Targeting protein arginine N-methyltransferases with peptide-based inhibitors: opportunities and challenges

Peptide Backbone Conformation Affects the Substrate Preference of Protein Arginine Methyltransferase I

(2012) Knut Kölbel et al.   BIOCHEMISTRY

Substrate-Induced Control of Product Formation by Protein Arginine Methyltransferase 1

(2012) Shanying Gui et al.   BIOCHEMISTRY

Protein arginine methyltransferases (PRMTs) as therapeutic targets

(2012) Boksik Cha et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Peptides and peptide conjugates: therapeutics on the upward path

(2012) Verena M Ahrens et al.   Future Medicinal Chemistry

Therapeutic peptides

(2012) Fernando Albericio et al.   Future Medicinal Chemistry

Pharmacophore-Based Virtual Screening and Biological Evaluation of Small Molecule Inhibitors for Protein Arginine Methylation

(2012) Juxian Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Analogues of the HIV-Tat peptide containing Nη-modified arginines as potent inhibitors of protein arginine N-methyltransferases

(2012) Peter 't Hart et al.   MedChemComm

Activity-Based Protein Profiling of Protein Arginine Methyltransferase 1

(2011) Obiamaka Obianyo et al.   ACS Chemical Biology

Structural basis for CARM1 inhibition by indole and pyrazole inhibitors

(2011) John S. Sack et al.   BIOCHEMICAL JOURNAL

Peptidic Partial Bisubstrates as Inhibitors of the Protein Arginine N-Methyltransferases

(2011) Peter 't Hart et al.   CHEMBIOCHEM

Small molecule inhibitors that discriminate between protein arginine N-methyltransferases PRMT1 and CARM1

(2011) James Dowden et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Nη-Substituted Arginyl Peptide Inhibitors of Protein ArginineN-Methyltransferases

(2010) Ted M. Lakowski et al.   ACS Chemical Biology

Toward the development of potent and selective bisubstrate inhibitors of protein arginine methyltransferases

(2010) James Dowden et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Chloroacetamidine-Based Inactivator of Protein Arginine Methyltransferase 1: Design, Synthesis, and In Vitro and In Vivo Evaluation

(2010) Obiamaka Obianyo et al.   CHEMBIOCHEM

Histone arginine methylation

(2010) Alessandra Di Lorenzo et al.   FEBS LETTERS

A combinatorial approach to characterize the substrate specificity of proteinargininemethyltransferase 1

(2010) Kevin L. Bicker et al.   Molecular BioSystems

Förster resonance energy transfer measurements of cofactor-dependent effects on protein arginineN-methyltransferase homodimerization

(2010) Dylan Thomas et al.   PROTEIN SCIENCE

Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4

(2009) Ted M. Lakowski et al.   BIOCHEMICAL JOURNAL

Protein Arginine Methylation in Mammals: Who, What, and Why

(2009) Mark T. Bedford et al.   MOLECULAR CELL

Protein methyltransferases as a target class for drug discovery

(2009) Robert A. Copeland et al.   NATURE REVIEWS DRUG DISCOVERY

Substrate Profiling of PRMT1 Reveals Amino Acid Sequences That Extend Beyond the “RGG” Paradigm†

(2008) Whitney L. Wooderchak et al.   BIOCHEMISTRY

Virtual Screening and Biological Characterization of Novel Histone Arginine Methyltransferase PRMT1 Inhibitors

(2008) Ralf Heinke et al.   ChemMedChem

Preparation ofNG-Substitutedl-Arginine Analogues Suitable for Solid Phase Peptide Synthesis

(2008) Nathaniel I. Martin et al.   JOURNAL OF ORGANIC CHEMISTRY

In Situ Generation of a Bisubstrate Analogue for Protein Arginine Methyltransferase 1

(2008) Tanesha Osborne et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY