Article
Chemistry, Medicinal
Ling-Jie Gao, Yuan Lin, Steven De Jonghe, Mark Waer, Piet Herdewijn
Summary: Researchers prepared three different types of prodrugs of Mizoribine, and found that the ester derivatives effectively inhibited the secretion of specific immune molecules and prolonged graft survival. The combination therapy of these prodrugs with tacrolimus also showed a synergistic effect in vivo.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Multidisciplinary Sciences
Takao Morimune, Ayami Tano, Yuya Tanaka, Haruka Yukiue, Takefumi Yamamoto, Ikuo Tooyama, Yoshihiro Maruo, Masaki Nishimura, Masaki Mori
Summary: Research has shown that the protein Tbc1d24 forms unique cellular structures called cytoophidia in neuronal cells, which are different from other types of cytoophidia. The formation of Tbc1d24 cytoophidia is influenced by cellular juvenescence and affects its enzymatic activity.
Article
Chemistry, Organic
Xin Liu, Yan Fu, Qiqi Zhou, Su Wang, Lu Gao, Jiali Lei, Aibing Ke, Yeying Li, Xuexia Zhang, Changhong Huo, Xinhua Lu
Summary: Five unprecedented chromone derivatives were obtained from the fungus Aspergillus deflectus NCC0415, and their structures were identified using various techniques. The hexacyclic derivatives showed potent enzyme inhibition activity.
Letter
Clinical Neurology
Pin-Shiuan Chen, Meng-Chen Wu, Chun-Hwei Tai, Yung-Yee Chang, Min-Yu Lan, Ying-Fa Chen, Han- Lin, Ni-Chung Lee, Chin-Hsien Lin
Summary: We investigated 245 Taiwanese patients with dystonia and found no evidence to suggest a link between the inosine monophosphate dehydrogenase gene (IMPDH2) and the disease, suggesting that IMPDH2 may not play a major role in dystonia.
PARKINSONISM & RELATED DISORDERS
(2023)
Review
Pharmacology & Pharmacy
Zhiwen Fu, Liu Wang, Shijun Li, Fen Chen, Kathy Ka-Wai Au-Yeung, Chen Shi
Summary: miRNAs play a crucial role in cancer treatment by regulating gene expression and influencing the growth and survival of cancer cells. They are considered an attractive target for anticancer drug development and have shown promising results in research and therapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Shiyu Wang, Fan Chao, Cong Zhang, Dunsheng Han, Guoxiong Xu, Gang Chen
Summary: The study found that circPFKP was significantly increased in prostate cancer tissues compared to noncancerous tissues, and was correlated with PCa risk classification, N stage, and prognostic group. CircPFKP promotes PCa cell proliferation by interacting with IMPDH2, and its production may be facilitated by hnRNPF binding.
Article
Agriculture, Multidisciplinary
Yun Wang, Tianqing Xia, Chenhao Li, Duwen Zeng, Lili Xu, Liyun Song, Hengsong Yu, Shichao Chen, Jianzhi Zhao, Xiaoming Bao
Summary: Saccharomyces cerevisiae has been identified as a preferred source for industrial production of ribonucleic acids (RNAs) and their derivatives. In this study, a modified RNA polymerase I-mediated green fluorescent protein expression system was used to screen and identify an industrial S. cerevisiae strain with an 18.2% increase in RNA content. Transcriptome analysis showed enhanced activity of genes and pathways associated with rRNA transcription, purine metabolism, and phosphate transport. The study provides valuable insights into RNA synthesis and its application in the food industry.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Microbiology
Takayuki Hishiki, Takeshi Morita, Daisuke Akazawa, Hirofumi Ohashi, Eun-Sil Park, Michiyo Kataoka, Junki Mifune, Kaho Shionoya, Kana Tsuchimoto, Shinjiro Ojima, Aa Haeruman Azam, Shogo Nakajima, Madoka Kawahara, Tomoki Yoshikawa, Masayuki Shimojima, Kotaro Kiga, Ken Maeda, Tadaki Suzuki, Hideki Ebihara, Yoshimasa Takahashi, Koichi Watashi
Summary: Mpox is a zoonotic disease caused by mpox virus infection, and a global outbreak occurred in May 2022. The smallpox vaccine has been approved for clinical use against mpox, and gemcitabine, trifluridine, and mycophenolic acid have shown inhibitory effects on mpox virus propagation. IMP dehydrogenase has been identified as a potential target for the development of anti-mpox virus agents.
MICROBIOLOGY SPECTRUM
(2023)
Article
Medical Laboratory Technology
Xiaoyuan Jia, Yao Liu, Yan Cheng, Yin Wang, Hui Kang, Zhongren Ma, Kan Chen
Summary: This study reveals the role of IMPDH1 in promoting HCC growth and progression, and its association with patient cumulative survival.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Wolfgang Winnicki, Andreas Fichtenbaum, Harald Herkner, Florina Regele, Michael Baier, Sieglinde Zelzer, Ludwig Wagner, Guerkan Sengoelge
Summary: This study aimed to investigate individualized approaches to mycophenolic acid (MPA) therapy to improve clinical outcomes in renal transplant patients. The results showed that pharmacodynamic monitoring of IMPDH activity in peripheral blood cells may be an effective method for drug dose adjustment.
Review
Biochemistry & Molecular Biology
Anika L. Burrell, Justin M. Kollman
Summary: Inosine-5'-monophosphate dehydrogenase (IMPDH) is an important enzyme in purine metabolism, regulating flux at the branch point between adenine and guanine nucleotide synthesis and participating in transcription regulation. Mutations in IMPDH1 and IMPDH2 are associated with different human diseases, but their effects at the enzyme level are still unclear. Mutations in IMPDH1 lead to retinal degeneration and recent studies have revealed the molecular mechanisms behind the functional defects. IMPDH1 splice variants in the retina up-regulate guanine nucleotide synthesis by reducing sensitivity to feedback inhibition by downstream products. Understanding the role of IMPDH1 in the retina and characterizing an animal disease model will provide insights into the molecular mechanism of IMPDH1-associated blindness.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2022)
Article
Materials Science, Paper & Wood
Mohammed Ibrahim Alghonaim, Sulaiman A. Alsalamah, Ahmed Alsolami, Tarek M. Abdel Ghany
Summary: The microconstituents of Ganoderma lucidum biomass were evaluated for their antimicrobial and anticancer activities. The study identified 12-octadecadienoic acid and n-hexadecanoic acid as important compounds in Ganoderma lucidum biomass, which exhibited inhibitory effects on breast cancer cell proliferation and antimicrobial activities. These compounds could be potential candidates for the development of new anticancer and antimicrobial agents.
Article
Biochemical Research Methods
Piyush Agrawal, Dhruv Bhagat, Manish Mahalwal, Neelam Sharma, Gajendra P. S. Raghava
Summary: The study developed a computational model for predicting and designing anticancer peptides (ACPs), revealing residue composition preference, positional preference, and motif features of ACPs. Machine learning models were utilized and trained on different datasets, with the best models implemented on the webserver AntiCP 2.0 for free access.
BRIEFINGS IN BIOINFORMATICS
(2021)
Review
Biochemistry & Molecular Biology
Rohini Gupta, Vijay Luxami, Kamaldeep Paul
Summary: 8-Hydroxyquinoline is an important heterocyclic scaffold in organic and analytical chemistry, used for detecting metal ions and anions due to its chromophore properties. Recently, synthetic modification of 8-hydroxyquinoline has garnered attention for developing potent drug molecules for the treatment of diseases like cancer, HIV, and neurodegenerative disorders. The metal chelation properties of 8-hydroxyquinoline and its derivatives also make them potential drug candidates for various diseases.
BIOORGANIC CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Wojciech Trybus, Ewa Trybus, Teodora Krol
Summary: Lysosomes are organelles that contain acidic hydrolases and play a crucial role in cellular degradation and homeostasis. They are involved in autophagy and various cell death pathways, including lysosomal and apoptotic death. Compounds such as lysosomotropic compounds, antihistamines, DNA-damaging drugs, and chemotherapeutics can induce lysosomal membrane permeability, promoting lysosomal-mediated cell death. Combining lysosomotropic compounds with autophagy modulators may be a promising approach in cancer treatment and overcoming chemoresistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
