Drosophila models reveal novel insights into mechanisms underlying neurodegeneration

Loss of Drosophila Ataxin-7, a SAGA subunit, reduces H2B ubiquitination and leads to neural and retinal degeneration

(2014) R. D. Mohan et al.   GENES & DEVELOPMENT

RAS–MAPK–MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1

(2013) Jeehye Park et al.   NATURE

Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models

(2013) Hyung-Jun Kim et al.   NATURE GENETICS

Huntingtin’s Function in Axonal Transport Is Conserved in Drosophila melanogaster

(2013) Diana Zala et al.   PLoS One

N-Myc and GCN5 Regulate Significantly Overlapping Transcriptional Programs in Neural Stem Cells

(2012) Verónica Martínez-Cerdeño et al.   PLoS One

Polyglutamine Atrophin provokes neurodegeneration inDrosophilaby repressingfat

(2011) Francesco Napoletano et al.   EMBO JOURNAL

Post-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation

(2011) V. M. Weake et al.   GENES & DEVELOPMENT

The Tightly Controlled Deubiquitination Activity of the Human SAGA Complex Differentially Modifies Distinct Gene Regulatory Elements

(2011) G. Lang et al.   MOLECULAR AND CELLULAR BIOLOGY

Combinatorial depletion analysis to assemble the network architecture of the SAGA and ADA chromatin remodeling complexes

(2011) K. K. Lee et al.   Molecular Systems Biology

Structural Basis for Assembly and Activation of the Heterotetrameric SAGA Histone H2B Deubiquitinase Module

(2010) Alwin Köhler et al.   CELL

Neurodegeneration by polyglutamine Atrophin is not rescued by induction of autophagy

(2010) I Nisoli et al.   CELL DEATH AND DIFFERENTIATION

Multiple faces of the SAGA complex

(2010) Evangelia Koutelou et al.   CURRENT OPINION IN CELL BIOLOGY

Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS

(2010) Andrew C. Elden et al.   NATURE

Structural Insights into the Assembly and Function of the SAGA Deubiquitinating Module

(2010) N. L. Samara et al.   SCIENCE

Yeast Sgf73/Ataxin-7 serves to anchor the deubiquitination module into both SAGA and Slik(SALSA) HAT complexes

(2009) Kenneth K Lee et al.   Epigenetics & Chromatin

SAGA-mediated H2B deubiquitination controls the development of neuronal connectivity in the Drosophila visual system

(2008) Vikki M Weake et al.   EMBO JOURNAL

Cav2-Type Calcium Channels Encoded by cac Regulate AP-Independent Neurotransmitter Release at Cholinergic Synapses in Adult Drosophila Brain

(2008) Huaiyu Gu et al.   JOURNAL OF NEUROPHYSIOLOGY

Histone Ubiquitination: Triggering Gene Activity

(2008) Vikki M. Weake et al.   MOLECULAR CELL

NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration

(2008) R. Grace Zhai et al.   NATURE

Polyglutamine Genes Interact to Modulate the Severity and Progression of Neurodegeneration in Drosophila

(2008) Derek Lessing et al.   PLOS BIOLOGY