Photoredox-Catalyzed Cascade of o-Hydroxyarylenaminones to Access 3-Aminated Chromones

Reported herein is a photoredox-catalyzed amination of o-hydroxyarylenaminones with tert-butyl ((perfluoropyridin4-yl)oxy)carbamate, a versatile amidyl-radical precursor developed in our laboratory. This work establishes a new cascade pathway for the assembly of a range of 3-aminochromones under mild conditions. Downstream transformations of the obtained 3aminochromones to construct diverse amino pyrimidines greatly broaden the applications of this photocatalyzed protocol.

Automated summary

This study reports on a new photoredox-catalyzed reaction that can synthesize a range of 3-aminochromones under mild conditions, and further expand the applications of this reaction by constructing diverse amino pyrimidines through downstream transformations.