Nitroimidazoles for the treatment of TB: past, present and future

The Effects of Cimetidine (Tagamet®) on Renal Function in Patients with Renal Failure

(2010) Rutger Larsson et al.   ACTA MEDICA SCANDINAVICA

Dry Powder PA-824 Aerosols for Treatment of Tuberculosis in Guinea Pigs

(2010) L. Garcia-Contreras et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Early Bactericidal Activity and Pharmacokinetics of PA-824 in Smear-Positive Tuberculosis Patients

(2010) A. H. Diacon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The effect of 5-substitution on the electrochemical behavior and antitubercular activity of PA-824

(2010) Soledad Bollo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The nitroimidazooxazines (PA-824 and analogs): structure–activity relationship and mechanistic studies

(2010) William A Denny et al.   Future Medicinal Chemistry

Maximizing bactericidal activity with combinations of bioreduced drugs

(2010) Robert C Goldman   Future Medicinal Chemistry

Dry Powder Nitroimidazopyran Antibiotic PA-824 Aerosol for Inhalation

(2009) J. C. Sung et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Safety, Tolerability, and Pharmacokinetics of PA-824 in Healthy Subjects

(2009) A. M. Ginsberg et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Assessment of the Effects of the Nitroimidazo-Oxazine PA-824 on Renal Function in Healthy Subjects

(2009) A. M. Ginsberg et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Trends in tuberculosis incidence and their determinants in 134 countries

(2009) C Dye et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Structure−Activity Relationships of Antitubercular Nitroimidazoles. 2. Determinants of Aerobic Activity and Quantitative Structure−Activity Relationships

(2009) Pilho Kim et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure−Activity Relationships of Antitubercular Nitroimidazoles. 1. Structural Features Associated with Aerobic and Anaerobic Activities of 4- and 5-Nitroimidazoles

(2009) Pilho Kim et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Structure−activity Relationships of Antitubercular 2-Nitroimidazooxazines Bearing Heterocyclic Side Chains

(2009) Hamish S. Sutherland et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Structure−Activity Studies of Biphenyl Analogues of the Tuberculosis Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824)

(2009) Brian D. Palmer et al.   JOURNAL OF MEDICINAL CHEMISTRY

An Anaerobic-Type α-Ketoglutarate Ferredoxin Oxidoreductase Completes the Oxidative Tricarboxylic Acid Cycle of Mycobacterium tuberculosis

(2009) Anthony D. Baughn et al.   PLoS Pathogens

Efficacy of Quinoxaline-2-Carboxylate 1,4-Di-N-Oxide Derivatives in Experimental Tuberculosis

(2008) E. Vicente et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Enhanced Bactericidal Activity of Rifampin and/or Pyrazinamide When Combined with PA-824 in a Murine Model of Tuberculosis

(2008) R. Tasneen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Powerful Bactericidal and Sterilizing Activity of a Regimen Containing PA-824, Moxifloxacin, and Pyrazinamide in a Murine Model of Tuberculosis

(2008) E. Nuermberger et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824

(2008) Xiaojin Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New Anti-Tuberculosis Drugs with Novel Mechanisms of Action

(2008) Emma Rivers et al.   CURRENT MEDICINAL CHEMISTRY

Tuberculous Granulomas Are Hypoxic in Guinea Pigs, Rabbits, and Nonhuman Primates

(2008) L. E. Via et al.   INFECTION AND IMMUNITY

A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents

(2008) J. G. Hurdle et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Confronting the scientific obstacles to global control of tuberculosis

(2008) Douglas B. Young et al.   JOURNAL OF CLINICAL INVESTIGATION

Metronidazole Lacks Activity againstMycobacterium tuberculosisin an In Vivo Hypoxic Granuloma Model of Latency

(2008) Lee G. Klinkenberg et al.   JOURNAL OF INFECTIOUS DISEASES

Synthesis, Reduction Potentials, and Antitubercular Activity of Ring A/B Analogues of the Bioreductive Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824)

(2008) Andrew M. Thompson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of a copper-binding metallothionein in pathogenic mycobacteria

(2008) Ben Gold et al.   Nature Chemical Biology

The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis

(2008) S. P. S. Rao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release

(2008) R. Singh et al.   SCIENCE

Cytological and Transcript Analyses Reveal Fat and Lazy Persister-Like Bacilli in Tuberculous Sputum

(2008) Natalie J Garton et al.   PLOS MEDICINE