Journal
FOOD CHEMISTRY
Volume 113, Issue 2, Pages 464-470Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2008.07.086
Keywords
Immunomodulatory peptide; T cell subpopulation; Cytokine; Bead-based multiplex assay
Funding
- Ministry of Science and Technology of the People's Republic of China [2006BAD271308]
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To observe the immunomodulatory effects of marine oligopeptide preparation (MOP) from Chum Salmon (Oncorhynchus keta) by the method of enzymatic hydrolysis, female ICR mice (6-8 weeks old) were administered the MOP for four weeks with the dose of 0, 0.22, 0.45 and 1.35 g/kg/body weight. In comparison with the control group, the MOP could significantly enhance the capacity of lymphocyte proliferation induced by the mitogen concanavalin A, the number of plaque-forming cells, natural killer cell activity, the percentage of CD4(+) T helper (Th) cells in spleen and the secretion of Th1 (IL-2, IFN-gamma) and Th2 (IL-5, IL-6) type cell cytokines. Nevertheless, no significant differences in weight gain, lymphoid organ indices and phagocytosis capacity were observed in our study. These results suggest that MOP is a possible immune stimulant and may strengthen the immune response of its host. (c) 2008 Elsevier Ltd. All rights reserved.
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