Article
Nutrition & Dietetics
Jinwang Li, Siyu Xie, Wendi Teng
Summary: Sulforaphane (SFA) has the potential to improve lipid metabolism, inhibit lipid accumulation and apoptosis, making it a potential candidate for preventing and treating nonalcoholic fatty liver disease (NAFLD).
Review
Immunology
Ke-qian Chen, Bo-yi Ke, Lu Cheng, Xiao-qing Yu, Zong-bao Wang, Shu-zhi Wang
Summary: With the development of the social economy, unhealthy living habits and eating styles are gradually affecting people's health in recent years. NAFLD, as a chronic liver disease, has become an increasingly serious public health problem due to these factors. Inflammasomes, as a protein complex, play a crucial role in the development of NAFLD and other diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Javier Ampuero, Rocio Aller, Rocio Gallego-Duran, Javier Crespo, Javier Abad, Agueda Gonzalez-Rodriguez, Judith Gomez-Camarero, Joan Caballeria, Oreste Lo Iacono, Luis Ibanez, Javier Garcia-Samaniego, Rosa Martin-Mateos, Ruben Frances, Conrado Fernandez-Rodriguez, Moises Diago, German Soriano, Raul J. Andrade, Raquel Latorre, Francisco Jorquera, Rosa M. Morillas, Desam Escudero, Pamela Estevez, Manuel Hernandez-Guerra, Salvador Augustin, Maria Jesus Pareja-Megia, Jesus M. Banales, Patricia Aspichueta, Salvador Benlloch, Jose Miguel Rosales, Javier Salmeron, Juan Turnes, Manuel Romero-Gomez
Summary: The study investigated the distribution of NASH and its components across fibrosis stages, revealing a decrease in steatohepatitis prevalence in advanced liver disease. However, most patients still showed inflammatory activity and metabolic disturbances. The risk of cirrhosis progression was similar between NASH and indeterminate NASH patients.
LIVER INTERNATIONAL
(2021)
Article
Nutrition & Dietetics
Hsuan-Chih Huang, Pei-Ni Lee, Wen-Chih Huang, Hsin-Yi Yang
Summary: This study found that the dietary intake of dehulled adlay may slow down the progression of NAFLD by improving hepatic steatosis, inflammation, oxidative stress, and gut dysbiosis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Amir M. Pirmoazen, Aman Khurana, Andreas M. Loening, Tie Liang, Vijay Shamdasani, Hua Xie, Ahmed El Kaffas, Aya Kamaya
Summary: In this study, we found that AC, Nakagami, SI, SS, MBF, and HRI have the best correlation with MRI-PDFF and show high diagnostic performance for detecting and classifying hepatic steatosis.
INVESTIGATIVE RADIOLOGY
(2022)
Review
Cell Biology
Amila Iriskic Atic, Maja Thiele, Alexander Munk, Louise Torp Dalgaard
Summary: MicroRNAs (miRNAs) secreted by the liver have the potential to be important biomarkers for nonalcoholic liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Several miRNAs, including miR-122, miR-21, miR-34a, miR-192, miR-193, and the miR-17-92 miRNA-cluster, are consistently associated with NAFLD/NASH. These miRNAs show potential as diagnostic markers for NAFLD/NASH, although more research is needed to understand their specificity and regulation.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Gastroenterology & Hepatology
Monika Adori, Sadam Bhat, Roberto Gramignoli, Ismael Valladolid-Acebes, Tore Bengtsson, Mathias Uhlen, Csaba Adori
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disorder. Increased sympathetic nerve tone and impaired liver sympathetic nerve functionality play complex roles in the development and progression of NAFLD. Lipid sensing by vagal afferent fibers also contributes to hepatic steatosis. Understanding the structural and functional changes in the hepatic nervous system may lead to targeted pharmacotherapeutic advances in NAFLD.
SEMINARS IN LIVER DISEASE
(2023)
Article
Immunology
Jingxuan Zhou, Nanhai Zhang, Adil Aldhahrani, Mohamed Mohamed Soliman, Liebing Zhang, Feng Zhou
Summary: Puerarin improves high-fat and high-fructose diet-induced nonalcoholic fatty liver disease (NAFLD) by modulating liver lipid accumulation, liver function, oxidative stress, and inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Guilherme da Silva Ferreira, Sergio Catanozi, Marisa Passarelli
Summary: Restriction in sodium intake is important for reducing cardiovascular diseases, but the influence on the development of nonalcoholic fatty liver disease (NAFLD) has been less studied. This systematic review compiled evidence from human and animal studies to examine the influence of dietary sodium intake patterns on NAFLD markers;
Article
Medicine, General & Internal
Jieun Chung, Hee-Sun Park, Young-Jun Kim, Mi-Hye Yu, Sungeun Park, Sung-Il Jung
Summary: This study investigated the association of hepatic steatosis determined by non-enhanced CT criteria with clinical parameters in a screening population. The presence of hepatic steatosis was significantly associated with levels of serum fasting glucose and triglycerides, the ALT/AST ratio, BMI, and HSI values. Logistic regression analysis revealed significant associations between serum fasting glucose level and HSI with hepatic steatosis using criterion (a), and between ALT/AST ratio and HSI with hepatic steatosis using criteria (b) and (c). Hepatic steatosis on non-enhanced CT should be considered to indicate possible clinical profile abnormalities regarding metabolic syndrome.
Article
Gastroenterology & Hepatology
Rui-Nan Zhang, Feng Shen, Qin Pan, Hai-Xia Cao, Guang-Yu Chen, Jian-Gao Fan
Summary: The study confirmed the association between PPARGC1A rs8192678 and NAFLD, and found that the risk A allele was related to more severe steatosis, higher activity, and NASH in NAFLD patients, independently of PNPLA3 rs738409.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mara Caputo, Yeshwant Kurhe, Sima Kumari, Emmelie Cansby, Manoj Amrutkar, Eli Scandalis, Sheri L. Booten, Marcus Stahlman, Jan Boren, Hanns-Ulrich Marschall, Mariam Aghajan, Margit Mahlapuu
Summary: This study identifies MST3 as a critical regulator of ectopic fat accumulation in human hepatocytes and shows that targeting MST3 signaling with ASOs can effectively mitigate NAFLD progression in obese mice. MST3 ASOs suppress lipogenic gene expression, reduce lipotoxicity-mediated oxidative and endoplasmic reticulum stress, and correlate with NAFLD severity in human liver biopsies. These findings suggest that MST3 inhibitors may offer a new strategy for treating NAFLD patients.
Review
Gastroenterology & Hepatology
Sang Bong Ahn
Summary: Nonalcoholic fatty liver disease (NAFLD) affects a significant portion of the global population and includes various stages such as nonalcoholic fatty liver, nonalcoholic steatohepatitis (NASH), and cirrhosis. Early detection and diagnosis of liver steatosis are important in preventing the progression of severe liver diseases. This report provides an overview of currently known serum biomarkers for liver steatosis and offers guidance on their practical application in clinical settings.
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Article
Plant Sciences
Rongshuang Huang, Fan Guo, Yanping Li, Yan Liang, Guobo Li, Ping Fu, Liang Ma
Summary: The study shows that low-dose triptolide can alleviate NAFLD-induced hepatic steatosis, inflammation, and fibrosis, while activating AMPK protein to prevent lipogenesis and fibrosis.
Article
Gastroenterology & Hepatology
George N. Ioannou, Sum P. Lee, Peter S. Linsley, Vivian Gersuk, Matthew M. Yeh, Yen-Ying Chen, Yi-Jen Peng, Moumita Dutta, Gabby Mascarinas, Bruk Molla, Julia Yue Cui, Christopher Savard
Summary: Under a high-cholesterol diet, Pcsk9 knockout mice exhibited increased hepatic free cholesterol and cholesterol crystals, along with more severe fibrosing steatohepatitis and a higher predisposition to liver cancer compared to wild-type mice.
HEPATOLOGY COMMUNICATIONS
(2022)
