Screening technologies for ion channel drug discovery

Evaluation of the QPatch HT and HTX Systems As Methods for Ion Channel Screening

(2010) Mark McPate et al.   BIOPHYSICAL JOURNAL

A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel

(2009) Steven A. Titus et al.   ANALYTICAL BIOCHEMISTRY

Automated Planar Electrode Electrophysiology in Drug Discovery: Examples of the Use of QPatch in Basic Characterization and High Content Screening on Nav, KCa2.3, and Kv11.1 Channels

(2009) Mads Korsgaard et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Use of Planar Array Electrophysiology for the Development of Robust Ion Channel Cell Lines

(2009) Jeffrey Clare et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Port-a-Patch and Patchliner: High Fidelity Electrophysiology for Secondary Screening and Safety Pharmacology

(2009) Niels Fertig et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

QPatch: The Missing Link Between HTS and Ion Channel Drug Discovery

(2009) Yi Liu et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Sodium Channel Inhibitor Drug Discovery Using Automated High Throughput Electrophysiology Platforms

(2009) Neil Castle et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Optimization of Cav1.2 screening with an automated planar patch clamp platform

(2009) Bharathi Balasubramanian et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Effect of compound plate composition on measurement of hERG current IC50 using PatchXpress

(2009) Zun-Li Mo et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

An Automated Electrophysiology Serum Shift Assay for KV Channels

(2008) Kevin S. Ratliff et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

A High-Throughput Assay for Evaluating State Dependence and Subtype Selectivity of Cav2 Calcium Channel Inhibitors

(2008) Ge Dai et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Miniaturization and HTS of a FRET-Based Membrane Potential Assay for Kir Channel Inhibitors

(2008) Kelli Solly et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Ion Channel Screening

(2008) John Dunlop et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Impact of Novel Screening Technologies on Ion Channel Drug Discovery

(2008) Qiang Lu et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Characterization of compounds on nicotinic acetylcholine receptor alpha7 channels using higher throughput electrophysiology

(2008) S. Friis et al.   JOURNAL OF NEUROSCIENCE METHODS

High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology

(2008) John Dunlop et al.   NATURE REVIEWS DRUG DISCOVERY

Cellular HTS Assays for Pharmacological Characterization of NaV1.7 Modulators

(2007) Shephali Trivedi et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Novel pharmacological activity of loperamide and CP-339,818 on human HCN channels characterized with an automated electrophysiology assay

(2007) Yan T. Lee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Optimisation and validation of a medium-throughput electrophysiology-based hNav1.5 assay using IonWorks™

(2007) A.R. Harmer et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS