Article
Biochemistry & Molecular Biology
Rachel Gingold-Belfer, Gania Kessler-Icekson, Sara Morgenstern, Lea Rath-Wolfson, Romy Zemel, Doron Boltin, Zohar Levi, Michal Herman-Edelstein
Summary: The study showed dysregulation of the POPDC1 and POPDC3 genes in the transition from intestinal metaplasia to gastric cancer, suggesting a role in tumor suppression and highlighting them as potential biomarkers and treatment targets for gastric cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Shuangshuang Fang, Yuhan Fu, Sijing Du, Lin Wang, Xiangli Qing, Xiaoying Luo, Gengqing Song, Yang Yang, Wei Wei
Summary: This study conducted a meta-analysis to evaluate the value of EGGIM in the histological assessment of gastric intestinal metaplasia. The results showed that EGGIM is highly consistent with OLGIM, and patients with EGGIM(5-10) have a higher risk for early gastric cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Paulius Jonaitis, Limas Kupcinskas, Juozas Kupcinskas
Summary: Gastric cancer is a common cause of mortality worldwide, with intestinal metaplasia considered a key factor in its development. Recent research has identified various molecular alterations in intestinal metaplasia, some of which show strong associations with the disease and potential for prevention and treatment, though study homogeneity is a key limiting factor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Fen Wu, Liying Yang, Yuhan Hao, Boyan Zhou, Jiyuan Hu, Yaohua Yang, Sukhleen Bedi, Navin Ganesh Sanichar, Charley Cheng, Guillermo Perez-Perez, Wenche Tseng, Wenzhi Tseng, Mengkao Tseng, Fritz Francois, Abraham R. Khan, Yihong Li, Martin J. Blaser, Xiao-ou Shu, Jirong Long, Huilin Li, Zhiheng Pei, Yu Chen
Summary: The study suggests that certain oral and gastric microbiota are associated with the development of gastric precancerous lesions, with some bacteria enriched in cases while others under-represented compared to controls. Inflammation-related pathways may play a role in this association.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Editorial Material
Oncology
James R. Goldenring
Summary: Intestinal-type gastric cancer can arise from precancerous metaplastic lineages, specifically from spasmolytic polypeptide-expressing metaplasia (SPEM) cells. A recent study identified an activating Kras(G12D) mutation in SPEM cells, which propagated into adenomatous and cancerous lesions, suggesting that SPEM lineages can serve as a direct precursor for dysplasia and intestinal-type gastric cancer.
JOURNAL OF PATHOLOGY
(2023)
Review
Oncology
Douglas Tjandra, Rita A. Busuttil, Alex Boussioutas
Summary: Gastric adenocarcinoma is a common and lethal cancer, often asymptomatic at early stages. Gastric intestinal metaplasia (GIM) is a premalignant lesion associated with chronic inflammation, predisposing to gastric cancer. This article summarizes the best clinical practice in the diagnosis, assessment and management of GIM, as well as opportunities for precision predictions in the future.
Article
Gastroenterology & Hepatology
Theresa H. Nguyen, Mimi C. Tan, Yan Liu, Massimo Rugge, Aaron P. Thrift, Hashem B. El-Serag
Summary: Hispanic and African American patients have a higher risk of gastric intestinal metaplasia detected by upper endoscopy biopsy compared to non-Hispanic white patients. This increased risk is partially independent of H. pylori infection.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Pathology
Ruth Zhang, Peter S. Rabinovitch, Aras N. Mattis, Gregory Y. Lauwers, Won-Tak Choi
Summary: The majority of gastric intestinal metaplasia samples lack the aneuploidy that characterizes gastric dysplasia or cancer. Presence of gastric intestinal metaplasia alone may not be sufficient to indicate an increased risk for gastric cancer, and other high-risk features should be considered.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Gastroenterology & Hepatology
Monika Laszkowska, Han Truong, Adam S. Faye, Judith Kim, Sarah Xinhui Tan, Francesca Lim, Julian A. Abrams, Chin Hur
Summary: 28% of individuals with GIM have the extensive subtype, and are more likely to be older and of Hispanic ethnicity. There was no difference in progression to GC between extensive and limited GIM. Further research is needed to better assess risk of GIM in the US context.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Masashi Kawamura, Noriya Uedo, Tomoyuki Koike, Takashi Kanesaka, Waku Hatta, Yohei Ogata, Tomoyuki Oikawa, Wataru Iwai, Satoshi Yokosawa, Junya Honda, Sho Asonuma, Hideki Okata, Motoki Ohyauchi, Hirotaka Ito, Yasuhiko Abe, Nobuyuki Ara, Shoichi Kayaba, Hirohiko Shinkai, Toshio Shimokawa
Summary: The OLGIM stage III/IV, high EGGIM score, and open-typed Kimura-Takemoto were strongly associated with GC risk in Japanese patients. The modified Kyoto classification risk scoring system, incorporating specific endoscopic findings, showed better performance in GC risk assessment compared to the original Kyoto classification.
DIGESTIVE ENDOSCOPY
(2022)
Article
Genetics & Heredity
Biao Song, Tingting Li, Yi Zhang, Qi Yang, Bei Pei, Yun Liu, Jieyu Wang, Gang Dong, Qin Sun, Shanshan Fan, Xuejun Li
Summary: This study identified and verified the role of ferroptosis-related genes (FRGs) in gastric intestinal metaplasia (IM) through bioinformatics analysis. The results showed that HMOX1 may be a diagnostic biomarker and therapeutic target for IM.
FRONTIERS IN GENETICS
(2023)
Article
Gastroenterology & Hepatology
Lusheng Song, Minkyo Song, Charles S. Rabkin, Yunro Chung, Stacy Williams, Javier Torres, Alejandro H. Corvalan, Robinson Gonzalez, Enrique Bellolio, Mahasish Shome, Joshua LaBaer, Ji Qiu, M. Constanza Camargo
Summary: Our study provides a comprehensive assessment of anti-H. pylori antibody profiles in gastric intestinal metaplasia (IM). The identified novel antibodies against target antigens, in addition to CagA, may play a role in the progression of IM. Specific H. pylori antibodies, along with other biomarkers, can help identify IM patients for surveillance.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Oncology
Ryo Sugimoto, Wataru Habano, Naoki Yanagawa, Risaburo Akasaka, Yosuke Toya, Akira Sasaki, Takayuki Matsumoto, Tamotsu Sugai
Summary: DNA methylation status and the mir34-b/c gene status have an impact on IM development in isolated samples of IMs and non-IM glands. HME was frequently found in isolated cancer glands, while MLH1 gene was not methylated in isolated non-IM glands.
Article
Microbiology
Zijing Xu, Ling Xiao, Shuaishuai Wang, Yuqin Cheng, Jianping Wu, Yufen Meng, Kaifan Bao, Junfeng Zhang, Chun Cheng
Summary: In this study, a rat model was used to investigate the biological mechanism of gastric intestinal metaplasia (GIM) induced by bile reflux. The results showed that GIM enhanced gastric fat digestion and absorption function, while impairing gastric acid secretion function. This effect might be mediated by the interactions among deoxycholic acid (DCA), Rikenellaceae RC9 gut group, RGD1311575 gene, and Fabp1 gene.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Cell Biology
Xinhua Liang, Wenjun Du, Ling Huang, Li Xiang, Wenxu Pan, Fangying Yang, Fengfeng Zheng, Yongwu Xie, Lanlan Geng, Sitang Gong, Wanfu Xu
Summary: This study found that Helicobacter pylori promotes gastric intestinal metaplasia through the kynurenine pathway of tryptophan metabolism, which activates CDX2 gene expression in gastric epithelial cells. Inhibition of kynurenine aminotransferase II (KAT2) activity can reverse the effect of H. pylori on CDX2 expression.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Multidisciplinary Sciences
Peng Wang, Chao Du, Fei-Xue Chen, Chang-Qing Li, Yan-Bo Yu, Ting Han, Suhail Akhtar, Xiu-Li Zuo, Xiao-Di Tan, Yan-Qing Li
SCIENTIFIC REPORTS
(2016)
Article
Gastroenterology & Hepatology
Chuan-Lian Chu, Yan-Bo Zhen, Guo-Ping Lv, Chang-Qing Li, Zhen Li, Qing-Qing Qi, Xiao-Meng Gu, Tao Yu, Ting-Guo Zhang, Cheng-Jun Zhou, Rui-Ji, Yan-Qing Li
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2012)
Article
Gastroenterology & Hepatology
Chang-Qing Li, Jun Liu, Rui Ji, Zhen Li, Xiang-Jun Xie, Yan-Qing Li
BMC GASTROENTEROLOGY
(2014)
Article
Gastroenterology & Hepatology
Ming Li, Xiu-Li Zuo, Tao Yu, Xiao-Meng Gu, Cheng-Jun Zhou, Zhen Li, Hong Liu, Rui Ji, Yan-Yan Dong, Chang-Qing Li, Yan-Qing Li
Article
Gastroenterology & Hepatology
Qing Qing Qi, Xiu Li Zuo, Chang Qing Li, Rui Ji, Zhen Li, Cheng Jun Zhou, Yan Qing Li
JOURNAL OF DIGESTIVE DISEASES
(2013)
Article
Gastroenterology & Hepatology
Xue Min Yuan, Zhen Li, Rui Ji, Chang Qing Li, Xiu Li Zuo, Tao Yu, Xiao Meng Gu, Jun Liu, Peng Wang, Ming Li, Yan Qing Li
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2014)
Article
Multidisciplinary Sciences
Jing Liu, Ming Li, Zhen Li, Xiu-Li Zuo, Chang-Qing Li, Yan-Yan Dong, Cheng-Jun Zhou, Yan-Qing Li
Article
Surgery
Rui Ji, Xiu-Li Zuo, Chang-Qing Li, Cheng-Jun Zhou, Yan-Qing Li
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2011)
Article
Gastroenterology & Hepatology
Chang-Qing Li, Ya Li, Xiu-Li Zuo, Rui Ji, Zhen Li, Xiao-Meng Gu, Tao Yu, Qing-Qing Qi, Cheng-Jun Zhou, Yan-Qing Li
WORLD JOURNAL OF GASTROENTEROLOGY
(2013)
Article
Multidisciplinary Sciences
Peng Wang, Fei-Xue Chen, Chao Du, Chang-Qing Li, Yan-Bo Yu, Xiu-Li Zuo, Yan-Qing Li
SCIENTIFIC REPORTS
(2015)
Meeting Abstract
Gastroenterology & Hepatology
C-Q Li, X-J Xie, T. Yu, X-M Gu, X-L Zuo, C-J Zhou, W-Q Huang, H. Chen, Y-Q Li
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2009)
