Inosine monophosphate dehydrogenase as a target for antiviral, anticancer, antimicrobial and immunosuppressive therapeutics

The Immunosuppressor Mycophenolic Acid Kills Activated Lymphocytes by Inducing a Nonclassical Actin-Dependent Necrotic Signal

(2014) B. Chaigne-Delalande et al.   JOURNAL OF IMMUNOLOGY

T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections

(2009) Yousuke Furuta et al.   ANTIVIRAL RESEARCH

A heterocyclic molecule with significant activity against dengue virus

(2009) Vasu Nair et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Persistence of Leukemia-Initiating Cells in a Conditional Knockin Model of an Imatinib-Responsive Myeloproliferative Disorder

(2009) Katherine I. Oravecz-Wilson et al.   CANCER CELL

IMP Dehydrogenase: Structure, Mechanism, and Inhibition

(2009) Lizbeth Hedstrom   CHEMICAL REVIEWS

Taribavirin: a potential alternative to ribavirin

(2009) Fred F Poordad et al.   Future Virology

Triazole Inhibitors ofCryptosporidium parvumInosine 5′-Monophosphate Dehydrogenase

(2009) Sushil K. Maurya et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mycophenolate pharmacokinetics and pharmacodynamics in belatacept treated renal allograft recipients – a pilot study

(2009) Sara Bremer et al.   Journal of Translational Medicine

The Necrotic Signal Induced by Mycophenolic Acid Overcomes Apoptosis-Resistance in Tumor Cells

(2009) Gwendaline Guidicelli et al.   PLoS One

A New Kind of Drug Target

(2009) Melinda Wenner   SCIENTIFIC AMERICAN

A Kinetic Alignment of Orthologous Inosine-5′-monophosphate Dehydrogenases†

(2008) Thomas V. Riera et al.   BIOCHEMISTRY

Targeting a Prokaryotic Protein in a Eukaryotic Pathogen: Identification of Lead Compounds against Cryptosporidiosis

(2008) Nwakaso N. Umejiego et al.   CHEMISTRY & BIOLOGY

Taribavirin for the treatment of chronic hepatitis C

(2008) Keith R Kearney et al.   EXPERT OPINION ON PHARMACOTHERAPY

Expression of IMPDH1 is regulated in response to mycophenolate concentration

(2008) Sara Bremer et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Antiproliferative effects of AVN944, a novel inosine 5-monophosphate dehydrogenase inhibitor, in prostate cancer cells

(2008) Daniel Floryk et al.   INTERNATIONAL JOURNAL OF CANCER

A Phase I Dose-Ranging Study of the Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of AVN944, an IMPDH Inhibitor, in Healthy Male Volunteers

(2008) J. Michael Hamilton et al.   JOURNAL OF CLINICAL PHARMACOLOGY

The CBS subdomain of inosine 5′-monophosphate dehydrogenase regulates purine nucleotide turnover

(2008) Maxim Pimkin et al.   MOLECULAR MICROBIOLOGY

An Enzymatic Atavist Revealed in Dual Pathways for Water Activation

(2008) Donghong Min et al.   PLOS BIOLOGY

Inosine monophosphate dehydrogenase (IMPDH) as a target in drug discovery

(2007) Qingning Shu et al.   MEDICINAL RESEARCH REVIEWS