Dual- and triple-acting agents for treating core and co-morbid symptoms of major depression: novel concepts, new drugs

Antidepressant-like effects of serotonin type-3 antagonist, ondansetron: an investigation in behaviour-based rodent models

(2009) Rajkumar Ramamoorthy et al.   BEHAVIOURAL PHARMACOLOGY

Double-Blind, Randomized Comparison of Memantine and Escitalopram for the Treatment of Major Depressive Disorder Comorbid With Alcohol Dependence

(2009) Leea H. Muhonen et al.   JOURNAL OF CLINICAL PSYCHIATRY

A 6-Week Randomized, Placebo-Controlled Trial of CP-316,311 (a Selective CRH1Antagonist) in the Treatment of Major Depression

(2008) Brendon Binneman et al.   AMERICAN JOURNAL OF PSYCHIATRY

Is co-administration of bupropion with SSRIs and SNRIs in forced swimming test in mice, predictive of efficacy in resistant depression?

(2008) Corina Prica et al.   BEHAVIOURAL BRAIN RESEARCH

Circadian abnormalities, molecular clock genes and chronobiological treatments in depression

(2008) J. N. Bunney et al.   BRITISH MEDICAL BULLETIN

Recent Developments in the Design of Anti-Depressive Therapies: Targeting the Serotonin Transporter

(2008) S. Butler et al.   CURRENT MEDICINAL CHEMISTRY

From Single- to Multi-Target Drugs in Cancer Therapy: When Aspecificity Becomes an Advantage

(2008) S. Giordano et al.   CURRENT MEDICINAL CHEMISTRY

What Does Systems Biology Mean for Drug Development?

(2008) Andre Schrattenholz et al.   CURRENT MEDICINAL CHEMISTRY

5-HT1 Receptor Augmentation Strategies as Enhanced Efficacy Therapeutics for Psychiatric Disorders

(2008) Lee Dawson et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Pharmacological treatments of fibromyalgia: Do complex conditions need complex therapies?

(2008) Kim Lawson   DRUG DISCOVERY TODAY

Glucocorticoid antagonists in neuropsychotic disorders

(2008) Alan F. Schatzberg et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

In-vitro and in-vivo characterization of JNJ-7925476, a novel triple monoamine uptake inhibitor

(2008) Leah Aluisio et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The selective 5-HT6 receptor antagonist SB-399885 enhances anti-immobility action of antidepressants in rats

(2008) Anna Wesołowska et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cellular and behavioural profile of the novel, selective neurokinin1 receptor antagonist, vestipitant: A comparison to other agents

(2008) Mauricette Brocco et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

P.2.b.015 Lu AA21004: a novel potential treatment for mood disorders

(2008) N. Moore et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Escitalopram for the treatment of major depression and anxiety disorders

(2008) Cyril Höschl et al.   Expert Review of Neurotherapeutics

Protein networks in disease

(2008) T. Ideker et al.   GENOME RESEARCH

The melanin-concentrating hormone1 receptor antagonists, SNAP-7941 and GW3430, enhance social recognition and dialysate levels of acetylcholine in the frontal cortex of rats

(2008) Mark J. Millan et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

A Double-Blind Comparison of Sexual Functioning, Antidepressant Efficacy, and Tolerability Between Agomelatine and Venlafaxine XR

(2008) Sidney H. Kennedy et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Nicotinic Antagonist Augmentation of Selective Serotonin Reuptake Inhibitor-Refractory Major Depressive Disorder

(2008) Tony P. George et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Discovery of Potent, Orally Bioavailable, Selective 5-HT1A/B/DReceptor Antagonists

(2008) Simon E. Ward et al.   JOURNAL OF MEDICINAL CHEMISTRY

Exploiting Complexity and the Robustness of Network Architecture for Drug Discovery

(2008) M. K. Hellerstein   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Addressing circadian rhythm disturbances in depressed patients

(2008) RW Lam   JOURNAL OF PSYCHOPHARMACOLOGY

Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study

(2008) Rachelle S Doody et al.   LANCET

How can we realize the promise of personalized antidepressant medicines?

(2008) Florian Holsboer   NATURE REVIEWS NEUROSCIENCE

Confirmation of antidepressant potential of the selective β3 adrenoceptor agonist amibegron in an animal model of depression

(2008) David H. Overstreet et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Behavioral effects of saredutant, a tachykinin NK2 receptor antagonist, in experimental models of mood disorders under basal and stress-related conditions

(2008) Vincenzo Micale et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Antidepressant-like effect of the novel thiadiazolidinone NP031115 in mice

(2008) Angelo O. Rosa et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models

(2008) Anne Dekeyne et al.   PSYCHOPHARMACOLOGY

Drug Target Identification Using Side-Effect Similarity

(2008) M. Campillos et al.   SCIENCE

Cognitive Impairment in Schizophrenia: a Review of Developmental and Genetic Models, and Pro-cognitive Profile of the Optimised D3 > D2 Antagonist, S33138

(2008) Mark J. Millan et al.   THERAPIE

Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions

(2008) M MILLAN et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A role for the 5-HT1A, 5-HT4 and 5-HT6 receptors in learning and memory

(2008) M KING et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Novel paradigms for drug discovery: computational multitarget screening

(2008) E JENWITHEESUK et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Serotonin research: contributions to understanding psychoses

(2008) M GEYER et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors

(2007) Sungho Maeng et al.   BIOLOGICAL PSYCHIATRY

Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds

(2007) Lorna Piazzi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Effects of chronic desipramine treatment on α2-adrenoceptors and μ-opioid receptors in the guinea pig cortex and hippocampus

(2007) Cristina Giaroni et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Involvement of AMPA receptors in the antidepressant-like effects of lithium in the mouse tail suspension test and forced swim test

(2007) Todd D. Gould et al.   NEUROPHARMACOLOGY

Additional evidence for anxiolytic- and antidepressant-like activities of saredutant (SR48968), an antagonist at the neurokinin-2 receptor in various rodent-models

(2007) Caroline Louis et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

In vivo/ex vivo and behavioural study on central effects of 5-HT1B/1D and 5-HT1A antagonists in guinea pigs

(2007) A REX et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR