Article
Food Science & Technology
Fulya Tasci, Hale Secilmis Canbay, Mahmut Doganturk
Summary: The study found antibiotic residues in non-compliant milk samples, suggesting that not all milk producers adhere to good veterinary practices.
Article
Chemistry, Applied
Irma E. A. Bongers, Milou G. M. van de Schans, Coen V. M. Nibbeling, Ingrid J. W. Elbers, Bjorn J. A. Berendsen, Tina Zuidema
Summary: This study aimed to improve the analytical control strategy by developing a single method to analyze residues of prohibited pharmacologically active substances in milk. The method was validated for bovine milk and caprine milk, proving its effectiveness to detect, confirm, and quantify these substances in two types of milk.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2021)
Article
Biochemistry & Molecular Biology
Marta Pietruk, Piotr Jedziniak, Malgorzata Olejnik
Summary: A novel LC-MS/MS method for NSAIDs determination in meat and milk was developed and validated. Modifications were made to the sample preparation and clean-up procedures, and the method was found suitable for confirmatory purposes in milk and muscle. Two out of 452 samples tested in 2019 and 2020 were identified as non-compliant.
Article
Environmental Sciences
Fawzi Rostane Meklati, Anthi Panara, Ahmed Hadef, Amel Meribai, Meriem H. Ben-Mahdi, Marilena E. Dasenaki, Nikolaos S. Thomaidis
Summary: This study assessed the presence of antibiotic residues in raw milk in Algeria using a rapid screening test and LC-MS/MS. The results showed that 90.4% of the samples were contaminated and 55.3% exceeded the maximum residue limit. Beta-lactams and their metabolites were the most frequently detected, with cloxacillin and penicillin G having the highest levels.
Article
Nutrition & Dietetics
Xiujuan Guo, Hao Tian, Fan Yang, Sufang Fan, Jingwen Zhang, Junmei Ma, Lianfeng Ai, Yan Zhang
Summary: A multi-residue method has been developed to identify and quantify common veterinary drug residues in milk and dairy products. This method showed high recovery rates and low variability, and was successfully applied to real samples.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemical Research Methods
Garnet McRae, Donald M. Leek, Juris Meija, Bryn Shurmer, Steven J. Lehotay, Joachim Polzer, Jeremy E. Melanson, Zoltan Mester
Summary: A freeze-dried bovine muscle-certified reference material (CRM), called BOTS-1, containing residues of commonly used veterinary drugs, was produced and certified. Liquid chromatography tandem mass spectrometry (LC-MS/MS) methods were used for value assignment, along with isotope dilution and standard addition approaches. Data from multiple organizations were used for value assignment. Results were obtained through an international inter-laboratory comparison. Primary standards were characterized using quantitative NMR (1H-qNMR). The certified mass fractions of the veterinary drug residues were reported with expanded uncertainties.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Applied
Estelle Dreano, Michel Laurentie, Dominique Hurtaud-Pessel, Sophie Mompelat
Summary: A multi-class liquid chromatographic method coupled with tandem mass spectrometry was developed to detect and determine residues of 30 antibiotics in feathers, with extraction using the salting out technique and separation employing a Kinetex C18 column. The method showed good accuracy and intermediate precision, validated according to performance criteria, and is suitable for monitoring and quantifying antibiotic residues in feathers.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2021)
Article
Fisheries
G. D. T. M. Jayasinghe, Joanna Szpunar, Ryszard Lobinski, E. M. R. K. B. Edirisinghe
Summary: A UPLC-MS/MS method was developed and validated for the quantitative confirmatory analysis of multi-class antibiotics residues in fish and shrimp. The method successfully detected 14 antibiotics belonging to different classes. The concentrations of antibiotics found in the samples complied with the EU regulation limits for veterinary drug residues in seafood and did not pose a risk in terms of food safety.
Article
Veterinary Sciences
Zehra Hajrulai-Musliu, Risto Uzunov, Stefan Jovanov, Dea Musliu, Elizabeta Dimitrieska-Stojkovikj, Biljana Stojanovska-Dimzoska, Aleksandra Angeleska, Velimir Stojkovski, James Jacob Sasanya
Summary: A sensitive and reliable quantitative LC-MS/MS method has been developed and validated for simultaneous determination of a wide range of veterinary drug and pesticide residues and mycotoxins in bovine urine. The method fulfills the requirements under Regulation 2021/808/EC and can be used for routine analysis of bovine urine samples.
BMC VETERINARY RESEARCH
(2023)
Article
Chemistry, Applied
Cristina Santos-Santorum Suarez, Pascal Sanders, Agnes Perrin-Guyomard, Dominique Hurtaud-Pessel, Michel Laurentie, Alexis Viel, Jean-Francois Taillandier, Marie-Pierre Lagree, Murielle Gaugain
Summary: Cross-contamination between medicated and non-medicated feed can lead to the presence of low concentrations of antibiotics in animal feed, posing potential risks to consumers and the emergence of resistant bacteria.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2022)
Article
Agriculture, Dairy & Animal Science
Zehra Hajrulai-Musliu, Risto Uzunov, Maksud Krluku, Stefan Jovanov, Velimir Stojkovski, Mila Arapcheska, Dea Musliu, James Jacob Sasanya
Summary: Antimicrobial resistance is a global problem that affects humans, animals, and the environment. The extensive use of antibiotics in animal production can lead to the spread of antibiotic resistance genes. This study found that the levels of antimicrobial residues decreased gradually during the withdrawal period in dairy cattle, and the highest antimicrobial resistance was observed in beta-lactam antibiotics.
Article
Biochemical Research Methods
Steven J. Lehotay
Summary: UHPLC coupled with MS/MS is a powerful tool for multiclass, multiresidue analysis. The study validated quantification and identification of 169 veterinary drugs in eggs, recommending monitoring >2 ion transitions per analyte for improved analysis with MS/MS.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Sven Guddat, Christian Goergens, Tim Sobolevsky, Mario Thevis
Summary: The veterinary drug Emidonol (R) may inadvertently lead to doping in sports due to its rapid dissociation into meldonium, a prohibited substance. Experimental studies showed that urine concentrations of meldonium peaked within hours of administration, emphasizing the potential for inadvertent doping through residues in edible products.
DRUG TESTING AND ANALYSIS
(2021)
Article
Chemistry, Multidisciplinary
Abdullah Al Tamim, Saeed Alzahrani, Sarah Al-Subaie, Mohammed A. Almutairi, Ahmed Al Jaber, Abdullah M. Alowaifeer
Summary: This study presented a simple method for the accurate determination of beta-lactams, quinolones, sulphonamides, and tetracyclines in animal origin food, showing excellent linearity, good recovery rates, and low quantification limits, which can be effectively applied in food residue analysis.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Abdullah Al Tamim, Saeed Alzahrani, Sarah Al-Subaie, Mohammed A. Almutairi, Ahmed Al Jaber, Abdullah M. Alowaifeer
Summary: In this study, a simple method for the accurate determination of several veterinary drug residues in fish, poultry, and red meat was described. The method involved a straightforward extraction process without using extraction cartridges. Extensive validation demonstrated the method's excellent linearity, recovery, and repeatability. The quantification limits of drug residues were well below the maximum residue limits set by regulatory authorities. The method was successfully applied to the routine analysis of actual samples.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
