Article
Immunology
Ferhat Guzel, Micol Romano, Erdi Keles, David Piskin, Seza Ozen, Hakan Poyrazoglu, Ozgur Kasapcopur, Erkan Demirkaya
Summary: This study describes the development and validation of an NGS-based multiplex array for targeted sequencing of nine genes associated with common AIDs, offering a cost-effective, comprehensive, and informative screening tool compared to other methods.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Virology
Mohammad Tanvir Islam, A. S. M. Rubayet Ul Alam, Najmuj Sakib, Mohammad Shazid Hasan, Tanay Chakrovarty, Mohammad Tawyabur, Ovinu Kibria Islam, Hassan M. Al-Emran, Mohammad Iqbal Kabir Jahid, Mohammad Anwar Hossain
Summary: The study introduces a rapid, simple, and cost-effective multiplex PCR assay to identify six phylogenetic clades of SARS-CoV-2, which has been optimized and validated. This multiplex detection method can quickly and inexpensively discriminate the phylogenetic clade variants of infected individuals.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Chemistry, Analytical
Hannah N. Kozlowski, Ayden Malekjahani, Vanessa Y. C. Li, Ayokunle A. Lekuti, Stephen Perusini, Natalie G. Bell, Veronique Voisin, Delaram Pouyabahar, Shraddha Pai, Gary D. Bader, Samira Mubareka, Jonathan B. Gubbay, Warren C. W. Chan
Summary: Designing diagnostic assays for rapidly mutating viruses is challenging, but we developed a quantum dot barcode multiplexing system that can genotype mutated viruses. By designing multiple quantum dot barcodes, we were able to detect and identify different sequence types of SARS-CoV-2, including conserved genes, nucleotide deletions, and single nucleotide substitutions. Our system showed high sensitivity and specificity in detecting SARS-CoV-2 patient specimens and tracking the emergence of viral mutations over time. This technology, combined with smartphone detection, has the potential for real-time point-of-care tracking of viral mutations.
ANALYTICAL CHEMISTRY
(2023)
Article
Genetics & Heredity
Ling Chen, Xiyong Pan, Yuan Wang, Weian Du, Weibin Wu, Zhenya Tang, Cheng Xiao, Xiaolong Han, Chao Liu, Changhui Liu
Summary: The AGCU X-InDel 38 kit demonstrated high sensitivity, precision, reproducibility, and informativeness for forensic applications. It showed better performance for degraded and trace DNA samples and good tolerance to common inhibitors, while also exhibiting strong discrimination capability through high values of forensic parameters.
FRONTIERS IN GENETICS
(2021)
Article
Multidisciplinary Sciences
Qing Sun, Jonathan Li, Hui Ren, Larry Pastor, Yulia Loginova, Roberta Madej, Kristopher Taylor, Joseph K. Wong, Zhao Zhang, Aiguo Zhang, Chuanyi M. Lu, Michael Y. Sha
Summary: The QuantiVirus(TM) SARS-CoV-2 test has a limit of detection of 200 copies/mL in contrived saliva samples. The clinical performance of saliva-based testing is comparable to NPS-based testing. Pooling of saliva specimens for SARS-CoV-2 detection is feasible.
Article
Cell Biology
Eun-Jeong Choi, In-Cheol Baek, Silvia Park, Hee-Je Kim, Tai-Gyu Kim
Summary: KIR genes control NK cell functions by recognizing HLA molecules. The diversity of KIR region is achieved through differences in gene content, polymorphism, and gene copy number. KIR genotyping is important in epidemiological studies.
Article
Biochemical Research Methods
Qiuya Zhang, Dan Wen, Qin Liu, Tanja Opriessnig, Xiaoya Yu, Yonghou Jiang
Summary: In this study, a novel multiplex PCR method was developed for the rapid and specific detection of single or mixed genotype infections of porcine astroviruses (PAstV). The method was evaluated using 273 pig fecal samples, and PAstV4 was found to be the most common genotype.
JOURNAL OF VIROLOGICAL METHODS
(2023)
Article
Chemistry, Analytical
Jixue Weng, Nan Sheng, Runyuan Wang, Shuo Liang, Chen Wang, Xue Bai, Guohua Zhou, Bingjie Zou, Qinxin Song
Summary: Cervical cancer is a significant cause of death in women, with HPV typing being crucial for diagnosis and control. The Multi-Vision method, utilizing closed-tube PCR, offers high specificity and sensitivity for typing various HPV types, making it a useful tool for HPV detection in resource-limited regions.
ANALYTICAL CHEMISTRY
(2021)
Article
Pathology
Joel J. Credle, Matthew L. Robinson, Jonathan Gunn, Daniel Monaco, Brandon Sie, Alexandra Tchir, Justin Hardick, Xuwen Zheng, Kathryn Shaw-Saliba, Richard E. Rothman, Susan H. Eshleman, Andrew Pekosz, Kasper Hansen, Heba Mostafa, Martin Steinegger, H. Benjamin Larman
Summary: The novel detection method cRASL-seq proposed in the study can efficiently and sensitively detect pathogens, the analysis of COVID-19 patient samples does not require nucleic acid purification or reverse transcription, with low cost and easy operation, it is a powerful new technology.
Article
Biochemical Research Methods
Yongsong Zhou, Wei Cui, Buling Wu, Bofeng Zhu
Summary: A 6-dye multiplex Y-chromosomal short tandem repeat (Y-STR) panel named Y34plex was constructed to increase discrimination capacity and reduce adventitious match probability, combining 25 Y-chromosomal markers and nine highly polymorphic Y-STR loci. A validation study showed that Y34plex has high discrimination power and applicability for forensic investigations.
Article
Virology
Jian Yin, Siying Peng, Changning Zhang, Xinyue Li, Fangfang Hu, Wen Chen, Youlin Qiao
Summary: The performance of LiPA-25 and Hybribio-23 in HPV detection and genotyping was compared. The results showed that the two methods had similar outcomes, suggesting that Hybribio-23 can be used for HPV detection and genotyping in epidemiological and vaccine studies worldwide.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Microbiology
Hannah Wang, Jacob A. Miller, Michelle Verghese, Mamdouh Sibai, Daniel Solis, Kenji O. Mfuh, Becky Jiang, Naomi Iwai, Marilyn Mar, ChunHong Huang, Fumiko Yamamoto, Malaya K. Sahoo, James Zehnder, Benjamin A. Pinsky
Summary: This study developed a new nucleic acid amplification test to detect SARS-CoV-2 variants with high sensitivity and specificity. Screening a large cohort of infected individuals in the San Francisco Bay Area revealed a rapid increase in the prevalence of the L452R variant over time.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Isadora Alonso Correa, Tamires de Souza Rodrigues, Alex Queiroz, Leon de Franca Nascimento, Thiago Wolff, Rubens Nobumoto Akamine, Sergio Noboru Kuriyama, Luciana Jesus da Costa, Antonio Augusto Fidalgo-Neto
Summary: RT-qPCR is the gold standard for SARS-CoV-2 detection, but it has long run times and high costs. In this study, a pooling strategy was evaluated and validated using samples from a mass testing program. The results showed that pooling can increase testing capacity and save costs without sacrificing sensitivity.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Analytical
Tzu-Yu Pan, Hwang-Shang Kou, Shou-Mei Wu, Chun-Chi Wang
Summary: A rapid method for genotyping of red and green pigment genes is developed in this study. Using fluorescence labeling and capillary electrophoresis analysis, this method can accurately detect individuals with color vision deficiencies and shows good agreement with DNA sequencing results.
Article
Biochemical Research Methods
Cheng Xiao, Quyi Xu, Huan Li, Xiaolin Zhu, Zhonghao Yu, Jian Zhao, Yue Li, Hong Liu, He Shi, Chao Liu
Summary: This study presented a novel multiplex PCR system for detecting drowning-related diatoms, cyanobacteria, and aeromonas. It showed good sensitivity and specificity, providing additional evidence for drowning diagnosis and ruling out nondrowning cases. The system has great potential for forensic drowning diagnosis.
Review
Biochemistry & Molecular Biology
Hardeep Singh Tuli, Vivek K. Garg, Renuka Choudhary, Ashif Iqubal, Katrin Sak, Adesh K. Saini, Reena V. Saini, Kanupriya Vashishth, Kuldeep Dhama, Ranjan K. Mohapatra, Dhruv Sanjay Gupta, Ginpreet Kaur
Summary: Lung cancer is a highly lethal form of cancer with rapidly increasing incidence. Non-small cell lung cancer (NSCLC) accounts for 80-85% of all cases, with adenocarcinoma, squamous cell carcinoma and large cell carcinoma as the main subtypes. Immune checkpoint inhibitors have led to significant advances in the treatment of solid tumors, improving cancer patient survival rates.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Multidisciplinary Sciences
Mitja Kurki, Juha Karjalainen, Priit Palta, Timo P. Sipila, Kati Kristiansson, Kati M. Donner, Mary P. Reeve, Hannele Laivuori, Mervi Aavikko, Mari A. Kaunisto, Anu Loukola, Elisa Lahtela, Hannele Mattsson, Paivi Laiho, Pietro Della Briotta Parolo, Arto A. Lehisto, Masahiro Kanai, Nina Mars, Joel Ramo, Tuomo Kiiskinen, Henrike O. Heyne, Kumar Veerapen, Sina Rueger, Susanna Lemmela, Wei Zhou, Sanni Ruotsalainen, Kalle Parn, Tero Hiekkalinna, Sami Koskelainen, Teemu Paajanen, Vincent Llorens, Javier Gracia-Tabuenca, Harri Siirtola, Kadri Reis, Abdelrahman G. Elnahas, Benjamin Sun, Christopher N. Foley, Katriina Aalto-Setala, Kaur Alasoo, Mikko Arvas, Kirsi Auro, Shameek Biswas, Argyro Bizaki-Vallaskangas, Olli Carpen, Chia-Yen Chen, Oluwaseun A. Dada, Zhihao Ding, Margaret G. Ehm, Kari Eklund, Martti Farkkila, Hilary Finucane, Andrea Ganna, Awaisa Ghazal, Robert R. Graham, Eric M. Green, Antti Hakanen, Marco Hautalahti, Asa K. Hedman, Mikko Hiltunen, Reetta Hinttala, Iiris Hovatta, Xinli Hu, Adriana Huertas-Vazquez, Laura Huilaja, Julie Hunkapiller, Howard Jacob, Jan-Nygaard Jensen, Heikki Joensuu, Sally John, Valtteri Julkunen, Marc Jung, Juhani Junttila, Kai Kaarniranta, Mika Kahonen, Risto Kajanne, Lila Kallio, Reetta Kalviainen, Jaakko Kaprio, Nurlan Kerimov, Johannes Kettunen, Elina Kilpelainen, Terhi Kilpi, Katherine Klinger, Veli-Matti Kosma, Teijo Kuopio, Venla Kurra, Triin Laisk, Jari Laukkanen, Nathan Lawless, Aoxing Liu, Simonne Longerich, Reedik Magi, Johanna Makela, Antti Makitie, Anders Malarstig, Arto Mannermaa, Joseph Maranville, Athena Matakidou, Tuomo Meretoja, Sahar Mozaffari, Mari E. K. Niemi, Marianna Niemi, Teemu Niiranen, George Okafo, Hanna M. Ollila, Antti Palomaki, Tuula Palotie, Jukka Partanen, Dirk S. Paul, Margit Pelkonen, Rion K. Pendergrass, Slave Petrovski, Anne Pitkaranta, Adam Platt, David Pulford, Eero Punkka, Pirkko Pussinen, Neha Raghavan, Fedik Rahimov, Deepak Rajpal, Nicole A. Renaud, Bridget Riley-Gillis, Rodosthenis Rodosthenous, Elmo Saarentaus, Aino Salminen, Eveliina Salminen, Veikko Salomaa, Johanna Schleutker, Raisa Serpi, Huei-yi Shen, Richard Siegel, Kaisa Silander, Sanna Siltanen, Sirpa Soini, Hilkka Soininen, Jae Hoon Sul, Ioanna Tachmazidou, Kaisa Tasanen, Pentti Tienari, Sanna Toppila-Salmi, Taru Tukiainen, Tiinamaija Tuomi, Joni A. Turunen, Jacob C. Ulirsch, Felix Vaura, Petri Virolainen, Jeffrey Waring, Dawn Waterworth, Robert Yang, Mari Nelis, Anu Reigo, Andres Metspalu, Lili Milani, Tonu Esko, Caroline Fox, Aki S. Havulinna, Markus Perola, Samuli Ripatti, Anu Jalanko, Tarja Laitinen, Tomi P. Makela, Robert Plenge, Mark McCarthy, Heiko Runz, Mark J. Daly, Aarno Palotie
Summary: Population isolates, like those in Finland, provide valuable insights for genetic research due to the concentration of deleterious alleles in low-frequency variants. FinnGen aims to study the genome and health data of 500,000 Finnish individuals, enabling the identification of new associations and the exploration of their implications for common diseases. The study identified 30 new associations and 2,733 genome-wide significant associations, highlighting the power of bottlenecked populations in uncovering disease biology.
Article
Oncology
Hardeep Singh Tuli, Vivek Kumar Garg, Sakshi Bhushan, Vivek Uttam, Uttam Sharma, Aklank Jain, Katrin Sak, Vikas Yadav, Jose M. Lorenzo, Kuldeep Dhama, Tapan Behl, Gautam Sethi
Summary: Cancer prevalence and incidence rates have been increasing over the past few decades. To combat this disease, it is necessary to explore safer and more effective molecules. Flavonoids, a class of polyphenols, have shown potential against cancer without significant toxicity to normal cells. They modulate microRNAs to enhance drug sensitivity and suppress cancer cell proliferation, metastasis, and angiogenesis. This review comprehensively discusses the structure, chemistry, and effects of flavonoids like quercetin, luteolin, silibinin, genistein, epigallocatechin gallate, and cyanidin on various cancer types. Targeting miRNAs by flavonoids in cancer cells could be a promising approach for future clinical investigations and affirmation.
TRANSLATIONAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Eeva Sliz, Jaakko S. Tyrmi, Nilufer Rahmioglu, Krina T. Zondervan, Christian M. Becker, Outi Uimari, Johannes Kettunen, Aarno Palotie, Mark Daly, Bridget Riley-Gills, Howard Jacob, Dirk Paul, Athena Matakidou, Adam Platt, Heiko Runz, Sally John, George Okafo, Nathan Lawless, Heli Salminen-Mankonen, Robert Plenge, Joseph Maranville, Mark McCarthy, Margaret G. Ehm, Kirsi Auro, Simonne Longerich, Caroline Fox, Anders Malarstig, Katherine Klinger, Clement Chatelain, Matthias Gossel, Karol Estrada, Robert Graham, Robert Yang, Chris O'Donnell, Tomi P. Makela, Jaakko Kaprio, Petri Virolainen, Antti Hakanen, Terhi Kilpi, Markus Perola, Jukka Partanen, Anne Pitkaranta, Taneli Raivio, Raisa Serpi, Tarja Laitinen, Veli-Matti Kosma, Jari Laukkanen, Marco Hautalahti, Outi Tuovila, Raimo Pakkanen, Jeffrey Waring, Bridget Riley-Gillis, Fedik Rahimov, Ioanna Tachmazidou, Chia-Yen Chen, Zhihao Ding, Marc Jung, Shameek Biswas, Rion Pendergrass, David Pulford, Neha Raghavan, Adriana Huertas-Vazquez, Jae-Hoon Sul, Xinli Hu, Asa Hedman, Manuel Rivas, Dawn Waterworth, Nicole Renaud, Ma'en Obeidat, Samuli Ripatti, Johanna Schleutker, Mikko Arvas, Olli Carpen, Reetta Hinttala, Arto Mannermaa, Katriina Aalto-Setala, Mika Kahonen, Johanna Makela, Reetta Kalviainen, Valtteri Julkunen, Hilkka Soininen, Anne Remes, Mikko Hiltunen, Jukka Peltola, Minna Raivio, Pentti Tienari, Juha Rinne, Roosa Kallionpaa, Juulia Partanen, Ali Abbasi, Adam Ziemann, Nizar Smaoui, Anne Lehtonen, Susan Eaton, Sanni Lahdenpera, Natalie Bowers, Edmond Teng, Fanli Xu, Laura Addis, John Eicher, Qingqin S. Li, Karen He, Ekaterina Khramtsova, Martti Farkkila, Jukka Koskela, Sampsa Pikkarainen, Airi Jussila, Katri Kaukinen, Timo Blomster, Mikko Kiviniemi, Markku Voutilainen, Tim Lu, Linda McCarthy, Amy Hart, Meijian Guan, Jason Miller, Kirsi Kalpala, Melissa Miller, Kari Eklund, Antti Palomaki, Pia Isomaki, Laura Pirila, Oili Kaipiainen-Seppanen, Johanna Huhtakangas, Nina Mars, Apinya Lertratanakul, Marla Hochfeld, Jorge Esparza Gordillo, Fabiana Farias, Nan Bing, Margit Pelkonen, Paula Kauppi, Hannu Kankaanranta, Terttu Harju, Riitta Lahesmaa, Glenda Lassi, Hubert Chen, Joanna Betts, Rajashree Mishra, Majd Mouded, Debby Ngo, Teemu Niiranen, Felix Vaura, Veikko Salomaa, Kaj Metsarinne, Jenni Aittokallio, Jussi Hernesniemi, Daniel Gordin, Juha Sinisalo, Marja-Riitta Taskinen, Tiinamaija Tuomi, Timo Hiltunen, Amanda Elliott, Mary Pat Reeve, Sanni Ruotsalainen, Benjamin Challis, Audrey Chu, Dermot Reilly, Mike Mendelson, Jaakko Parkkinen, Tuomo Meretoja, Heikki Joensuu, Johanna Mattson, Eveliina Salminen, Annika Auranen, Peeter Karihtala, Paivi Auvinen, Klaus Elenius, Esa Pitkanen, Relja Popovic, Jennifer Schutzman, Diptee Kulkarni, Alessandro Porello, Andrey Loboda, Heli Lehtonen, Stefan McDonough, Sauli Vuoti, Kai Kaarniranta, Joni A. Turunen, Terhi Ollila, Hannu Uusitalo, Juha Karjalainen, Mengzhen Liu, Stephanie Loomis, Erich Strauss, Hao Chen, Kaisa Tasanen, Laura Huilaja, Katariina Hannula-Jouppi, Teea Salmi, Sirkku Peltonen, Leena Koulu, David Choy, Ying Wu, Pirkko Pussinen, Aino Salminen, Tuula Salo, David Rice, Pekka Nieminen, Ulla Palotie, Maria Siponen, Liisa Suominen, Paivi Mantyla, Ulvi Gursoy, Vuokko Anttonen, Kirsi Sipila, Hannele Laivuori, Venla Kurra, Laura Kotaniemi-Talonen, Oskari Heikinheimo, Ilkka Kalliala, Lauri Aaltonen, Varpu Jokimaa, Marja Vaarasmaki, Laure Morin-Papunen, Maarit Niinimaki, Terhi Piltonen, Katja Kivinen, Elisabeth Widen, Taru Tukiainen, Niko Valimaki, Eija Laakkonen, Heidi Silven, Riikka Arffman, Susanna Savukoski, Triin Laisk, Natalia Pujol, Janet Kumar, Iiris Hovatta, Erkki Isometsa, Hanna Ollila, Jaana Suvisaari, Thomas Damm Als, Antti Makitie, Argyro Bizaki-Vallaskangas, Sanna Toppila-Salmi, Tytti Willberg, Elmo Saarentaus, Antti Aarnisalo, Elisa Rahikkala, Kristiina Aittomaki, Fredrik Aberg, Mitja Kurki, Aki Havulinna, Juha Mehtonen, Priit Palta, Shabbeer Hassan, Pietro Della Briotta Parolo, Wei Zhou, Mutaamba Maasha, Susanna Lemmela, Aoxing Liu, Arto Lehisto, Andrea Ganna, Vincent Llorens, Henrike Heyne, Joel Ramo, Rodos Rodosthenous, Satu Strausz, Tuula Palotie, Kimmo Palin, Javier Garcia-Tabuenca, Harri Siirtola, Tuomo Kiiskinen, Jiwoo Lee, Kristin Tsuo, Kati Kristiansson, Kati Hyvarinen, Jarmo Ritari, Katri Pylkas, Minna Karjalainen, Tuomo Mantere, Eeva Kangasniemi, Sami Heikkinen, Nina Pitkanen, Samuel Lessard, Clement Chatelain, Perttu Terho, Tiina Wahlfors, Eero Punkka, Sanna Siltanen, Teijo Kuopio, Anu Jalanko, Huei-Yi Shen, Risto Kajanne, Mervi Aavikko, Henna Palin, Malla-Maria Linna, Masahiro Kanai, Zhili Zheng, L. Elisa Lahtela, Mari Kaunisto, Elina Kilpelainen, Timo P. Sipila, Oluwaseun Alexander Dada, Awaisa Ghazal, Anastasia Kytola, Rigbe Weldatsadik, Kati Donner, Anu Loukola, Paivi Laiho, Tuuli Sistonen, Essi Kaiharju, Markku Laukkanen, Elina Jarvensivu, Sini Lahteenmaki, Lotta Mannikko, Regis Wong, Auli Toivola, Minna Brunfeldt, Hannele Mattsson, Sami Koskelainen, Tero Hiekkalinna, Teemu Paajanen, Kalle Parn, Mart Kals, Shuang Luo, Shanmukha Sampath Padmanabhuni, Marianna Niemi, Javier Gracia-Tabuenca, Mika Helminen, Tiina Luukkaala, Iida Vahatalo, Jyrki Tammerluoto, Sarah Smith, Tom Southerington, Petri Lehto
Summary: Uterine leiomyomata (UL) are the most common tumours in women and often result in surgical removal of the uterus. This study identified 22 new genetic loci associated with UL risk, in addition to the previously known 50 loci. The identified genes are involved in development, growth, and cellular senescence, particularly in the smooth muscle cell differentiation and proliferation pathways.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Joel Raemoe, Tuomo Kiiskinen, Richard Seist, Kristi Krebs, Masahiro Kanai, Juha Karjalainen, Mitja Kurki, Eija Haemaelaeinen, Paavo S. Haeppoelae, Aki Havulinna, Heidi Hautakangas, Reedik Maegi, Priit Palta, Tonu Esko, Andres Metspalu, Matti J. Pirinen, Konrad Karczewski, Samuli Ripatti, Lili M. Milani, Konstantina Stankovic, Antti J. Maekitie, Mark Daly, Aarno Palotie
Summary: Otosclerosis is a common form of hearing loss, with an unclear genetic etiology. A genome-wide association study meta-analysis of otosclerosis identified 27 genetic loci, pointing to genes involved in bone remodeling, skeletal disorders, and transforming growth factor beta signaling.
NATURE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Hardeep Singh Tuli, Prangya Rath, Abhishek Chauhan, Anuj Ranjan, Seema Ramniwas, Katrin Sak, Diwakar Aggarwal, Manoj Kumar, Kuldeep Dhama, E. Hui Clarissa Lee, Kenneth Chun-Yong Yap, Sharah Mae Capinpin, Alan Prem Kumar
Summary: Cucurbitacins, a group of highly oxidized tetracyclic triterpenoids found in cucumbers, have potential medical uses. They interact with various cellular targets to inhibit cancer cell growth through induction of apoptosis, cell-cycle arrest, anti-metastasis, and anti-angiogenesis. They may also be used in combination with other drugs to overcome treatment resistance in cancer cells. This study focuses on finding molecular targets for cucurbitacins in suppressing malignant processes.
Correction
Multidisciplinary Sciences
Mitja I. Kurki, Juha Karjalainen, Priit Palta, Timo P. P. Sipila, Kati Kristiansson, Kati M. Donner, Mary P. Reeve, Hannele Laivuori, Mervi Aavikko, Mari A. Kaunisto, Anu Loukola, Elisa Lahtela, Hannele Mattsson, Paivi Laiho, Pietro Della Briotta Parolo, Arto A. Lehisto, Masahiro Kanai, Nina Mars, Joel Ramo, Tuomo Kiiskinen, Henrike O. Heyne, Kumar Veerapen, Sina Rueger, Susanna Lemmela, Wei Zhou, Sanni Ruotsalainen, Kalle Parn, Tero Hiekkalinna, Sami Koskelainen, Teemu Paajanen, Vincent Llorens, Javier Gracia-Tabuenca, Harri Siirtola, Kadri Reis, Abdelrahman G. Elnahas, Benjamin Sun, Christopher N. Foley, Katriina Aalto-Setala, Kaur Alasoo, Mikko Arvas, Kirsi Auro, Shameek Biswas, Argyro Bizaki-Vallaskangas, Olli Carpen, Chia-Yen Chen, Oluwaseun A. Dada, Zhihao Ding, Margaret G. Ehm, Kari Eklund, Martti Farkkila, Hilary Finucane, Andrea Ganna, Awaisa Ghazal, Robert R. Graham, Eric M. Green, Antti Hakanen, Marco Hautalahti, Asa K. Hedman, Mikko Hiltunen, Reetta Hinttala, Iiris Hovatta, Xinli Hu, Adriana Huertas-Vazquez, Laura Huilaja, Julie Hunkapiller, Howard Jacob, Jan-Nygaard Jensen, Heikki Joensuu, Sally John, Valtteri Julkunen, Marc Jung, Juhani Junttila, Kai Kaarniranta, Mika Kahonen, Risto Kajanne, Lila Kallio, Reetta Kalviainen, Jaakko Kaprio, Nurlan Kerimov, Johannes Kettunen, Elina Kilpelainen, Terhi Kilpi, Katherine Klinger, Veli-Matti Kosma, Teijo Kuopio, Venla Kurra, Triin Laisk, Jari Laukkanen, Nathan Lawless, Aoxing Liu, Simonne Longerich, Reedik Magi, Johanna Makela, Antti Makitie, Anders Malarstig, Arto Mannermaa, Joseph Maranville, Athena Matakidou, Tuomo Meretoja, Sahar V. Mozaffari, Mari E. K. Niemi, Marianna Niemi, Teemu Niiranen, Christopher J. J. O'Donnell, Ma'en Obeidat, George Okafo, Hanna M. Ollila, Antti Palomaki, Tuula Palotie, Jukka Partanen, Dirk S. Paul, Margit Pelkonen, Rion K. Pendergrass, Slave Petrovski, Anne Pitkaranta, Adam Platt, David Pulford, Eero Punkka, Pirkko Pussinen, Neha Raghavan, Fedik Rahimov, Deepak Rajpal, Nicole A. Renaud, Bridget Riley-Gillis, Rodosthenis Rodosthenous, Elmo Saarentaus, Aino Salminen, Eveliina Salminen, Veikko Salomaa, Johanna Schleutker, Raisa Serpi, Huei-yi Shen, Richard Siegel, Kaisa Silander, Sanna Siltanen, Sirpa Soini, Hilkka Soininen, Jae Hoon Sul, Ioanna Tachmazidou, Kaisa Tasanen, Pentti Tienari, Sanna Toppila-Salmi, Taru Tukiainen, Tiinamaija Tuomi, Joni A. Turunen, Jacob C. Ulirsch, Felix Vaura, Petri Virolainen, Jeffrey Waring, Dawn Waterworth, Robert Yang, Mari Nelis, Anu Reigo, Andres Metspalu, Lili Milani, Tonu Esko, Caroline Fox, Aki S. Havulinna, Markus Perola, Samuli Ripatti, Anu Jalanko, Tarja Laitinen, Tomi P. P. Makela, Robert Plenge, Mark McCarthy, Heiko Runz, Mark J. Daly, Aarno Palotie
Review
Pharmacology & Pharmacy
Hardeep Singh Tuli, Hemant Joshi, Kanupriya Vashishth, Seema Ramniwas, Mehmet Varol, Manoj Kumar, Isha Rani, Vibha Rani, Katrin Sak
Summary: This review article discusses the anticancer properties of a natural biflavone compound called amentoflavone, derived from various plants such as ginkgo, hinoki, and St. John`s wort. It has been found to suppress malignant growth, induce apoptosis in tumor cells, and inhibit angiogenesis and metastasis. Amentoflavone shows promise as a potential lead compound for the development of novel anticancer drugs, and further in vivo studies and clinical trials are warranted.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Ophthalmology
Joel T. Ramo, Erik Abner, Elon H. C. van Dijk, Xin Wang, Joost Brinks, Tiit Nikopensius, Margit Noukas, Heidi Marjonen, Kaisa Silander, Sakari Jukarainen, Tuomo Kiiskinen, Seung Hoan Choi, Risto Kajanne, Juha Mehtonen, Priit Palta, Steven A. Lubitz, Kai Kaarniranta, Lucia Sobrin, Mitja Kurki, Suzanne Yzer, Patrick T. Ellinor, Tonu Esko, Mark J. Daly, Anneke I. den Hollander, Aarno Palotie, Joni A. Turunen, Camiel J. F. Boon, Elizabeth J. Rossin
Summary: This study identified 5 genetic risk loci associated with CSC, indicating the likely involvement of genes related to choroidal vascular function and complement regulation in the pathogenesis of CSC.
JAMA OPHTHALMOLOGY
(2023)
Review
Pharmacology & Pharmacy
Gautam Sethi, Prangya Rath, Abhishek Chauhan, Anuj Ranjan, Renuka Choudhary, Seema Ramniwas, Katrin Sak, Diwakar Aggarwal, Isha Rani, Hardeep Singh Tuli
Summary: Due to the rising incidence rates of liver cancer and concerns regarding toxicity of current chemotherapy drugs, there is an increasing need for alternative treatment methods. Quercetin, a flavonoid found in fruits, vegetables, and herbs, has shown promising results in inducing apoptotic cell death in cancer cells. It targets apoptosis-related proteins and has the potential for chemoprevention. This review discusses the mechanisms of action, nanodelivery strategies, and other potential cellular effects of quercetin in liver cancer.
Review
Chemistry, Medicinal
Hardeep Singh Tuli, Sakshi Bhushan, Ajay Kumar, Poonam Aggarwal, Katrin Sak, Seema Ramniwas, Kanupriya Vashishth, Tapan Behl, Rashmi Rana, Shafiul Haque, Miguel A. Prieto
Summary: This review article focuses on the role of Scutellaria flavones in regulating the autophagic machinery in diverse cancer models, highlighting their potential as lead compounds for the fight against malignant neoplasms. Flavonoids exhibit a dual-edged sword property of acting as both anti- and proautophagic agents.
Review
Pharmacology & Pharmacy
Hemant Joshi, Dhruv Sanjay Gupta, Ginpreet Kaur, Tejveer Singh, Seema Ramniwas, Katrin Sak, Diwakar Aggarwal, Raunak Singh Chhabra, Madhu Gupta, Adesh K. Saini, Hardeep Singh Tuli
Summary: Quercetin, a natural antioxidant, has shown numerous pharmacological properties in preclinical and clinical research, including anti-inflammatory and anti-cancer effects. Recent studies suggest that using nanoformulations can help overcome the hydrophobicity of quercetin while enhancing its stability and cellular bioavailability.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Correction
Ophthalmology
Joel T. Ramo, Erik Abner, Elon H. C. van Dijk, Xin Wang, Joost Brinks, Tiit Nikopensius, Margit Noukas, Heidi Marjonen, Kaisa Silander, Sakari Jukarainen, Tuomo Kiiskinen, Seung Hoan Choi, Risto Kajanne, Juha Mehtonen, Priit Palta, Steven A. Lubitz, Kai Kaarniranta, Lucia Sobrin, Mitja Kurki, Suzanne Yzer, Patrick T. Ellinor, Tonu Esko, Mark J. Daly, Anneke I. den Hollander, Aarno Palotie, Joni A. Turunen, Camiel J. F. Boon, Elizabeth J. Rossin
JAMA OPHTHALMOLOGY
(2023)
Article
Cell Biology
Ying Wang, Shinichi Namba, Esteban Lopera, Sini Kerminen, Kristin Tsuo, Kristi Lall, Masahiro Kanai, Wei Zhou, Kuan-Han Wu, Marie-Julie Fave, Laxmi Bhatta, Philip Awadalla, Ben Brumpton, Patrick Deelen, Kristian Hveem, Valeria Lo Faro, Reedik Magi, Yoshinori Murakami, Serena Sanna, Jordan W. Smoller, Jasmina Uzunovic, Cristen Willer, Eric R. Gamazon, Nancy J. Cox, Ida Surakka, Yukinori Okada, Alicia R. Martin, Jibril Hirbo
Summary: This study utilized data from GBMI to explore methodological considerations and performance of PRS for 14 disease endpoints across global populations. The study provides lessons for PRS construction, evaluation, and interpretation and highlights the importance of PRS in the biobank-scale genomics era.
Review
Chemistry, Multidisciplinary
Hardeep Singh Tuli, Ruchira Joshi, Ginpreet Kaur, Vivek Kumar Garg, Katrin Sak, Mehmet Varol, Jagjit Kaur, Sulaiman Ali Alharbi, Tahani Awad Alahmadi, Diwakar Aggarwal, Kuldeep Dhama, Vivek Sheel Jaswal, Sonam Mittal, Gautam Sethi
Summary: Nanotechnology has led to the development of new materials (metal nanoparticles) that have specific applications in healthcare, particularly in the diagnosis and treatment of cancer. Metal nanoparticles can modulate molecular expression in the tumor microenvironment and have anti-cancer effects by inducing apoptosis and cell cycle arrest. They can also inhibit tumor angiogenesis, metastasis, and inflammation, thus preventing cancer proliferation.
JOURNAL OF NANOSTRUCTURE IN CHEMISTRY
(2023)