Article
Plant Sciences
Kithsiri B. Herath, Stephen F. Previs, Thomas P. Roddy, Athula B. Attygalle, Ignacio Gonzalez, Olga Genilloud, Sheo B. Singh
Summary: Natural product congeners play an important role in understanding biosynthesis and structure-activity relationships, but there is currently a lack of effective methods to rapidly, specifically, and selectively discover targeted congeners. A new method based on liquid-chromatography tandem-mass spectrometry combination has been successfully used for targeted discovery of congeners of platensimycin and platencin from Streptomyces platensis extracts, providing an efficient approach for congener research and discovery.
JOURNAL OF NATURAL PRODUCTS
(2021)
Review
Biochemistry & Molecular Biology
Mirian Pateiro, Julian Andres Gomez-Salazar, Mariana Jaime-Patlan, Maria Elena Sosa-Morales, Jose M. Lorenzo
Summary: Plants are rich in bioactive compounds such as polyphenols, which can replace synthetic antioxidants in meat products. These natural antioxidants, obtained from fruits, vegetables, herbs, and spices, contribute to the quality of meat products and offer benefits in terms of environmental protection and resource reutilization.
Article
Food Science & Technology
Zuzana Kovalikova, Jan Lnenicka, Rudolf Andrys
Summary: Gemmotherapy is a therapeutic technique that utilizes extracts from fresh meristematic plant tissues, mainly buds and sprouts. This study found that environmental factors can significantly affect the chemical composition of the buds, leading to variations in antioxidant potential. Additionally, the levels of different phenolic compounds in buds may not directly correlate with their antioxidant activity, suggesting the involvement of other active molecules in the antioxidant mechanism.
Review
Biochemistry & Molecular Biology
Eyana Thomas, Laura E. Stewart, Brien A. Darley, Ashley M. Pham, Isabella Esteban, Siva S. Panda
Summary: Viral infections are complex medical issues that pose a threat to the economy and global health. Natural products from plant sources, known for their diversity, have been a major inspiration for new drug development, yet they have received little attention from large pharmaceutical industries.
Article
Green & Sustainable Science & Technology
Shahid Adeel, Maryam Habiba, Shumaila Kiran, Sarosh Iqbal, Shazia Abrar, Ch Moazzam Hassan
Summary: This study evaluated the antioxidant and sun protection effects of apple, banana, and orange peel extracts in skincare formulations. The extracts containing polyphenols showed antioxidant activity and were incorporated into stable cosmetic emulsions. The fruit peel waste could serve as a sustainable source of natural antioxidants for the personal care industry.
Review
Pharmacology & Pharmacy
Giovane de Jesus Gomes Ribeiro, Sun Liu Rei Yan, Giuseppe Palmisano, Carsten Wrenger
Summary: Malaria, mainly affecting Africa and Southeast Asia, claims over 500,000 lives annually. The disease is caused by the protozoan parasite Plasmodium, with Plasmodium vivax and Plasmodium falciparum being the main culprits in humans. The emergence of artemisinin-resistant strains in Southeast Asia underscores the urgent need for more effective and safe antimalarial drugs. This mini-review explores the potential of plant extracts and isolated natural products as antimalarial agents, focusing on in vitro studies conducted in the last five years (2018-2022).
Article
Biochemical Research Methods
Yangzom Dawa, Yurong Du, Qi Wang, Chengbiao Chen, Denglang Zou, Desheng Qi, Jianbin Ma, Jun Dang
Summary: Traditional Tibetan medicine (TTM) provides valuable novel therapeutic lead molecules from natural products. This study successfully separated and identified 4 main radical scavenging compounds from the methanolic extract of Saxifraga atrata using efficient methods. The developed methodology is effective for targeted isolation of high-purity compounds and rapid identification and isolation of DPPH inhibitors from various natural products.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Article
Biochemistry & Molecular Biology
Kasper K. Sorensen, Narendra K. Mishra, Maciej P. Paprocki, Amit Mehrotra, Knud J. Jensen
Summary: The study investigated the use of high-performance reversed-phase flash chromatography (HPFC) for rapidly purifying laboratory-scale quantities of crude, synthetic peptides and chemically modified insulins, demonstrating its versatility for various types of peptides. Depending on the peptide's purity profile, HPFC can serve as a standalone purification method or as a pre-purification step before final HPLC purification, providing guidelines for synthetic peptides and small proteins. HPFC is considered a valuable alternative to HPLC purification for peptides and small proteins.
Article
Agriculture, Multidisciplinary
Elisabeth Koch, Michelle Wiebel, Ariane Loewen, Ina Willenberg, Nils Helge Schebb
Summary: Enzymatic and nonenzymatic oxidation of linoleic (LA) and alpha-linolenic acid (ALA) during pressing and storage of plant oils leads to the formation of various oxylipins. The concentrations of oxylipins are found to be correlated with the peroxide value (PV) of the oils, while secondary volatile aldehydes do not show similar correlations. Comprehensive analysis of different types of hydroxy-, epoxy-, and dihydroxy-LA/-ALA provides new insights into the composition of plant oils and ongoing oxidation processes.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Adriano Rutz, Jean-Luc Wolfender
Summary: Recent developments in mass spectrometry-based metabolite profiling have allowed for unprecedented qualitative coverage of complex biological extract composition. However, the use of electrospray ionization in metabolite profiling leads to multiple artifactual signals for a single analyte. In this study, we developed a generic qualitative and quantitative approach using a combination of liquid chromatography-mass spectrometry (LC-MS) and Charged Aerosol Detection (CAD) to annotate and contextualize features in a high-resolution tandem MS dataset. Signals not attributed to CAD peaks are considered minor metabolites. This approach enables the automatic assessment of the composition of single natural extracts or broader collections, facilitating new ingredient registrations or natural-extracts-based drug discovery campaigns.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Plant Sciences
Abraham Hernandez-Ceja, Pedro Damian Loeza-Lara, Francisco Javier Espinosa-Garcia, Yolanda M. Garcia-Rodriguez, Jose Roberto Medina-Medrano, German Fernando Gutierrez-Hernandez, Luis Fernando Ceja-Torres
Summary: Three pathogenic fungi of blueberry were isolated in Michoacan, Mexico, and extracts from medicinal plants such as Lantana hirta, Argemone ochroleuca, and Adenophyllum porophyllum were found to inhibit their growth in vitro. These extracts contain potential antifungal compounds that could be further explored for their efficacy against plant pathogens.
Article
Chemistry, Analytical
Shixuan Zhang, Yonggui Ma, Ronghua Ma, Qilan Wang, Jun Dang
Summary: In this study, medium-pressure liquid chromatography and high-pressure liquid chromatography methods were used to successfully isolate the quality marker L-tryptophan from Medicago sativa with satisfactory purity.
Review
Food Science & Technology
Annalisa De Girolamo, Vincenzo Lippolis, Michelangelo Pascale
Summary: This article reviews the relevant literature on liquid chromatography mass spectrometry methods for the analysis of various natural toxins in food. A total of 96 papers from 2011 to 2021 were selected for review. Different approaches in sample preparation, chromatographic separation, and detection mode are discussed. The article particularly focuses on the analytical performance characteristics obtained during the validation process and the application to real samples.
Article
Biochemical Research Methods
Mikhail Vokuev, Timur Baygildiev, Arkadiy Braun, Anastasia Frolova, Igor Rybalchenko, Igor Rodin
Summary: This study demonstrates the potential use of plants as a material for retrospective analysis by injecting nerve agent metabolites into soil and monitoring their presence in both the plants and soil for at least one month.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Chemistry, Analytical
Chuang Liu, Yuqing Lei, Jun Dang, Weidong Wang, Jing Zhang, Lijuan Mei, Zenggen Liu, Yanduo Tao, Yun Shao
Summary: This study successfully developed a rapid method for isolating 1,1-diphenyl-2-picrylhydrazyl inhibitors using Ribes himalense as a model herb, providing a useful reference for the chemical composition research of traditional Tibetan medicines.
JOURNAL OF SEPARATION SCIENCE
(2021)
Article
Chemistry, Medicinal
Saeed Reza Simaei, Vahid Reza Askari, Mahboobeh Rostami, Mohammad Kamalinejad, Mohammad Hosein Farzaei, Mohammadreza Morovati, Fatemeh Heydarpour, Zahra Jafari, Vafa Baradaran Rahimi
Summary: This study demonstrates that lavender and metformin have similar effects in treating PCOS patients, as both significantly increase progesterone levels and regulate menstrual cycles.
Article
Chemistry, Medicinal
Peng-Ran Cao, Xiao Ren, Jie Lin, Yun-Long Mu, Yue-Qi Shan, Jing-Tong Zhu, Rong-Yi Xu, Xue-Xia Zhang, Wei-Guo Hu, Xin-Hua Lu
Summary: Four previously unknown angucyclinones umezawaones A-D (1-4) were isolated from the liquid cultures of Umezawaea beigongshangensis. Their structures were determined using spectroscopic analysis, single crystal X-ray diffraction, quantum chemical 13C NMR, and electronic circular dichroism calculations. All compounds exhibited potent inhibitory activities against indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in enzymatic assays, with compound 2 showing the highest activity.
Article
Chemistry, Medicinal
Marwa Mersni, Bingqing Zhou, Guillaume Reversat, Mohamed Larbi Khouja, Alexandre Guy, Camille Oger, Jean-Marie Galano, Thierry Durand, Chokri Messaoud, Claire Vigor
Summary: The relevance of oxylipins as biomarkers of oxidative stress has been established in recent years. This study evaluated the lipidomic profiling of different aerial parts of Acacia cyanophylla Lindl. using LC-MS/MS technology for the first time. The analysis revealed the existence of six PhytoPs and three PhytoFs, with stems having the highest amount of these metabolites. This study provides a foundation for exploring Acacia cyanophylla Lindl. as a potential source of plant oxylipins for therapeutic or pharmaceutical uses.
Review
Chemistry, Medicinal
Lorenzo Buzzelli, Andrea Segreti, Daniela Di Gioia, Erika Lemme, Maria Rosaria Squeo, Antonio Nenna, Giuseppe Di Gioia
Summary: This review provides a comprehensive assessment of red yeast rice, including its biochemical composition, historical studies, cardiovascular disease prevention, and other clinical effects. Red yeast rice preparations have been proven safe and effective in improving lipid profiles, with a potential role in reducing cardiovascular risk.
Article
Chemistry, Medicinal
Xiuwen Zheng, Yuxin Zhang, Yinfeng Tan, Yonghui Li, Qianrong Xue, Hailong Li, Xuguang Zhang, Yipeng Pan, Jian Xu, Junqing Zhang
Summary: Alpinia officinarum Hance (AOH) may protect against diabetic gastroparesis (DGP) through multiple mechanisms, including lowering blood glucose levels, increasing gastrointestinal propulsion rate, improving gastric histological morphology, and regulating gut microbiota.
Article
Chemistry, Medicinal
Na Chen, Rui Xie, Jia-pei Chen, Ying-li Zhong, Xian-wen Zhang, Qing-wen Gui, Chun Guo, Hua Yang
Summary: The study clones the SinSyn gene from Sinomenium acutum and analyzes its catalytic activity, confirming the biosynthetic pathway of sinoacutine and discussing its classification and pharmacological action.
Article
Chemistry, Medicinal
Noura Bentarhlia, Badr Eddine Kartah, Mouhcine Fadil, Said El Harkaoui, Bertrand Matthaeus, Oualid Abboussi, Hanaa Abdelmoumen, Omar Bouhnik, Hanae El Monfalouti
Summary: The lipidic extract of Dittrichia viscosa exhibits significant wound healing activity and antimicrobial effects. It is rich in fatty acids such as linolenic acid, oleic acid, and linoleic acid, as well as compounds like gamma-tocopherols and sterols.
Article
Chemistry, Medicinal
Hawraa Zbeeb, Hala Khalifeh, Giulio Lupidi, Francesca Baldini, Lama Zeaiter, Mohamad Khalil, Annalisa Salis, Gianluca Damonte, Laura Vergani
Summary: This study assessed the biological properties of S. spinosum fruits and found that the ethanolic extract exhibited significant anti-steatotic and antioxidant activities.