Review
Immunology
Lauren W. Kaminsky, Rana Al-Sadi, Thomas Y. Ma
Summary: The intestinal epithelial tight junction (TJ) barrier plays a crucial role in intestinal diseases, especially inflammatory bowel diseases. The IL-1 beta-induced increase in intestinal TJ permeability is a key factor in the inflammatory process.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Environmental Sciences
Ha-Young Park, Jin-Hee Yu
Summary: This study investigated the effects of radiation on TJ-related proteins in an intestinal epithelial cell model. The results showed that X-ray exposure reduced cell viability, proliferation, and growth rate, while increasing intestinal permeability. The expression of TJ-related genes and proteins was also downregulated.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Food Science & Technology
Shen Zhuang, Ke Ming, Ning Ma, Jinrui Sun, Dehai Wang, Mingxing Ding, Yi Ding
Summary: A specific polysaccharide fraction (POPZ) from Portulaca oleracea L. was found to inhibit LPS-induced barrier injury and inflammatory responses in porcine intestinal epithelial monolayer, possibly through inactivating TLR4/NF-κB pathway and activating EGF/EGFR pathway.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Cell Biology
Yuju Kim, Yunna Lee, Gwangbeom Heo, Sihyun Jeong, Soyeong Park, Jin-Wook Yoo, Yunjin Jung, Eunok Im
Summary: The study found that PAR2-induced autophagy can maintain mucosal barrier integrity by regulating intestinal epithelial permeability, possibly through the β-arrestin-ERK1/2 pathway. Therefore, regulating PAR2 can be a suitable strategy for treating intestinal diseases.
Article
Food Science & Technology
Sefat E. Khuda, Ann V. Nguyen, Girdhari M. Sharma, Mohammad S. Alam, Kannan V. Balan, Kristina M. Williams
Summary: This study found that polysorbate-80 may enhance the absorption of allergens in a size-dependent manner by modulating paracellular permeability.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Microbiology
Yi Zhou, Ling Duan, Yan Zeng, Xu Song, Kangcheng Pan, Lili Niu, Yang Pu, Jiakun Li, Abdul Khalique, Jing Fang, Bo Jing, Dong Zeng, Bairong Shen, Xueqin Ni
Summary: The intestinal microbiota of captive pandas, characterized by a high abundance of Enterobacteriaceae, has led to intestinal infection. Probiotic supplement Lactiplantibacillus plantarum BSG201683 (L. plantarum G83) has shown effectiveness in improving intestinal barrier function and inflammation. In vitro studies demonstrated that L. plantarum G83 reduced paracellular permeability, decreased proinflammatory cytokines, and enhanced anti-inflammatory responses through Toll-like receptor 4/ nuclear factor kappa-B (TLR4/NF-?B) signaling pathways.
Article
Geriatrics & Gerontology
Kevin M. Najarro, Devin M. Boe, Travis M. Walrath, Juliet E. Mullen, Madison T. Paul, John H. Frankel, Holly J. Hulsebus, Juan-Pablo Idrovo, Rachel H. McMahan, Elizabeth J. Kovacs
Summary: The study demonstrates that advanced age exacerbates intestinal epithelial permeability after burn injury. Increased apoptosis may lead to elevated intestinal leakiness and bacterial accumulation in mesenteric lymph nodes, while S100a8/9 may serve as a biomarker for heightened inflammation in the intestine.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Cell Biology
Ashwinkumar Subramenium Ganapathy, Kushal Saha, Eric Suchanec, Vikash Singh, Aayush Verma, Gregory Yochum, Walter Koltun, Meghali Nighot, Thomas Ma, Prashant Nighot
Summary: This study revealed that increased clathrin-mediated endocytosis under starvation conditions promotes degradation of CLDN2 and enhances the TJ barrier. The association of CLDN2 with clathrin and AP2 as well as LC3 and lysosomes increased upon starvation, indicating the role of clathrin-mediated endocytosis in autophagy-induced CLDN2 degradation.
Article
Food Science & Technology
Jae Hoon Lee, Sera Kim, Min-Cheol Kang, Yong Gi Chun, Bum-Keun Kim, Kyung-Mo Song
Summary: This study confirms the protective effect of four nut oils on the damaged intestinal epithelial barrier. Nut oils improve barrier function, inhibit inflammatory response and cytokine production, and enhance the expression and distribution of tight junction proteins in damaged cells.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Biochemistry & Molecular Biology
Tracy Paradis, Herve Begue, Louise Basmaciyan, Frederic Dalle, Fabienne Bon
Summary: Tight junctions are crucial for maintaining the integrity and impermeability of the intestinal barrier, making them an ideal target for pathogens to breach the barrier. Pathogens use various strategies to destabilize the junctional network or modulate signaling pathways to attack the tight junctions and compromise gut barrier permeability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Marianne R. Spalinger, Anica Sayoc-Becerra, Christ Ordookhanian, Vinicius Canale, Alina N. Santos, Stephanie J. King, Moorthy Krishnan, Meera G. Nair, Michael Scharl, Declan F. McCole
Summary: Loss of PTPN2 compromises epithelial cell-macrophage interactions and barrier integrity, both of which can be corrected by tofacitinib in vitro and in vivo. Tofacitinib may have greater therapeutic efficacy in IBD patients with loss-of-function mutations in PTPN2.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Biochemistry & Molecular Biology
Zhi-Yuan Lu, Lin Feng, Wei-Dan Jiang, Pei Wu, Yang Liu, Xiao-Wan Jin, Hong-Mei Ren, Sheng-Yao Kuang, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Xiao-Qiu Zhou
Summary: This study focused on the protective effects of dietary mannoligosaccharides (MOS) supplementation on the intestinal structural integrity of grass carp. The results showed that dietary MOS supplementation protected the microvillus of the intestine, reduced mucosal permeability, and maintained intestinal structural integrity through the inhibition of MLCK and RhoA/ROCK signaling pathways. These findings highlight the positive impact of dietary MOS supplementation on intestinal health.
Article
Biochemistry & Molecular Biology
Huaping Tao, Zhiwei Bao, Zhengwei Fu, Yuanxiang Jin
Summary: Exposure to chlorothalonil (CTL) can induce structural and functional damage to the human IEB, leading to barrier dysfunction through the activation of the mitogen-activated protein kinase pathway.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Gastroenterology & Hepatology
Kushal Saha, Ashwinkumar Subramenium Ganapathy, Alexandra Wang, Nathan Michael Morris, Eric Suchanec, Wei Ding, Gregory Yochum, Walter Koltun, Meghali Nighot, Thomas Ma, Prashant Nighot
Summary: Inflammatory bowel disease (IBD) is associated with the loss of the protein occludin, which forms the epithelial barrier. Autophagy, a cell-survival mechanism, can upregulate occludin levels and enhance the tight junction barrier, protecting against barrier loss and inflammation-induced damage.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Agriculture, Multidisciplinary
Yunika Mayangsari, Natsumi Sugimachi, Wenxi Xu, Chinatsu Mano, Yuki Tanaka, Osamu Ueda, Tomohiro Sakuta, Yoshiharu Suzuki, Yoshinari Yamamoto, Takuya Suzuki
Summary: This study demonstrated that 3,5,7,3',4'- pentamethoxyflavone (PMF) can enhance the intestinal tight junction (TJ) barrier integrity by regulating the transcription of TJ proteins, such as occludin, claudin-3, and claudin-4.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
