Chromenes: potential new chemotherapeutic agents for cancer

2-Amino-3-cyano-4-(5-arylisoxazol-3-yl)-4H-chromenes: Synthesis and In Vitro Cytotoxic Activity

(2012) Tahmineh Akbarzadeh et al.   ARCHIV DER PHARMAZIE

Anti-proliferative and apoptotic effects of the derivatives from 4-aryl-4H-chromene family on human leukemia K562 cells

(2012) Hassan Aryapour et al.   ARCHIVES OF PHARMACAL RESEARCH

A domino Knoevenagel hetero-Diels–Alder reaction for the synthesis of polycyclic chromene derivatives and evaluation of their cytotoxicity

(2012) B.V. Subba Reddy et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New substituted 4H-chromenes as anticancer agents

(2012) Shivaputra A. Patil et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

2,4-Diaryl-5H-chromeno [4,3-b]pyridines: Synthesis, Topoisomerase I and II Inhibitory Activity, and Cytotoxicity

(2012) Pritam Thapa et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Cancer statistics, 2012

(2012) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Synthesis and in vitro antiproliferative activity of new 11-aminoalkylamino-substituted chromeno[2,3-b]indoles

(2012) Wei Peng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure–Activity Relationship (SAR) Study of Ethyl 2-Amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017) and the Potential of the Lead against Multidrug Resistance in Cancer Treatment

(2012) Gopalakrishnan Aridoss et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antitumor Agents. 289. Design, Synthesis, and Anti-Breast Cancer Activity in Vivo of 4-Amino-2H-benzo[h]chromen-2-one and 4-Amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one Analogues with Improved Water Solubility

(2012) Yizhou Dong et al.   JOURNAL OF NATURAL PRODUCTS

Polyalkoxy Substituted 4H-Chromenes: Synthesis by Domino Reaction and Anticancer Activity

(2012) Anatoliy M. Shestopalov et al.   ACS Combinatorial Science

Concomitant activation of caspase-9 and down-regulation of IAP proteins as a mechanism of apoptotic death in HepG2, T47D and HCT-116 cells upon exposure to a derivative from 4-aryl-4H-chromenes family

(2011) Majid Mahdavi et al.   BIOMEDICINE & PHARMACOTHERAPY

Synthesis, structure–activity relationship of novel substituted 4H-chromen-1,2,3,4-tetrahydropyrimidine-5-carboxylates as potential anti-mycobacterial and anticancer agents

(2011) B. China Raju et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

QSAR Study of 4-Aryl-4H-Chromenes as a New Series of Apoptosis Inducers Using Different Chemometric Tools

(2011) Mehdi Khoshneviszadeh et al.   Chemical Biology & Drug Design

Structure–Activity Relationship and Molecular Mechanisms of Ethyl 2-Amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017) and Its Analogues

(2011) Sonia G. Das et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent Advances in Semisynthesis, Biosynthesis, Biological Activities,Mode of Action, and Structure-Activity Relationship of Podophyllotoxins:An Update (2008-2010)

(2011) M. Lv et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Synthesis and in-vitro Cytotoxicity of Poly-functionalized 4-(2-Arylthiazol-4-yl)-4H-chromenes

(2010) Majid Mahmoodi et al.   ARCHIV DER PHARMAZIE

Design, Synthesis and Evaluation of Cytotoxicity of Novel Chromeno[4,3-b]quinoline Derivatives

(2010) Ramin Miri et al.   ARCHIV DER PHARMAZIE

Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents

(2010) Yizhou Dong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Antitumor agents 281. Design, synthesis, and biological activity of substituted 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogs (ATBO) as potent in vitro anticancer agents

(2010) Yizhou Dong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Antitumor Agents. 272. Structure−Activity Relationships and In Vivo Selective Anti-Breast Cancer Activity of Novel Neo-tanshinlactone Analogues

(2010) Yizhou Dong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-angiogenic/proliferative behavior of a “4-aryl-4H-chromene” on blood vessel’s endothelial cells: A possible evidence on dual “anti-tumor” activity

(2010) Kamran Mansouri et al.   MEDICINAL CHEMISTRY RESEARCH

Microtubule-binding agents: a dynamic field of cancer therapeutics

(2010) Charles Dumontet et al.   NATURE REVIEWS DRUG DISCOVERY

Structure−Activity Relationship and Molecular Mechanisms of Ethyl 2-Amino-4-(2-ethoxy-2-oxoethyl)-6-phenyl-4H-chromene-3-carboxylate (sHA 14-1) and Its Analogues

(2009) Sonia G. Das et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery and Optimization of Chromenotriazolopyrimidines as Potent Inhibitors of the Mouse Double Minute 2−Tumor Protein 53 Protein−Protein Interaction

(2009) John G. Allen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 4-aryl-2-oxo-2H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay

(2008) William Kemnitzer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Small Molecule Inhibitors of the p53-MDM2

(2008) Chun-Qi Hu et al.   CURRENT MEDICINAL CHEMISTRY

A Review on Hemisynthesis, Biosynthesis, Biological Activities, Mode of Action, and Structure-Activity Relationship of Podophyllotoxins: 2003- 2007

(2008) Hui Xu et al.   CURRENT MEDICINAL CHEMISTRY

Small-molecule inhibitors of the p53-HDM2 interaction for the treatment of cancer

(2008) Sharmila Patel et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Discovery of 4-Aryl-4H-chromenes as a New Series of Apoptosis Inducers Using a Cell- and Caspase-Based High Throughput Screening Assay. 4. Structure–Activity Relationships ofN-Alkyl Substituted Pyrrole Fused at the 7,8-Positions

(2008) William Kemnitzer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Biological Properties of Benzothiazole, Benzoxazole, and Chromen-4-one Analogues of the Potent Antitumor Agent 2-(3,4-Dimethoxyphenyl)-5-fluorobenzothiazole (PMX 610, NSC 721648)(1)

(2008) Stefania Aiello et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based HTS assay. Part 5: Modifications of the 2- and 3-positions

(2007) William Kemnitzer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

sHA 14-1, a stable and ROS-free antagonist against anti-apoptotic Bcl-2 proteins, bypasses drug resistances and synergizes cancer therapies in human leukemia cell

(2007) Defeng Tian et al.   CANCER LETTERS