Article
Medical Laboratory Technology
Ashekul Islam, Dhiman Chowdhury, Pulak Kanti Palit, Md Sohel, Md. Mozibullah, Mohammod Johirul Islam, Abdullah Al Mamun, Joyonti Datta, Annanya Dev, Pradip Kumar Nath, Md Faisal Fahad Chowdhury, Sabuj Kanti Nath, Abu Syed Mohammed Mujib
Summary: This study investigated the correlation between serum creatine phosphokinase (CPK) and lactate dehydrogenase (LDH) levels and the severity of acute organophosphorus compound (OPC) poisoning. The results showed that serum CPK level strongly correlated with the degree of OPC poisoning and could be used as a predictor for clinical intervention approaches.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2023)
Article
Cardiac & Cardiovascular Systems
S. Preethi, Hitesh Kumar, C. Ramesh, B. A. Sowmya, K. Niveditha, Ramkishan Ajmeer, Vikas Jain
Summary: The research identifies the cardioprotective effects of the ethanolic extract of Sauropus androgynus leaves, showing it possesses antioxidant activity and provides protection against myocardial infarction induced by isoproterenol.
CARDIOVASCULAR TOXICOLOGY
(2022)
Article
Agricultural Engineering
Yunxia Qin, Jia Wang, Yongjun Fang, Jilai Lu, Xiangyu Shi, Jianghua Yang, Xiaohu Xiao, Xuehua Luo, Xiangyu Long
Summary: Research has shown that anaerobic metabolism plays a crucial role in rubber biosynthesis in laticifers of Hevea brasiliensis. The key genes HbLDH1 and HbPDC4 in anaerobic metabolism are activated during tapping, resulting in the production of acetaldehyde and ATP through ethanol and lactate fermentation, which contribute to rubber synthesis.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Biotechnology & Applied Microbiology
Toshiyuki Ueki
Summary: Laboratory adaptive evolution enhanced the growth of Geobacter sulfurreducens PCA on lactate, with succinyl-CoA synthetase identified as a key enzyme in lactate metabolism. Genomic analysis of Geobacter species identified lactate dehydrogenase genes essential for lactate utilization. The differential gene expression during growth on lactate and acetate suggests metabolic switches and adaptations in response to available substrates.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Food Science & Technology
Hyo Hee Kim, Bipin Vaidya, Se-Young Cho, Joseph Kwon, Duwoon Kim
Summary: The anti-hyperglycemic activity of alginate oligosaccharide (AOS) was demonstrated in a hyperglycemic zebrafish model. AOS treatment reduced blood glucose levels and improved survival in hyperglycemic zebrafish by enhancing glucose oxidation and suppressing the lactic acid pathway.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Chemistry, Applied
Ruxin Chang, Bin Liu, Qimeng Wang, Jipeng Zhang, Fang Yuan, Huijuan Zhang, Shanan Chen, Shuang Liang, Yuan Li
Summary: "Nano-encapsulation using food-sourced protein nanotubes (NTs) from self-assembled partially hydrolyzed alpha-lactalbumin (alpha-lac) has shown promise in improving the stability and biological activity of bioactive compounds. Lycopene (LYC) loaded into the hydrophobic inner wall of NTs exhibited improved antioxidant properties and stability against temperature and UV light. The NTs also enhanced the colloidal stability of LYC and could be successfully incorporated into dairy drinks for increased viscosity and long-term stability."
FOOD HYDROCOLLOIDS
(2022)
Article
Plant Sciences
Tong Jiang, Kaitong Du, Pei Wang, Xinhai Wang, Lianyi Zang, Dezhi Peng, Xi Chen, Geng Sun, Hao Zhang, Zaifeng Fan, Zhiyan Cao, Tao Zhou
Summary: This study reveals that viruses alter host metabolism by inducing lactate accumulation and manipulating plant defense responses. The up-regulation of lactate dehydrogenase (LDH) and its interaction with the SCMV-encoded 6K2 protein in viral replicase complexes (VRCs) play important roles in supporting robust SCMV infection.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Immunology
Long Yu, Qin Liu, Wanxin Luo, Junlong Zhao, Heba F. Alzan, Lan He
Summary: This study provides the structural basis of Babesia spp. lactate dehydrogenase (BoLDH) for the first time and reveals its differences from other parasite enzymes. The study also finds that BoLDH is sensitive to inhibition by gossypol, suggesting its potential as a target for new LDH inhibitors to control the intracellular proliferation of Babesia spp.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Cell Biology
Xiukun Hou, Xianle Shi, Wei Zhang, Dapeng Li, Linfei Hu, Jihong Yang, Jingzhu Zhao, Songfeng Wei, Xi Wei, Xianhui Ruan, Xiangqian Zheng, Ming Gao
Summary: High expression levels of LDHA in papillary thyroid carcinoma are associated with aggressive clinicopathological features and poor prognosis. LDHA promotes cancer cell migration, invasion, and proliferation, making it a potential therapeutic target.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Keun-Yeong Jeong, Jae-Jun Sim, Min Hee Park, Hwan Mook Kim
Summary: This study demonstrated the changes in cancer-specific metabolism induced by lactate calcium salt in colorectal cancer cells, leading to anti-cancer effects. The results suggest that lactate calcium salt can alter anaerobic glycolysis, reduce HIF-1 alpha and VEGF expression, and inhibit tumor growth and metastasis.
Article
Agriculture, Dairy & Animal Science
Md Touhiduzzaman Sarker, Xiaoli Wan, Haiming Yang, Zhiyue Wang
Summary: This study evaluated the effects of lycopene (LYC) supplementation on the intestinal immune function, barrier function, and antioxidant capacity of broilers fed with aflatoxin B1 (AFB(1)) contaminated diet. The results showed that dietary LYC supplementation improved AFB(1) induced intestinal changes, decreased inflammatory cytokines, and enhanced the antioxidant status in broilers.
Article
Biochemistry & Molecular Biology
Francesca Arfuso, Maria Rizzo, Claudia Giannetto, Elisabetta Giudice, Roberta Cirincione, Giovanni Cassata, Luca Cicero, Giuseppe Piccione
Summary: This study aimed to evaluate the changes in serum oxidant and antioxidant parameters, as well as the levels of homocysteine and muscle enzymes, in regularly trained athletic horses during official races of different distances. The results showed that exercise had an effect on oxidative stress markers, homocysteine, and muscle enzymes, while the race distance did not have a significant impact on these parameters.
Article
Medicine, General & Internal
Elzbieta Kalicinska, Monika Biernat, Justyna Rybka, Aleksander Zinczuk, Justyna Janocha-Litwin, Marta Rosiek-Biegus, Marta Morawska, Anna Waszczuk-Gajda, Joanna Drozd-Sokolowska, Lukasz Szukalski, Marcin Rymko, Paula Jablonowska, Krzysztof Simon, Tomasz Wrobel
Summary: EASIX score serves as a strong predictor of prognosis in COVID-19 patients, especially in those with hematological malignancies, demonstrating its potential as a universal prognostic tool for overall survival in different patient populations.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Murat Yilmaz, Beliz Oztok Tekten
Summary: This study aimed to determine the potential role of postictal serum LDH activities in differentiating epileptic seizures from non-epileptic seizures. The results showed significantly higher LDH activities in patients with epileptic seizures compared to those with non-epileptic seizures, suggesting the potential use of LDH activities as a diagnostic tool in distinguishing between seizure types.
Article
Biochemistry & Molecular Biology
Anastasya Boyarski, Noam Shlush, Shiraz Paz, Jerry Eichler, Lital Alfonta
Summary: In this study, four different enzymatic constructs of L-lactate dehydrogenase were compared and the fusion enzyme containing two cytochromes showed superior catalytic and electrochemical properties. This fusion enzyme exhibited higher activity, lower redox potential, wider dynamic range, and higher product inhibition concentration than the native enzyme. Additionally, it displayed measurable lactate-dependent oxygen reduction.
BIOELECTROCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Zoi Skaperda, Fotios Tekos, Periklis Vardakas, Charitini Nepka, Demetrios Kouretas
Summary: Exposure to low levels of toxic agents or stressful stimuli leads to cellular adaptive mechanisms, displaying hormesis and redox adaptations. The dose, duration of exposure, and the specific cell, tissue or organ exposed play crucial roles in the hormetic effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Ahmed Ismaeel, Joseph A. Laudato, Emma Fletcher, Evlampia Papoutsi, Abigail Tice, Lara S. Hwa, Dimitrios Miserlis, Athanasios Z. Jamurtas, Jennifer Steiner, Panagiotis Koutakis
Summary: This study aimed to assess the concurrent effect of chronic heavy alcohol consumption and consumption of a high-fat diet on skeletal muscle oxidative stress and mitochondrial dysfunction. The results showed that a high-fat diet may exacerbate the negative effects of alcohol on skeletal muscle mitochondrial health and oxidative stress.
Article
Medicine, General & Internal
Christos Chatzakis, Alexandros Sotiriadis, Ioannis G. Fatouros, Athanasios Z. Jamurtas, Chariklia K. Deli, Maria Papagianni, Konstantinos Dinas, George Mastorakos
Summary: Moderate intensity exercise improves oxidation capacity in women with gestational diabetes mellitus (GDM) and uncomplicated pregnancies, although to a lesser extent in the GDM group. Exercise also leads to decreased resistance in uterine arteries in women with GDM.
Article
Nutrition & Dietetics
Kalliopi Georgakouli, Eirini Manthou, Ioannis G. Fatouros, Chariklia K. Deli, Yiannis Koutedakis, Yannis Theodorakis, Athanasios Z. Jamurtas
Summary: This study found differences in nutrient intake, body composition, and HPA-axis activity between individuals with and without alcohol use disorder (AUD), but no clear correlation between HPA-axis activity and nutritional status components was found.
Article
Medicine, General & Internal
Ismail Topal, Mustafa Yasar Ozdamar, Tulin Catakli, Ismail Malkoc, Ahmet Hacimuftuoglu, Charalampos Mamoulakis, Aristidis Tsatsakis, Konstantinos Tsarouhas, Christina Tsitsimpikou, Ali Taghizadehghalehjoughi
Summary: This study aimed to evaluate the renoprotective effects of taxifolin (TXF) in a paracetamol (PAR)-induced nephrotoxicity rat model. The results showed that the levels of blood urea nitrogen, creatinine and malondialdehyde were significantly increased in the PAR group, while the levels of glutathione peroxidase, glutathione reductase and total glutathione were significantly higher in the TXF group. Histopathological examination revealed severe tubular epithelium damage in the PAR group, while the TXF group showed mild dilated/congested blood vessels. These findings suggest that TXF has potential renoprotective effects against PAR-induced nephrotoxicity through its antioxidant activity and should be further investigated.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Chrysoula Taskou, Antigoni Sarantaki, Apostolos Beloukas, Vasiliki E. Georgakopoulou, Georgios Daskalakis, Petros Papalexis, Aikaterini Lykeridou
Summary: Immunizations during pregnancy are vital for perinatal care, yet the rates of influenza vaccination among pregnant women are low due to a lack of clear recommendations from healthcare providers. This study aims to assess healthcare professionals' knowledge and attitudes towards influenza vaccination and their recommendations during the perinatal period.
Article
Biochemistry & Molecular Biology
Maria Kourti, Maria V. V. Alvanou, Zoi Skaperda, Fotis Tekos, Georgios Papaefstathiou, Panagiotis Stathopoulos, Demetrios Kouretas
Summary: An extract from brine samples obtained through the Greek style debittering process of Kalamon olive fruits showed strong antioxidant capacity and DNA-protective activity. The extract consisted mainly of hydroxytyrosol, verbascoside, and tyrosol. In cell-free assays, the extract demonstrated radical scavenging ability, while in cell cultures, it exhibited cell type specific responses and protected against H2O2-induced DNA damage. Overall, this study highlights the potential of table olive wastewaters as a valuable source of bioactive compounds for various industries.
Article
Biochemistry & Molecular Biology
Fotios Tekos, Zoi Skaperda, Periklis Vardakas, Despina Kyriazi, Georgios C. C. Maravelis, Konstantinos Poulas, Ioannis A. A. Taitzoglou, Charitini Nepka, Demetrios Kouretas
Summary: Wine and its by-products, such as grape stems, contain bioactive polyphenolic compounds that can potentially benefit animal and human health. However, there are limited studies on the safety and toxicological risks of these compounds in vivo. This study examined the effects of oral administration of grape stem and wine extracts on redox biomarkers in mice and rats. The results showed that grape stem extract improved redox homeostasis in mice, while wine extract had both beneficial and harmful effects on rat redox status, indicating the complexity of biological systems.
Review
Oncology
Chrysoula Mytareli, Dimitrios C. C. Ziogas, Athina Karampela, Petros Papalexis, Vasiliki Siampanopoulou, Alexandros Lafioniatis, Olga Benopoulou, Helen Gogas, Anna Angelousi
Summary: Immune checkpoint inhibitors (ICIs) are the standard treatment for various types of cancer, but they can also cause immune-related adverse events (irAEs), including endocrine irAEs. This systematic review examines rare and very rare endocrine irAEs associated with ICIs, focusing on their diagnosis, treatment, and underlying pathogenesis. The aim is to increase clinical awareness and promote early detection and proper management of these potentially fatal endocrine irAEs.
Article
Biochemistry & Molecular Biology
Emmanouil Karampinis, Athina-Maria Aloizou, Efterpi Zafiriou, Alexandra Bargiota, Zoi Skaperda, Demetrios Kouretas, Angeliki-Viktoria Roussaki-Schulze
Summary: UV radiation has both harmful and beneficial effects on skin health. It can cause oxidative stress, leading to skin cancer and photoaging. However, it is also necessary for the production of vitamin D, which has important antioxidant and anticancer properties. This study found that skin cancer patients have lower levels of vitamin D and increased oxidative stress.
Article
Health Care Sciences & Services
Betul Cicek, Ahmet Hacimuftuoglu, Yesim Yeni, Betul Danisman, Mustafa Ozkaraca, Behzad Mokhtare, Mecit Kantarci, Marios Spanakis, Dragana Nikitovic, Georgios Lazopoulos, Konstantinos Tsarouhas, Aristidis Tsatsakis, Ali Taghizadehghalehjoughi
Summary: This research evaluated the cardioprotective properties of chlorogenic acid (CGA) in doxorubicin (DOX)-induced cardiotoxicity and identified one of the possible mechanisms for its protective effects. The study found that CGA ameliorated oxidative stress and cardiomyocyte apoptosis by upregulating the Nrf2/HO-1-dependent pathway and downregulating dityrosine (DT) expression. These findings suggest that CGA may be cardioprotective, particularly in patients receiving DOX-based chemotherapy.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Biology
Efthalia Angelopoulou, Eleni Karlafti, Vasiliki E. Georgakopoulou, Petros Papalexis, Sokratis G. Papageorgiou, Thomas Tegos, Christos Savopoulos
Summary: Coronavirus disease 2019 (COVID-19) is often accompanied by neurological symptoms, and Parkinson's disease (PD) has gained attention as a comorbidity. The entry of SARS-CoV-2 into host cells is facilitated by ACE2, which is also implicated in the severity of COVID-19-related respiratory distress. ACE2 imbalance is involved in common pathophysiological mechanisms of PD and COVID-19, including inflammation, oxidative stress, mitochondrial dysfunction, and immune dysregulation. ACE2 may also contribute to dopaminergic degeneration, gut-brain axis dysregulation, blood-brain barrier disruption, autonomic dysfunction, depression, anxiety, and hyposmia, which are key features of PD.
Article
Veterinary Sciences
Efterpi Bouroutzika, Ekaterini K. Theodosiadou, Mariana S. Barbagianni, Serafeim Papadopoulos, Dimitrios Kalogiannis, Stella Chadio, Zoi Skaperda, Demetrios Kouretas, Eleni G. Katsogiannou, Irene Valasi
Summary: This study aimed to assess the impact of melatonin administration on the redox status and hematological variables in heat-stressed ewes during the preovulatory period and early stages of embryogenesis. The results indicated that melatonin treatment improved the fertility rate and redox status of the ewes, suggesting that it may enhance their ability to adapt to high ambient temperatures.
VETERINARY SCIENCES
(2022)
Article
Health Care Sciences & Services
Eleftheria Papachristoforou, Aikaterini Kountouri, Eirini Maratou, Dimitris Kouretas, Zoi Skaperda, Maria Tsoumani, Panagiotis Efentakis, Ignatios Ikonomidis, Vaia Lambadiari, Konstantinos Makrilakis
Summary: This study aimed to investigate the association between hypoglycemia encountered in daily clinical practice and oxidative stress (OS). The results showed that hypoglycemia does not affect OS.
Review
Cardiac & Cardiovascular Systems
Nikolaos Georgiadis, Konstantinos Tsarouhas, Jean-Lou C. M. Dorne, George E. N. Kass, Petroula Laspa, Konstantinos Toutouzas, Elisabeth A. Koulaouzidou, Dimitrios Kouretas, Christina Tsitsimpikou
Summary: This study proposes a roadmap for identifying and regulating cardiotoxic substances. By using animal studies, scientific evidence and threshold values are established, and specific cardiac indices and biochemical markers are preliminarily validated. The results suggest that these indices and markers have the potential to be developed as regulatory criteria.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
