Review
Pharmacology & Pharmacy
Yong Li, Mihong Ren, Jiajun Wang, Rong Ma, Hai Chen, Qian Xie, Hongyan Li, Jinxiu Li, Jian Wang
Summary: Borneol demonstrates neuroprotective effects in the cascade reaction of experimental ischemic stroke, with mechanisms including improvement of cerebral blood flow, inhibition of neuronal excitotoxicity, and resistance to oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Yuqi Mei, Linnan Li, Linghong Fan, Wenxiang Fan, Longchan Liu, Fangli Zhang, Zhizhi Hu, Kang Wang, Li Yang, Zhengtao Wang
Summary: This article systematically summarizes the history, stereochemistry, ethnopharmacology, and quality assessment of borneol, providing valuable information and strategies for its rational application and development.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Rong Yang, Zhenxing Chen, Fuda Xie, Mingxiang Xie, Na Liu, Ziren Su, Jiangyong Gu, Ruizhi Zhao
Summary: The study investigated the inhibitory effect of (+)-borneol and (-)-borneol on P-glycoprotein (Pgp) in reversing mitoxantrone (MTO) resistance. The results showed that both borneol enantiomers could enhance the efficacy of MTO in cancer cells by reducing the protein expression of Pgp and interfering with the binding affinity between MTO and Pgp in the drug-binding pocket. Using molecular docking and dynamics simulations, the study identified key amino acid residues responsible for borneols' ability to reverse MTO resistance through noncompetitive inhibition.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2021)
Article
Chemistry, Multidisciplinary
Kaichao Song, Yumei Hao, Xiaochuan Tan, Hongdong Huang, Lulu Wang, Wensheng Zheng
Summary: This study developed microneedles (MNs) by fusing borneol-modified liposomes (LIPs) with exosomes from mesenchymal stem cells (MSCs) and loading them with Ziconotide (ZIC), aiming to improve the delivery efficiency of ZIC across the blood-brain barrier. The results demonstrated that ZIC-loaded MNs had significant analgesic effects in different pain models.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biotechnology & Applied Microbiology
Michael Hofer, Julia Diener, Benjamin Begander, Robert Kourist, Volker Sieber
Summary: Terpenoids are valuable compounds with various industrial applications, such as camphor in pharmaceuticals. The synthesis of (-)-camphor from renewable resources has become an inexpensive alternative, and enzymatic kinetic resolution can yield high enantiomeric purity. By utilizing enzyme engineering, enantioselective variants have been created to achieve efficient production of (-)-camphor.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Plant Sciences
Zerui Yang, Ting Zhan, Chunzhu Xie, Song Huang, Xiasheng Zheng
Summary: In this study, 82 CcTPS genes were identified and characterized in the camphor tree genome. Tandem duplication was observed within the TPS family, and three genes with relatively high expression in the borneol-type camphor tree were found, indicating the presence of multiple BPPSs within a single species. Furthermore, other six CcTPS genes were found to be involved in the biosynthesis of other monoterpenes in camphor tree. Overall, this study provides insights into the role of the CcTPS gene family and the biosynthesis of monoterpenes in camphor tree.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Bei Qin, Lili Yu, Rong Wang, Yimei Tang, Yunmei Chen, Nana Wang, Yixin Zhang, Xiong Tan, Kuan Yang, Bo Zhang, Maofang He, Yuzhen Zhang, Yaqi Hu
Summary: In this study, a novel compound 221s (2,9) was synthesized using the strategy of combinatorial molecular chemistry, which showed significant antihypertensive effects in SHR rats and had similar efficacy to captopril. The compound also reduced the levels of Ren, Ang II, and ACE in the serum, inhibited RAAS, and enhanced vascular endothelial function. Pathological studies demonstrated its protective effects on myocardial fibrosis and reduction of cardiac degeneration, necrosis, inflammatory cell infiltration, and fibrous tissue proliferation. These findings provide a foundation for further preclinical and clinical research of 221s (2,9) as a new drug.
Article
Chemistry, Applied
D. V. S. Santana, I. A. S. Trindade, Y. M. B. G. Carvalho, A. G. Carvalho-Neto, E. C. D. Silva, E. F. Silva-Junior, R. F. S. Leite, L. J. Quintans-Junior, T. M. Aquino, M. R. Serafini, S. S. Guterres, L. Scotti, M. T. Scotti, A. A. S. Araujo, L. A. Frank, P. P. Menezes
Summary: This study used (-)-borneol as a model monoterpene to prepare inclusion complexes with beta-CD and HP-beta-CD, finding that freeze-drying was more effective in forming the complexes. This research underscores the importance of choosing the best method to prepare inclusion complexes for improved results.
Article
Pharmacology & Pharmacy
Rong Ma, Qian Xie, Hongyan Li, Xiaoqing Guo, Jian Wang, Yong Li, Mihong Ren, Daoyin Gong, Tian Gao
Summary: L-borneol can improve neurological deficits, reduce cerebral infarction, and promote angiogenesis by increasing levels of Ang-1 and VEGF, while also promoting neurogenesis, as well as affecting the expression of VEGF, BDNF, TGF-beta 1, and MMP9 to play a neuroprotective role in cerebral ischemia.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Ka Youn Lee, Ju Young Shin, Myung Suk Ahn, Se Jin Kim, Hye Ryun An, Yae Jin Kim, O. Hyeon Kwon, Su Young Lee
Summary: This study successfully established conditions for efficient callus induction from the petals of the rose breeding line 15R-12-2. The callus contained various volatile organic compounds (VOCs) and could potentially serve as a valuable industrial raw material and an alternative source for VOCs extraction.
Article
Immunology
Jin-ya Wang, Xiaoyan Dong, Zhiwei Yu, Lei Ge, Lu Lu, Ling Ding, Weihua Gan
Summary: The study demonstrated that borneol alleviated asthma in mice by downregulating miR-26a and miR-142-3p, which reduced CD4+ T cells infiltration, thereby attenuating disease progression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
Rong Ma, Danni Lu, Jian Wang, Qian Xie, Jialiang Guo
Summary: The purpose of this study was to clarify differences in the biological activity, safety, and structure-activity relationship of the three kinds of borneol. The results showed that L-borneol has better potential in cerebrovascular diseases, the three kinds of borneol have stronger penetration-promoting effects on hydrophilic drugs, L-borneol and isoborneol promote intestinal mucosal absorption of drugs via bidirectional regulation of P-glycoprotein, D-borneol exhibits better antitumour sensitizing effects than L-borneol, L-borneol exhibits better inhibition of bacterial adhesion because of its C2 chiral centre, and synthetic borneol is less safe. Therefore, L-borneol has excellent potential in many aspects and can effectively replace expensive D-borneol in some applications.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Multidisciplinary
Hualan Li, Haibin Liao, Yanxin Li, Yanlong Qi, Haiyan Ni, Zhengrong Zou, Zaizhi Liu
Summary: Solvent-free microwave-assisted extraction (SFME) was used to efficiently extract Cinnamomum camphora chvar. Borneol essential oil with a high proportion of endo-borneol. The extracted oil showed remarkable inhibitory activity against five Fusarium spp. species that cause potato dry rot.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Huang Ding, Ke Wang, Lin-Qin He, Xiao-Yu Yang, Hai-Hong Huang, Wen-Long Liu, Chen Xiao, Ze-Xuan Du, Lian-Yu, Wei Zhang
Summary: Objective of this study was to prepare novel nanoliposomes (Borneol Angelica Polysaccharide Liposomes, BAPL) for anti-cerebral ischaemia and investigate its curative effects and mechanism. The optimal combination of ingredients for BAPL was determined, resulting in high encapsulation efficiency and suitable particle size and surface charge. Animal experiments confirmed that BAPL significantly reduced infarct volume and modulated the expression levels of key proteins in brain tissue. Thus, BAPL is a promising nano material for the treatment of cerebral ischaemia.
JOURNAL OF LIPOSOME RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jia-Ru Wu, Pei-Chieh Lu, Aye Aye Khine, Sailent Rizki Sari Simaremare, Chien-Chi Hung, Lin-Ming Yiin, Tsung-Jung Ho, Chi-Hua Tung, Hao-Ping Chen
Summary: This study investigates the structural and functional relationship between Borneol dehydrogenase (BDH) and 3-quinuclidinone reductase (QR). The results show that BDH can catalyze the conversion of 3-quinuclidinone into (R)-3-(-)-quinuclidinol, while QR cannot act on (+)-/(-)-borneol.
BIOCATALYSIS AND BIOTRANSFORMATION
(2023)
