francesco Maresca, Asuncion Cao, Antonio Villalba
Summary: Bivalve molluscs are ecologically successful and valuable commercial resources, with their immune defense function playing a crucial role in their success. Characterization of bivalve haemocyte subpopulations and their functional responses in immune reactions is essential for understanding the bivalve immune system. Studies often combine various assays to determine differences in immune-related activities and responses to stressors such as pathogens and pollution.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Environmental Sciences
Amalia Grau, Antonio Villalba, Jose I. Navas, Beatriz Hansjosten, Jose M. Valencia, Jose R. Garcia-March, Patricia Prado, Guillermo Follana-Berna, Titouan Morage, Maite Vazquez-Luis, Elvira alvarez, Pantelis Katharios, Christina Pavloudi, Elisabet Nebot-Colomer, Jose Tena-Medialdea, Monserrat Lopez-Sanmartin, Claire Peyran, Hrvoje Cizmek, Georgia Sarafidou, Yiannis Issaris, Inci Tueney-Kizilkaya, Salud Deudero, Serge Planes, Gaetano Catanese
Summary: This study investigates the role of various pathogens in the mass mortality event (MME) of the fan mussel Pinna nobilis in the Mediterranean Sea. The researchers found that infection by Haplosporidium pinnae played a major role in the onset and spread of the MME, while infection with mycobacteria was independent of the MME and associated with host size. Gram (-) bacteria were not associated with the MME.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Evolutionary Biology
Ines Martinez Sambade, Adrian Casanova, Andres Blanco, Manu K. Gundappa, Tim P. Bean, Daniel J. Macqueen, Ross D. Houston, Antonio Villalba, Manuel Vera, Pauline Kamermans, Paulino Martinez
Summary: This study used a flat oyster SNP array to validate outlier loci associated with Bonamia ostreae in European flat oysters. The results showed that there were differences in genetic diversity and differentiation between outlier loci and neutral markers, with outlier loci mainly located on chromosome 8 of the flat oyster genome. Genes in this genomic region may be associated with resilience mechanisms to the parasite.
EVOLUTIONARY APPLICATIONS
(2022)
Article
Zoology
Ilze Skujina, Chantelle Hooper, David Bass, Stephen W. Feist, Kelly S. Bateman, Antonio Villalba, Maria J. Carballal, David Iglesias, Asuncion Cao, Georgia M. Ward, David R. G. Ryder, John P. Bignell, Rose Kerr, Stuart Ross, Richard Hazelgrove, Nicolae A. Macarie, Melanie Prentice, Nathan King, Jamie Thorpe, Shelagh K. Malham, Niall J. McKeown, Joseph E. Ironside
Summary: A new species of Marteilia parasite, closely related to the parasite causing mass mortality in cockle fisheries in Spain, has been detected in Welsh cockle populations. This parasite is primarily located within inflammation areas in the gills and digestive gland of the cockles. The impact of this new species on Welsh fisheries is currently unknown.
JOURNAL OF INVERTEBRATE PATHOLOGY
(2022)
Article
Fisheries
Antonio Villalba, Maria Skazina, Seila Diaz, Angel P. Diz, Petr Strelkov
Summary: Histopathological analysis of soft-shell clams Mya arenaria collected from 2 northwest Russian locations revealed two pathological gill conditions, which may have a viral etiology.
DISEASES OF AQUATIC ORGANISMS
(2022)
Article
Ecology
Alessia Lunetta, Marina Albentosa, Elisabet Nebot-Colomer, Belen G. Pardo, Paulino Martinez, Antonio Villalba, Gemma Donato, Makanjuola Akinyemi, Maite Vazquez-Luis
Summary: The Mar Menor, a hypersaline coastal lagoon in Southeastern Spain, has suffered from severe eutrophication due to environmental events. A study assessed oyster recruitment, taxonomic allocation, and functionality in the lagoon. Oyster recruits were collected using spat collectors, and genetic analysis identified two species, Ostrea edulis and O. stentina. The majority of recruits (95%) were O. stentina. Laboratory experiments explored the growth rate and clearance measurements of oysters for potential bioremediation purposes.
REGIONAL STUDIES IN MARINE SCIENCE
(2023)
Article
Environmental Sciences
M. Pampin, A. Casanova, C. Fernandez, A. Blanco, M. Hermida, M. Vera, B. G. Pardo, R. M. Coimbra, A. Cao, D. Iglesias, M. J. Carballal, A. Villalba, P. Martinez
Summary: In this study, SNP markers associated with resilience to marteiliosis were identified using a population genomics approach. These markers can be used for obtaining cockle strains resilient to marteiliosis and restoring affected cockle beds. The selected SNPs were closely related to immune response, defense, and stress functions.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Fisheries
David Iglesias, Asuncion Cao, Maria J. Carballal, Antonio Villalba
Summary: A mass mortality of cockles in Galicia caused by Marteilia cochillia led to the collapse of the cockle fishery in 2012. However, since 2016, wild cockle populations have shown increased resistance to the parasite, potentially due to natural selection and a decrease in parasite abundance and/or virulence.
DISEASES OF AQUATIC ORGANISMS
(2023)
Article
Evolutionary Biology
Antonio Villalba, Raquel M. Coimbra, Marina Pampin, David Iglesias, Damian Costas, Carlos Marino, Andres Blanco, Manuel Vera, Marta Dominguez, Eva Cacabelos, Emilio Abella, Monica Incera, Rosa Fernandez Otero, Paulino Martinez
Summary: The common cockle in the Atlantic European coasts has developed resilience to the parasite Marteilia cochillia through natural selection after consecutive outbreaks. Researchers identified markers associated with this resilience and confirmed their role through experiments.
EVOLUTIONARY APPLICATIONS
(2023)
Article
Ecology
Manuel Vera, Sophie B. Wilmes, Francesco Maroso, Miguel Hermida, Andres Blanco, Adrian Casanova, David Iglesias, Asuncion Cao, Sarah C. Culloty, Kate Mahony, Francis Orvain, Carmen Bouza, Peter E. Robins, Shelagh K. Malham, Sharon Lynch, Antonio Villalba, Paulino Martinez
Summary: Knowledge of fine-scale genetic structure is critical for conserving genetic resources. Significant genetic structure has been found in marine species despite no visible barriers to gene flow. The study focused on the common cockle and analyzed two contrasting regions: the highly fragmented British Isles and the putatively homogeneous Galicia. The analysis of SNP data confirmed previous findings, and identified physical barriers and abiotic environmental factors as the main drivers of genetic structure. The results have implications for management policies and sustainable use of cockle resources in these regions and across the species' distribution range.
Article
Parasitology
Denis Benito, Urtzi Izagirre, Xabier Lekube, Benat Zaldibar, Antonio Villalba, Xavier De Montaudouin, Guillemine Daffe, Manu Soto, Oihane Diaz de Cerio
Summary: In recent field studies, suspected gymnophallid metacercariae were histologically located in the mantle of mussels from the Norwegian Sea. Mussels from the sites in which that infection was detected also presented abnormally high pearl numbers. This study identified Gymnophallus bursicola metacercariae infecting Norwegian Mytilus edulis and confirmed the parasitological origin of the pearls by extracting and amplifying parasite DNA from the core of the pearls for the first time.
Article
Oncology
Alicia L. Bruzos, Martin Santamarina, Daniel Garcia-Souto, Seila Diaz, Sara Rocha, Jorge Zamora, Yunah Lee, Alejandro Vina-Feas, Michael A. Quail, Iago Otero, Ana Pequeno-Valtierra, Javier Temes, Jorge Rodriguez-Castro, Leyre Aramburu, Andre Vidal-Capon, Antonio Villanueva, Damian Costas, Rosana Rodriguez, Tamara Prieto, Laura Tomas, Pilar Alvarino, Juana Alonso, Asuncion Cao, David Iglesias, Maria J. Carballal, Ana M. Amaral, Pablo Balseiro, Ricardo Calado, Bouchra El Khalfi, Urtzi Izagirre, Xavier de Montaudouin, Nicolas G. Pade, Ian Probert, Fernando Ricardo, Pamela Ruiz, Maria Skazina, Katarzyna Smolarz, Juan J. Pasantes, Antonio Villalba, Zemin Ning, Young Seok Ju, David Posada, Jonas Demeulemeester, Adrian Baez-Ortega, Jose M. C. Tubio
Summary: This study investigates the evolution of bivalve transmissible neoplasia in cockles and reveals the origins and factors influencing this disease. The study identifies two lineages of the disease with potential links to mitochondrial capture and host co-infection. The study also uncovers genomic instability and likely drivers of the disease, such as whole-genome duplication, oncogene amplification, and alkylation-repair suppression.
Article
Zoology
David Iglesias, Antonio Villalba, Carlos Marino, Edgar No, Maria J. Carballal
Summary: Despite the growing impact of marine disease outbreaks, the drivers behind them are poorly understood. A unique case study on cockles in Galician rias revealed that the introduction of the protistan Marteilia cochillia led to fishery collapse in 2012. However, intensive surveys over eight years showed evidence of increasing resistance to marteiliosis in the cockle population, possibly due to natural selection. Factors triggering marteiliosis outbreaks were analyzed, but no clear relationships were found. The findings have potential implications for managing diseased populations, but continued research is needed.
JOURNAL OF INVERTEBRATE PATHOLOGY
(2023)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.