Journal
FOOD CHEMISTRY
Volume 141, Issue 4, Pages 4115-4121Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2013.06.059
Keywords
Prunus mume fruit; Myotube; Anti-diabetes; High fat diet; PPAR-gamma
Funding
- Ministry of Food, Agriculture, Forestry and Fisheries
- Korea Food Research Institute, Republic of Korea
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In this study, we performed in vitro and in vivo studies to examine whether a 70% ethanol extract of Prunus mume fruits (EMS) exhibits anti-diabetic effects. Treatment with EMS increased glucose uptake in C2C12 myotubes, and also increased PPAR-gamma activity or PPAR-gamma mRNA expression. To confirm these in vitro results, we next conducted an animal experiment. A high-fat diet significantly increased the body weight, fat accumulation, and glucose levels in mice. Under the same conditions, 5% EMS attenuated the high-fat diet-induced increase in body weight and fat accumulation and improved the impaired fasting glucose level and glucose tolerance. High performance liquid chromatography analysis demonstrated that EMS contained chlorogenic acid, caffeic acid, rutin, luteolin-7-glucoside, naringin, apigenin-7-glucoside, and hesperidin. Taken together, these findings suggest that EMS exerts an anti-diabetic effect both in vitro and in vivo, which is mediated, at least in part, by the activation of PPAR-gamma. (C) 2013 Elsevier Ltd. All rights reserved.
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