Review
Medicine, Research & Experimental
Francesco Marongiu, Maria Filomena Ruberto, Silvia Marongiu, Marco Matucci Cerinic, Doris Barcellona
Summary: Systemic sclerosis is a connective tissue disease characterized by immune activation of endothelial cells, leading to fibrosis and angiogenesis loss. This disease disrupts the endothelial barrier, allowing vascular leaks and contact between platelets and collagen, resulting in platelet aggregation and blood coagulation. Tissue factor plays a crucial role in blood coagulation by triggering the cascade reaction. This review focuses on understanding the mechanisms underlying hemostasis and thrombosis in systemic sclerosis and the potential role of anticoagulation therapy.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Agronomy
You Jin Lim, Hyejeong Park, Wooki Kim, Seok Hyun Eom
Summary: Postharvest UV treatment enhances coloration of apple skin and increases antioxidant activity. UV-B treatment stimulates the accumulation of certain components in apple skin extracts and increases nitric oxide and TNF-alpha suppression. However, it does not affect IL-6 inhibition significantly.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fatih Karadeniz, Jung Hwan Oh, Youngwan Seo, Jiho Yang, Hyunjung Lee, Chang-Suk Kong
Summary: The current study investigated the anti-melanogenic effect of Quercetin 3-O-galactoside (Q3G) and revealed its underlying mechanism of action in B16F10 melanoma cells. Q3G treatment downregulated melanogenesis-related enzymes and transcription factor MITF, inhibited cAMP/PKA and MAPK signaling pathways, and reduced melanin production. These findings suggest that Q3G has potential as a cosmetic ingredient for treating hyperpigmentation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Daishen Luo, Erika M. Chelales, Millicent M. Beard, Nithya Kasireddy, Damir B. Khismatullin
Summary: The study introduces a containerless drop-of-blood method for coagulation analysis, termed i-QATT (TM), which can rapidly detect hyper- and hypo-coagulable states and identify single deficiency in coagulation factors.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Review
Gastroenterology & Hepatology
Alberto Zanetto, Patrick Northup, Lara Roberts, Marco Senzolo
Summary: Hospitalised patients with decompensated cirrhosis experience a rebalanced haemostasis, but this balance can easily be disrupted, leading to bleeding. Acute kidney injury, bacterial infections/sepsis, and progression to acute-on-chronic liver failure further increase the risk of bleeding. Unfortunately, there is no single laboratory method to accurately assess bleeding risk and guide preventive measures. Understanding the haemostatic alterations during acute illness could improve the management of these patients.
JOURNAL OF HEPATOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Zhuoyan Fan, Haichao Wen, Xiaoxu Zhang, Jingming Li, Jiachen Zang
Summary: Metabolic disorder is an important sign of aging, and early dietary intervention can be effective in preventing or delaying brain aging. This study found that cyanidin 3-O-beta-galactoside from black chokeberry has positive effects on energy metabolism and cognitive function in aging mice.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Plant Sciences
Yan Chen, Jing Zhao, Han-Han Li, Wen Qian, Bing-Yu Zhou, Chang-Qing Yang
Summary: Cyanidin-3-O-galactoside has better pharmacokinetic properties compared to cyanidin-3-O-arabinoside, as revealed by an animal experiment investigating the pharmacokinetics of these two anthocyanin monomers.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2023)
Article
Hematology
Johannes Thaler, Ton Lisman, Peter Quehenberger, Lena Hell, Philipp Schwabl, Bernhard Scheiner, Theresa Bucsics, Rienk Nieuwland, Cihan AY, Michael Trauner, Ingrid Pabinger, Thomas Reiberger, Mattias Mandorfer
Summary: This study investigated the coagulation system in ascites of patients with cirrhosis and found that ascitic fluid was procoagulant with high extracellular vesicle-associated tissue factor activity. Fibrinolytic enzymes were activated in ascitic fluid, potentially re-entering the systemic circulation and inducing systemic fibrinolysis. Plasma D-dimer levels were independently linked to ascites severity in a separate cohort of patients.
THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Virology
Sirpa Koskela, Satu Makela, Tomas Strandin, Antti Vaheri, Tuula Outinen, Lotta Joutsi-Korhonen, Ilkka Porsti, Jukka Mustonen, Outi Laine
Summary: Puumala hantavirus, mainly endemic in Europe and Russia, causes hemorrhagic fever with renal syndrome, characterized by low platelet count, altered coagulation, endothelial activation, and acute kidney injury. Patients may experience mild bleeding symptoms and have an increased risk of disseminated intravascular coagulation (DIC) and thrombosis.
Article
Biochemistry & Molecular Biology
Claire S. Whyte, Akriti Rastogi, Ellis Ferguson, Michela Donnarumma, Nicola J. Mutch
Summary: This study compared the efficacy of cryoprecipitate and two fibrinogen concentrates in restoring clot integrity in a trauma-induced coagulopathy (TIC) model. Results showed that FibCLOT(R) was superior in normalizing clot structure and stabilizing clots against mechanical and fibrinolytic degradation compared to the other treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Qun Ji, Honglian Zhu, Xinfang Huang, Kai Zhou, Zhengwei Liu, Yalin Sun, Zhixin Wang, Weidong Ke
Summary: Water dropworts O. linearis and O. javanica display distinct leaf shapes and leaflet characteristics, with genetic diversity slightly higher in the latter. Single-nucleotide polymorphism markers can aid in future genomic studies of water dropwort varieties.
Article
Chemistry, Organic
Zhi-Wei Wang, Yu Zheng, Yu-En Qian, Jian-Ping Guan, Wei-Dong Lu, Chu-Ping Yuan, Jun-An Xiao, Kai Chen, Hao-Yue Xiang, Hua Yang
Summary: This study reports on a new photoredox-catalyzed reaction that can synthesize a range of 3-aminochromones under mild conditions, and further expand the applications of this reaction by constructing diverse amino pyrimidines through downstream transformations.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Engineering, Chemical
Ji Hwan Lee, Sanghyun Lee, Jun Yeon Park, Il-Ho Park, Ki Sung Kang, Myoung-Sook Shin
Summary: Salicornia herbacea, a halophyte with antioxidant, anti-inflammatory, and anti-adipogenic properties, has been traditionally used for gastrointestinal issues. This study examined the anti-obesity effects of S. herbacea extract and its component IR3G on adipocytes and obese mice. Both the extract and IR3G inhibited lipase activity and suppressed lipid accumulation and adipogenesis in adipocytes. In obese mice, S. herbacea extract limited weight gain, reduced feed efficiency and adipose tissue weight, and improved blood lipid profile. These findings suggest that S. herbacea extract and IR3G inhibit adipogenesis and prevent obesity by regulating lipid metabolism and adipose tissue weight.
Article
Chemistry, Analytical
Jikang Wang, Cheol Ung Choi, Sehyun Shin
Summary: In this study, we propose an innovative method of microfluidic thromboelastography (mu-TEG) that rapidly measures the viscoelastic properties of blood coagulation in oscillating flow through circular tubes. The mu-TEG system showed good agreement with the TEG5000 and can be a useful tool for analyzing hemostasis and fibrinolysis in emergency and operating rooms.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Food Science & Technology
Caijun Ren, Kai Wang, Teng Luo, Xiaofeng Xue, Miao Wang, Liming Wu, Liuwei Zhao
Summary: This study characterized the physicochemical parameters and palynological characteristics of Lespedeza bicolor honey, and established a screening method for authenticating L. bicolor honey. Mass spectrometry analysis identified kaempferol-3-O-galactoside as a candidate chemical marker for L. bicolor honey.
FOOD RESEARCH INTERNATIONAL
(2022)