Article
Chemistry, Multidisciplinary
Satish S. Phalake, Sandeep B. Somvanshi, Syed A. M. Tofail, Nanasaheb D. Thorat, Vishwajeet M. Khot
Summary: This study investigated the effectiveness of MIONP-based magneto-chemotherapy (MCT) in a 3D breast cancer model, using advanced 3D in vitro tumor models as a promising alternative to replicate the complete range of tumor characteristics. The results demonstrated that MCT using MIONPs reduced the viability of breast cancer cells, with the most promising therapeutic effects observed in the 3D cancer model.
Article
Chemistry, Multidisciplinary
Satish S. Phalake, Sandeep B. Somvanshi, Syed A. M. Tofail, Nanasaheb D. Thorat, Vishwajeet M. Khot
Summary: Localized heat generation from manganese iron oxide nanoparticles conjugated with chemotherapeutics under the exposure of an alternating magnetic field can revolutionize targeted breast cancer therapy. Advanced 3D in vitro tumor models are explored as a promising alternative to replicate the complete range of tumor characteristics. The effectiveness of magneto-chemotherapy using chitosan-coated MIONPs is investigated in a 3D breast cancer model, with successful reduction in cancer cell viability.
Review
Multidisciplinary Sciences
Md Sohel, Habiba Sultana, Tayeba Sultana, Md. Al Amin, Suraiya Aktar, Md. Chayan Ali, Zahed Bin Rahim, Md. Arju Hossain, Abdullah Al Mamun, Mohammad Nurul Amin, Raju Dash
Summary: This study summarizes the sources, pharmacological properties, and anticancer activities of Hesperetin (HSP) against various types of cancer. The results show that HSP can suppress tumor formation by targeting multiple cellular proteins and has the potential to overcome multidrug resistance. It also demonstrates better pharmacokinetic properties, making it a promising alternative drug for cancer treatment.
Letter
Chemistry, Medicinal
Alberto Boretti
Summary: Quercetin has a wide range of potential health benefits as it can act as a supplement or treatment for various conditions. It possesses antioxidant and anti-inflammatory properties, making it a potential cancer chemopreventive and chemotherapeutic agent that can kill cancer cells and possess senolytic properties. While clinical trials are needed for specific drug uses, it can be used as a general chemo-preventive supplement without contraindications.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Anil Ahsan, Zhiwei Liu, Ruibing Su, Chencai Liu, Xiaoqi Liao, Min Su
Summary: Selenium has a significant chemo-preventive effect on esophageal squamous cell carcinoma by reducing cell proliferation, DNA damage, and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
T. Kloskowski, K. Szeliski, K. Krzeszowiak, Z. Fekner, L. Kazimierski, A. Jundzill, T. Drewa, M. Pokrywczynska
Summary: The study found that Mumio exhibited significant cytotoxicity to urinary bladder cancer cells, while having minimal impact on normal cells. Mumio works by inhibiting the cell cycle of cancer cells and inducing apoptosis.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Duoli Xie, Zhuqian Wang, Jie Li, De-an Guo, Aiping Lu, Chao Liang
Summary: Osteosarcoma is an aggressive bone cancer with unknown molecular pathways, making it difficult to improve patient survival. Conventional therapies have severe side effects due to the lack of selectivity for malignant tissue. Researchers are exploring targeted treatment methods by combining specific ligands and chemotherapeutic agents to treat tumor cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Busra Dincer, Gizem Yildiztekin, Irfan Cinar
Summary: This study investigates the potential of combining agomelatine (AGO), a synthetic melatoninergic drug, with paclitaxel (PTX) for the treatment of breast cancer. The results show that AGO has cytotoxic effects on breast cancer cells similar to melatonin (MTN), and combining AGO and MTN with PTX shows synergistic effects. The study also reveals differences in molecular mechanisms and the importance of MTN receptors in breast cancer cell types.
CHEMISTRY & BIODIVERSITY
(2023)
Review
Biochemistry & Molecular Biology
Damiano Cirri, Francesco Bartoli, Alessandro Pratesi, Emma Baglini, Elisabetta Barresi, Tiziano Marzo
Summary: This article provides an overview of research approaches to improve metal-based agents for cancer and infection treatments. Despite the success of approved inorganic drugs in tumor chemotherapy, the discovery and clinical application of new inorganic drugs are slow and limited due to pharmaceutical industry influences.
Article
Food Science & Technology
Ai-Mei Liao, Bangrong Cai, Ji-Hong Huang, Ming Hui, Kyung-Ku Lee, Kwang Youl Lee, ChangJu Chun
Summary: The research on DG-Ara-C conjugate showed that DG can change the biomembrane affinity of Ara-C and successfully replace cholesterol during liposome preparation, demonstrating better anti-cancer activity.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Review
Pharmacology & Pharmacy
Jingyang Liu, Yang Yu, Cun Liu, Chundi Gao, Jing Zhuang, Lijuan Liu, Qibiao Wu, Wenzhe Ma, Qiming Zhang, Changgang Sun
Summary: Combining chemotherapy with immune checkpoint inhibitors has improved immunotherapy outcomes in cancer patients. However, the efficacy of chemotherapy monotherapy is limited by the immunosuppressive tumor microenvironment. To enhance the immunomodulatory effect of chemotherapy, researchers have proposed various strategies, including improving targeted distribution of chemotherapeutic agents and designing combination therapies.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Bingke Bai, Qianbo Chen, Rui Jing, Xuhui He, Hongrui Wang, Yanfei Ban, Qi Ye, Weiheng Xu, Chengjian Zheng
Summary: Prostate cancer is the second most common malignant cancer in males, and the cure remains challenging. Natural compounds have the potential to provide chemical agents for treatment. While natural products are becoming ideal choices for prostate cancer treatment, further research is still needed.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Prisha S. Patel, Christopher Castelow, Disha S. Patel, Syamal K. Bhattacharya, Cem Kuscu, Canan Kuscu, Liza Makowski, James D. Eason, Amandeep Bajwa
Summary: Triple negative breast cancer (TNBC) is an aggressive cancer with a high rate of treatment failure and poor prognosis. Mitochondria play key roles in oncogenesis and tumor progression through mechanisms such as altered metabolism, ROS production, and evasion of apoptosis. Studies show that mitochondrial infusion can effectively reduce glycolysis, enhance oxidative phosphorylation, reduce proliferation, and promote apoptosis as anti-tumor therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Yan-Nan Chi, Jia-Mei Yang, Ning Liu, Yan-Hong Cui, Lin Ma, Xiao-Bing Lan, Wen-Qian Ma, Yan-Jie Liu, Jian-Qiang Yu, Juan Du
Summary: Chemotherapeutic agents can cause death or activation acceleration of follicles and damage to blood vessels in the ovary, resulting in inflammation. There is a need for the development of drugs to protect the ovaries from injury. Although there are many preclinical studies on potential protective drugs, more clinical experiments are urgently needed to verify their potential use.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Chemistry, Medicinal
Valeria Ciaffaglione, Maria N. Modica, Valeria Pittala, Giuseppe Romeo, Loredana Salerno, Sebastiano Intagliata
Summary: This review discusses the progress made in the development of 5-FU-based mutual prodrugs over the past decade to improve therapeutic efficacy and achieve targeted delivery to cancer tissues, aiming to minimize toxicity to healthy cells and reduce side effects.
Article
Biochemistry & Molecular Biology
J. Niu, A. Xue, Y. Chi, J. Xue, W. Wang, Z. Zhao, M. Fan, C. H. Yang, Z-M Shao, L. M. Pfeffer, J. Wu, Z-H Wu
Article
Biochemistry & Molecular Biology
J. Xue, Y. Chi, Y. Chen, S. Huang, X. Ye, J. Niu, W. Wang, L. M. Pfeffer, Z-m Shao, Z-H Wu, J. Wu
Article
Biochemistry & Molecular Biology
Ruishan Wang, Andrew M. Davidoff, Lawrence M. Pfeffer
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2016)
Article
Oncology
Cezary Skobowiat, Allen S. W. Oak, Tae-Kang Kim, Chuan He Yang, Lawrence M. Pfeffer, Robert C. Tuckey, Andrzej T. Slominski
Article
Biochemistry & Molecular Biology
Suriyan Ponnusamy, Ryan D. Sullivan, Dahui You, Nadeem Zafar, Chuan He Yang, Thirumagal Thiyagarajan, Daniel L. Johnson, Maron L. Barrett, Nikki J. Koehler, Mayra Star, Erin J. Stephenson, Dave Bridges, Stephania A. Cormier, Lawrence M. Pfeffer, Ramesh Narayanan
HUMAN MOLECULAR GENETICS
(2017)
Article
Oncology
Chuan He Yang, Yinan Wang, Michelle Sims, Chun Cai, Ping He, Hans Hacker, Junming Yue, Jinjun Cheng, Frederick A. Boop, Lawrence M. Pfeffer
Article
Oncology
Wenying Huo, Guannan Zhao, Jinggang Yin, Xuan Ouyang, Yinan Wang, Chuanhe Yang, Baojing Wang, Peixin Dong, Zhixiang Wang, Hidemichi Watari, Edward Chaum, Lawrence M. Pfeffer, Junming Yue
Article
Oncology
Tao Zhang, Guannan Zhao, Chuanhe Yang, Peixin Dong, Hidemichi Watari, Lin Zeng, Lawrence M. Pfeffer, Junming Yue
Article
Chemistry, Medicinal
Chuanhe Yang, Yinan Wang, Michelle M. Sims, Yali He, Duane D. Miller, Lawrence M. Pfeffer
Summary: The study showed that PFI-3 can bind to BRDs in GBM cells, enhance the antiproliferative and cell death-inducing effects of TMZ in sensitive GBM cells, overcome chemoresistance in highly resistant GBM cells, and alter gene expression in GBM. Additionally, PFI-3 enhanced the anticancer effect of TMZ in an intracranial GBM animal model, leading to increased survival in animals with GBM tumors.
Review
Chemistry, Medicinal
Ronald Nicholas Laribee, Andrew B. Boucher, Saivikram Madireddy, Lawrence M. Pfeffer
Summary: This article explores the association between over-activation of autophagy and cell death in glioblastoma, as well as the inherent resistance of cancer stem cells to therapy. It suggests that autophagy promotes and maintains the stem-like state of cancer stem cells and contributes to their resistance to treatment.
Article
Chemistry, Medicinal
Debolina Ganguly, Chun Cai, Michelle M. Sims, Chuan He Yang, Matthew Thomas, Jinjun Cheng, Ali G. Saad, Lawrence M. Pfeffer
Article
Biochemistry & Molecular Biology
Ziyun Du, Chun Cai, Michelle Sims, Frederick A. Boop, Andrew M. Davidoff, Lawrence M. Pfeffer
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
Article
Biochemistry & Molecular Biology
Susan R. Pfeffer, Meiyun Fan, Ziyun Du, Chuan He Yang, Lawrence M. Pfeffer
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
Article
Biochemistry & Molecular Biology
Baojin Wang, Airong Shen, Xuan Ouyang, Guannan Zhao, Ziyun Du, Wenying Huo, Tao Zhang, Yinan Wang, Chuanhe Yang, Peixin Dong, Hidemichi Watari, Lawrence M. Pfeffer, Junming Yue
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
Article
Oncology
Aarti Sethuraman, Martin Brown, Tiffany N. Seagroves, Zhao-Hui Wu, Lawrence M. Pfeffer, Meiyun Fan
BREAST CANCER RESEARCH
(2016)
