Replacing sulfa drugs with novel DHPS inhibitors

Transition States, Analogues, and Drug Development

(2012) Vern L. Schramm   ACS Chemical Biology

The 2012 Garrod Lecture: Discovery of antibacterial drugs in the 21st century

(2012) I. Chopra   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

2012 and beyond: potential for the start of a second pre-antibiotic era?

(2012) P. C. Appelbaum   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Para-Aminosalicylic Acid Acts as an Alternative Substrate of Folate Metabolism in Mycobacterium tuberculosis

(2012) S. Chakraborty et al.   SCIENCE

Catalysis and Sulfa Drug Resistance in Dihydropteroate Synthase

(2012) M.-K. Yun et al.   SCIENCE

Challenges of Antibacterial Discovery

(2011) L. L. Silver   CLINICAL MICROBIOLOGY REVIEWS

Crystal structures of Burkholderia cenocepacia dihydropteroate synthase in the apo-form and complexed with the product 7,8-dihydropteroate

(2011) Rachel E Morgan et al.   BMC STRUCTURAL BIOLOGY

Synthesis of bi-substrate state mimics of dihydropteroate synthase as potential inhibitors and molecular probes

(2010) Jianjun Qi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A Practical Use of Ligand Efficiency Indices Out of the Fragment-Based Approach: Ligand Efficiency-Guided Lead Identification of Soluble Epoxide Hydrolase Inhibitors

(2010) Daisuke Tanaka et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal Structure of the 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase•Dihydropteroate Synthase Bifunctional Enzyme from Francisella tularensis

(2010) Charles W. Pemble et al.   PLoS One

Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding

(2010) K. P. Romano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pneumocystis Pneumonia in Solid Organ Transplant Recipients

(2009) S. I. Martin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase

(2009) Kirk E. Hevener et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dihydropteroate synthase fromStreptococcus pneumoniae: structure, ligand recognition and mechanism of sulfonamide resistance

(2008) Colin Levy et al.   BIOCHEMICAL JOURNAL

Design and synthesis of benzenesulfonanilides active against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus

(2008) Kensuke Namba et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

(2008) Helen W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

Fragment-Based Approach to Drug??Lead Discovery

(2008) Daniela Fattori et al.   Drugs in research & development