Journal
FOOD CHEMISTRY
Volume 120, Issue 2, Pages 512-516Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2009.10.045
Keywords
Inula hupehensis; Thymol derivatives; Antimicrobial activity
Funding
- National Basic Research Program of China [2007CB108903]
- National Natural Science Foundation of China [20621091]
Ask authors/readers for more resources
In a search for some naturally occurring antimicrobial compounds found in medicinal plants, herbs and spice extracts, four thymol derivatives were isolated from the roots of inula hupehensis (a medicinal plant) and identified as the new compound 9-0-beta-D-glucopyranosyl-9-hydroxythymol (1), together with 8,9-epoxy-10-isobutyryloxythymyl isobutyrate (2), 8-hydroxy-9, 10-diisobutyloxythymol (3) and 8,9,10-trihydroxythymol (4). These thymol derivatives, with a semi-synthetic compound 9,10-dihydroxy8-methoxythymol (5), were tested for their antimicrobial activities against three bacteria and six plant pathogenic fungi. Within the series of thymol derivatives tested, compound 3 was the most active, particularly displaying moderate antibacterial activities against Staphylococcus aureus, Methicillin-resistant S. aureus and Escherichia coli with MICs of 62.3, 62.8. and 250 mu g/ml. Moreover, this compound exhibited inhibitory activities against three plant pathogenic fungi: Rhizoctonia solani, Phytophthora melonis and Peronophythora litchi, with EC50 values of 157, 180 and 141 mu g/ml. To our knowledge, this is the first report that these five thymol derivatives show inhibitory activity against plant pathogenic fungi. (C) 2009 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available