Article
Plant Sciences
Su-Juan Wang, Min Yu, Hua Li, Gui-Jie Zhang
Summary: Sixteen new and three known polyacylated ent-kaurane diterpenoid glycosides were isolated from Inula hupehensis, with compound 5 showing notable inhibition of nitric oxide production. Additionally, compound 13 displayed strong inhibitory effects in an alpha-glucosidase assay.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Jiang-Jiang Tang, Cong Guo, Xiao-Na Peng, Xiao-Chen Guo, Qiang Zhang, Jun-Mian Tian, Jin-Ming Gao
Summary: A fire broke out on the sixth floor of a building in London, with multiple people jumping out of windows on the south side for rescue.
BIOORGANIC CHEMISTRY
(2021)
Review
Integrative & Complementary Medicine
Fei Cao, Chu Chu, Jiang-Jiang Qin, Xiaoqing Guan
Summary: This article reviews the pharmacological effects and anti-tumor potential of Inula sesquiterpene lactones reported in recent years, as well as their status as candidate drugs for cancer treatment.
Article
Biochemistry & Molecular Biology
Romit Seth, Amna Devi, Balraj Sharma, Mamta Masand, Gopal Singh, Poonam Pal, Ashlesha Holkar, Shikha Sharma, Vishal Sharma, Shivanti Negi, Ram Kumar Sharma
Summary: This study investigated the global transcriptional atlas underlying specialized metabolite biosynthesis in different tissues of Inula racemosa. The results revealed organ-specific expression patterns of certain genes related to antimicrobial activities and alantolactone biosynthesis in the root tissue. Additionally, a significant interaction between leaf-specific carbohydrate metabolism and root-specific inulin biosynthesis was observed. These findings provide insights into the transcriptional regulation of specialized metabolite biosynthesis in I. racemosa and contribute to the development of targeted breeding strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Libing Zheng, Huimin Cao, Jiayin Qiu, Changfeng Chi
Summary: Neuropeptide FMRFamide acts as an inhibitory factor in the immune response of Sepiella japonica by suppressing the production of nitric oxide (NO). It exerts its inhibitory effect not only through the NOS pathway but also through other pathways that require further exploration.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Medicinal
Yun-Yun Zhou, Chen-Zhong Jin, Ying-Qun Ma, Xue-Jiao Zhang, Xiu Liu, Shun-Li Xiao
Summary: A new eudesmane sesquiterpene compound was isolated from Inula japonica and its chemical structure was determined by advanced spectroscopy techniques. The compound exhibited phytotoxic effect on the growth of lettuce.
CHEMISTRY OF NATURAL COMPOUNDS
(2022)
Article
Plant Sciences
Hua-Rong Zhao, Xiao-Qin Liu, Xiu-Tao Wu, Ling-Yi Kong, Jian-Guang Luo
Summary: Four new highly oxidized sesquiterpene lactones, Argyoxynolides A-D, were isolated from Artemisia argyi H.Le ' v. & Vaniot, along with two known analogs. One of the compounds showed inhibitory activity against LPS-induced nitric oxide production, with an IC50 value of 37.95 +/- 4.39 μM. The structures of these compounds were characterized using extensive spectroscopic methods.
PHYTOCHEMISTRY LETTERS
(2021)
Article
Plant Sciences
Fan Wei, Yuzhen Yin, Jie Li, Yibo Chang, Shuyuan Zhang, Wenyu Zhao, Xiaochi Ma
Summary: Inula japonica essential oil (EOI) shows potential therapeutic effects on pulmonary injury and fibrosis in mouse models. EOI can inhibit inflammatory response, regulate redox equilibrium, and suppress pulmonary fibrosis by mediating the TGF-beta/Smad and PI3K/Akt signaling pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Ciara-Ruth Kenny, Anna Stojakowska, Ambrose Furey, Brigid Lucey
Summary: With the increasing antimicrobial resistance worldwide, it is critical to explore alternative sources of candidate molecules. This study evaluated the antimicrobial activity of elecampane roots grown in Ireland, and identified sesquiterpene lactones as potential candidates for controlling staphylococcal infections. The geographical origin of the plant did not affect its antibacterial potency or chemical composition.
Article
Chemistry, Medicinal
Paola De Cicco, Rosalia Busa, Giuseppe Ercolano, Carmen Formisano, Mario Allegra, Orazio Taglialatela-Scafati, Angela Ianaro
Summary: Research has shown that cynaropicrin has potential anti-melanoma effects by inhibiting proliferation and inducing apoptosis in melanoma cells. Additionally, cynaropicrin reduces malignant features of melanoma cells such as migration, invasion, and colony formation by inhibiting various protumorigenic signaling pathways like ERK1/2 and NF-kappa B.
PHYTOTHERAPY RESEARCH
(2021)
Article
Food Science & Technology
Fahriye Seyma Ozcan, Hilal Dikmen, Nihat Ozcan, Ozlem Cetin, Mustafa Celik, Antoaneta Trendafilova
Summary: This study focused on optimizing the microwave-assisted extraction (MAE) process for extracting sesquiterpene lactones from Inula helenium roots. The results showed that MAE had higher extraction efficiency and antimicrobial activity, as well as lower energy consumption and carbon emissions compared to conventional maceration.
FOOD SCIENCE & NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Yan Huo, Xiangyi Huang, Yanan Wang, Cong Zhao, Ting Zheng, Weihong Du
Summary: The misfolding and conformational transformation of prion protein (PrP) play a crucial role in the progression of prion diseases. Screening for natural inhibitors against PrP proteins can contribute to the development of new anti-prion drugs. In this study, two sesquiterpene lactones were found to effectively prevent amyloid fibril formation and remodel preformed fibrils of PrP106-126. These compounds exhibited neuroprotective effects by reducing peptide oligomerization.
Article
Plant Sciences
Rui-Fang Wu, Wen-Qiong Wang, Bing-Duo Zhou, Yi Wang, Ya-Ding Li, Sheng-Liang Zhu, Li-Jiang Xuan
Summary: Phytochemical investigation of the aerial part of Inula japonica led to the isolation of three new compounds, inulanolides F-G (1-2) and 17 alpha-carboxaldehyde-ent-kaur-18-oic acid (3), along with four known compounds (4-7). The new compounds were elucidated using spectroscopic data and showed significant anti-inflammatory activities.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Dong-Mei Xie, Qiang Zhang, Ling-Kai Xin, Guo-Kai Wang, Cong-Bin Liu, Min-Jian Qin
Summary: In this study, two GAO genes were identified and cloned from Xanthium sibiricum, and it was found that these genes catalyzed the two-step conversion of germacrene A to germacrene A acid. This study provides a basis for further elucidation of the biosynthesis pathway of sesquiterpene lactones in Xanthium sibiricum.
Article
Chemistry, Analytical
Rama Tyagi, Perwez Alam, Md. Tabish Rehman, Mohamed Fahad AlAjmi, Afzal Hussain, Saima Amin, Mohd. Mujeeb, Showkat R. Mir
Summary: A new dimeric sesquiterpene compound, disesquicin (compound 1), isolated from Inula racemosa roots, exhibited significant cytotoxic activity against various human cancer cell lines. Docking study revealed its binding at the catalytic domain of PLK-1, indicating a potential mechanism for its cytotoxic effects. In vivo investigations further confirmed the cytotoxic potential of compound 1.
Article
Chemistry, Applied
Yanyan Liao, Xuan Hong, Jing Yang, Jiang-Jiang Qin, Beibei Zhang, Jianhui Lin, Zongze Shao, Weiyi Wang
Summary: A novel cyclic tripeptide, sclerotiotide M (1), was isolated from the culture of marine derived fungus Aspergillus ochraceopetaliformis DSW-2, along with four known compounds. The structure of sclerotiotide M (1) was determined through various analytical methods, and it, along with the other compounds, exhibited weak cytotoxic activities against cancer cell lines HPAC and BXPC3.
NATURAL PRODUCT RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Maohua Cai, Jinyun Dong, Haobin Li, Jiang-Jiang Qin
Summary: Bromodomain and extra-terminal domain (BET) proteins are associated with various diseases, and the development of new BET inhibitors is urgently needed.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Mengyi Shan, Chen Jiang, Jing Chen, Lu-Ping Qin, Jiang-Jiang Qin, Gang Cheng
Summary: In this study, a classification model for identifying hERG blockers was developed using the D-MPNN model based on diverse datasets, and the D-MPNN + moe206 model showed significantly improved performance. Our results indicated that the D-MPNN + moe206 model is among the best classification models and has potential applications in the discovery of novel and effective hERG blockers.
Editorial Material
Pharmacology & Pharmacy
Songtao Li, Zhenyuan Song, Ping Yao, Jiangjiang Qin
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Xuan Hong, Xiaoqing Guan, Qiliang Lai, Dehua Yu, Zhongwei Chen, Xiaoteng Fu, Beibei Zhang, Changkun Chen, Zongze Shao, Jinmei Xia, Jiang-Jiang Qin, Weiyi Wang
Summary: A new meroterpenoid, taladrimanin A (1), was isolated from a marine-derived fungus, and its structure and activity were studied. Compound 1 showed inhibitory activity against gastric cancer cells and certain bacteria.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Simin Qi, Xiaoqing Guan, Jia Zhang, Dehua Yu, Xuefei Yu, Qinglin Li, Wenjuan Yin, Xiang-Dong Cheng, Weidong Zhang, Jiang-Jiang Qin
Summary: Inhibiting UbcH5c has been identified as a novel and effective strategy for treating pancreatic cancer, and DHPO represents a new class of UbcH5c inhibitor with potential as an anti-pancreatic cancer therapeutic agent.
Article
Pharmacology & Pharmacy
Jing-Li Xu, Li Yuan, Can Hu, Chun-Yan Weng, Han-Dong Xu, Yun-Fu Shi, Ling Huang, Jie-Er Ying, Zhi-Yuan Xu, Jiang-Jiang Qin, Xiang-Dong Cheng
Summary: The combination of TRM extract (TRMBE) and 5-FU can enhance the anticancer activity of 5-FU, prolong the survival time of mice bearing MFC xenograft tumors, and reduce the risk of liver metastasis in gastric cancer. This combination therapy also modulates immune cytokines, reshapes the tumor microenvironment, and improves the therapeutic effects of 5-FU.
FRONTIERS IN PHARMACOLOGY
(2022)
Editorial Material
Cell Biology
Yancheng Tang, Liming Wang, Jiangjiang Qin, Yingying Lu, Han-Ming Shen, Hu-Biao Chen
Summary: Inhibition of PINK1-PRKN-mediated mitophagy enhances the anticancer efficacy of magnolol and could be a promising therapeutic strategy for overcoming cancer drug resistance and improving the therapeutic efficacy of anticancer agents.
Review
Biochemistry & Molecular Biology
Chunxiao Zhu, Xiaoqing Guan, Xinuo Zhang, Xin Luan, Zhengbo Song, Xiangdong Cheng, Weidong Zhang, Jiang-Jiang Qin
Summary: KRAS is the most frequently mutated oncogene in various tumor types and has been considered undruggable due to the lack of classic drug binding sites. However, the development of KRAS inhibitors has made KRAS mutations druggable. Despite remarkable clinical responses, resistance to monotherapy of KRAS inhibitors has been observed. Significant progress has been made in understanding the mechanisms of drug resistance to KRAS-mutant inhibitors.
Article
Pharmacology & Pharmacy
Jing Yang, Lingling Wang, Xiaoqing Guan, Jiang-Jiang Qin
Summary: STAT3 is a critical player in cell signal transmission, making it a promising target for anticancer drug development. Many natural products have been shown to inhibit the STAT3 signaling pathway, demonstrating significant anticancer activities, but there is currently no FDA-approved STAT3 inhibitor.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Microbiology
Dongli Lv, Jinmei Xia, Xiaoqing Guan, Qiliang Lai, Beibei Zhang, Jianhui Lin, Zongze Shao, Sulan Luo, Dongting Zhangsun, Jiang-Jiang Qin, Weiyi Wang
Summary: Two new bioactive compounds were isolated from a deep-sea-derived fungus and their structures were determined. Compounds 1, 5-7 exhibited significant inhibition against Staphylococcus aureus, while compound 8 showed potent reduction in cell viability of gastric cancer cells.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Haobin Li, Lingling Wang, Fei Cao, Dehua Yu, Jing Yang, Xuefei Yu, Jinyun Dong, Jiang-Jiang Qin, Xiaoqing Guan
Summary: The study reports the design and synthesis of a class of STAT3 degraders based on proteolysis-targeting chimeras (PROTACs). The SDL-1 compound achieved degradation of STAT3 protein in vitro and exhibited good anti-gastric cancer cell proliferation activity, as well as inhibiting invasion and metastasis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Haobin Li, Maohua Cai, Fei Cao, Dehua Yu, Jing Yang, Wenkai Yu, Chu Chu, Xiaoqing Guan, Jiang-Jiang Qin, Jinyun Dong
Summary: A series of new STAT3 inhibitors were synthesized and the representative compound SIL-14 demonstrated strong anti-proliferation activity, inhibited colony formation and migration of gastric cancer cells, and induced cell apoptosis. It also inhibited the STAT3 signaling pathway, indicating its potential as an anticancer agent.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Xiaofan Wu, Hongjian Yang, Xingfei Yu, Jiang-Jiang Qin
Summary: Breast cancer is a common malignancy in women, and HER2 overexpression is associated with poor prognosis. Pertuzumab and trastuzumab are the primary treatment options for early-stage HER2-positive breast cancer, and antibody-drug conjugates and tyrosine kinase inhibitors improve prognosis for metastatic breast cancer patients. However, resistance to targeted therapy is an issue that needs to be addressed.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Handong Xu, Can Hu, Yi Wang, Yunfu Shi, Li Yuan, Jingli Xu, Yanqiang Zhang, Jiahui Chen, Qin Wei, Jiangjiang Qin, Zhiyuan Xu, Xiangdong Cheng
Summary: Gastric cancer (GC) is a deadly malignancy that requires new therapeutic targets for effective treatment. Glutathione peroxidase-2 (GPx2) was found to be overexpressed in clinical GC samples and negatively correlated with prognosis. Knockdown of GPx2 inhibited GC progression and metastasis by suppressing the KYNU-kyn-AhR signaling pathway, which was activated by reactive oxygen species (ROS) accumulation.
Article
Chemistry, Medicinal
Saeed Reza Simaei, Vahid Reza Askari, Mahboobeh Rostami, Mohammad Kamalinejad, Mohammad Hosein Farzaei, Mohammadreza Morovati, Fatemeh Heydarpour, Zahra Jafari, Vafa Baradaran Rahimi
Summary: This study demonstrates that lavender and metformin have similar effects in treating PCOS patients, as both significantly increase progesterone levels and regulate menstrual cycles.
Article
Chemistry, Medicinal
Peng-Ran Cao, Xiao Ren, Jie Lin, Yun-Long Mu, Yue-Qi Shan, Jing-Tong Zhu, Rong-Yi Xu, Xue-Xia Zhang, Wei-Guo Hu, Xin-Hua Lu
Summary: Four previously unknown angucyclinones umezawaones A-D (1-4) were isolated from the liquid cultures of Umezawaea beigongshangensis. Their structures were determined using spectroscopic analysis, single crystal X-ray diffraction, quantum chemical 13C NMR, and electronic circular dichroism calculations. All compounds exhibited potent inhibitory activities against indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in enzymatic assays, with compound 2 showing the highest activity.
Article
Chemistry, Medicinal
Marwa Mersni, Bingqing Zhou, Guillaume Reversat, Mohamed Larbi Khouja, Alexandre Guy, Camille Oger, Jean-Marie Galano, Thierry Durand, Chokri Messaoud, Claire Vigor
Summary: The relevance of oxylipins as biomarkers of oxidative stress has been established in recent years. This study evaluated the lipidomic profiling of different aerial parts of Acacia cyanophylla Lindl. using LC-MS/MS technology for the first time. The analysis revealed the existence of six PhytoPs and three PhytoFs, with stems having the highest amount of these metabolites. This study provides a foundation for exploring Acacia cyanophylla Lindl. as a potential source of plant oxylipins for therapeutic or pharmaceutical uses.
Review
Chemistry, Medicinal
Lorenzo Buzzelli, Andrea Segreti, Daniela Di Gioia, Erika Lemme, Maria Rosaria Squeo, Antonio Nenna, Giuseppe Di Gioia
Summary: This review provides a comprehensive assessment of red yeast rice, including its biochemical composition, historical studies, cardiovascular disease prevention, and other clinical effects. Red yeast rice preparations have been proven safe and effective in improving lipid profiles, with a potential role in reducing cardiovascular risk.
Article
Chemistry, Medicinal
Xiuwen Zheng, Yuxin Zhang, Yinfeng Tan, Yonghui Li, Qianrong Xue, Hailong Li, Xuguang Zhang, Yipeng Pan, Jian Xu, Junqing Zhang
Summary: Alpinia officinarum Hance (AOH) may protect against diabetic gastroparesis (DGP) through multiple mechanisms, including lowering blood glucose levels, increasing gastrointestinal propulsion rate, improving gastric histological morphology, and regulating gut microbiota.
Article
Chemistry, Medicinal
Na Chen, Rui Xie, Jia-pei Chen, Ying-li Zhong, Xian-wen Zhang, Qing-wen Gui, Chun Guo, Hua Yang
Summary: The study clones the SinSyn gene from Sinomenium acutum and analyzes its catalytic activity, confirming the biosynthetic pathway of sinoacutine and discussing its classification and pharmacological action.
Article
Chemistry, Medicinal
Noura Bentarhlia, Badr Eddine Kartah, Mouhcine Fadil, Said El Harkaoui, Bertrand Matthaeus, Oualid Abboussi, Hanaa Abdelmoumen, Omar Bouhnik, Hanae El Monfalouti
Summary: The lipidic extract of Dittrichia viscosa exhibits significant wound healing activity and antimicrobial effects. It is rich in fatty acids such as linolenic acid, oleic acid, and linoleic acid, as well as compounds like gamma-tocopherols and sterols.
Article
Chemistry, Medicinal
Hawraa Zbeeb, Hala Khalifeh, Giulio Lupidi, Francesca Baldini, Lama Zeaiter, Mohamad Khalil, Annalisa Salis, Gianluca Damonte, Laura Vergani
Summary: This study assessed the biological properties of S. spinosum fruits and found that the ethanolic extract exhibited significant anti-steatotic and antioxidant activities.
