Medicinal mushrooms in supportive cancer therapies: an approach to anti-cancer effects and putative mechanisms of action

Secondary metabolites of oil palm isolates of Ganoderma zonatum Murill. from Cameroon and their cytotoxicity against five human tumour cell lines

(2016) R Kinge Tonjock et al.   AFRICAN JOURNAL OF BIOTECHNOLOGY

Compounds from Wild Mushrooms with Antitumor Potential

(2012) Isabel C.F.R. Ferreira et al.   Anti-Cancer Agents in Medicinal Chemistry

The Fungi: 1, 2, 3 … 5.1 million species?

(2011) Meredith Blackwell   AMERICAN JOURNAL OF BOTANY

Agaritine from Agaricus blazei Murrill induces apoptosis in the leukemic cell line U937

(2011) Hidehiko Akiyama et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Bioactive proteins from mushrooms

(2011) Xiaofei Xu et al.   BIOTECHNOLOGY ADVANCES

A novel adjuvant Ling Zhi-8 enhances the efficacy of DNA cancer vaccine by activating dendritic cells

(2011) Chi-Chen Lin et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Antioxidant properties and cytotoxicity of crude polysaccharides from Lentinus polychrous Lév.

(2011) Chatchai Thetsrimuang et al.   FOOD CHEMISTRY

Inhibitory effect of oral administration of Sangwhang mushroom (Phellinus linteus) grown on germinated brown rice on experimental lung metastasis and tumor growth in mice

(2011) Taeil Jeon et al.   FOOD SCIENCE AND BIOTECHNOLOGY

Major clades in tropical Agaricus

(2011) Ruilin Zhao et al.   FUNGAL DIVERSITY

Fifty years of drug discovery from fungi

(2011) Amal H. Aly et al.   FUNGAL DIVERSITY

Immunostimulating activity of the polysaccharides isolated from Cordyceps militaris

(2011) Jong Seok Lee et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

New Dietary Supplements from Medicinal Mushrooms: Dr Myko San—A Registration Report

(2011) Ivan Jakopovich   INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS

Vitamin D and Sterol Composition of 10 Types of Mushrooms from Retail Suppliers in the United States

(2011) Katherine M. Phillips et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

4-Acetylantroquinonol B Isolated fromAntrodia cinnamomeaArrests Proliferation of Human Hepatocellular Carcinoma HepG2 Cell by Affecting p53, p21 and p27 Levels

(2011) Yu-Wei Lin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Pharmacological, Structural, and Drug Delivery Properties and Applications of 1,3-β-Glucans

(2011) Benjamin C. Lehtovaara et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Anticancer Activities of Thelephantin O and Vialinin A Isolated from Thelephora aurantiotincta

(2011) Toshio Norikura et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Composition and Mechanism of Antitumor Effects ofHericium erinaceusMushroom Extracts in Tumor-Bearing Mice

(2011) Sung Phil Kim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Styrylpyrone-class compounds from medicinal fungi Phellinus and Inonotus spp. and their medicinal importance

(2011) In-Kyoung Lee et al.   JOURNAL OF ANTIBIOTICS

Maitake (D Fraction) Mushroom Extract Induces Apoptosis in Breast Cancer Cells by BAK-1 Gene Activation

(2011) Raquel Soares et al.   JOURNAL OF MEDICINAL FOOD

Targeted metabolites analysis in wild Boletus species

(2011) Sandrina A. Heleno et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Ganoderma lucidum: A Source for Novel Bioactive Lectin

(2011) Vinay U. Girjal et al.   PROTEIN AND PEPTIDE LETTERS

Evaluation of Agaricus blazei in vivo for antigenotoxic, anticarcinogenic, phagocytic and immunomodulatory activities

(2011) Priscila Lumi Ishii et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Purification and characterization of a novel immunomodulatory protein from the medicinal mushroom Trametes versicolor

(2011) Feng Li et al.   Science China-Life Sciences

Induction of apoptosis by cordycepin via reactive oxygen species generation in human leukemia cells

(2011) Jin-Woo Jeong et al.   TOXICOLOGY IN VITRO

An Exopolysaccharide from Cultivated Cordyceps sinensis and its Effects on Cytokine Expressions of Immunocytes

(2010) Lu Sheng et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Cytokines Expression Induced by Ganoderma sinensis Fungal Immunomodulatory Proteins (FIP-gsi) in Mouse Spleen Cells

(2010) Qizhang Li et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Proteins with antifungal properties and other medicinal applications from plants and mushrooms

(2010) Jack H. Wong et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Production of antioxidant and antitumor metabolites by submerged cultures of Inonotus obliquus cocultured with Phellinus punctatus

(2010) Weifa Zheng et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Current findings, future trends, and unsolved problems in studies of medicinal mushrooms

(2010) Solomon P. Wasser   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Agaritine purified from Agaricus blazei Murrill exerts anti-tumor activity against leukemic cells

(2010) Masahiro Endo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

A polysaccharide extracted from Grifola frondosa enhances the anti-tumor activity of bone marrow-derived dendritic cell-based immunotherapy against murine colon cancer

(2010) Yuki Masuda et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Hericium erinaceus enhances doxorubicin-induced apoptosis in human hepatocellular carcinoma cells

(2010) Jong Seok Lee et al.   CANCER LETTERS

Optimization of extraction of Tremella fuciformis polysaccharides and its antioxidant and antitumour activities in vitro

(2010) Bin Chen   CARBOHYDRATE POLYMERS

Polysaccharide purified from Polyporus umbellatus (Per) Fr induces the activation and maturation of murine bone-derived dendritic cells via toll-like receptor 4

(2010) Xinqun Li et al.   CELLULAR IMMUNOLOGY

Pro-apoptotic activity of ergosterol peroxide and (22E)-ergosta-7,22-dien-5α-hydroxy-3,6-dione in human prostate cancer cells

(2010) A. Russo et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Biochemical mechanism of Caffeic Acid Phenylethyl Ester (CAPE) selective toxicity towards melanoma cell lines

(2010) Shashi K. Kudugunti et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The in vitro and in vivo experimental evidences disclose the chemopreventive effects of Ganoderma lucidum on cancer invasion and metastasis

(2010) Chia-Jui Weng et al.   CLINICAL & EXPERIMENTAL METASTASIS

Immunoregulatory effects of Sizofiran (SPG) on lymphocytes and polymorphonuclear leukocytes

(2010) K. YONEDA et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Grifolin, a potent antitumour natural product upregulates death-associated protein kinase 1 DAPK1 via p53 in nasopharyngeal carcinoma cells

(2010) Xiang-jian Luo et al.   EUROPEAN JOURNAL OF CANCER

Role for toll-like receptor 4 in TNF-alpha secretion by murine macrophages in response to polysaccharide Krestin, a Trametes versicolor mushroom extract

(2010) Lisa A. Price et al.   FITOTERAPIA

The effects of ganoderma alcohols isolated from Ganoderma lucidum on the androgen receptor binding and the growth of LNCaP cells

(2010) Jie Liu et al.   FITOTERAPIA

Edible mushrooms: Role in the prevention of cardiovascular diseases

(2010) Eva Guillamón et al.   FITOTERAPIA

Structure, chain conformation and antitumor activity of a novel polysaccharide from Lentinus edodes

(2010) Zhang Yu et al.   FITOTERAPIA

Wild mushrooms Clitocybe alexandri and Lepista inversa: In vitro antioxidant activity and growth inhibition of human tumour cell lines

(2010) Josiana A. Vaz et al.   FOOD AND CHEMICAL TOXICOLOGY

Advances in lentinan: Isolation, structure, chain conformation and bioactivities

(2010) Yangyang Zhang et al.   FOOD HYDROCOLLOIDS

Biochemical characterization of a proteoglycan complex from an edible mushroom Ganoderma lucidum fruiting bodies and its immunoregulatory activity

(2010) LiBin Ye et al.   FOOD RESEARCH INTERNATIONAL

A monograph of Micropsalliota in Northern Thailand based on morphological and molecular data

(2010) Rui-lin Zhao et al.   FUNGAL DIVERSITY

The genus Macrolepiota (Agaricaceae, Basidiomycota) in China

(2010) Z. W. Ge et al.   FUNGAL DIVERSITY

Lactarius volemus sensu lato (Russulales) from northern Thailand: morphological and phylogenetic species concepts explored

(2010) Kobeke Van de Putte et al.   FUNGAL DIVERSITY

Spatial distribution of Beta glucan containing wild mushroom communities in subtropical dry forest, Thailand

(2010) Jaruntorn Boonyanuphap et al.   FUNGAL DIVERSITY

Hymenochaetaceae (Basidiomycota) in China

(2010) Yu-Cheng Dai   FUNGAL DIVERSITY

Fungal endophytes from higher plants: a prolific source of phytochemicals and other bioactive natural products

(2010) Amal H. Aly et al.   FUNGAL DIVERSITY

Fungi—an unusual source for cosmetics

(2010) K. D. Hyde et al.   FUNGAL DIVERSITY

Endo-polysaccharide of Phellinus igniarius exhibited anti-tumor effect through enhancement of cell mediated immunity

(2010) Li Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The prostate transglutaminase, TGase-4, coordinates with the HGFL/MSP-RON system in stimulating the migration of prostate cancer cells

(2010) Jiang   INTERNATIONAL JOURNAL OF ONCOLOGY

A very short visual analog form of the Center for Epidemiologic Studies Depression Scale (CES-D) for the idiographic measurement of depression

(2010) Grégory Moullec et al.   JOURNAL OF AFFECTIVE DISORDERS

Hispolon Suppresses SK-Hep1 Human Hepatoma Cell Metastasis by Inhibiting Matrix Metalloproteinase-2/9 and Urokinase-Plasminogen Activator through the PI3K/Akt and ERK Signaling Pathways

(2010) Guan-Jhong Huang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

In Vitro Antitumor and Immunomodulatory Effects of the Protein PCP-3A from MushroomPleurotus citrinopileatus

(2010) Jian-Nan Chen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Polysaccharides PS-G and Protein LZ-8 from Reishi (Ganoderma lucidum) Exhibit Diverse Functions in Regulating Murine Macrophages and T Lymphocytes

(2010) Chen-Hao Yeh et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Isolation of a polysaccharide with anticancer activity from Auricularia polytricha using high-speed countercurrent chromatography with an aqueous two-phase system

(2010) Guanglei Song et al.   JOURNAL OF CHROMATOGRAPHY A

Induction of ICAM-1 by Armillariella mellea is mediated through generation of reactive oxygen species and JNK activation

(2010) Young Sook Kim et al.   JOURNAL OF ETHNOPHARMACOLOGY

Anti-angiogenic activity of methanol extract of Phellinus linteus and its fractions

(2010) Yeon Sil Lee et al.   JOURNAL OF ETHNOPHARMACOLOGY

Orally administered mycelial culture of Phellinus linteus exhibits antitumor effects in hepatoma cell-bearing mice

(2010) Hui-Yu Huang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Potential Antitumor Activity of a Low-Molecular-Weight Protein Fraction from Grifola frondosa Through Enhancement of Cytokine Production

(2010) Noriko Kodama et al.   JOURNAL OF MEDICINAL FOOD

Chronic diseases: global action must match global evidence

(2010) Robert Beaglehole et al.   LANCET

Inhibition of TNFα-induced iNOS expression in HSV-tk transduced 9L glioblastoma cell lines by Marasmius oreades substances through NF-κB- and MAPK-dependent mechanisms

(2010) Nili Ruimi et al.   MOLECULAR BIOLOGY REPORTS

Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in Balbc/c mice bearing Sarcoma-180 cells

(2010) Mi Ja Chung et al.   Nutrition Research and Practice

Cytotoxic triterpenoids from Ganoderma lucidum

(2010) Chun-Ru Cheng et al.   PHYTOCHEMISTRY

First isolation and characterization of a novel lectin with potent antitumor activity from a Russula mushroom

(2010) G. Zhang et al.   PHYTOMEDICINE

Cytotoxic Steroids fromPolyporus umbellatus

(2010) Ying-Yong Zhao et al.   PLANTA MEDICA

Phellinus Linteus Extract Sensitizes Advanced Prostate Cancer Cells to Apoptosis in Athymic Nude Mice

(2010) Takanori Tsuji et al.   PLoS One

Antimetastatic effect of ganoderic acid T in vitro through inhibition of cancer cell invasion

(2010) Ke Xu et al.   PROCESS BIOCHEMISTRY

A new immunomodulatory protein from Ganoderma microsporum inhibits epidermal growth factor mediated migration and invasion in A549 lung cancer cells

(2010) Ching-Hsiung Lin et al.   PROCESS BIOCHEMISTRY

Ganoderic acid Me induces apoptosis through mitochondria dysfunctions in human colon carcinoma cells

(2010) Li Zhou et al.   PROCESS BIOCHEMISTRY

Cost-saving effect of supervised exercise associated to COPD self-management education program

(2010) G. Ninot et al.   RESPIRATORY MEDICINE

Structural Analysis of a Bioactive Polysaccharide, PISP1, from the Medicinal MushroomPhellinus igniarius

(2009) Yan YANG et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Synergistic potentiation of interferon activity with maitake mushroom d-fraction on bladder cancer cells

(2009) Brandon Louie et al.   BJU INTERNATIONAL

Cancer Statistics, 2009

(2009) A. Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Cytotoxic triterpenes from Antrodia camphorata and their mode of action in HT-29 human colon cancer cells

(2009) Chi-Tai Yeh et al.   CANCER LETTERS

Apoptosis-Inducing Effects of Sterols from the Dried Powder of Cultured Mycelium of Cordyceps sinensis

(2009) Hisashi Matsuda et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Investigating pleuromutilin-producingClitopilusspecies and related basidiomycetes

(2009) Amanda J. Hartley et al.   FEMS MICROBIOLOGY LETTERS

Hispolon from Phellinus linteus has antiproliferative effects via MDM2-recruited ERK1/2 activity in breast and bladder cancer cells

(2009) Te-Ling Lu et al.   FOOD AND CHEMICAL TOXICOLOGY

Characterization and immunostimulatory activity of a polysaccharide from the spores of Ganoderma lucidum

(2009) Liang Guo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Evaluation of Antiproliferative Activities and Action Mechanisms of Extracts from Two Species ofGanodermaon Tumor Cell Lines

(2009) Yu-Wei Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Cordycepin Inhibits Protein Synthesis and Cell Adhesion through Effects on Signal Transduction

(2009) Ying Ying Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Radical cyberknife radiosurgery with tumor tracking: an effective treatment for inoperable small peripheral stage I non-small cell lung cancer

(2009) Brian T Collins et al.   Journal of Hematology & Oncology

Isolation and characterization of endophytic taxol-producing fungi from Taxus chinensis

(2009) Kaihui Liu et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

An immunomodulatory protein, Ling Zhi-8, induced activation and maturation of human monocyte-derived dendritic cells by the NF-κB and MAPK pathways

(2009) Yu-Li Lin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Structure and Cytotoxicity of Arnamial and Related Fungal Sesquiterpene Aryl Esters

(2009) Mathias Misiek et al.   JOURNAL OF NATURAL PRODUCTS

Anti-Tumor-Promoting Effects of 25-Methoxyporicoic Acid A and Other Triterpene Acids fromPoria cocos

(2009) Toshihiro Akihisa et al.   JOURNAL OF NATURAL PRODUCTS

Pharmacological Values of Medicinal Mushrooms for Prostate Cancer Therapy: The Case of Ganoderma Lucidum

(2009) Jamal Mahajna et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Drug Discovery and Natural Products: End of an Era or an Endless Frontier?

(2009) J. W.-H. Li et al.   SCIENCE

Glucans as Biological Response Modifiers

(2009) M. Novak et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Marmorin, a new ribosome inactivating protein with antiproliferative and HIV-1 reverse transcriptase inhibitory activities from the mushroom Hypsizigus marmoreus

(2008) Jack H. Wong et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Purification, characterization and cloning of a ricin B-like lectin from mushroom Clitocybe nebularis with antiproliferative activity against human leukemic T cells

(2008) Jure Pohleven et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

A comparison of two methods for estimating odds ratios: Results from the National Health Survey

(2008) Enayatollah Bakhshi et al.   BMC Medical Research Methodology

Synergy of irofulven in combination with other DNA damaging agents: synergistic interaction with altretamine, alkylating, and platinum-derived agents in the MV522 lung tumor model

(2008) Michael J. Kelner et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Ovarian tumor growth regression using a combination of vascular targeting agents anginex or topomimetic 0118 and the chemotherapeutic irofulven

(2008) Ruud P.M. Dings et al.   CANCER LETTERS

Anti-proliferative effect of clitocine from the mushroom Leucopaxillus giganteus on human cervical cancer HeLa cells by inducing apoptosis

(2008) Gang Ren et al.   CANCER LETTERS

A Medicinal Mushroom: Phellinus Linteus

(2008) Tongbo Zhu et al.   CURRENT MEDICINAL CHEMISTRY

Antiproliferative and immunostimulatory protein fraction from edible mushrooms

(2008) Swatilekha Maiti et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

The Immunobiology of Mushrooms

(2008) Andrea T. Borchers et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Anti-tumor effect of Coriolus versicolor methanol extract against mouse B16 melanoma cells: In vitro and in vivo study

(2008) Lj. Harhaji et al.   FOOD AND CHEMICAL TOXICOLOGY

Characterisation and immunostimulatory activity of an α-(1→6)-d-glucan from the cultured Armillariella tabescens mycelia

(2008) Xia Luo et al.   FOOD CHEMISTRY

Isolation and quantitative determination of ergosterol peroxide in various edible mushroom species

(2008) Wojciech Krzyczkowski et al.   FOOD CHEMISTRY

Hispolon induces apoptosis in human gastric cancer cells through a ROS-mediated mitochondrial pathway

(2008) Wei Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Diversity and Use of Traditional Mexican Medicinal Fungi. A Review

(2008) Gaston Guzman   INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS

Lucidenic Acid B Induces Apoptosis in Human Leukemia Cells via a Mitochondria-Mediated Pathway

(2008) Chin-Lin Hsu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

In vivo growth-inhibition of Sarcoma 180 by an α-(1 → 4)-glucan–β-(1 → 6)-glucan-protein complex polysaccharide obtained from Agaricus blazei Murill

(2008) Maria Leônia Costa Gonzaga et al.   Journal of Natural Medicines

Ganoderic Acid Me Inhibits Tumor Invasion Through Down-Regulating Matrix Metalloproteinases 2/9 Gene Expression

(2008) Nian-Hong Chen et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Active specific immunotherapy and cell-transfer therapy for the treatment of non-small cell lung cancer

(2008) Kazuhiro Kakimi et al.   LUNG CANCER

Marasmius oreades substances block NF-κB activity through interference with IKK activation pathway

(2008) Roumyana D. Petrova et al.   MOLECULAR BIOLOGY REPORTS

Structure Determination of β-Glucans from Ganoderma lucidum with Matrix-assisted Laser Desorption/ionization (MALDI) Mass Spectrometry

(2008) Wei-Ting Hung et al.   MOLECULES

Cancer is a Preventable Disease that Requires Major Lifestyle Changes

(2008) Preetha Anand et al.   PHARMACEUTICAL RESEARCH

Effect of a fungal immunomodulatory protein from Ganoderma tsugae on cell cycle and interferon-gamma production through phosphatidylinositol 3-kinase signal pathway

(2008) Yi-Min Hsiao et al.   PROCESS BIOCHEMISTRY

Sulfated modification can enhance the adjuvanticity of lentinan and improve the immune effect of ND vaccine

(2008) Zhenhuan Guo et al.   VACCINE

Optimization of extraction process of crude polysaccharides from wild edible BaChu mushroom by response surface methodology

(2007) Hou XuJie et al.   CARBOHYDRATE POLYMERS

The Immune System — is it Relevant to Cancer Development, Progression and Treatment?

(2007) R.J. Prestwich et al.   CLINICAL ONCOLOGY

The Medicinal MushroomAgaricus blazeiMurrill: Review of Literature and Pharmaco-Toxicological Problems

(2007) F. Firenzuoli et al.   Evidence-based Complementary and Alternative Medicine

Effects of the exopolysaccharide fraction (EPSF) from a cultivated Cordyceps sinensis on immunocytes of H22 tumor bearing mice

(2007) Weiyun Zhang et al.   FITOTERAPIA