Small molecule drug discovery for Dengue and West Nile viruses: applying experience from hepatitis C virus

Lethal Antibody Enhancement of Dengue Disease in Mice Is Prevented by Fc Modification

(2010) Scott J. Balsitis et al.   PLoS Pathogens

Review article: investigational agents for chronic hepatitis C

(2009) A. J. V. THOMPSON et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Novel Imino Sugar Derivatives Demonstrate Potent Antiviral Activity against Flaviviruses

(2009) J. Chang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Preclinical Characterization of PF-00868554, a Potent Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase

(2009) S. T. Shi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Small-Molecule Dengue Virus Entry Inhibitor

(2009) Q.-Y. Wang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Flaviviral methyltransferase/RNA interaction: Structural basis for enzyme inhibition

(2009) Mario Milani et al.   ANTIVIRAL RESEARCH

Identification and characterization of inhibitors of West Nile virus

(2009) Francesc Puig-Basagoiti et al.   ANTIVIRAL RESEARCH

Structure-based discovery of dengue virus protease inhibitors

(2009) Suzanne M. Tomlinson et al.   ANTIVIRAL RESEARCH

Antiviral activity of geneticin against dengue virus

(2009) Xianchao G. Zhang et al.   ANTIVIRAL RESEARCH

A heterocyclic molecule with significant activity against dengue virus

(2009) Vasu Nair et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure–activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase

(2009) Shyama Sidique et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Functional Genomic Screen Identifies Cellular Cofactors of Hepatitis C Virus Replication

(2009) Andrew W. Tai et al.   Cell Host & Microbe

RNA-dependent RNA polymerases from Flaviviridae

(2009) Kyung H Choi et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Targeting the non-structural proteins of hepatitis C virus: beyond hepatitis C virus protease and polymerase

(2009) Tod P Holler et al.   Expert Opinion on Drug Discovery

Progress towards improving antiviral therapy for hepatitis C with hepatitis C virus polymerase inhibitors. Part I: Nucleoside analogues

(2009) Nathaniel A Brown   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Recent advances in the development of NS5B polymerase inhibitors for the treatment of hepatitis C virus infection

(2009) Pierre L Beaulieu   EXPERT OPINION ON THERAPEUTIC PATENTS

NMR study of complexes between low molecular mass inhibitors and the West Nile virus NS2B-NS3 protease

(2009) Xun-Cheng Su et al.   FEBS Journal

Identification of novel target sites and an inhibitor of the dengue virus E protein

(2009) Ragothaman Yennamalli et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Safety and efficacy of viramidine versus ribavirin in ViSER2: Randomized, double-blind study in therapy-naive hepatitis C patients

(2009) Patrick Marcellin et al.   JOURNAL OF HEPATOLOGY

N-Sulfonylanthranilic Acid Derivatives as Allosteric Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase

(2009) Zheng Yin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal Structure of Dengue Virus Type 1 Envelope Protein in the Postfusion Conformation and Its Implications for Membrane Fusion

(2009) V. Nayak et al.   JOURNAL OF VIROLOGY

Progress towards a dengue vaccine

(2009) Daniel P Webster et al.   LANCET INFECTIOUS DISEASES

An adenosine nucleoside inhibitor of dengue virus

(2009) Z. Yin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A genome-wide genetic screen for host factors required for hepatitis C virus propagation

(2009) Q. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intravenous immunoglobulins in the treatment of dengue illness

(2009) Senaka Rajapakse   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

Identification of a lipid kinase as a host factor involved in hepatitis C virus RNA replication

(2009) Frédéric H. Vaillancourt et al.   VIROLOGY

Hepatitis C Virus entry: the early steps in the viral replication cycle

(2009) Ali Sabahi   Virology Journal

Discovery of a Non-Peptidic Inhibitor of West Nile Virus NS3 Protease by High-Throughput Docking

(2009) Dariusz Ekonomiuk et al.   PLoS Neglected Tropical Diseases

Peptidomimetic Therapeutic Agents Targeting the Protease Enzyme of the Human Immunodeficiency Virus and Hepatitis C Virus

(2008) Youla S. Tsantrizos   ACCOUNTS OF CHEMICAL RESEARCH

Antiviral Compounds Discovered by Virtual Screening of Small−Molecule Libraries against Dengue Virus E Protein

(2008) Zhigang Zhou et al.   ACS Chemical Biology

Identification and Biochemical Characterization of Small-Molecule Inhibitors of West Nile Virus Serine Protease by a High-Throughput Screen

(2008) N. H. Mueller et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In vitro inhibition of dengue virus entry by p-sulfoxy-cinnamic acid and structurally related combinatorial chemistries

(2008) C REES et al.   ANTIVIRAL RESEARCH

West Nile Virus NS2B/NS3 Protease As An Antiviral Target

(2008) K. Chappell et al.   CURRENT MEDICINAL CHEMISTRY

Present perspectives on flaviviral chemotherapy

(2008) Debapriya Ghosh et al.   DRUG DISCOVERY TODAY

Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein

(2008) Dahai Luo et al.   EMBO JOURNAL

HCV796: A selective nonstructural protein 5B polymerase inhibitor with potent anti-hepatitis C virus activity In Vitro, in mice with chimeric human livers, and in humans infected with hepatitis C virus

(2008) Norman M. Kneteman et al.   HEPATOLOGY

Understanding the contribution of cellular immunity to dengue disease pathogenesis

(2008) Anuja Mathew et al.   IMMUNOLOGICAL REVIEWS

Design, Synthesis, and Biological Evaluation of Antiviral Agents Targeting Flavivirus Envelope Proteins

(2008) Ze Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Potent Cationic Inhibitors of West Nile Virus NS2B/NS3 Protease With Serum Stability, Cell Permeability and Antiviral Activity

(2008) Martin J. Stoermer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Analysis of Flavivirus NS5 Methyltransferase Cap Binding

(2008) Brian J. Geiss et al.   JOURNAL OF MOLECULAR BIOLOGY

West Nile Virus Methyltransferase Catalyzes Two Methylations of the Viral RNA Cap through a Substrate-Repositioning Mechanism

(2008) H. Dong et al.   JOURNAL OF VIROLOGY

The Mannose Receptor Mediates Dengue Virus Infection of Macrophages

(2008) Joanna L. Miller et al.   PLoS Pathogens

DC-SIGN enhances infection of cells with glycosylated West Nile virus in vitro and virus replication in human dendritic cells induces production of IFN-α and TNF-α

(2008) Byron E.E. Martina et al.   VIRUS RESEARCH