The nitroimidazooxazines (PA-824 and analogs): structure–activity relationship and mechanistic studies
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Title
The nitroimidazooxazines (PA-824 and analogs): structure–activity relationship and mechanistic studies
Authors
Keywords
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Journal
Future Medicinal Chemistry
Volume 2, Issue 8, Pages 1295-1304
Publisher
Future Science, LTD
Online
2010-08-24
DOI
10.4155/fmc.10.207
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Related references
Note: Only part of the references are listed.- Safety, Tolerability, and Pharmacokinetics of PA-824 in Healthy Subjects
- (2009) A. M. Ginsberg et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
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- (2009) A. M. Ginsberg et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Structure−Activity Relationships of Antitubercular Nitroimidazoles. 2. Determinants of Aerobic Activity and Quantitative Structure−Activity Relationships
- (2009) Pilho Kim et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structure−Activity Relationships of Antitubercular Nitroimidazoles. 1. Structural Features Associated with Aerobic and Anaerobic Activities of 4- and 5-Nitroimidazoles
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- (2009) Luiz Pedro S. de Carvalho et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2009) Hamish S. Sutherland et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and Structure−Activity Studies of Biphenyl Analogues of the Tuberculosis Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824)
- (2009) Brian D. Palmer et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824
- (2008) Xiaojin Li et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Crystal Structures of F420-dependent Glucose-6-phosphate Dehydrogenase FGD1 Involved in the Activation of the Anti-tuberculosis Drug Candidate PA-824 Reveal the Basis of Coenzyme and Substrate Binding
- (2008) Ghader Bashiri et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Diarylquinolines Are Bactericidal for Dormant Mycobacteria as a Result of Disturbed ATP Homeostasis
- (2008) Anil Koul et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Crystal Structure of the Oxazolidinone Antibiotic Linezolid Bound to the 50S Ribosomal Subunit∥
- (2008) Joseph A. Ippolito et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis, Reduction Potentials, and Antitubercular Activity of Ring A/B Analogues of the Bioreductive Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824)
- (2008) Andrew M. Thompson et al. JOURNAL OF MEDICINAL CHEMISTRY
- Intermediates in the reduction of the antituberculosis drug PA-824, (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine, in aqueous solution
- (2008) Robert F. Anderson et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release
- (2008) R. Singh et al. SCIENCE
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