Article
Nutrition & Dietetics
Ghada Ismail, Randa Abo El Naga, Maysaa El Sayed Zaki, Jana Jabbour, Ayoub Al-Jawaldeh
Summary: Around one third of products in the Egyptian market have a high TFA content, especially traditional meat products and fried foods with used oils.
Review
Biochemistry & Molecular Biology
Ting Gao, Yixuan Li, Xiaoyu Wang, Fazheng Ren
Summary: Sunlight has adverse effects on the skin, including hyperpigmentation, collagen degradation, fibrosis, and even skin cancer. This article focuses on the negative impact of sunlight on the skin, not only in terms of photoaging but also its influence on the skin's circadian rhythm.
Review
Agronomy
Olga Bykova, Oleg Shevkunov, Olga Kostyunina
Summary: This article provides an overview of international studies on the identification of genomic regions and SNPs associated with trans fatty acids in cow's milk. The results show that 68 SNPs were localized on specific chromosomes. Further research in this direction will contribute to the development of modern breeding technologies and high-quality dairy products.
Article
Nutrition & Dietetics
Liping Huang, Adedayo E. E. Ojo, Judith Kimiywe, Alex Kibet, Boni M. M. Ale, Clementina E. E. Okoro, Jimmy Louie, Fraser Taylor, Mark D. D. Huffman, Dike B. B. Ojji, Jason H. Y. Wu, Matti Marklund
Summary: While the prevalence of industrially produced trans-fatty acids (iTFA) in African countries is largely unknown, this study investigated the presence of ingredients indicative of iTFAs in pre-packaged foods collected from Kenya and Nigeria. The findings revealed a low proportion of products containing specific ingredients suggestive of iTFAs, but a higher proportion containing non-specific ingredients. Additionally, the reporting of trans-fatty acid levels was generally low in both countries.
Article
Biochemistry & Molecular Biology
Camilla Morresi, Alessia Luccarini, Fabio Marcheggiani, Gianna Ferretti, Elisabetta Damiani, Tiziana Bacchetti
Summary: PON2, an intracellular protein, plays a protective role against cell oxidative stress and apoptosis. This study explored the modulation of PON2 in human dermal fibroblasts exposed to UVA radiation and found that PON2 is up-regulated immediately after UVA exposure and gradually decreases in the post-exposure phase. This upregulation may be related to the increase in intracellular reactive oxygen species (ROS) and could play an important role in mitigating UVA-induced damage and preventing the consequences of UV exposure.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Food Science & Technology
Hechun Liu, Hangju Zhu, Hui Xia, Xian Yang, Ligang Yang, Shaokang Wang, Jingyuan Wen, Guiju Sun
Summary: The study investigated the effects of high-fat diets rich in different oils on lipid metabolism, oxidative stress, and gut microbiota in C57BL/6 mice. The results showed that high-fat diets can increase serum and liver lipids, induce oxidative stress, and cause dysbiosis in gut microbiota. Actinobacteria and Lactobacillales abundance were found to be linked to serum lipid levels, indicating harmful influences of high-fat diets on overall health.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Kai Wang, Yashan Deng, Yingying He, Junhan Cao, Liping Zhang, Ling Qin, Changfeng Qu, Hongmei Li, Jinlai Miao
Summary: This study investigated the effect of mycosporine-like amino acids (MAAs) extracted from Antarctic diatom Phaeodactylum tricornutum ICE-H on UVB-induced skin damage. The study found that these MAA components protected against UVB-induced skin damage by inhibiting ROS generation, relieving skin inflammation, and slowing down collagen degradation. This suggests that these MAA components could be effective cosmetic candidate molecules for the protection and therapy of UVB damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biophysics
Yixuan Liu, Di Qin, Haonan Wang, Yue Zhu, Shichao Bi, Ya Liu, Xiaojie Cheng, Xiguang Chen
Summary: Skin lesions caused by UV radiation seriously affect people's life quality. The natural composite gel derived from fish scales (SE-gel) has been found to effectively protect and repair UV-irradiated skin by inhibiting oxidative stress and inflammatory responses. SE-gel demonstrated good UV absorption, water absorption, moisturizing, and free radical scavenging abilities. In vitro and in vivo experiments showed that SE-gel could improve cell viability, reduce oxidative stress, and prevent UV-induced skin damage and inflammation, suggesting its potential application in UV-irradiated skin damage prevention and repair.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Dermatology
Mascia Benedusi, Delphine Kerob, Anna Guiotto, Franco Cervellati, Francesca Ferrara, Erika Pambianchi
Summary: This study assessed the preventive benefit of a dermocosmetic product, M89PF, containing Vichy mineralising water, probiotic fractions, antioxidant vitamins and hyaluronic acid, in protecting skin physical barrier and defense functions after exposure to UV or O3. The results showed that M89PF significantly prevented the decrease of skin barrier markers' expression levels and inhibited the induction of oxidative stress and inflammatory markers by UV, O3, or both combined.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2023)
Article
Nutrition & Dietetics
Simone Boesch, Lucinda Westerman, Nina Renshaw, Igor Pravst
Summary: COVID-19 has highlighted the critical issue of non-communicable diseases (NCDs), especially cardiovascular disease (CVD), and the urgent need for policy measures to protect cardiovascular health. Eliminating industrially-produced trans fatty acids (iTFA) could prevent millions of deaths by 2040, marking the first time an NCD risk factor has been eliminated globally.
FRONTIERS IN NUTRITION
(2021)
Article
Nutrition & Dietetics
Zhen Luo, Qingying Gao, Yuanfei Li, Yifei Bai, Jing Zhang, Weina Xu, Jianxiong Xu
Summary: The study found that Flammulina velutipes mycorrhizae contain abundant trace elements, polysaccharide, amino acids and derivatives, and organic compounds. They were effective in attenuating high fat diet-induced lipid disorder, oxidative stress, and inflammation in the liver and perirenal adipose tissue of mice, indicating their potential applications in functional foods and herbal medicine.
Article
Agriculture, Multidisciplinary
Meng Wei, Xian Niu, Hong-Shen Jing, Jin-Jing Zhong, Yi-Ling Deng, Yan-Mei Hou, Wen-Qun Liu, Ze-Yuan Deng, Jing Li
Summary: The study demonstrated that butter-derived R-TFA does not alleviate but promotes atherosclerotic lesions in high-fat diet-fed ApoE-/- mice. Additionally, it was found that butter-derived R-TFA affected the serum lipid profile of high-fat diet-fed ApoE4/4 mice and the lipid metabolism of human umbilical vein endothelial cells (HUVECs).
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Xiangfei Li, Shuhua Tian, Yunfan Wang, Jie Liu, Jing Wang, Yingjian Lu
Summary: The study found that broccoli microgreens juice can reduce adipose tissue mass, body weight, and adipocyte size in obese mice, improve glucose tolerance, and reduce insulin levels, with significant anti-inflammatory effects. In addition, by influencing the gut microbiota, BMJ can help reduce liver fat accumulation and enhance antioxidant capacity.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Patricia K. Farris, Giuseppe Valacchi
Summary: Our current understanding of the mechanisms behind skin aging involves various environmental factors such as ultraviolet light, visible light, infrared, pollution, cigarette smoke, and others. These factors disrupt the cellular redox balance and lead to an oxidative stress condition by increasing the formation of reactive oxygen species. This disruption triggers downstream pathways that contribute to tissue inflammation and accelerate skin aging. Additionally, ultraviolet light and pollution increase intracellular free iron, which further promotes oxidative stress and contributes to extrinsic skin aging. Recent studies have shown that iron chelators can enhance the benefits of topically applied antioxidants. Therefore, a more comprehensive approach to protect against environmental aging should include sun protection, antioxidants, chelating agents, and DNA repair enzymes.
Article
Biochemistry & Molecular Biology
Ok-Kyung Kim, Dakyung Kim, Minhee Lee, Seong-Hoo Park, Wakana Yamada, Sangwon Eun, Jeongmin Lee
Summary: The standardized edible bird's nest extract showed potential in preventing UVB irradiation-induced oxidative stress and photoaging by increasing skin hydration, suppressing melanogenesis, and reducing wrinkle formation, while activating pathways related to skin health.
Article
Toxicology
Camila Reck Rampelotto, Viviane Goncalves Pereira, Larissa da Silva Silveira, Aline Rossato, Alencar Kolinski Machado, Michele Rorato Sagrillo, Andre Gundel, Marilise Escobar Burger, Scheila Rezende Schaffazick, Cristiane de Bona da Silva
Summary: The study developed FA-loaded nanocapsule suspensions prepared with ethylcellulose and evaluated their in vitro release profile, mucoadhesion, cytotoxicity, and protective effect against oxidative damage. Results showed that the nanocapsules had controlled release of FA, mucoadhesive properties, non-toxicity to cells, and protective effects against oxidative conditions. This nanocarrier formulation shows promise for further preclinical investigations in oxidative mechanism-related diseases.
TOXICOLOGY IN VITRO
(2022)
Article
Nutrition & Dietetics
Tabata P. Pavao, Diego Chemello, Arielen Ferigollo, Marco Aurelio Lumertz Saffi, Rafael Noal Moresco, Carolina dos Santos Stein, Tatiana Emanuelli, Sabrina Somacal, Emilio Hideyuki Moriguchi, Lina Badimon, Patricia Chagas
Summary: This study aimed to investigate the acute effects of caffeinated and decaffeinated coffee intake on endothelial function and arterial stiffness in overweight and obese individuals. The results showed that caffeinated coffee increased central blood pressure and pulse wave velocity, while decaffeinated coffee had no effect on these variables. However, caffeinated coffee showed an improvement in hyperemia-induced endothelial function.
CLINICAL NUTRITION ESPEN
(2022)
Article
Chemistry, Applied
Carla A. A. Farias, Debora P. Moraes, Naiara H. Neuenfeldt, Giovani L. Zabot, Tatiana Emanuelli, Juliano S. Barin, Cristiano A. Ballus, Milene T. Barcia
Summary: This study investigated the efficiency of microwave hydrodiffusion and gravity (MHG) in extracting anthocyanins from strawberries and raspberries. The results showed that MHG was able to extract a high percentage of anthocyanins from both fruits in a single extraction step. The use of green solvents and re-extraction of the co-product further enhanced the anthocyanin extraction. The MHG process demonstrated low environmental impact and economic viability, making it a sustainable alternative for anthocyanin extraction.
Article
Food Science & Technology
Sabrina Somacal, Andreia Quatrin, Amanda R. Ruviaro, Lisiane Conte, Dariane T. da Silva, Miguel Roehrs, Marcelo L. da Veiga, Marta M. F. Duarte, Andreza F. de Bem, Paula R. Augusti, Tatiana Emanuelli
Summary: The study investigates the anti-atherogenic properties of norbixin and finds that norbixin supplementation can improve serum lipid profile and prevent oxidative modifications in circulating LDL and aortic tissue.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Lucia Lopez-Salas, Isabel Borras-Linares, Rosa Quirantes-Pine, Tatiana Emanuelli, Antonio Segura-Carretero, Jesus Lozano-Sanchez
Summary: In this study, advanced extraction and analytical techniques were used to evaluate the phytochemical composition of green asparagus from a specific geographic area in Spain. The results demonstrated the potential of advanced pressurized liquid extraction techniques for the recovery of bioactive compounds from asparagus. Additionally, major phenolic compounds were identified and quantified through analytical characterization. This novel methodology provides a better understanding of the bioactive composition of this widely consumed food.
Article
Endocrinology & Metabolism
Ermelindo C. Leal, Tatiana Emanuelli, Diana Santos, Joao Moura, Ana Catarina Rg Fonseca, Ana Burgeiro, Eugenia Carvalho
Summary: This study investigated the impact of alterations in the unfolded protein response (UPR), autophagy, and mitochondrial function on wound healing (WH) under diabetic conditions. The findings showed that the UPR and autophagy pathways were activated in the skin of control mice and non-wounded skin of diabetic mice. Additionally, high-glucose conditions induced autophagy in keratinocyte and fibroblast cell cultures. However, there were no changes in mitophagy in the skin of diabetic mice or wounded skin.
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Julia Baranzelli, Sabrina Somacal, Camila Sant'Anna Monteiro, Renius de Oliveira Mello, Eliseu Rodrigues, Osmar Damian Prestes, Rosalia Lopez-Ruiz, Antonia Garrido Frenich, Roberto Romero-Gonzalez, Martha Zavariz de Miranda, Tatiana Emanuelli
Summary: Pre-harvest sprouting in wheat can be simulated in the laboratory, and different wheat cultivars have distinct behavior in terms of changes in phytochemical compounds during germination. Hard wheat cultivars have higher contents of benzoxazinoids and flavonoids compared to soft wheat cultivars. The matrix-bound phytochemicals decrease only in hard-texture wheat cultivars during germination, due to decreased levels of phenolic acids and flavonoids that are bound to the cell wall. Germination also increases the content of benzoxazinoids and antioxidant capacity in wheat, enhancing its health benefits.
Article
Food Science & Technology
Laura Gizele Mascarin, Fernanda Wouters Franco, Rafaela Castro Dornelles, Kassia Caroline Figueredo, Roberta Oliveira Santos, Liliane de Freitas Bauermann, Tatiana Emanuelli, Sabrina Somacal, Claudia Kaehler Sautter
Summary: This study evaluated the contribution of chamomile, lemongrass, and peppermint extracts to a fermented orange beverage. The addition of 2% herbal extracts resulted in the highest phenolic and flavonoid content as well as antioxidant potential in the beverages. The evaluated compounds were found to be non-toxic and possessed therapeutic effects such as antioxidant, gastroprotective, and anti-ulcerative properties. Among the herbs, peppermint extract showed the greatest potential for use in functional fermented beverages.
Article
Chemistry, Medicinal
Verciane Schneider Cezarotto, Eduarda Piovesan Franceschi, Ana Cristina Stein, Tatiana Emanuelli, Luana Haselein Maurer, Marcel Henrique Marcondes Sari, Luana Mota Ferreira, Leticia Cruz
Summary: This study used synthetic nanoparticles as carriers to combine hydroalcoholic extract of V. ashei leaves for evaluating their antioxidant and antidepressant effects. The nanoparticles exhibited good physicochemical characteristics, antioxidant activity, and antidepressant-like action, making them a promising treatment for depression.
Article
Neurosciences
Luana Barreto Meichtry, Guilherme Silva da Silva, Larissa Londero, Mustafa Munir Mustafa Dahleh, Vandreza Cardoso Bortolotto, Stifani Machado Araujo, Elize Aparecida Musachio, Dariane Trivisiol da Silva, Tatiana Emanuelli, Murilo Ricardo Sigal Carric, Rafael Roehrs, Gustavo Petri Guerra, Marina Prigol
Summary: This study investigated the effects of hydrogenated vegetable fat (HVF) on the neurobehavioral parameters of fruit flies during development and found that HVF reduced longevity and hatching rates, while increasing depression-like, anxious-like, anhedonia-like, and aggressive behaviors. In terms of biochemical parameters, fruit flies exposed to HVF had higher levels of trans fatty acids (TFA) and lower levels of serotonin (5HT) and dopamine (DA). These findings highlight the importance of the type of fat offered during early life stages.
Article
Food Science & Technology
Daniela Rigo Guerra, Lidia Betina Hendges Pletsch, Suelen Priscila Santos, Silvino Sasso Robalo, Stephanie Reis Ribeiro, Tatiana Emanuelli, Daniel Assumpcao Bertuol, Alexandre Jose Cichoski, Roger Wagner, Milene Teixeira Barcia, Cristiano Augusto Ballus
Summary: The aromatization of olive pomace oil with rosemary and basil using ultrasound-assisted maceration (UAM) was able to increase its bioactive potential. Results showed that UAM resulted in no significant difference in quality parameters and fatty acids compared to pure olive pomace oil, but led to a significant increase in total phenolic compounds, antioxidant capacity, and oxidative stability. Thus, ultrasound-assisted maceration is an efficient method to enhance the bioactive potential of olive pomace oil in a short time.
Article
Agriculture, Multidisciplinary
Liliana de Los Santos Moraes, Nathane Rosa Rodrigues, Ana Helena Dal Forno, Jean Ramos Boldori, Tatiana Emanuelli, Cristiane Casagrande Denardin, Marcia Vizzotto, Andreia Quatrin
Summary: Yellow- and red-colored berry varieties of arac ' a have excellent antioxidant capacity both in vitro and in vivo. The extracts showed no toxicity to Caenorhabditis elegans, and the different colors of the fruits had different responses to stressors. The yellow extract demonstrated a greater ability to remove free radicals and both extracts prolonged the worms' lifespan and reduced oxidative stress. Changes in hsp-16.2 expression may be related to the observed results.
JOURNAL OF AGRICULTURE AND FOOD RESEARCH
(2023)
Article
Chemistry, Applied
Camila Sant'Anna Monteiro, Paula Colpo Bortolazzo, Camila Araujo Amorim Bonini, Luana Tamires Dluzniewski, Dariane Trivisiol da Silva, Julia Baranzelli, Franciele Aline Smaniotto, Cristiano Augusto Ballus, Jesus Lozano-Sanchez, Sabrina Somacal, Tatiana Emanuelli
Summary: The effect of granulometric fractionation and micronization on the biotransformation of phenolic compounds in olive pomace (OP) by intestinal microbiota was investigated. The results showed that granulometric fractionation and micronization increased the release of hydroxytyrosol, oleuropein aglycone, apigenin, and phenolic acid metabolites during colonic fermentation compared to non-fractionated OP (up to 41-fold higher). Micronization associated with granulometric fractionation was more effective in releasing phenolic compounds and could be further studied for nutraceutical purposes.
Article
Agriculture, Dairy & Animal Science
Daniele Missio, Fabio Gallas Leivas, Francielli Cibin, Tatiana Emanuelli, Sabrina Somacal, Vanessa Buss, Bernardo Gasperin, Dimas Estrasulas de Oliveira, Paulo Bayard Dias Goncalves, Rogerio Ferreira
Summary: During the postpartum period in cattle, there is an increase in non-esterified fatty acids (NEFA) in both serum and follicular fluid (FF), leading to the production of reactive oxygen species (ROS) that can affect fertility. This study aimed to characterize the lipid profile in FF of cows experiencing negative energy balance (NEB) and evaluate the effect of α-tocopherol in preventing oxidative stress in serum and FF. Fasting caused fat mobilization in cows and resulted in increased serum concentration of C18:1c9, which was also reflected in the FF. α-tocopherol concentration was higher in control and fasting + VitE groups, and there was an increase in FF α-tocopherol in the fasting + VitE group compared to fasting cows. ROS production was higher in fasting cows' serum and FF, with the fasting + VitE group showing lower ROS production in FF.
REPRODUCTION IN DOMESTIC ANIMALS
(2023)
Article
Food Science & Technology
Luana Schmidt, Bruna Krieger Vargas, Camila Sant'Anna Monteiro, Lauren Pappis, Renius de Oliveira Mello, Alencar Kolinski Machado, Tatiana Emanuelli, Marco Antonio Zachia Ayub, Jose Claudio Fonseca Moreira, Paula Rossini Augusti
Summary: Bioavailable phenolic compounds from olive pomace have antioxidant and anti-inflammatory properties, and can act as anti-neuroinflammatory agents. Phenolic compounds from olive pomace of different particle sizes can reduce the generation of reactive oxygen and nitrogen species in activated cells. However, further research is needed to improve the bioavailability of phenolic compounds and examine possible toxic effects.
