Article
Biochemistry & Molecular Biology
Silvia S. Barbieri, Leonardo Sandrini, Laura Musazzi, Maurizio Popoli, Alessandro Ieraci
Summary: Anxiety disorders are common mental health diseases, with stress being a major risk factor. The study found that apocynin can prevent the development of anxiety-like phenotype, reduce histone acetylation decrease, and block the upregulation of specific biochemical molecules.
Article
Biochemistry & Molecular Biology
Rana M. Nassif, Elias Chalhoub, Pia Chedid, Margarita Hurtado-Nedelec, Elia Raya, Pham My-Chan Dang, Jean-Claude Marie, Jamel El-Benna
Summary: Metformin exhibits anti-inflammatory effects by inhibiting the differentiation of human monocytes into proinflammatory macrophages and by limiting ROS production by macrophages via the activation of AMPK.
Review
Biochemistry & Molecular Biology
Jessica Bouviere, Rodrigo S. Fortunato, Corinne Dupuy, Joao Pedro Werneck-de-Castro, Denise P. Carvalho, Ruy A. Louzada
Summary: Physical exercise induces acute and adaptative responses at the cellular and systemic levels through the modulation of various signaling pathways in skeletal muscle. Antioxidants can blunt these adaptations, highlighting the crucial role of ROS in exercise. Understanding the balance between beneficial and harmful effects of ROS during and after exercise is a challenging question in exercise biology.
Article
Biochemistry & Molecular Biology
Sebastien Dilly, Miguel Romero, Stephanie Solier, Olivier Feron, Chantal Dessy, Anny Slama Schwok
Summary: ROS in cancer cells play a crucial role in regulating cell death, stemness maintenance, and metabolic reprogramming, which are associated with resistance to chemo/immunotherapy. This paper introduces new inhibitors of NADPH oxidase (NOX), which is important in the tumor microenvironment. One of the inhibitors, called Nanoshutter-1 (NS1), decreases tumor-promoting M2 macrophages in human blood monocytes. NS1 disrupts the NOX2 complex in the macrophages' membrane and mitochondria, leading to vasodilation of blood vessels and potential reduction of hypoxia. By targeting specific cells, NOX2-specific inhibitors could provide precision therapies.
Review
Cell Biology
Thaonhi Cung, Haibo Wang, M. Elizabeth Hartnett
Summary: This review summarizes studies conducted in the past five years on the roles of NOX and EPO in angiogenesis and the pathophysiology of ROP. The findings suggest that NOX, an enzyme responsible for ROS generation in endothelial cells, plays a significant role in both physiological and pathological angiogenesis. EPO, on the other hand, has antioxidant properties and promotes angiogenesis. This review is important for gaining a deeper understanding of the pathogenesis of ROP and exploring potential therapeutic strategies.
Article
Biochemistry & Molecular Biology
Jiangyan Liu, Qinglin Sun, Mengqi Sun, Lisen Lin, Xiaoke Ren, Tianyu Li, Qing Xu, Zhiwei Sun, Junchao Duan
Summary: This study investigated the mechanism of PM2.5-induced atherosclerosis and the protective role of melatonin. The results showed that PM2.5 exposure decreased aortic elasticity, caused dyslipidemia and oxidative damage, and increased atherosclerotic plaque area. Melatonin administration effectively alleviated macrophage M1 polarization and atherosclerosis. Further investigation revealed that NOX2 and mitochondria were prominent sources of PM2.5-induced ROS production, and melatonin inhibited NOX2-mediated crosstalk of signaling pathways, mitigating macrophage M1 polarization and foam cell formation.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Toxicology
Masahide Inoue, Koji Sakamoto, Atsushi Suzuki, Shinya Nakai, Akira Ando, Yukihiko Shiraki, Yoshio Nakahara, Mika Omura, Atsushi Enomoto, Ikuhiko Nakase, Makoto Sawada, Naozumi Hashimoto
Summary: Our study using a murine model demonstrated that the pulmonary toxicity of silica nanoparticles depended on their physico-chemical properties through distinct mechanisms. Cellular uptake of larger particles by macrophages decreased, while surface amine modification modulated endosomal reactive oxygen species (ROS) signaling via NADPH oxidase 2 (NOX2), both of which were involved in mitigating the immune response in macrophages and resulting lung injury.
PARTICLE AND FIBRE TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Anthony L. Sylvester, David X. Zhang, Sophia Ran, Natalya S. Zinkevich
Summary: Reactive oxygen species (ROS) play important roles in health and disease, with both beneficial and harmful effects. Different sources of ROS have different roles in various pathologies. NOX1 is associated with hypertension through ROS production, making it a promising therapeutic target. NOX2 and NOX4 produce hydrogen peroxide, influencing cellular processes. Increased ROS production from NOX5 contributes to atherosclerosis.
Article
Biochemistry & Molecular Biology
Jiuchun Qiu, Daiqi Liu, Pengsha Li, Lingling Zhou, Lu Zhou, Xing Liu, Yue Zhang, Meng Yuan, Gary Tse, Guangping Li, Tong Liu
Summary: Oxidative stress and mitochondrial dysfunction play important roles in the development of diabetic cardiomyopathy in type 2 diabetes mellitus. This study established a type 2 diabetes model and found that inhibiting NADPH oxidase can improve ventricular remodeling and reduce the incidence of DCM.
Review
Biochemistry & Molecular Biology
Leticia Guadalupe Fragoso-Morales, Jose Correa-Basurto, Martha Cecilia Rosales-Hernandez
Summary: Alzheimer's disease is a major human dementia characterized by memory loss associated with oxidative stress in brain cells. Overexpression of NADPH oxidase in AD leads to the production of large amounts of reactive oxygen species, damaging brain cells and vasculature, making it a potential therapeutic target for AD.
Review
Pharmacology & Pharmacy
Sudhanshu Sharma, Dia Advani, Ankita Das, Nishtha Malhotra, Akanksha Khosla, Vanshika Arora, Ankita Jha, Megha Yadav, Rashmi K. Ambasta, Pravir Kumar
Summary: Oxidative stress is a significant factor in neurological diseases, with antioxidant signaling pathways and natural compounds serving as pharmacological tools to combat the cellular deformities caused by oxidative stress. These pathways can be defined targets to reduce the harmful effects of neurological diseases, showing protective effects against stressors and anti-inflammatory responses.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hana Valenta, Sophie Dupre-Crochet, Mouna Abdesselem, Tania Bizouarn, Laura Baciou, Oliver Nusse, Ariane Deniset-Besseau, Marie Erard
Summary: The phagocyte NADPH oxidase is a key enzyme of the innate immune system, and the use of the chimeric protein Trimera can activate the enzyme and sustain high levels of activity, but it leads to intracellular acidification, apoptosis, and local peroxidation of lipids in the membrane.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Cell Biology
Biljana Musicki, Serkan Karakus, Justin D. La Favor, Haolin Chen, Fabio H. Silva, Mikael Sturny, Barry R. Zirkin, Arthur L. Burnett
Summary: The study suggests that stimulating the production of endogenous testosterone can help reduce priapism in patients with SCD without affecting fertility. This treatment approach may work by activating TSPO, restoring phosphodiesterase 5 activity, and reducing oxidative stress levels.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Chemistry, Medicinal
Mohamed A. A. Morsy, Seham A. A. Abdel-Gaber, Sahar A. A. Mokhemer, Mahmoud Kandeel, Wael F. F. Sedik, Anroop B. B. Nair, Katharigatta N. N. Venugopala, Hany Ezzat Khalil, Bandar E. E. Al-Dhubiab, Mervat Z. Z. Mohamed
Summary: The current study aimed to investigate the cardioprotective potential of pregnenolone against doxorubicin-induced cardiotoxicity. The results showed that pregnenolone could alleviate the side effects of doxorubicin on the heart, including histopathological changes and elevated levels of creatine kinase-MB and lactate dehydrogenase. Moreover, pregnenolone exhibited antioxidant, anti-inflammatory, and antiapoptotic effects, contributing to its cardioprotection in doxorubicin-treated rats.
Article
Endocrinology & Metabolism
R. Giancaspro, M. Cassano, M. Gelardi
Summary: This review aims to elucidate the mechanisms of oxidative stress and the development and progression of various diseases related to oxidative stress.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Maya Izumi, Kazuo Sonoki, Yuko Ohta, Masayo Fukuhara, Masaharu Nagata, Sumio Akifusa
Summary: In this study, tongue cleaning was found to help maintain respiratory function in older adults requiring care, with the intervention group showing a significant improvement in peak expiratory flow rate and tongue pressure compared to the control group after 1 year.
JOURNAL OF ORAL REHABILITATION
(2021)
Article
Environmental Sciences
Maya Izumi, Ayaka Isobe, Sumio Akifusa
Summary: The study found that trypsin-like activity in the oral cavity is associated with the risk of fever in independent older residents of nursing homes, with ADCHECK(R) scores of 4 and 5 indicating a higher risk of fever.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Noriaki Kamio, Mayumi Hayata, Muneaki Tamura, Hajime Tanaka, Kenichi Imai
Summary: Chronic periodontitis is a risk factor for pneumonia, and periodontopathic bacteria enhance pneumococcal adhesion to human alveoli by inducing PAFR expression. Among the virulence factors of Porphyromonas gingivalis, gingipains play a key role in this process.
Article
Dentistry, Oral Surgery & Medicine
Maya Izumi, Ayaka Isobe, Sumio Akifusa
Summary: Posterior teeth occlusion is correlated with the risk of fever in older residents of nursing homes.
Article
Dentistry, Oral Surgery & Medicine
Maya Izumi, Kazuo Sonoki, Yuko Ohta, Masayo Fukuhara, Masaharu Nagata, Sumio Akifusa
Summary: The decline in swallowing function among older residents in nursing homes is related to the onset of fever, with a higher risk of fever observed as swallowing dysfunction worsens.
Article
Biochemistry & Molecular Biology
Yuwa Takahashi, Marni E. Cueno, Noriaki Kamio, Toshimitsu Iinuma, Yoshiyuki Hasegawa, Kenichi Imai
Summary: The study demonstrates that Porphyromonas gingivalis Mfa1 protein can interact functionally with human bronchial epithelial cells, inducing an inflammatory response involving IL-8 and IL-6 gene expression and protein levels. Specifically, Mfa1-TLR2 showed a functional interaction, suggesting a potential role in pulmonary disease development.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Mako Naniwa, Chihiro Nakatomi, Suzuro Hitomi, Kazunari Matsuda, Takuya Tabuchi, Daijiro Sugiyama, Sayaka Kubo, Yuichi Miyamura, Kenichi Yoshino, Sumio Akifusa, Kentaro Ono
Summary: This study found that Tmc alleviates pain in oral ulcerative mucositis models by suppressing inflammatory responses and nerve sensitivity. Long-lasting ointments are crucial for effective drug delivery to induce therapeutic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Dentistry, Oral Surgery & Medicine
Maya Izumi, Sumio Akifusa
Summary: Oral dysfunction and tongue coating may lead to oral microbiota imbalance, increasing the risk of aspiration pneumonia. Regular tongue cleaning can improve tongue function, enhance swallowing and respiratory function, and prevent aspiration pneumonia.
JOURNAL OF ORAL REHABILITATION
(2021)
Article
Biochemistry & Molecular Biology
Ryuta Suzuki, Noriaki Kamio, Tadayoshi Kaneko, Yoshiyuki Yonehara, Kenichi Imai
Summary: Fusobacterium nucleatum may play a role in exacerbation of chronic obstructive pulmonary disease (COPD), causing inflammatory responses and exacerbating disease progression.
Article
Dentistry, Oral Surgery & Medicine
Naoki Murakami, Kenji Yoshikawa, Kohei Tsukada, Noriaki Kamio, Yoshinori Hayashi, Suzuro Hitomi, Yuki Kimura, Ikuko Shibuta, Ayaka Osada, Shuichi Sato, Koichi Iwata, Masamichi Shinoda
Summary: This study examines the involvement of butyric acid (BA) in periodontal pain sensitivity in Porphyromonas gingivalis (P. gingivalis)-induced periodontitis. The results suggest that gingival BA modulates periodontal mechanical nociception via GPR41 signaling.
JOURNAL OF ORAL SCIENCE
(2022)
Article
Environmental Sciences
Ayaka Koga, Wataru Ariyoshi, Kaoru Kobayashi, Maya Izumi, Ayaka Isobe, Sumio Akifusa, Tatsuji Nishihara
Summary: This study found that the bacterial burden of T. forsythia in the oral cavity is associated with the risk of fever onset in older nursing home residents.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Maya Izumi, Kazuo Sonoki, Sumio Akifusa
Summary: This study evaluated the relationship between salivary occult blood (SOB) and plasma branched-chain amino acids (BCAA) levels in middle-aged Japanese individuals. The results showed a positive correlation between SOB and plasma BCAA levels, suggesting that SOB may be a predictor of elevated plasma BCAA levels.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Maya Izumi, Wataru Fujii, Sumio Akifusa
Summary: This study aimed to examine the influence of ageism among dental students and clinical trainees on their attitudes towards older adults in dental care. By conducting a questionnaire survey, it was found that ageism specific to dental students and clinical trainees was independently correlated with negative attitudes towards dental care for older adults.
EUROPEAN JOURNAL OF DENTAL EDUCATION
(2023)
Article
Dentistry, Oral Surgery & Medicine
Maya Izumi, Sumio Akifusa
Summary: The purpose of this study was to investigate the self-compassion of dental hygiene students in Japan and its correlation with their uneasiness about their professional future. The findings suggest that the negative factor of self-compassion is related to an increased risk of feeling uneasy about one's professional future.
INTERNATIONAL JOURNAL OF DENTISTRY
(2023)
Article
Medicine, Research & Experimental
Ryuta Suzuki, Noriaki Kamio, Kozue Sugimoto, Shuichiro Maruoka, Yasuhiro Gon, Tadayoshi Kaneko, Yoshiyuki Yonehara, Kenichi Imai
Summary: There is a correlation between periodontopathic bacteria and pulmonary diseases, although the molecular mechanisms are not yet fully understood. This study investigated the effects of Fusobacterium nucleatum on the expression of MMP9 in mouse lung and human alveolar epithelial cells. The results indicate that F. nucleatum can induce MMP9 expression, suggesting its potential role in the onset of pulmonary diseases.
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)