Article
Biochemistry & Molecular Biology
Bowen Shuai, Tingyue Deng, Liping Xie, Rongqing Zhang
Summary: This study systematically investigated the regulatory effect of the NF-KB signaling pathway on biomineralization and shell regeneration in Pinctada fucata. The transcription factor Pf-Rel was found to play a positive regulatory role in the growth of the prismatic and nacreous layers, while the inhibitory protein poI-KB prevented excessive growth and accumulation. RNA-seq analysis identified potential regulatory genes controlled by Pf-Rel. Shell damage repair experiments revealed different functions of the NF-KB signaling pathway at different times. This study provides a macroscopic perspective based on transcription factors for studying biomineralization and shell regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Lipeng Tang, Tong Li, Bowen Zhang, Zihao Zhang, Xiaoyi Sun, Ying Zhu, Bing Feng, Zuqing Su, Laijun Yang, Hongxia Li, Huazhen Liu, Yuchao Chen, Zhenhua Dai, Xirun Zheng, Mingxian Li, Chutian Li, Jie Zhao, Xinmin Qiu, Shuyan Ye, Han Liu, Guangjuan Zheng, Ben Li, Chuanjian Lu
Summary: Punicalagin (PUN) shows therapeutic potential for psoriasis by inhibiting inflammatory response and cell signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Physiology
Aswathy M. Cheriyan, Adaku C. Ume, Cynthia E. Francis, Keyona N. King, Valerie A. Linck, Yun Bai, Hui Cai, Robert S. Hoover, Heping P. Ma, Jennifer L. Gooch, Clintoria R. Williams
Summary: CnA alpha deficiency stimulates Nox2 upregulation, and NF-kappa B serves as a novel CnA alpha-regulated transcription factor that mediates Nox2 and ROS regulation. These findings suggest potential for selective CNIs to improve long-term outcomes by mitigating renal side effects.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Immunology
Shouye Hu, Yanqi Li, Bo Wang, Kan Peng
Summary: The study showed that TRIM38 can alleviate IL-1 beta-induced apoptosis and degeneration of chondrocytes by suppressing the NF-kappa B signaling pathway. This work suggests a potential role of TRIM38 in osteoarthritis and proposes it as a new therapeutic target for the disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Zengxin Jiang, Guobin Qi, Wei Lu, Hao Wang, Defang Li, Weibin Chen, Lei Ding, Xiuying Yang, Hengfeng Yuan, Qingmin Zeng
Summary: This study found that omaveloxolone exerts antioxidative, anti-inflammatory, antiapoptotic and anti-ECM degradation effects via activation of the Nrf2/ARE signaling pathway and inhibition of the NF-kappa B signaling pathway in chondrocytes in vitro and attenuates osteoarthritis progression in vivo, suggesting its potential as a therapeutic agent for OA.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lei Xu, Yangfan Ye, Zeqiang Tao, Tian Wang, Yutian Wei, Wanzhi Cai, Xin Wan, Pengzhan Zhao, Wei Gu, Bin Gu, Liuchao Zhang, Yufei Tian, Ning Liu, Yiming Tu, Jing Ji
Summary: This study elucidated the role of MLPH in GBM radiation resistance, showing that MLPH promotes radiotherapy resistance by regulating the NF-kappa B pathway. Additionally, O-GlcNAcylation of MLPH protects it from degradation and stabilizes its presence in cells. These findings provide insights into a potential mechanism of GBM radiation resistance and suggest a therapeutic strategy for GBM treatment.
Article
Allergy
SuJin Hwang, Christina Tatsi, Hye Sun Kuehn, Julie E. Niemela, Jennifer Stoddard, Yan Su, Maya Lodish, Gulbu Uzel, Rosanne Spolski, Warren J. Leonard, Steven M. Holland, Thomas A. Fleisher, Constantine A. Stratakis, Sergio D. Rosenzweig
Summary: This study investigated the immunological effects of pediatric endogenous Cushing syndrome (eCs) and its treatment. The results showed that the decrease in thymic output, lymphocyte proliferation, and increase in apoptosis were the underlying causes of T-cell lymphopenia in eCs patients. Additionally, IL-21 levels were decreased in both natural and in vitro glucocorticoid environments, but the addition of IL-21 in vitro counteracted the proapoptotic effects of glucocorticoid therapy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Cell Biology
Yan-Lin Chen, De-Yi Yan, Chen-Yu Wu, Jiang-Wei Xuan, Chen-Qiang Jin, Xin-Li Hu, Guo-Dong Bao, Yu-Jie Bian, Zhi-Chao Hu, Zhong-Hai Shen, Wen-Fei Ni
Summary: OA is characterized by destruction of articular cartilage and inflammation plays a key role in its progression. Maslinic acid (MA) from olive fruit has been shown to have anti-inflammatory effects. In in vitro and in vivo experiments, MA was found to attenuate inflammatory mediators and inhibit the progression of OA disease.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Plant Sciences
Yixi Yang, Yujin Zhang, Xun Chen, Zhou Su, Yu Deng, Qi Zhao
Summary: This study explored the bioactivity of Khasianine and showed that it possessed highly anti-inflammatory bioactivity which rapidly alleviated psoriasis-like mice skin inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Fraser D. Russell, Jeanne C. Visagie, Jamie L. Noll
Summary: Endotoxin in honey can stimulate IL-6 secretion and activate TLR4 signaling.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Qi-qi Liu, Wei-wei Wu, Jian Yang, Rui-bin Wang, Ling-ling Yuan, Pei-zhao Peng, Mao-yun Zeng, Ke Yu
Summary: In this study, the GP130-targeting molecule LMT-28 was found to effectively reduce lipopolysaccharide-induced bone resorption around implants in diabetic rats. LMT-28 downregulated the expression of RANKL and decreased osteoclast activity through the JAK2/STAT3 signaling pathway. These findings highlight the potential of LMT-28 as a therapeutic agent for peri-implantitis in diabetic patients.
MEDIATORS OF INFLAMMATION
(2023)
Article
Biochemistry & Molecular Biology
Elizabeta Georgieva, Stefan L. Leber, Cora Wex, Christoph Garbers
Summary: The study reveals that perturbation of the actin cytoskeleton is not sufficient to induce NF-kappa B activation and IL-6 secretion, but it reduces IL-6-induced activation of STAT3 in Hep3B cells. Additionally, IL-6 receptor proteolysis by ADAM10 is not dependent on the integrity of the actin cytoskeleton.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Jee Hyun Kang, Suyoung Park, Jinhyung Rho, Eun-Ju Hong, Young-Eun Cho, Young-Suk Won, Hyo-Jung Kwon
Summary: IL-17A promotes gastric carcinogenesis, potentially through the regulation of the IL-17RC/NF-κB/NOX1 pathway. This finding provides a new target for the treatment of gastric cancer.
Article
Fisheries
Yu Han, Yu Tang, Shuge Sun, Tongchol Kim, Kwangjin Ju, Sanghyok Ri, Xueying Du, Weishang Zhou, Wei Shi, Shiguo Li, Guangxu Liu
Summary: This study demonstrates the important role of CaM in immune modulation and hemocyte phagocytosis in bivalve species. Inhibition of CaM significantly decreases phagocytic activity of hemocytes, affects intracellular Ca2+ elevation, actin cytoskeleton assembly, and immune-related pathways. The findings suggest potential pathways through which CaM modulates phagocytosis in bivalves.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Cell Biology
Yiping Mu, Yang Zhang, Jie Wu, Qi Li
Summary: NLRC5 is a critical mediator of inflammatory response and its overexpression in chondrocytes suppressed IL-1β-induced inflammation. Knockdown of NLRC5 had the opposite effect. NLRC5 attenuated IL-1β-induced inflammatory injury through regulating the NF-κB signaling pathway in chondrocytes.
Article
Engineering, Civil
Hanqiu Wang, Rongqing Zhang, Xiang Cheng, Liuqing Yang
Summary: Traffic flow prediction is an important field, and our proposed hierarchical prediction protocol based on spatial-temporal graph convolutional network (ST-GCN) can achieve more accurate traffic flow prediction. The protocol can also effectively predict the traffic flow of intersections without historical data.
IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS
(2022)
Article
Engineering, Electrical & Electronic
Ang Ji, Xu Guo, Rongqing Zhang, Jianjun Wu, Xiang Cheng
Summary: This paper studies the deployment of a high-altitude platform (HAP) as a supplement for terrestrial networks in the fifth-generation (5G) network. It focuses on serving both conventional terrestrial users (TUs) and unmanned aerial vehicles (UAVs) simultaneously. The paper addresses the challenges of HAP deployment and complex channel and resource allocation.
IET COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Bowen Shuai, Tingyue Deng, Liping Xie, Rongqing Zhang
Summary: In this study, a novel matrix protein named PNU5 was discovered to play a regulatory role in both prismatic layer and nacreous layer formation in Pinctada fucata. Functional studies showed that PNU5 might be involved in shell formation in a positive manner. Repression of pnu5 affected the structure of both layers, while the recombinant protein rPNU5 enhanced the precipitation rate of CaCO3 and altered the morphology of the crystals.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Li Yi, Bing Zou, Liping Xie, Rongqing Zhang
Summary: This article investigates a novel vaterite stabilizer acidic matrix protein PNU7, which is found in both the prism and nacre of Pinctada fucata. The study shows that PNU7 can trigger the formation of stable vaterite even with a deficiency in Mg2+ and low Ca2+ levels. Moreover, increasing PNU7 in the calcium carbonate crystallization system leads to a decrease in crystal size and an increase in nucleation quantity. The results suggest that PNU7 not only plays a role in shell formation but also regulates the formation of nacre through surface energy minimization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Geochemistry & Geophysics
Guozhi Xie, Haibo Yan, Guangming Li, Jia Guo, Fang Liu, Qian Chen, Rongqing Zhang, Lipeng Zhang
Summary: This study focused on the in-situ major and trace element and boron isotope compositions of tourmalines from two-mica granites in the Cuona area. The results indicated that tourmalines in the Cuonadong leucogranite crystallized earlier than those in the Cuona leucogranite during magmatic differentiation. The volatile contents of tourmaline were genetically related to incompatible elements, which led to tourmaline zonation and the enrichment of Sr, Zn, and Pb. The B isotopic composition of tourmaline suggested that the granitic magma was dominantly derived from the partial melting of the metasedimentary source rocks, and their B isotope variations were likely due to fluid exsolution during B-rich melt evolution. High rare metal contents in tourmalines indicated great mineralization potential in the two-mica granites of the Cuona area.
Article
Engineering, Chemical
Rongqing Zhang, Haifeng Chen, Qiang Yu, Yu Zhang, Fen Liu, Fan Wang, Xiaoyan Chen, Yunyun Liu
Summary: The recycling of bioactive compounds from Chinese herb residue is hindered by low extraction efficiency and high energy environmental impact. A microwave-assisted deep eutectic solvent (DES) extraction method was developed to enhance the extraction yield of bioactive compounds from cinnamon twigs residue. The optimal DES system of choline chloride/ethylene glycol achieved a significant increase in extraction yield, with a 41.528% and 41.443% improvement for cinnamic acid and cinnamic aldehyde, respectively, compared to traditional extraction processes. The extraction process was found to be a spontaneous, exothermic, and irreversible reaction, following a second-order kinetic model. Quantum chemistry analysis revealed that the extraction capacity relied mainly on hydrogen bonding force, and the difference in binding energy between the solvent and the target compounds explained the variation in extraction yields.
CHEMICAL ENGINEERING SCIENCE
(2023)
Article
Engineering, Electrical & Electronic
Xinge Li, Xiaoya Hu, Rongqing Zhang, Chunjie Zhou, Quan Yin, Liuqing Yang
Summary: This paper proposes a 5G network security analysis approach combining formal modeling and attack penetration to reveal the impact of network threats on 5G-based industrial systems. The approach establishes 5G network models based on topology and transmission events to handle diverse and hidden attack routes and behaviors. It integrates an attack module into the network model to exploit and quantify potential vulnerabilities. Simulation results identify and quantify network vulnerabilities under various attacks, and a threshold of access probability is found to measure the impacts of attacks on network reliability. The feasibility of the approach is further proven through a practical case study.
IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Jingliang Huang, Yangjia Liu, Taifeng Jiang, Wentao Dong, Liping Xie, Rongqing Zhang
Summary: Molluscs rapidly repair damaged shells to ensure survival, but the control mechanism of this process is unclear. Using scanning electron microscope and histochemical analysis, this study examined shell regeneration in Pinctada fucata. Damage to the shell caused the mantle tissue to retract, resulting in the rearrangement of mantle zones and the alteration of shell morphology. The up-regulation of shell matrix protein genes and the change in CaCO3 dynamics promoted shell formation. This study reveals the relationship between mantle tissue activities and regenerated shell morphology.
JOURNAL OF STRUCTURAL BIOLOGY
(2023)
Review
Plant Sciences
Ning Yang, Qingyang Zhang, Jingyun Chen, Shilin Wu, Ran Chen, Liping Yao, Bailei Li, Xiaojun Liu, Rongqing Zhang, Zhen Zhang
Summary: Natural antioxidants, such as microalgal bioactive components, are preferred due to their non-toxic and effective properties. This study analyzed antioxidant research on microalgae-based bioactive compounds using a bibliometric approach. The findings highlight the most studied areas, including effectiveness, antioxidant mechanism, and applications in food, cosmetics, and medicine. Future trends focus on improving extraction rates and stability through altering the microalgae culture environment or incorporating chemicals like nanoparticles.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Computer Science, Information Systems
Zhiwei Wei, Bing Li, Rongqing Zhang, Xiang Cheng
Summary: This paper proposes an integrated charging and computing (IC2) architecture, which combines vehicular fog computing (VFC) and smart EV charging for optimization of electric vehicle (EV) charging and computing tasks in a smart grid. A multiattribute contract-based charging protocol is provided using contract theory, and a convex-concave-procedure-based contract optimization algorithm is designed. A heuristic offloading algorithm is also proposed for task assignment to heterogeneous EVs. Numerical results show that the proposed multiattribute contract-based charging-computing scheme effectively benefits both the charging stations and EVs, while improving task computation capability in the EV-integrated smart grid.
IEEE INTERNET OF THINGS JOURNAL
(2023)
Article
Geosciences, Multidisciplinary
Guozhi Xie, Haibo Yan, Rongqing Zhang, Kun Wang, Lipeng Zhang
Summary: This study examines two types of hydrothermal tourmaline (Tur-1 and Tur-2) and concludes that Tur-1 originated from a magmatic-hydrothermal fluid with little influence from surrounding rocks, whereas Tur-2 in the skarn involved more fluid from surrounding rocks. The findings have important implications for understanding the formation and ore-forming mechanisms of leucogranite.
FRONTIERS IN EARTH SCIENCE
(2023)
Article
Biology
Zhonghui Xia, Xin Zhang, Yujuan Zhou, Liping Yao, Zhen Zhang, Rongqing Zhang, Xiaojun Liu
Summary: In this study, a novel matrix protein cysrichin was cloned and shown to induce vaterite crystallization. Cysrichin plays an important role in shell formation of freshwater mussels, providing new insights into mineralization in these organisms.
Article
Computer Science, Information Systems
Zhiwei Wei, Bing Li, Rongqing Zhang, Xiang Cheng, Liuqing Yang
Summary: This article proposes a novel task-block-based offloading paradigm for vehicular fog computing, which reduces computation latency and solves the complex offloading problem through the overlapping matching coalition scheme.
IEEE INTERNET OF THINGS JOURNAL
(2023)
Proceedings Paper
Computer Science, Hardware & Architecture
Lingyun Zhou, Wenqiang Pu, Ming-yi You, Rongqing Zhang, Qingjiang Shi
Summary: In this paper, the problem of cooperative sensing via a system of multi-unmanned aerial vehicles (UAVs) is considered. Each UAV is equipped with a directional antenna to perform detection tasks for multiple targets. The detection probability is chosen as the metric to measure the system's perception ability, and the goal is to maximize the sum detection probability by optimizing UAVs' deployment and directional antenna orientations. To tackle the nonconvexity of the problem, it is decomposed into two sub-problems and efficient algorithms are developed using block coordinate descent and Gibbs Sampling approaches.
2023 IEEE WIRELESS COMMUNICATIONS AND NETWORKING CONFERENCE, WCNC
(2023)
Article
Computer Science, Information Systems
Zhiwei Wei, Bing Li, Rongqing Zhang, Xiang Cheng, Liuqing Yang
Summary: This article proposes a cooperative vehicular fog computing architecture called OCVC, which fully utilizes the potential resources of vehicular fog nodes to address the overload issue in computation-intensive tasks. Unlike traditional architectures, OCVC enables vehicles to participate in multiple computing groups simultaneously, utilizing resources in an overlapping manner. The article also presents a distributed OCVC scheme that employs the overlapping coalition formation game framework and a heuristic offloading algorithm to solve complex group formation, resource allocation, and task assignment problems, with simulation results showing better performance compared to other benchmarks.
IEEE TRANSACTIONS ON MOBILE COMPUTING
(2023)