Journal
FOOD CHEMISTRY
Volume 116, Issue 1, Pages 265-270Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2009.02.044
Keywords
Dimer-gallate; Procyanidin; Trimer; Glucose uptake; Triacylglycerol secretion; Cholesterol secretion; Anti-inflammatory effect
Funding
- Comision Interministerial de Ciencia y Tecnologia (CICYT) of the Spanish Government [GL2005-04889/ALI]
- Rovira i Virgili University in Tarragona, Spain
- Comision Interministerial de Ciencia y Tecnologia (CICYT) of the Spanish Government
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The relationship between grape seed-derived procyanidin extract components and their bioactivity was explored. The monomeric and dimeric structures only acted as anti-inflammatory agents. Similarly, pure C1 trimer was highly effective on LPS-activated macrophages. To reproduce all of the bioactivities of the total extract, a fraction enriched with trimeric structures was needed. This trimeric-enriched fraction was divided into subfractions, the most bioactive of which contained two compounds with a molecular weight equal to a trimer (865) and a dimer-gallate (729), according to spectrometric analysis. Thus, it may be concluded that a mixture of both molecules reproduces the bioactivity in glucose metabolism (3T3-L1), lipid metabolism (HepG2) and macrophage functionality (RAW 264.6). (C) 2009 Elsevier Ltd. All rights reserved.
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