Article
Biochemistry & Molecular Biology
Wei Lou, Meng-di Zhang, Qi Chen, Tu-Ya Bai, Yu-Xia Hu, Feng Gao, Jun Li, Xiao-Li Lv, Qian Zhang, Fu-Hou Chang
Summary: This study aimed to investigate whether Benzo[a]pyrene (BaP) regulates lipid metabolism via the aryl hydrocarbon receptor (AhR). The results showed that BaP inhibited fat synthesis and oxidation while inducing inflammation by activating AhR, leading to dysfunction of white adipose tissue and metabolic complications.
LIPIDS IN HEALTH AND DISEASE
(2022)
Article
Environmental Sciences
Guozhu Ye, Han Gao, Xu Zhang, Xinyu Liu, Jinsheng Chen, Xu Liao, Han Zhang, Qiansheng Huang
Summary: Exposure to polycyclic aromatic hydrocarbon BaP accelerates lung cancer initiation and progression through AHR signaling and metabolic reprogramming. The study reveals that amino acid and fatty acid metabolism, along with AHR and PPAR-FATP1 signaling, could be potential therapeutic targets for intervening BaP-induced toxicity and related diseases. The novel findings of fatty acid accumulation and high correlations of AHR signaling with amino acid and fatty acid metabolism in BaP-exposed lung epithelial cells are highlighted.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Yanwei Wang, Jiahui Zhao, Yipeng Xu, Cimin Tao, Jie Tong, Yingjie Luo, Yong Chen, Xuesong Liu, Tengfei Xu
Summary: This study integrated metabolomics and chemical proteomics approaches to comprehensively identify the potential target proteins affected by Bap in liver cells. The results showed that Bap weakened the antioxidant capacity by destroying the activities of SOD3 and GPX4, providing a new understanding of the mechanism of hepatotoxicity induced by Bap.
Article
Biology
ShylajaNaciyar Mohandass, Mangalalakshmi Ragavan, Dineshbabu Gnanasekaran, Uma Lakshmanan, Prabaharan Dharmar, Sushanta Kumar Saha
Summary: Synthetic azo dyes are widely used but their improper discharge poses a threat to the environment. Genetically modified cyanobacteria with enhanced H2O2 accumulation through SOD overexpression can effectively degrade these dyes, suggesting a valuable bioremediation strategy.
Article
Environmental Sciences
Shou-En Wu, Ju-Chun Hsu, Yung-Lung Chang, Hsiao-Chi Chuang, Yi-Lin Chiu, Wei-Liang Chen
Summary: This study investigated the effects of Benzo[a]pyrene (BaP) on muscle and found that BaP can induce conditions similar to sarcopenia. Antioxidant supplementation may be a treatment option for BaP-induced sarcopenia.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Cell Biology
Dong-Dong Wu, Sheng Jin, Ruo-Xiao Cheng, Wen-Jie Cai, Wen-Long Xue, Qing-Qing Zhang, Le-Jie Yang, Qi Zhu, Meng-Yao Li, Ge Lin, Yi-Zhen Wang, Xue-Pan Mu, Yu Wang, Igor Ying Zhang, Qi Zhang, Ying Chen, Sheng-Yang Cai, Bo Tan, Ye Li, Yun-Qian Chen, Pu-Juan Zhang, Chen Sun, Yue Yin, Ming-Jie Wang, Yi-Zhun Zhu, Bei-Bei Tao, Jia-Hai Zhou, Wei-Xue Huang, Yi-Chun Zhu
Summary: This study investigates the possibility of a mechanism beyond post-translational modifications to regulate protein function. It shows that hydrogen sulfide (H2S) can bind to the active-site copper of Cu/Zn-SOD, enhancing electrostatic forces and facilitating electron transfer. The physiological relevance of this H2S effect is demonstrated in in vitro and in vivo models where the cardioprotective effects of H2S depend on Cu/Zn-SOD.
Review
Chemistry, Multidisciplinary
Namrata Singh, G. R. Sherin, Govindasamy Mugesh
Summary: Nanozymes, nanomaterials with enzyme-mimicking activity, have attracted significant interest in biomedical applications, particularly in oxidative stress-mediated disorders. The challenge lies in designing nanozymes that can selectively differentiate between physiological oxidative stress and pathological oxidative stress and mediate appropriate redox reactions in cells, tissues, and organs. This review summarizes the advancements in redox-active nanozymes and their therapeutic significance in various disease models, such as cancer, neurodegeneration, and cardiovascular diseases. It also discusses the future prospects and challenges associated with the biomedical applications of nanozymes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Nanoscience & Nanotechnology
Xiangshi Sun, Kongtong Yu, Yulin Zhou, Shiyan Dong, Wenji Hu, Yating Sun, Yuhuan Li, Jing Xie, Robert J. Lee, Fengying Sun, Yifan Ma, Shengnian Wang, Betty Y. S. Kim, Yifan Wang, Zhaogang Yang, Wen Jiang, Youxin Li, Lesheng Teng
Summary: The newly synthesized amphiphilic polymers can self-assemble into micellar nanoparticles with favorable hydrolysis kinetics, biocompatibility, and long circulation time. These materials not only exhibit better inflammation-targeting effects, but also do not induce an acidic microenvironment during degradation.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Bindu Chandrasekharan, Claudia Montllor-Albalate, Alyson E. Colin, Joshua L. Andersen, Young C. Jang, Amit R. Reddi
Summary: Cu/Zn superoxide dismutase (Sod1) catalyzes the breakdown of superoxide radicals into oxygen and hydrogen peroxide, which acts as a signaling molecule. In yeast, Sod1 is involved in a redox signaling pathway that connects nutrient availability to energy metabolism control. This pathway stabilizes plasma membrane kinases Yck1/2, promoting glycolytic growth and repressing respiration.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Ecology
Bruno Serra de Lacerda Valverde, Heidi Samantha Moraes Utsunomiya, Cleoni dos Santos Carvalho, Lilian Franco-Belussi, Classius de Oliveira
Summary: Studies on anurans have been conducted for over 40 years to evaluate the adverse effects of benzo(alpha)pyrene (B alpha P), showing genotoxic, hepatotoxic, and immunotoxic effects. This study aimed to assess whether the route of administration of B alpha P influences its effects on hepatic biomarkers, with morphological biomarkers being more significantly affected than biochemical ones. The exposure pathway and time both modulate the effects of B alpha P on hepatic biomarkers in anurans.
Article
Engineering, Environmental
Falin He, Qiang Liu, Mingyang Jing, Jingqiang Wan, Chengqian Huo, Wansong Zong, Jingchun Tang, Rutao Liu
Summary: Phenanthrene (PHE) is a significant organic compound found widely in soil, which can induce oxidative stress and cytotoxicity in earthworm coelomocytes at high concentrations. The interaction between PHE and antioxidant enzymes SOD/CAT plays a role in these toxic effects.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Environmental Sciences
Zhihan Cui, Falin He, Xiangxiang Li, Yuze Li, Chengqian Huo, Hao Wang, Yuntao Qi, Guang Tian, Wansong Zong, Rutao Liu
Summary: This study reveals the response mechanisms of SOD/CAT under the regulation of TCC-induced oxidative stress and sheds new light on the toxic pathways of exogenous pollutants on antioxidant-related proteins function.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Jangsoon Kim, See-Hyoung Park, Seyoung Yang, Sae Woong Oh, Kitae Kwon, Se Jung Park, Eunbi Yu, Hyeyoun Kim, Jung Yoen Park, Seoyoung Choi, Seoyeon Yang, Minkyung Song, Jae Youl Cho, Jongsung Lee
Summary: Maclurin exhibited antagonistic activity against B[a]P effects by inhibiting AHR signaling and activating Nrf2-mediated signaling, suggesting its potential in protecting from B[a]P-containing pollutants. Additionally, its antioxidant property was demonstrated through ROS inhibition and activation of ARE signaling.
Article
Horticulture
Mohammad Pourebrahimi, Saeid Eshghi, Asghar Ramezanian, Shiva Faghih
Summary: High salinity levels can lead to various adverse effects on plants, including osmotic stress and nutritional disorders. In this study, the combined use of hydrogen sulfide and selenium compounds was found to alleviate the negative effects of salt stress on strawberry yield and enhance the antioxidant and nutritional quality of the fruits.
SCIENTIA HORTICULTURAE
(2023)
Article
Chemistry, Multidisciplinary
Ahmet Can Timucin, Suleyman Selim Cinaroglu, Osman Ugur Sezerman, Emel Timucin
Summary: The metallation status of human Cu/Zn superoxide dismutase 1 (SOD1) is crucial in the development of amyotrophic lateral sclerosis (ALS). Mutations at the ALS-linked positions H63R and K136A significantly affect dimer dynamics, leading to demetallation and potential ALS toxicity. This study highlights the potential use of atomistic simulations in studying disease variants related to SOD1.
FRONTIERS IN CHEMISTRY
(2021)
Article
Environmental Sciences
Paul D. Juarez, Mohammad Tabatabai, Robert Burciaga Valdez, Darryl B. Hood, Wansoo Im, Charles Mouton, Cynthia Colen, Mohammad Z. Al-Hamdan, Patricia Matthews-Juarez, Maureen Y. Lichtveld, Daniel Sarpong, Aramandla Ramesh, Michael A. Langston, Gary L. Rogers, Charles A. Phillips, John F. Reichard, Macarius M. Donneyong, William Blot
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Biochemical Research Methods
Kenneth J. Harris, Seenivasan Subbiah, Mohammad Tabatabai, Anthony E. Archibong, Kamaleshwar P. Singh, Todd A. Anderson, Samuel E. Adunyah, Aramandla Ramesh
JOURNAL OF CHROMATOGRAPHY A
(2020)
Review
Public, Environmental & Occupational Health
Paul D. Juarez, Darryl B. Hood, Min-Ae Song, Aramandla Ramesh
FRONTIERS IN PUBLIC HEALTH
(2020)
Article
Cell Biology
Jeremy N. Myers, Kelly L. Harris, Perumalla V. Rekhadevi, Siddharth Pratap, Aramandla Ramesh
Summary: The study demonstrated that exposure of colon cancer cells to benzo(a)pyrene resulted in dose-dependent decrease in cell growth, cytotoxicity, and modulation of the cell cycle, as well as elevated concentrations of BaP metabolites contributing to DNA damage and stable DNA adduct formation. Additionally, the expression of phase I biotransformation enzymes showed BaP concentration-dependent changes, while phase II enzymes remained relatively stable. This study highlights the role of BaP biotransformation in cytotoxicity, proliferation of tumor cells, and alteration of gene expression.
CELL BIOLOGY AND TOXICOLOGY
(2021)
Article
Environmental Sciences
R. Burciaga Valdez, Mohammad Z. Al-Hamdan, Mohammad Tabatabai, Darryl B. Hood, Wansoo Im, Derek Wilus, Amruta Nori-Sarma, Aramandla Ramesh, Macarius M. Donneyong, Michael A. Langston, Charles P. Mouton, Paul D. Juarez
Summary: Exposure to high levels of PM2.5 was found to be significantly associated with an increased risk of self-reported CVD at enrollment, particularly among individuals with clinical risk factors such as hypertension, hypercholesterolemia, and smoking. Black participants were more likely to live in areas with higher PM2.5 concentrations and had a higher prevalence of clinical risk factors, indicating a greater future risk of CVD.
Article
Endocrinology & Metabolism
Jinhwan Lim, Aramandla Ramesh, Toshi Shioda, Kathleen Leon Parada, Ulrike Luderer
Summary: This study investigated the effects of prenatal exposure to benzo[a]pyrene (BaP) on embryonic gonads and potential mechanisms for increased ovarian tumor risk. The results showed that developing ovaries are more sensitive than testes to prenatal BaP exposure, which may be related to higher concentrations of BaP metabolites in female embryos.
Letter
Primary Health Care
Aramandla Ramesh, Paul D. Juarez, Patricia Matthews-Juarez
JOURNAL OF PRIMARY CARE AND COMMUNITY HEALTH
(2022)
Article
Environmental Sciences
Myriam Patricia Cifuentes, Clara Mercedes Suarez, Ricardo Cifuentes, Noel Malod-Dognin, Sam Windels, Jose Fernando Valderrama, Paul D. Juarez, R. Burciaga Valdez, Cynthia Colen, Charles Phillips, Aramandla Ramesh, Wansoo Im, Maureen Lichtveld, Charles Mouton, Natasa Przulj, Darryl B. Hood
Summary: A comparative network inferential analysis of variables and factors associated with Zika virus infections in Brazil during 2015-2016, coinciding with a microcephaly epidemic, identified multiple contributing determinants. This study advances our understanding of the cumulative interactive effects of exposures to chemical and non-chemical stressors in the built, natural, physical, and social environments on adverse pregnancy and health outcomes in vulnerable populations.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Psychology, Clinical
Robert Lyle Cooper, Aramandla Ramesh, Asa E. Radix, Jayne S. Reuben, Paul D. Juarez, Cheryl L. Holder, Allyson S. Belton, Katherine Y. Brown, Leandro A. Mena, Patricia Matthews-Juarez
Summary: This article provides a systematic review of studies conducted between 2000 and 2020 on the training of medical students and residents to address the health needs of sexual and gender minorities (SGM). The review found that training had a positive impact on knowledge, comfort, attitudes, confidence, and skills in working with SGM patients. However, no studies examined the impact of training on patient outcomes.
TRANSGENDER HEALTH
(2023)
Review
Health Care Sciences & Services
Robert L. Cooper, Paul D. Juarez, Matthew C. Morris, Aramandla Ramesh, Ryan Edgerton, Lauren L. Brown, Leandro Mena, Samuel A. MacMaster, Shavonne Collins, Patricia Matthews-Juarez, Mohammad Tabatabai, Katherine Y. Brown, Michael J. Paul, Wansoo Im, Thomas A. Arcury, Marybeth Shinn
Summary: Physician-identified barriers to PrEP provision include Purview Paradox, Patient Financial Constraints, Risk Compensation, and Concern for ART Resistance. Recommendations for increasing PrEP knowledge and competence among physicians and students include adopting HIV risk assessment as standard care, improving physician ability to identify PrEP candidates, enhancing interest in and ability to encourage PrEP uptake, and increasing utilization of continuous care management for retention and adherence.
INQUIRY-THE JOURNAL OF HEALTH CARE ORGANIZATION PROVISION AND FINANCING
(2021)
Article
Primary Health Care
Robert L. Cooper, Mohammad Tabatabai, Paul D. Juarez, Aramandla Ramesh, Matthew C. Morris, Katherine Y. Brown, Thomas A. Arcury, Marybeth Shinn, Leandro A. Mena, Patricia-Matthews Juarez
Summary: Pre-Exposure Prophylaxis (PrEP) is an effective method of HIV prevention for certain high-risk populations, but less than 50,000 individuals currently use this regimen. A survey of medical schools in the United States found that only a minority offered PrEP education, with limited training for LGBT patients. Most schools used didactic sessions to deliver PrEP content, and students were more prepared to provide PrEP to MSM compared to other high-risk patients.
JOURNAL OF PRIMARY CARE AND COMMUNITY HEALTH
(2021)
Review
Health Policy & Services
Paul D. Juarez, Aramandla Ramesh, R. Lyle Cooper, Mohammad Tabatabai, Thomas A. Arcury, Marybeth Shinn, Michael Paul, Patricia Matthews-Juarez
JOURNAL OF HEALTH CARE FOR THE POOR AND UNDERSERVED
(2020)
Review
Health Policy & Services
Aramandla Ramesh, Paul D. Juarez, Michael J. Paul, Matthew C. Morris, Robert L. Cooper, Mohammad Tabatabai, Thomas A. Arcury, Marybeth Shinn, Patricia Matthews-Juarez, Katherine Y. Brown, Leandro A. Mena, Wansoo Im
JOURNAL OF HEALTH CARE FOR THE POOR AND UNDERSERVED
(2020)
Review
Health Policy & Services
R. Lyle Cooper, Aramandla Ramesh, Paul D. Juarez, Ryan Edgerton, Michael Paul, Mohammad Tabatabai, Katherine Y. Brown, Patricia Matthews-Juarez
JOURNAL OF HEALTH CARE FOR THE POOR AND UNDERSERVED
(2020)
Article
Education, Scientific Disciplines
Matthew C. Morris, Robert Lyle Cooper, Aramandla Ramesh, Mohammad Tabatabai, Thomas A. Arcury, Marybeth Shinn, Wansoo Im, Paul Juarez, Patricia Matthews-Juarez
MEDICAL SCIENCE EDUCATOR
(2020)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
