Small molecule inhibitors that discriminate between protein arginine N-methyltransferases PRMT1 and CARM1

Structural basis for CARM1 inhibition by indole and pyrazole inhibitors

(2011) John S. Sack et al.   BIOCHEMICAL JOURNAL

Mechanistic Studies on Transcriptional Coactivator Protein Arginine Methyltransferase 1

(2011) Heather L. Rust et al.   BIOCHEMISTRY

Peptidic Partial Bisubstrates as Inhibitors of the Protein Arginine N-Methyltransferases

(2011) Peter 't Hart et al.   CHEMBIOCHEM

Structural Chemistry of the Histone Methyltransferases Cofactor Binding Site

(2011) Valérie Campagna-Slater et al.   Journal of Chemical Information and Modeling

Microwave-Assisted Solid-Phase Aza-peptide Synthesis: Aza Scan of a PKB/Akt Inhibitor Using Aza-arginine and Aza-proline Precursors

(2011) Noam S. Freeman et al.   JOURNAL OF ORGANIC CHEMISTRY

Nη-Substituted Arginyl Peptide Inhibitors of Protein ArginineN-Methyltransferases

(2010) Ted M. Lakowski et al.   ACS Chemical Biology

Development of novel bisubstrate-type inhibitors of histone methyltransferase SET7/9

(2010) Shuichi Mori et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Toward the development of potent and selective bisubstrate inhibitors of protein arginine methyltransferases

(2010) James Dowden et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Chloroacetamidine-Based Inactivator of Protein Arginine Methyltransferase 1: Design, Synthesis, and In Vitro and In Vivo Evaluation

(2010) Obiamaka Obianyo et al.   CHEMBIOCHEM

Design, Synthesis and Biological Evaluation of Carboxy Analogues of Arginine Methyltransferase Inhibitor 1 (AMI-1)

(2010) Sabrina Castellano et al.   ChemMedChem

Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production

(2010) Kevin Bonham et al.   FEBS Journal

Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers

(2010) Masanori Yoshimatsu et al.   INTERNATIONAL JOURNAL OF CANCER

Discovery and Mechanistic Study of a Class of Protein Arginine Methylation Inhibitors

(2010) You Feng et al.   JOURNAL OF MEDICINAL CHEMISTRY

A combinatorial approach to characterize the substrate specificity of proteinargininemethyltransferase 1

(2010) Kevin L. Bicker et al.   Molecular BioSystems

Targeting epigenetic modifiers: Inhibitors of histone methyltransferases

(2010) Elisabeth-Maria Bissinger et al.   MedChemComm

1,2-Diamines as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1)

(2009) Eric Therrien et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Optimization of pyrazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)

(2009) Tram Huynh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Benzo[d]imidazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)—Hit to Lead studies

(2009) Honghe Wan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Protein methyltransferases as a target class for drug discovery

(2009) Robert A. Copeland et al.   NATURE REVIEWS DRUG DISCOVERY

Chemical mechanisms of histone lysine and arginine modifications

(2008) Brian C. Smith et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Pyrazole inhibitors of coactivator associated arginine methyltransferase 1 (CARM1)

(2008) Ashok V. Purandare et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

N-Benzyl-1-heteroaryl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamides as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1)

(2008) Martin Allan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

In Situ Generation of a Bisubstrate Analogue for Protein Arginine Methyltransferase 1

(2008) Tanesha Osborne et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical probes for histone-modifying enzymes

(2008) Philip A Cole   Nature Chemical Biology