Recent advances and new perspectives in targeting CFTR for therapy of cystic fibrosis and enterotoxin-induced secretory diarrheas
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Title
Recent advances and new perspectives in targeting CFTR for therapy of cystic fibrosis and enterotoxin-induced secretory diarrheas
Authors
Keywords
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Journal
Future Medicinal Chemistry
Volume 4, Issue 3, Pages 329-345
Publisher
Future Science, LTD
Online
2012-03-06
DOI
10.4155/fmc.12.1
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Note: Only part of the references are listed.- Bioactive phospholipid signaling influences NHE3-dependent intestinal Na+ and fluid absorption: a macromolecular complex perspective. Focus on “Lysophosphatidic acid 5 receptor induces activation of Na+/H+ exchanger 3 via apical epidermal growth factor receptor in intestinal epithelial cells”
- (2011) Weiqiang Zhang et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Targeting the regulation of CFTR channels
- (2011) Paul D.W. Eckford et al. BIOCHEMICAL JOURNAL
- Functional regulation of cystic fibrosis transmembrane conductance regulator-containing macromolecular complexes: a small-molecule inhibitor approach
- (2011) Weiqiang Zhang et al. BIOCHEMICAL JOURNAL
- A Tannic Acid-Based Medical Food, Cesinex®, Exhibits Broad-Spectrum Antidiarrheal Properties: A Mechanistic and Clinical Study
- (2011) Aixia Ren et al. DIGESTIVE DISEASES AND SCIENCES
- Developing novel antisecretory drugs to treat infectious diarrhea
- (2011) Eugenio L de Hostos et al. Future Medicinal Chemistry
- Dual Activity of Aminoarylthiazoles on the Trafficking and Gating Defects of the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Caused by Cystic Fibrosis Mutations
- (2011) Nicoletta Pedemonte et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Potent, Metabolically Stable Benzopyrimido-pyrrolo-oxazine-dione (BPO) CFTR Inhibitors for Polycystic Kidney Disease
- (2011) David S. Snyder et al. JOURNAL OF MEDICINAL CHEMISTRY
- Cyanoquinolines with Independent Corrector and Potentiator Activities Restore Phe508-Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Function in Cystic Fibrosis
- (2011) P.-W. Phuan et al. MOLECULAR PHARMACOLOGY
- Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809
- (2011) F. Van Goor et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for theF508del-CFTRmutation
- (2011) J P Clancy et al. THORAX
- Crofelemer, a Novel Agent for Treatment of Secretory Diarrhea
- (2010) Rustin D Crutchley et al. ANNALS OF PHARMACOTHERAPY
- Cystic Fibrosis Transmembrane Conductance Regulator Modulators for Personalized Drug Treatment of Cystic Fibrosis
- (2010) Frédéric Becq DRUGS
- CFTR chloride channel in the apical compartments: spatiotemporal coupling to its interacting partners
- (2010) Chunying Li et al. Integrative Biology
- Small Molecule AKAP-Protein Kinase A (PKA) Interaction Disruptors That Activate PKA Interfere with Compartmentalized cAMP Signaling in Cardiac Myocytes
- (2010) Frank Christian et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening
- (2010) Ori Kalid et al. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
- A Plant-Derived Hydrolysable Tannin Inhibits CFTR Chloride Channel: A Potential Treatment of Diarrhea
- (2010) Nisa Wongsamitkul et al. PHARMACEUTICAL RESEARCH
- Biological and Chemical Approaches to Diseases of Proteostasis Deficiency
- (2009) Evan T. Powers et al. Annual Review of Biochemistry
- Design and synthesis of a hybrid potentiator–corrector agonist of the cystic fibrosis mutant protein ΔF508-CFTR
- (2009) Aaron D. Mills et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Lysophosphatidic Acid Stimulates the Intestinal Brush Border Na+/H+ Exchanger 3 and Fluid Absorption via LPA5 and NHERF2
- (2009) Songbai Lin et al. GASTROENTEROLOGY
- Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice
- (2009) Anurag Kumar Singh et al. JOURNAL OF CLINICAL INVESTIGATION
- Nanomolar Potency Pyrimido-pyrrolo-quinoxalinedione CFTR Inhibitor Reduces Cyst Size in a Polycystic Kidney Disease Model
- (2009) Lukmanee Tradtrantip et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structure and Dynamics of NBD1 from CFTR Characterized Using Crystallography and Hydrogen/Deuterium Exchange Mass Spectrometry
- (2009) H.A. Lewis et al. JOURNAL OF MOLECULAR BIOLOGY
- Crofelemer, an Antisecretory Antidiarrheal Proanthocyanidin Oligomer Extracted from Croton lechleri, Targets Two Distinct Intestinal Chloride Channels
- (2009) L. Tradtrantip et al. MOLECULAR PHARMACOLOGY
- A Small-Molecule Modulator Interacts Directly with Phe508-CFTR to Modify Its ATPase Activity and Conformational Stability
- (2009) L. Wellhauser et al. MOLECULAR PHARMACOLOGY
- Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD
- (2009) T. S. Thorsen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770
- (2009) F. Van Goor et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Enhanced cell-surface stability of rescued ΔF508 cystic fibrosis transmembrane conductance regulator (CFTR) by pharmacological chaperones
- (2008) Karoly Varga et al. BIOCHEMICAL JOURNAL
- Direct interaction of a small-molecule modulator with G551D-CFTR, a cystic fibrosis-causing mutation associated with severe disease
- (2008) Stan Pasyk et al. BIOCHEMICAL JOURNAL
- Nanomolar CFTR Inhibition by Pore-Occluding Divalent Polyethylene Glycol-Malonic Acid Hydrazides
- (2008) N.D. Sonawane et al. CHEMISTRY & BIOLOGY
- Effectiveness of PTC124 treatment of cystic fibrosis caused by nonsense mutations: a prospective phase II trial
- (2008) Eitan Kerem et al. LANCET
- Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function
- (2008) A. W. R. Serohijos et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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