Journal
FOOD CHEMISTRY
Volume 136, Issue 3-4, Pages 1350-1357Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2012.09.070
Keywords
Chaperones; Stress; Dietary protein; Whey protein
Funding
- Foundation for Research of the State of Sao Paulo, Brazil (FAPESP) [2010/02419-0, 2011/13035-1]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [10/02419-0, 11/13035-1] Funding Source: FAPESP
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Whey protein has been suggested to be potential protective agent against various forms of stress. The heat shock protein HSP70 confers greater cellular tolerance against stressors. The present study evaluated the effects of whey protein intake on HSP70 expression. Forty-eight male Wistar rats were divided into sedentary and exercised groups, and each group was fed as a protein source casein (CAS), whey protein (WP) or whey protein hydrolysate (WPH) for 3 weeks. Exercise on a treadmill was used as the source of stress in the animals from the exercised group. The results showed a larger increase in HSP70 expression in the soleus, gastrocnemius and lung of the WPH-fed rats than WP or casein-fed rats. HSP70 expression in the sedentary rats was very low, independent of the diet or tissue. Protein carbonyls were lower in the group that consumed WPH. These data suggest that the consumption of WPH enhances HSP70 expression. (C) 2012 Elsevier Ltd. All rights reserved.
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