Review
Biochemistry & Molecular Biology
Xu Zhang, Depei Zhang, Li Xiang, Qiying Wang
Summary: Manganese superoxide dismutase exhibits rapid product inhibition at high temperatures but is less inhibited at lower temperatures. The temperature-dependent kinetics can be explained by changes in coordination of manganese superoxide dismutase. Cold activation of the enzyme is an adaptive response to low temperatures and plays a role in cold stress signaling and physiological responses.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Debbie S. Retnoningrum, Hiromi Yoshida, Ismiana Pajatiwi, Rahmat Muliadi, Ratna A. Utami, Anita Artarini, Wangsa T. Ismaya
Summary: The manganese superoxide dismutase from Staphylococcus equorum (MnSODSeq) has shown robust activity under various conditions. Strengthening the interactions between the monomers is crucial for improving the enzyme stability. A new strategy using K38R-A121E/Y double substitutions has been proposed, resulting in mutants with similar enzyme activity and enhanced thermal stability. The structure of the L169W mutant was also elucidated, revealing the impact of intramolecular modification on enzyme stability.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chia-Chu Liu, Chia-Fang Wu, Yung-Chin Lee, Tsung-Yi Huang, Shih-Ting Huang, Hsun-Shuan Wang, Jhen-Hao Jhan, Shu-Pin Huang, Ching-Chia Li, Yung-Shun Juan, Tusty-Jiuan Hsieh, Yi-Chun Tsai, Chu-Chih Chen, Ming-Tsang Wu
Summary: Environmental exposure to melamine increases the risk of oxidative stress and early kidney injury. The single-nucleotide polymorphisms (SNPs) of MnSOD, rs4880 and rs5746136, influence the risk of oxidative stress and renal tubular injury, respectively, in patients with calcium urolithiasis.
Article
Biotechnology & Applied Microbiology
Tanjun Zhao, Shengqi Ding, Zhenlin Hao, Xubo Wang, Yaoyao Zhan, Yaqing Chang
Summary: The selected Argopecten irradians showed significant improvements in body weight and adductor muscle wet weight compared to the control group. Analysis identified genes related to insulin signaling, immune pathways, and actin cytoskeleton regulation as potential factors contributing to growth improvement in the selected group.
Article
Mycology
Samim Dullah, Dibya Jyoti Hazarika, Gunajit Goswami, Tanushree Borgohain, Alokesh Ghosh, Madhumita Barooah, Ashok Bhattacharyya, Robin Chandra Boro
Summary: Fungal-fungal interactions result in changes in metabolite profiles, including production of defensive responses, increased laccase production, and alterations in hyphal morphology. Analytical techniques like LC-MS confirmed the production of pigments such as melanin and the upregulation of stress-related genes during these interactions.
Review
Chemistry, Medicinal
Stephen T. Sonis
Summary: Toxicities associated with radiation therapy can be effectively mitigated through interventions aimed at disrupting the biological cascade of toxicity development, with oxidative stress being a key initiator of normal tissue injury. Attempts to supplement endogenous superoxide dismutases or develop synthetic dismutase mimetics have shown some potential, with avasopasem manganese emerging as a promising dismutase mimetic in clinical trials for reducing severe oral mucositis in head and neck cancer patients undergoing chemoradiation.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Agriculture, Dairy & Animal Science
Tong Zhang, Jiaxin Zhang, Ruilan Li
Summary: This study investigated the expression pattern and functional characteristics of p66Shc during preimplantation embryo development in sheep. The results showed that p66Shc was expressed in all stages of sheep early embryos and its expression was regulated during embryonic genome activation. RNAi-mediated knockdown of p66Shc resulted in decreased levels of ROS and DNA damage, and increased levels of antioxidant enzymes. This suggests that p66Shc is involved in the regulation of oxidative stress and DNA damage during sheep early embryonic development.
Article
Fisheries
W. K. M. Omeka, D. S. Liyanage, Taehyug Jeong, Sukkyoung Lee, Jehee Lee
Summary: The study characterized manganese superoxide dismutase in disk abalone (AbMnSOD) through transcriptional analysis, tissue-specific expression studies, activity measurement, and functional validation in transfected cells. The findings indicate that AbMnSOD plays a crucial role in regulating developmental processes and defense mechanisms against oxidative stress in hosts.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Fisheries
Xia Wang, Xiaoxu Qu, Xia Lu, Min Chen, Junhao Ning, Haijun Liu, Guilong Liu, Xin Xu, Xiaotong Zhang, Kai Yu, He Xu, Bo Liu, Chunde Wang
Summary: This study identified five TRAF genes in Argopecten scallops, excluding TRAF1 and TRAF5. TRAF6 was found to play an important role in the immune response of scallops, and the expression of AiTRAF was significantly increased when challenged by Vibrio anguillarum, indicating its role in scallop immunity.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shylesh Bhaskaran, Gaurav Kumar, Nidheesh Thadathil, Katarzyna M. Piekarz, Sabira Mohammed, Sergio Dominguez Lopez, Rizwan Qaisar, Dorothy Walton, Jacob L. Brown, Ashley Murphy, Nataliya Smith, Debra Saunders, Michael J. Beckstead, Scott Plafker, Tommy L. Lewis, Rheal Towner, Sathyaseelan S. Deepa, Arlan Richardson, Robert C. Axtellb, Holly Van Remmen
Summary: This study investigates the effects of elevated oxidative stress induced in the mouse spinal cord through the deletion of Mn-Superoxide dismutase (MnSOD). The results show that the deletion of Sod2 in spinal cord neurons leads to mitochondrial alterations and peroxide generation. This phenotype is characterized by demyelination, inflammation, and progressive paralysis that mimic the symptoms of progressive multiple sclerosis.
Article
Chemistry, Multidisciplinary
Ruomei Li, Zhiyu Zhu, Bolin Zhang, Ting Jiang, Cheng Zhu, Peng Mei, Yu Jin, Ruiqing Wang, Yixin Li, Weiming Guo, Chengxiao Liu, Lunguo Xia, Bing Fang
Summary: Manganese doping is used to enhance bone regeneration by regulating adaptive immunity. It leads to increased recruitment of CD4+ T cells and promotes Th2 cell polarization while inhibiting Th1 cell polarization. This immune environment facilitates the osteogenic ability of bone marrow stromal cells and achieves consequential regeneration of mandibular bone defect.
Article
Multidisciplinary Sciences
Paulina Wigner-Jeziorska, Radoslaw Grebowski, Joanna Saluk, Michal Bijak, Janusz Szemraj
Summary: The study suggests that molecular disturbances of inflammation, oxidative and nitrative stresses may play a potential role in the pathogenesis of urolithiasis. The identified polymorphic variants and changes in mRNA expression of IL-6, IL-8, SOD2, and NOS2 may be involved in the development of urolithiasis.
Article
Plant Sciences
Shu-Hsuan Hu, Shu-Fan Lin, Ya-Chen Huang, Chien-Hsun Huang, Wen-Yu Kuo, Tsung-Luo Jinn
Summary: AtMTM1 and AtMTM2 in Arabidopsis are functional homologs of yMTM1 in yeast, crucial for activation of MnSOD and maintaining ion homeostasis. They are also involved in Mn and Fe homeostasis, root length, and flowering time. The study suggests an evolutionarily conserved activation mechanism for AtMnSOD in the chloroplast.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
M. Dolores Garrido, Jamal El Haskouri, Maria D. Marcos, Francisco Perez-Pla, Jose Vicente Ros-Lis, Pedro Amoros
Summary: This study reports the preparation of a novel nanocomposite with enzyme-like activity for decomposing reactive oxygen species (ROS). The nanocomposite, consisting of MnOx needles covered with SiO2 porous material, was synthesized using a two-step procedure. The material was characterized, and its bimodal porosity and efficient enzyme activities were observed. The study also proposed reaction mechanisms and demonstrated the role of silica in catalase activity.
Article
Multidisciplinary Sciences
Visarut Buranasudja, Dolly Rani, Ashwini Malla, Khwanlada Kobtrakul, Sornkanok Vimolmangkang
Summary: Formation of oxidative stress in dermal fibroblasts is crucial for skin aging, and using phytochemicals to enhance the cells' ability to combat oxidative stress is a promising strategy to prevent skin aging. Callus culture of Centella asiatica produces unique antioxidant compounds that exhibit anti-skin-aging activities, including upregulation of cellular antioxidant enzymes and inhibition of matrix metalloprotease-9 induction. This highlights the potential of C. asiatica callus extract as an effective anti-skin-aging agent in cosmeceutical preparations.
SCIENTIFIC REPORTS
(2021)