Antiplatelet drugs: which targets for which treatments?

New Approaches to Inhibiting Platelets and Coagulation

(2015) Jeremiah P. Depta et al.   Annual Review of Pharmacology and Toxicology

Interaction of von Willebrand factor with platelets and the vessel wall

(2015) Z. M. Ruggeri et al.   Hamostaseologie

Antiplatelet therapy after drug-eluting stent implantation

(2015) Josephine Warren et al.   Journal of Cardiology

Antiplatelet and anticoagulation agents in acute coronary syndromes: What is the current status and what does the future hold?

(2014) Kurt Huber et al.   AMERICAN HEART JOURNAL

RUC-4

(2014) Jihong Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

GpIb -VWF blockade restores vessel patency by dissolving platelet aggregates formed under very high shear rate in mice

(2014) A. Le Behot et al.   BLOOD

Role of phenotypic and genetic testing in managing clopidogrel therapy

(2014) N. C. Chan et al.   BLOOD

Prevalence, clinical profile and 3-year survival of acute myocardial infarction patients with and without obstructive coronary lesions: The FAST-MI 2005 registry

(2014) Romain André et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

When Should Aspirin Be Used for Prevention of Cardiovascular Events?

(2014) J. Michael Gaziano et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Adenosine-Mediated Effects of Ticagrelor

(2014) Marco Cattaneo et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Competitive mode and site of interaction of ticagrelor at the human platelet P2Y12-receptor

(2014) K. Hoffmann et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Agonist-bound structure of the human P2Y12 receptor

(2014) Jin Zhang et al.   NATURE

Structure of the human P2Y12 receptor in complex with an antithrombotic drug

(2014) Kaihua Zhang et al.   NATURE

Novel antiplatelet agents in acute coronary syndrome

(2014) Francesco Franchi et al.   Nature Reviews Cardiology

Twelve or 30 Months of Dual Antiplatelet Therapy after Drug-Eluting Stents

(2014) Laura Mauri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Discovery of Novel GPVI Receptor Antagonists by Structure-Based Repurposing

(2014) Lewis Taylor et al.   PLoS One

Direct Oral Anticoagulants in Acute Coronary Syndrome

(2014) Ingo Ahrens et al.   SEMINARS IN HEMATOLOGY

Reperfusion of cerebral artery thrombosis by the GPIb-VWF blockade with the Nanobody ALX-0081 reduces brain infarct size in guinea pigs

(2013) S. Momi et al.   BLOOD

Antiplatelet Therapy to Prevent Cardiovascular Events and Mortality in Patients With Intermittent Claudication

(2013) Peng Foo Wong et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Reduction of Stent Thrombosis in Patients With Acute Coronary Syndromes Treated With Rivaroxaban in ATLAS-ACS 2 TIMI 51

(2013) C. Michael Gibson et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Platelet receptors activated via mulitmerization: glycoprotein VI, GPIb-IX-V, and CLEC-2

(2013) Y. Ozaki et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Effect of Platelet Inhibition with Cangrelor during PCI on Ischemic Events

(2013) Deepak L. Bhatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

The GPVI-Fc Fusion Protein Revacept Improves Cerebral Infarct Volume and Functional Outcome in Stroke

(2013) Silvia Goebel et al.   PLoS One

Aspirin-insensitive thromboxane biosynthesis in essential thrombocythemia is explained by accelerated renewal of the drug target

(2012) S. Pascale et al.   BLOOD

Antithrombotic and Thrombolytic Therapy for Ischemic Stroke

(2012) Maarten G. Lansberg et al.   CHEST

The recovery of platelet cyclooxygenase activity explains interindividual variability in responsiveness to low-dose aspirin in patients with and without diabetes

(2012) B. ROCCA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The future of glycoprotein VI as an antithrombotic target

(2012) M. ZAHID et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Vorapaxar in the Secondary Prevention of Atherothrombotic Events

(2012) David A. Morrow et al.   NEW ENGLAND JOURNAL OF MEDICINE

P2Y12 receptors in platelets and other hematopoietic and non-hematopoietic cells

(2012) Christian Gachet   Purinergic Signalling

Diagnosis and Management of High Platelet Reactivity on Treatment with Clopidogrel

(2012) Marco Cattaneo   SEMINARS IN THROMBOSIS AND HEMOSTASIS

GPIIb/IIIa inhibitors: From bench to bedside and back to bench again

(2012) Paul C. Armstrong et al.   THROMBOSIS AND HAEMOSTASIS

The anti-von Willebrand factor aptamer ARC1779 increases von Willebrand factor levels and platelet counts in patients with type 2B von Willebrand disease

(2012) Petra Jilma-Stohlawetz et al.   THROMBOSIS AND HAEMOSTASIS

High on-treatment platelet reactivity and P2Y12 antagonists in clinical trials

(2012) Steen Kristensen et al.   THROMBOSIS AND HAEMOSTASIS

Platelet GPVI: a target for antithrombotic therapy?!

(2012) Sebastian Dütting et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Initial experience from a double-blind, placebo-controlled, clinical outcome study of ARC1779 in patients with thrombotic thrombocytopenic purpura

(2011) Spero R. Cataland et al.   AMERICAN JOURNAL OF HEMATOLOGY

Novel Antiplatelet Drug Revacept (Dimeric Glycoprotein VI-Fc) Specifically and Efficiently Inhibited Collagen-Induced Platelet Aggregation Without Affecting General Hemostasis in Humans

(2011) Martin Ungerer et al.   CIRCULATION

Aspirin

(2011) Valentin Fuster et al.   CIRCULATION

Historical perspective and future directions in platelet research

(2011) B. S. COLLER   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Terutroban versus aspirin in patients with cerebral ischaemic events (PERFORM): a randomised, double-blind, parallel-group trial

(2011) Marie-Germaine Bousser et al.   LANCET

Thrombin-Receptor Antagonist Vorapaxar in Acute Coronary Syndromes

(2011) Pierluigi Tricoci et al.   NEW ENGLAND JOURNAL OF MEDICINE

The von Willebrand Inhibitor ARC1779 Reduces Cerebral Embolization After Carotid Endarterectomy

(2011) Hugh S. Markus et al.   STROKE

The platelet P2Y12 receptor for adenosine diphosphate: congenital and drug-induced defects

(2010) M. Cattaneo   BLOOD

New P2Y 12 Inhibitors

(2010) Marco Cattaneo   CIRCULATION

Ticagrelor binds to human P2Y12independently from ADP but antagonizes ADP-induced receptor signaling and platelet aggregation

(2009) J. J. J. VAN GIEZEN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Arterial thrombosis: relevance of a model with two levels of severity assessed by histologic, ultrastructural and functional characterization

(2009) B. HECHLER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials

(2009)   LANCET

Prasugrel in Clinical Practice

(2009) Deepak L. Bhatt   NEW ENGLAND JOURNAL OF MEDICINE

Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes

(2009) Lars Wallentin et al.   NEW ENGLAND JOURNAL OF MEDICINE

The GPIIb/IIIa (integrin  IIb 3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend

(2008) B. S. Coller et al.   BLOOD

Interaction of the active metabolite of prasugrel, R-138727, with cysteine 97 and cysteine 175 of the human P2Y12receptor

(2008) I. ALGAIER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Trends in Usage of Alternative Antiplatelet Therapy After Stroke and Transient Ischemic Attack

(2008) Nancy K. Hills et al.   STROKE

Treating Patients With ‘Wake-Up’ Stroke

(2008) Harold P. Adams et al.   STROKE