RNA virus evolution at variable error rate

Alphavirus Mutator Variants Present Host-Specific Defects and Attenuation in Mammalian and Insect Models

(2014) Kathryn Rozen-Gagnon et al.   PLoS Pathogens

Variation in RNA Virus Mutation Rates across Host Cells

(2014) Marine Combe et al.   PLoS Pathogens

Evolution at increased error rate leads to the coexistence of multiple adaptive pathways in an RNA virus

(2013) Laura Cabanillas et al.   BMC EVOLUTIONARY BIOLOGY

Correlation Between Mutation Rate and Genome Size in Riboviruses: Mutation Rate of Bacteriophage Q 

(2013) K. Bradwell et al.   GENETICS

Variation of HIV-1 Mutation Spectra among Cell Types

(2013) C. M. Holtz et al.   JOURNAL OF VIROLOGY

Lethal Mutagenesis Failure May Augment Viral Adaptation

(2013) M. L. Paff et al.   MOLECULAR BIOLOGY AND EVOLUTION

The role of mutational robustness in RNA virus evolution

(2013) Adam S. Lauring et al.   NATURE REVIEWS MICROBIOLOGY

Experiments on the role of deleterious mutations as stepping stones in adaptive evolution

(2013) Arthur W. Covert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epistasis between mutations is host-dependent for an RNA virus

(2012) J. Lalic et al.   Biology Letters

Magnitude and sign epistasis among deleterious mutations in a positive-sense plant RNA virus

(2012) J Lalić et al.   HEREDITY

Molecular dissection of a viral quasispecies under mutagenic treatment: positive correlation between fitness loss and mutational load

(2012) A. Arias et al.   JOURNAL OF GENERAL VIROLOGY

Interrelationship between HIV-1 Fitness and Mutation Rate

(2012) Michael J. Dapp et al.   JOURNAL OF MOLECULAR BIOLOGY

Ribavirin-Resistant Mutants of Human Enterovirus 71 Express a High Replication Fidelity Phenotype during Growth in Cell Culture

(2012) Sara Sadeghipour et al.   JOURNAL OF VIROLOGY

Viral Quasispecies Evolution

(2012) E. Domingo et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Mutagenesis-Mediated Virus Extinction: Virus-Dependent Effect of Viral Load on Sensitivity to Lethal Defection

(2012) Héctor Moreno et al.   PLoS One

Coxsackievirus B3 mutator strains are attenuated in vivo

(2012) N. F. Gnadig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA virus genetic robustness: possible causes and some consequences

(2012) Santiago F Elena   Current Opinion in Virology

Exploring the Complexity of the HIV-1 Fitness Landscape

(2012) Roger D. Kouyos et al.   PLoS Genetics

Replicative Fitness Costs of Nonnucleoside Reverse Transcriptase Inhibitor Drug Resistance Mutations on HIV Subtype C

(2011) Kimberly L. Armstrong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Influence of Mutagenesis and Viral Load on the Sustained Low-Level Replication of an RNA Virus

(2011) Celia Perales et al.   JOURNAL OF MOLECULAR BIOLOGY

Mutational Robustness of an RNA Virus Influences Sensitivity to Lethal Mutagenesis

(2011) J. D. Graci et al.   JOURNAL OF VIROLOGY

Lethal Mutagenesis of Foot-and-Mouth Disease Virus Involves Shifts in Sequence Space

(2011) C. Perales et al.   JOURNAL OF VIROLOGY

Fitness Ranking of Individual Mutants Drives Patterns of Epistatic Interactions in HIV-1

(2011) Javier P. Martínez et al.   PLoS One

Ethanol and Reactive Species Increase Basal Sequence Heterogeneity of Hepatitis C Virus and Produce Variants with Reduced Susceptibility to Antivirals

(2011) Scott Seronello et al.   PLoS One

Fitness costs limit influenza A virus hemagglutinin glycosylation as an immune evasion strategy

(2011) S. R. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tempo and mode of inhibitor-mutagen antiviral therapies: A multidisciplinary approach

(2011) J. Iranzo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arbovirus high fidelity variant loses fitness in mosquitoes and mice

(2011) L. L. Coffey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of mutations conferring 5-azacytidine resistance in bacteriophage Qβ

(2011) María Arribas et al.   VIROLOGY

Lethal mutagenesis of viruses

(2011) Celia Perales et al.   Current Opinion in Virology

Effect of Host Species on the Distribution of Mutational Fitness Effects for an RNA Virus

(2011) Jasna Lalić et al.   PLoS Genetics

Epistasis between Beneficial Mutations and the Phenotype-to-Fitness Map for a ssDNA Virus

(2011) Darin R. Rokyta et al.   PLoS Genetics

Thermal Adaptation of Viruses and Bacteria

(2010) Peiqiu Chen et al.   BIOPHYSICAL JOURNAL

Selection for thermostability can lead to the emergence of mutational robustness in an RNA virus

(2010) P. DOMINGO-CALAP et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

Viral Mutation Rates

(2010) R. Sanjuan et al.   JOURNAL OF VIROLOGY

Host Alternation of Chikungunya Virus Increases Fitness while Restricting Population Diversity and Adaptability to Novel Selective Pressures

(2010) L. L. Coffey et al.   JOURNAL OF VIROLOGY

Rationalizing the development of live attenuated virus vaccines

(2010) Adam S Lauring et al.   NATURE BIOTECHNOLOGY

Mutational fitness effects in RNA and single-stranded DNA viruses: common patterns revealed by site-directed mutagenesis studies

(2010) R. Sanjuan   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Does Mutational Robustness Inhibit Extinction by Lethal Mutagenesis in Viral Populations?

(2010) Eamon B. O'Dea et al.   PLoS Computational Biology

Quasispecies Theory and the Behavior of RNA Viruses

(2010) Adam S. Lauring et al.   PLoS Pathogens

A Multi-Step Process of Viral Adaptation to a Mutagenic Nucleoside Analogue by Modulation of Transition Types Leads to Extinction-Escape

(2010) Rubén Agudo et al.   PLoS Pathogens

Fidelity Variants of RNA Dependent RNA Polymerases Uncover an Indirect, Mutagenic Activity of Amiloride Compounds

(2010) Laura I. Levi et al.   PLoS Pathogens

5-fluorouracil in lethal mutagenesis of foot-and-mouth disease virus

(2009) Rubén Agudo et al.   Future Medicinal Chemistry

5-Azacytidine Can Induce Lethal Mutagenesis in Human Immunodeficiency Virus Type 1

(2009) M. J. Dapp et al.   JOURNAL OF VIROLOGY

Epistatic Roles of E2 Glycoprotein Mutations in Adaption of Chikungunya Virus to Aedes Albopictus and Ae. Aegypti Mosquitoes

(2009) Konstantin A. Tsetsarkin et al.   PLoS One

Extremely High Mutation Rate of a Hammerhead Viroid

(2009) S. Gago et al.   SCIENCE

The Fitness Effects of Random Mutations in Single-Stranded DNA and RNA Bacteriophages

(2009) Pilar Domingo-Calap et al.   PLoS Genetics

Mosquitoes Put the Brake on Arbovirus Evolution: Experimental Evolution Reveals Slower Mutation Accumulation in Mosquito Than Vertebrate Cells

(2009) Nikos Vasilakis et al.   PLoS Pathogens

Topology of evolving, mutagenized viral populations: quasispecies expansion, compression, and operation of negative selection

(2008) Samuel Ojosnegros et al.   BMC EVOLUTIONARY BIOLOGY

Beneficial Effects of Population Bottlenecks in an RNA Virus Evolving at Increased Error Rate

(2008) Clara Cases-González et al.   JOURNAL OF MOLECULAR BIOLOGY

Determinants of RNA-Dependent RNA Polymerase (In)fidelity Revealed by Kinetic Analysis of the Polymerase Encoded by a Foot-and-Mouth Disease Virus Mutant with Reduced Sensitivity to Ribavirin

(2008) A. Arias et al.   JOURNAL OF VIROLOGY

Epistasis — the essential role of gene interactions in the structure and evolution of genetic systems

(2008) Patrick C. Phillips   NATURE REVIEWS GENETICS

No evidence of selection for mutational robustness during lethal mutagenesis of lymphocytic choriomeningitis virus

(2008) Verónica Martín et al.   VIROLOGY