Article
Cell Biology
Paula Santabarbara-Ruiz, Pierre Leopold
Summary: The study showed that tumor-induced steroid sink promotes catabolic alterations in healthy tissues, and Oatp33Eb is specifically induced in cachectic tumors, where its overexpression causes cachexia.
DEVELOPMENTAL CELL
(2021)
Article
Multidisciplinary Sciences
Louis P. Watanabe, Nicole C. Riddle
Summary: The study shows that climbing ability in Drosophila melanogaster varies after exercise treatment, with these changes being dependent on sex and genotype. Genes related to 'cell-cell signalling' are implicated in controlling climbing ability. Activity level and exercise-induced climbing ability change are not correlated, highlighting the difficulty in predicting individual responses to exercise.
ROYAL SOCIETY OPEN SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Taylor Barwell, Sehaj Raina, Laurent Seroude
Summary: This article introduces a versatile locomotion measuring device and custom MatLab scripts for data extraction, analysis, and compilation. The study demonstrates that normal aging is associated with a progressive decline in locomotion over time.
Article
Biology
Elise C. Croteau-Chonka, Michael S. Clayton, Lalanti Venkatasubramanian, Samuel N. Harris, Benjamin M. W. Jones, Lakshmi Narayan, Michael Winding, Jean-Baptiste Masson, Marta Zlatic, Kristina T. Klein
Summary: This study developed a high-throughput training system and demonstrated classical conditioning and operant conditioning in Drosophila larvae for the first time. The results expand our understanding of the associative learning abilities of Drosophila larvae and provide a platform for studying different forms of associative learning and the underlying neural circuits.
Article
Biochemistry & Molecular Biology
Qiong Zong, Bin Mao, Hua-Bao Zhang, Bing Wang, Wen-Juan Yu, Zhi-Wei Wang, Yu-Feng Wang
Summary: This study reveals the deubiquitylating effects induced by Wolbachia infection, suggesting that Wolbachia can widely deubiquitinate proteins that have crucial functions in male fertility of their hosts, but are not involved in cytoplasmic incompatibility (CI). The findings provide new insights into the regulatory mechanisms of endosymbiont/host interactions and male fertility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Jianzheng He, Shuzhen Han, Yixuan Wang, Qian Kang, Xiaoqian Wang, Yun Su, Yaling Li, Yongqi Liu, Hui Cai, Minghui Xiu
Summary: Chemotherapy drug CPT-11 leads to various side effects in patients, including delayed development, imbalance in offspring gender ratio, shortened lifespan, impaired locomotor ability, changed metabolic capacity, ovarian atrophy, and increased excretion. It also causes intestinal damages, such as decreased intestinal length, disrupted gastrointestinal acid-based homeostasis, epithelial cell death, and damaged ultrastructure and mitochondria of epithelial cells. CPT-11 induces intestinal damage mainly through regulating several signaling pathways and increasing ROS accumulation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Thilaga Thirugnanam, Kirankumar Santhakumar
Summary: Environmental toxins can be harmful to humans, causing neurodegenerative disorders. Certain neurotoxins, when present in optimal concentrations, can mimic the clinical features of neurodegenerative diseases in animal models, aiding in understanding the molecular mechanisms of neurodegeneration.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Toxicology
Ana Dias-Carvalho, Mariana Ferreira, Ana Reis-Mendes, Rita Ferreira, Maria Lourdes Bastos, Eduarda Fernandes, Susana Isabel Sa, Joao Paulo Capela, Felix Carvalho, Vera Marisa Costa
Summary: This study evaluated the neurotoxic pathways of mitoxantrone in the brain of adult mice and found that it caused significant damage in regions associated with memory and cognition.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Endocrinology & Metabolism
Adeola O. Adedara, Titilayomi A. Otenaike, Ayodeji A. Olabiyi, Isaac A. Adedara, Amos O. Abolaji
Summary: Exposure to low concentrations of iron and rotenone was found to have toxic effects on Drosophila melanogaster, leading to impaired locomotion, reduced survival rate, and compromised antioxidant status. Additionally, the combination of rotenone and iron resulted in accumulated oxidative damage and impaired mitochondrial function in the flies.
METABOLIC BRAIN DISEASE
(2023)
Article
Biology
Tatjana Krama, Diana Bahhir, Liina Ots, Sergejs Popovs, Vadims Bartkevics, Iveta Pugajeva, Ronalds Krams, Enno Merivee, Anne Must, Markus J. J. Rantala, Indrikis Krams, Priit Joers
Summary: Predation can have lethal and non-lethal effects on prey, and non-lethal effects can cause adaptive evolution. Chronic predation stress can lead to metabolic disorders, similar to conditions in humans. This study found that predator stress impairs carbohydrate metabolism in fruit flies, but the flies grown with predators have better survival under direct predation. Treatment with metformin and 5-hydroxytryptophan reversed these effects, suggesting a link between predator stress and metabolic impairment. This research provides an animal model to explore the mechanisms behind prevalent metabolic disorders in humans.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Nattapong Wongchum, Ananya Dechakhamphu
Summary: The study found that XN supplementation can extend the lifespan of fruit flies, increase their antioxidant enzyme activities, improve their survival rates against hydrogen peroxide and paraquat, and enhance their resistance to cold and heat shock as well as starvation stress.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Haofeng Wang, Yunjie Xiao, Xia Chen, Mengwen Zhang, Guangxin Sun, Feng Wang, Lin Wang, Hanxiao Zhang, Xiaoyu Zhang, Xin Yang, Wenling Li, Yi Wei, Deqiang Yao, Bing Zhang, Jun Li, Wen Cui, Fenghua Wang, Cheng Chen, Wei Shen, Dan Su, Fang Bai, Jinhai Huang, Sheng Ye, Lei Zhang, Xiaoyun Ji, Wei Wang, Zefang Wang, Mark Hochstrasser, Haitao Yang
Summary: This study reveals the importance of interface residues in the binding of CI factors CidA and CidB, which contributes to the diversity of cytoplasmic incompatibility. Sequence divergence in CidA and CidB proteins may explain the complex incompatibility patterns observed in mosquitoes infected with different Wolbachia strains.
NATURE COMMUNICATIONS
(2022)
Article
Plant Sciences
Brijesh Singh Chauhan, Rohit Kumar, Pradeep Kumar, Prabhat Kumar, Saket T. Sinha, Sunil Kumar Mishra, Kavindra Nath Tiwari, Alan T. Critchley, Balakrishnan Prithiviraj, Saripella Srikrishna
Summary: FRAN extract, rich in flavonoids, shows strong neuroprotective activity against A beta(42) aggregation in eye tissue of Drosophila. It acts by dissolving A beta(42) fibrils and altering cellular and molecular events involved in neurotoxicity.
Article
Toxicology
Paula Fernanda Ribas Neves, Bruna Bueno Milanesi, Lisie Valeria Paz, Valentina Aguiar Cardozo de Miranda Monteiro, Laura Tartari Neves, Louise Cordoni da Veiga, Rafaela Barboza da Silva, Juliana Henz Sulzbach, Gabriela Padilla Knijkik, Eduarda Correa de Revoredo Ribeiro, Ellen Larissa de Souza Silva, Moema Queiroz Vieira, Pamela Brambilla, Andrea Wieck, Regis Gemerasca Mestriner, Leder Leal Xavier
Summary: PQ exposure in Drosophila melanogaster can lead to parkinsonism, affecting muscle mitochondrial function. However, there are differences in susceptibility to PQ-induced parkinsonism compared to familial parkinsonism, with varying responses at different ages in fruit flies.
TOXICOLOGY LETTERS
(2022)
Review
Pharmacology & Pharmacy
Halina Was, Agata Borkowska, Ana Bagues, Longlong Tu, Julia Y. H. Liu, Zengbing Lu, John A. Rudd, Kulmira Nurgali, Raquel Abalo
Summary: Chemotherapeutic drugs are extensively used in cancer treatment, but their severe side effects on the nervous system can reduce the efficacy of treatment and patients' quality of life. This review discusses the main effects of chemotherapy on the peripheral and central nervous systems, including neuropathic pain, chemobrain, enteric neuropathy, as well as nausea and emesis.
FRONTIERS IN PHARMACOLOGY
(2022)
Editorial Material
Oncology
Charles L. Loprinzi, Dawn L. Hershman, Nathan Staff
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2020)
Editorial Material
Clinical Neurology
Nathan P. Staff, P. James B. Dyck
Article
Biochemical Research Methods
Jon P. Klein, Zhifu Sun, Nathan P. Staff
BMC BIOINFORMATICS
(2019)
Review
Neurosciences
Nathan P. Staff, Jill C. Fehrenbacher, Martial Caillaud, M. Imad Damaj, Rosalind A. Segal, Sandra Rieger
EXPERIMENTAL NEUROLOGY
(2020)
Review
Medicine, General & Internal
Ruple S. Laughlin, Rebecca L. Johnson, Christopher M. Burkle, Nathan P. Staff
MAYO CLINIC PROCEEDINGS
(2020)
Review
Clinical Neurology
Namita A. Goyal, James D. Berry, Anthony Windebank, Nathan P. Staff, Nicholas J. Maragakis, Leonard H. van den Berg, Angela Genge, Robert Miller, Robert H. Baloh, Ralph Kern, Yael Gothelf, Chaim Lebovits, Merit Cudkowicz
Review
Neurosciences
Helmar C. Lehmann, Nathan P. Staff, Ahmet Hoke
EXPERIMENTAL NEUROLOGY
(2020)
Article
Oncology
Costantine Albany, Travis Dockter, Eric Wolfe, Jennifer Le-Rademacher, Nina Wagner-Johnston, Lawrence Einhorn, Jacqueline M. Lafky, Ellen Smith, Deirdre Pachman, Nathan Staff, Cynthia Ma, Charles L. Loprinzi, Brian A. Costello
Summary: The study aimed to compare cisplatin-induced peripheral neuropathy with neuropathy induced by other chemotherapy drugs, showing that cisplatin-induced neuropathy was more similar to oxaliplatin-induced neuropathy compared to paclitaxel-induced neuropathy, potentially due to the younger age of cisplatin recipients. Understanding the similarities and differences in neuropathy caused by different chemotherapy agents may help in elucidating CIPN processes and in developing strategies to prevent and/or treat established CIPN.
SUPPORTIVE CARE IN CANCER
(2021)
Meeting Abstract
Clinical Neurology
S. Cook, N. Folch, L. Hasadsri, D. Oglesbee, N. Staff, D. Anderson, D. Haile, D. Selcen
NEUROMUSCULAR DISORDERS
(2020)
Article
Cell Biology
Mercedes Prudencio, Hector Garcia-Moreno, Karen R. Jansen-West, Rana Hanna AL-Shaikh, Tania F. Gendron, Michael G. Heckman, Matthew R. Spiegel, Yari Carlomagno, Lillian M. Daughrity, Yuping Song, Judith A. Dunmore, Natalie Byron, Bjorn Oskarsson, Katharine A. Nicholson, Nathan P. Staff, Sorina Gorcenco, Andreas Puschmann, Joao Lemos, Cristina Januario, Mark S. LeDoux, Joseph H. Friedman, James Polke, Robin Labrum, Vikram Shakkottai, Hayley S. McLoughlin, Henry L. Paulson, Takuya Konno, Osamu Onodera, Takeshi Ikeuchi, Mari Tada, Akiyoshi Kakita, John D. Fryer, Christin Karremo, Ines Gomes, John N. Caviness, Mark R. Pittelkow, Jan Aasly, Ronald F. Pfeiffer, Venka Veerappan, Eric R. Eggenberger, William D. Freeman, Josephine F. Huang, Ryan J. Uitti, Klaas J. Wierenga, Iris V. Marin Collazo, Philip W. Tipton, Jay A. van Gerpen, Marka van Blitterswijk, Guojun Bu, Zbigniew K. Wszolek, Paola Giunti, Leonard Petrucelli
SCIENCE TRANSLATIONAL MEDICINE
(2020)
Article
Clinical Neurology
Sabrina Paganoni, Fabiola De Marchi, James Chan, Sara K. Thrower, Nathan P. Staff, Neil Datta, Yaz Y. Kisanuki, Vivian Drory, Christina Fournier, Erik P. Pioro, Stephen A. Goutman, Nazem Atassi
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2020)
Article
Neurosciences
Sybil C. L. Hrstka, Soneela Ankam, Busranur Agac, Jon P. Klein, Raymond A. Moore, Bhavya Narapureddy, Isabella Schneider, Ronald F. Hrstka, Surendra Dasari, Nathan P. Staff
Summary: This study identified proteomic changes in human induced pluripotent stem cell-derived sensory neurons exposed to bortezomib, with significant impact on microtubule dynamics, cytoskeletal organization, and molecular transport. Pathway analysis revealed enrichment in unfolded protein response and integrated stress response signaling pathways, while alterations in MAP2 suggested its influential role in bortezomib-induced neurotoxicity.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Clinical Neurology
Tatsuya Oishi, Cory J. Kogelschatz, Nathan P. Young, Ernest M. Hoffmann, Nathan P. Staff, Sue L. Visscher, Bijan J. Borah, William E. Krauss, Kogulavadanan Arumaithurai, Shahar Shelly, Stephen M. Ansell, Christopher J. Klein
BRAIN COMMUNICATIONS
(2020)
Meeting Abstract
Clinical Neurology
Stephen Johnson, Nathan Staff, Ernest Hoffman, Christopher Klein
Meeting Abstract
Cell & Tissue Engineering
S. Bornschlegl, R. Johnson, E. Jacob, N. Staff, M. Gustafson, A. Dietz
