New paradigms in sepsis: from prevention to protection of failing microcirculation

Differential and opposing effects of imatinib on LPS- and ventilator-induced lung injury

(2015) E. Letsiou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Backs against the Wall: Novel and Existing Strategies Used during the 2014-2015 Ebola Virus Outbreak

(2015) Gary Wong et al.   CLINICAL MICROBIOLOGY REVIEWS

The Efficacy and Safety of Heparin in Patients With Sepsis

(2015) Ryan Zarychanski et al.   CRITICAL CARE MEDICINE

Randomized, Placebo-Controlled Trial of Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis

(2015) David R. Janz et al.   CRITICAL CARE MEDICINE

Human Monocytes Undergo Functional Re-programming during Sepsis Mediated by Hypoxia-Inducible Factor-1α

(2015) Irina N. Shalova et al.   IMMUNITY

A New Initiative on Precision Medicine

(2015) Francis S. Collins et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis

(2015) G. F. Weber et al.   SCIENCE

A systems approach to hemostasis: 2. Computational analysis of molecular transport in the thrombus microenvironment

(2014) M. Tomaiuolo et al.   BLOOD

New insights into the spatiotemporal localization of prothrombinase in vivo

(2014) L. Ivanciu et al.   BLOOD

Ebola Virus VP24 Targets a Unique NLS Binding Site on Karyopherin Alpha 5 to Selectively Compete with Nuclear Import of Phosphorylated STAT1

(2014) Wei Xu et al.   Cell Host & Microbe

Discovery of single-gene inborn errors of immunity by next generation sequencing

(2014) Mary Ellen Conley et al.   CURRENT OPINION IN IMMUNOLOGY

Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation

(2014) Christopher D. Buckley et al.   IMMUNITY

Vaccine Protection of Leukopenic Mice against Staphylococcus aureus Bloodstream Infection

(2014) Sabine Rauch et al.   INFECTION AND IMMUNITY

The Adaptor CRADD/RAIDD Controls Activation of Endothelial Cells by Proinflammatory Stimuli

(2014) Huan Qiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Staphylococcus aureusinfection induces protein A–mediated immune evasion in humans

(2014) Noel T. Pauli et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Resolvin D1 reduces ER stress-induced apoptosis and triglyceride accumulation through JNK pathway in HepG2 cells

(2014) Tae Woo Jung et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Regulatory Mandates for Sepsis Care — Reasons for Caution

(2014) Chanu Rhee et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ebola Vaccine — An Urgent International Priority

(2014) Rupa Kanapathipillai et al.   NEW ENGLAND JOURNAL OF MEDICINE

The “Genomic Storm” Induced by Bacterial Endotoxin Is Calmed by a Nuclear Transport Modifier That Attenuates Localized and Systemic Inflammation

(2014) Antonio DiGiandomenico et al.   PLoS One

Genomic responses in mouse models greatly mimic human inflammatory diseases

(2014) Keizo Takao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Abandon the Mouse Research Ship? Not Just Yet!

(2014) Marcin F. Osuchowski et al.   SHOCK

Why have clinical trials in sepsis failed?

(2014) John C. Marshall   TRENDS IN MOLECULAR MEDICINE

HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells

(2014) Fatiha Tabet et al.   Nature Communications

SOCS3, a Major Regulator of Infection and Inflammation

(2014) Berit Carow et al.   Frontiers in Immunology

Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia

(2013) M. J. Flick et al.   BLOOD

Benchmarking the Incidence and Mortality of Severe Sepsis in the United States*

(2013) David F. Gaieski et al.   CRITICAL CARE MEDICINE

Vasoplegia in septic shock: Do we really fight the right enemy?

(2013) Nivin Sharawy   JOURNAL OF CRITICAL CARE

Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach

(2013) Richard S Hotchkiss et al.   LANCET INFECTIOUS DISEASES

U.S. Hospitalizations for Pneumonia after a Decade of Pneumococcal Vaccination

(2013) Marie R. Griffin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Severe Sepsis and Septic Shock

(2013) Derek C. Angus et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Innate Immunity Adaptor SARM Translocates to the Nucleus to Stabilize Lamins and Prevent DNA Fragmentation in Response to Pro-Apoptotic Signaling

(2013) Chad R. Sethman et al.   PLoS One

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Integrated Clinico-Metabolomic Model Improves Prediction of Death in Sepsis

(2013) R. J. Langley et al.   Science Translational Medicine

Biomarkers of Endothelial Cell Activation in Early Sepsis

(2013) Simon Skibsted et al.   SHOCK

The role of mitochondrial dysfunction in sepsis-induced multi-organ failure

(2013) Mervyn Singer   Virulence

Nuclear Transport Modulation Reduces Hypercholesterolemia, Atherosclerosis, and Fatty Liver

(2013) Yan Liu et al.   Journal of the American Heart Association

Targeting Nuclear Import Shuttles, Importins/Karyopherins alpha by a Peptide Mimicking the NFκB1/p50 Nuclear Localization Sequence

(2013) Jozef Zienkiewicz et al.   Journal of the American Heart Association

Association between Endothelial Dysfunction and Acute Brain Dysfunction during Critical Illness

(2012) Christopher G. Hughes et al.   ANESTHESIOLOGY

Intravascular Neutrophil Extracellular Traps Capture Bacteria from the Bloodstream during Sepsis

(2012) Braedon McDonald et al.   Cell Host & Microbe

Effective Treatment of Edema and Endothelial Barrier Dysfunction With Imatinib

(2012) Jurjan Aman et al.   CIRCULATION

The relationship between delirium duration, white matter integrity, and cognitive impairment in intensive care unit survivors as determined by diffusion tensor imaging

(2012) Alessandro Morandi et al.   CRITICAL CARE MEDICINE

Multicenter Evaluation of the Staphylococcus QuickFISH Method for Simultaneous Identification of Staphylococcus aureus and Coagulase-Negative Staphylococci Directly from Blood Culture Bottles in Less than 30 Minutes

(2012) Melissa K. Deck et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Lethality in a Murine Model of Pulmonary Anthrax is Reduced by Combining Nuclear Transport Modifier with Antimicrobial Therapy

(2012) Ruth Ann Veach et al.   PLoS One

Inhibitor of streptokinase gene expression improves survival after group A streptococcus infection in mice

(2012) H. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate Response Activator B Cells Protect Against Microbial Sepsis

(2012) P. J. Rauch et al.   SCIENCE

The Link Between Vascular Features and Thrombosis

(2011) Charles T. Esmon et al.   Annual Review of Physiology

Infectious Diseases in Patients with IRAK-4, MyD88, NEMO, or I B  Deficiency

(2011) C. Picard et al.   CLINICAL MICROBIOLOGY REVIEWS

TAK1 in brain endothelial cells mediates fever and lethargy

(2011) Dirk A. Ridder et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A genomic storm in critically injured humans

(2011) Wenzhong Xiao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Broken Barriers: A New Take on Sepsis Pathogenesis

(2011) N. M. Goldenberg et al.   Science Translational Medicine

Prelamin A Acts to Accelerate Smooth Muscle Cell Senescence and Is a Novel Biomarker of Human Vascular Aging

(2010) Cassandra D. Ragnauth et al.   CIRCULATION

Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department*

(2010) David F. Gaieski et al.   CRITICAL CARE MEDICINE

Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis

(2010) Theodore J. Iwashyna et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Extended Anti-inflammatory Action of a Degradation-resistant Mutant of Cell-penetrating Suppressor of Cytokine Signaling 3

(2010) Tynetta C. Fletcher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neonatal Outcomes of Extremely Preterm Infants From the NICHD Neonatal Research Network

(2010) B. J. Stoll et al.   PEDIATRICS

Targeting Robo4-Dependent Slit Signaling to Survive the Cytokine Storm in Sepsis and Influenza

(2010) N. R. London et al.   Science Translational Medicine

Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008

(2009) R Phillip Dellinger et al.   CRITICAL CARE MEDICINE

International Study of the Prevalence and Outcomes of Infection in Intensive Care Units

(2009) Jean-Louis Vincent   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Suppression of Acute Lung Inflammation by Intracellular Peptide Delivery of a Nuclear Import Inhibitor

(2009) Danya Liu et al.   MOLECULAR THERAPY

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

Natural Course of Neonatal Progeroid Syndrome

(2009) Jia-Woei Hou   Pediatrics and Neonatology

Resuscitating the Microcirculation in Sepsis: The Central Role of Nitric Oxide, Emerging Concepts for Novel Therapies, and Challenges for Clinical Trials

(2008) Stephen Trzeciak et al.   ACADEMIC EMERGENCY MEDICINE

TLRs and innate immunity

(2008) B. A. Beutler   BLOOD

Human Endotoxemia as a Model of Systemic Inflammation

(2008) A. Andreasen et al.   CURRENT MEDICINAL CHEMISTRY

Divergent roles of endothelial NF-κB in multiple organ injury and bacterial clearance in mouse models of sepsis

(2008) Xiaobing Ye et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20

(2008) Emre E. Turer et al.   JOURNAL OF EXPERIMENTAL MEDICINE