Targeting the latest hallmark of cancer: another attempt at ‘magic bullet’ drugs targeting cancers’ metabolic phenotype

Metformin: A Diabetes Drug for Cancer, or a Cancer Drug for Diabetics?

(2012) Matthew Martin et al.   JOURNAL OF CLINICAL ONCOLOGY

Metformin elicits anticancer effects through the sequential modulation of DICER and c-MYC

(2012) Giovanni Blandino et al.   Nature Communications

PGC1  Promotes Tumor Growth by Inducing Gene Expression Programs Supporting Lipogenesis

(2011) K. Bhalla et al.   CANCER RESEARCH

Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF- B/IL-8 Pathway that Drives Tumor Angiogenesis

(2011) F. Vegran et al.   CANCER RESEARCH

Long-term Use of Cholesterol-Lowering Drugs and Cancer Incidence in a Large United States Cohort

(2011) E. J. Jacobs et al.   CANCER RESEARCH

Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells

(2011) Hiroto Izumi et al.   CANCER SCIENCE

N-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation

(2011) Carlotta Granchi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress

(2011) K. Zaugg et al.   GENES & DEVELOPMENT

The monocarboxylate transporter family-Structure and functional characterization

(2011) Andrew P. Halestrap   IUBMB LIFE

Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis

(2011) Fabio Pacchiano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Association of Statin Use With Pathological Tumor Characteristics and Prostate Cancer Recurrence After Surgery

(2011) Alison M. Mondul et al.   JOURNAL OF UROLOGY

Metformin and cancer: new applications for an old drug

(2011) Taxiarchis V. Kourelis et al.   MEDICAL ONCOLOGY

SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome

(2011) Matthew D. Hirschey et al.   MOLECULAR CELL

Increases in mitochondrial biogenesis impair carcinogenesis at multiple levels

(2011) Xiao Wang et al.   Molecular Oncology

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

(2011) Kristin M Nieman et al.   NATURE MEDICINE

Common cardiovascular medications in cancer therapeutics

(2011) Christos Vaklavas et al.   PHARMACOLOGY & THERAPEUTICS

Molecular Crowding Defines a Common Origin for the Warburg Effect in Proliferating Cells and the Lactate Threshold in Muscle Physiology

(2011) Alexei Vazquez et al.   PLoS One

Energy Metabolism in H460 Lung Cancer Cells: Effects of Histone Deacetylase Inhibitors

(2011) Nívea Dias Amoêdo et al.   PLoS One

Peroxisome proliferator-activated receptor-  coactivator 1-  (PGC1 ) is a metabolic regulator of intestinal epithelial cell fate

(2011) I. D'Errico et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adipose Triglyceride Lipase Contributes to Cancer-Associated Cachexia

(2011) S. K. Das et al.   SCIENCE

Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality

(2011) D. A. Chan et al.   Science Translational Medicine

Anticancer Targets in the Glycolytic Metabolism of Tumors: A Comprehensive Review

(2011) Paolo E. Porporato et al.   Frontiers in Pharmacology

Selection of Carbonic Anhydrase IX Inhibitors from One Million DNA-Encoded Compounds

(2010) Fabian Buller et al.   ACS Chemical Biology

Optical Detection of Single Cell Lactate Release for Cancer Metabolic Analysis

(2010) Xin Ting Zheng et al.   ANALYTICAL CHEMISTRY

Carbonic anhydrase inhibitors

(2010) Claudiu T. Supuran   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel inhibitors of basal glucose transport as potential anticancer agents

(2010) Weihe Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation

(2010) Jian-Bin Wang et al.   CANCER CELL

Inhibition of Glutaminase Preferentially Slows Growth of Glioma Cells with Mutant IDH1

(2010) M. J. Seltzer et al.   CANCER RESEARCH

Inhibitors of Lactate Dehydrogenase Isoforms and their Therapeutic Potentials

(2010) C. Granchi et al.   CURRENT MEDICINAL CHEMISTRY

Statin use and cancer risk: a comprehensive review

(2010) Denise M Boudreau et al.   Expert Opinion On Drug Safety

Carbonic anhydrase inhibition as a cancer therapy: a review of patent literature, 2007 – 2009

(2010) Sally-Ann Poulsen   EXPERT OPINION ON THERAPEUTIC PATENTS

Structure of the Human Fatty Acid Synthase KS–MAT Didomain as a Framework for Inhibitor Design

(2010) Günter Pappenberger et al.   JOURNAL OF MOLECULAR BIOLOGY

Jekyll and Hyde: the role of the microenvironment on the progression of cancer

(2010) Michael Allen et al.   JOURNAL OF PATHOLOGY

Mitochondrially targeted anti-cancer agents

(2010) Lucia Biasutto et al.   MITOCHONDRION

Recombinant yeast screen for new inhibitors of human acetyl-CoA carboxylase 2 identifies potential drugs to treat obesity

(2010) J. Marjanovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dysregulation of the mevalonate pathway promotes transformation

(2010) J. W. Clendening et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Modulation of Glioblastoma with Dichloroacetate

(2010) E. D. Michelakis et al.   Science Translational Medicine

Regulation of intermediary metabolism by protein acetylation

(2010) Kun-Liang Guan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Acetyl-CoA carboxylase-α inhibitor TOFA induces human cancer cell apoptosis

(2009) Chun Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7–10

(2009) Matthew J. Ovens et al.   BIOCHEMICAL JOURNAL

Identification of small molecule inhibitors of pyruvate kinase M2

(2009) Matthew G. Vander Heiden et al.   BIOCHEMICAL PHARMACOLOGY

De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy

(2009) T Mashima et al.   BRITISH JOURNAL OF CANCER

Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases

(2009) I. F. Robey et al.   CANCER RESEARCH

Suppression of Tumor Growth In vivo by the Mitocan  -tocopheryl Succinate Requires Respiratory Complex II

(2009) L.-F. Dong et al.   CLINICAL CANCER RESEARCH

Modulation of pentose phosphate pathway during cell cycle progression in human colon adenocarcinoma cell line HT29

(2009) Pedro Vizán et al.   INTERNATIONAL JOURNAL OF CANCER

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Malonyl-CoA decarboxylase inhibition is selectively cytotoxic to human breast cancer cells

(2009) W Zhou et al.   ONCOGENE

Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX

(2009) V. Alterio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

The Warburg Effect: Why and How Do Cancer Cells Activate Glycolysis in the Presence of Oxygen?

(2008) Miguel Lopez-Lazaro   Anti-Cancer Agents in Medicinal Chemistry

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

Arginine deiminase, a potential anti-tumor drug

(2008) Ye Ni et al.   CANCER LETTERS

ATP Citrate Lyase: Activation and Therapeutic Implications in Non-Small Cell Lung Cancer

(2008) T. Migita et al.   CANCER RESEARCH

Control of Cell Growth and Survival by Enzymes of the Fatty Acid Synthesis Pathway in HCT-116 Colon Cancer Cells

(2008) Y. Zhan et al.   CLINICAL CANCER RESEARCH

Discovery of GSK837149A, an inhibitor of human fatty acid synthase targeting the β-ketoacyl reductase reaction

(2008) María Jesús Vázquez et al.   FEBS Journal

Causes and Consequences of Increased Glucose Metabolism of Cancers

(2008) R. J. Gillies et al.   JOURNAL OF NUCLEAR MEDICINE

Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth

(2008) B. Clem et al.   MOLECULAR CANCER THERAPEUTICS