Review
Immunology
Shanshan Wang, France Moreau, Kris Chadee
Summary: Gasdermins (GSDMs) are a group of proteins that can induce cell death or pyroptosis by forming pores in the plasma membrane. This review provides a comprehensive overview of the expression, activation, biological functions, and regulation of GSDMs, with a focus on their role in host defense against Eh and other protozoan parasitic infections.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Felicity K. Hunter, Thomas D. Butler, Julie E. Gibbs
Summary: The mammalian immune system follows a circadian rhythm and influences the immune response to threats from parasites. Parasites may have evolved to benefit from the host's circadian timing mechanisms.
PARASITE IMMUNOLOGY
(2022)
Article
Fisheries
Azim Azimi, Seyed Pezhman Hosseini Shekarabi, Hamed Paknejad, Mohammad Harsij, Zohre Khorshidi, Mehdi Zolfaghari, Abdo-Salam Hatami, Mahmoud A. O. Dawood, Nasataran Mazloumi, Hamideh Zakariaee
Summary: This study found that common carp raised in a biofloc system with a C/N ratio of 20:1 showed the best growth indices and feed conversion ratio, while those in the C/N-10 system exhibited higher serum glucose and enzyme activities. The immunoglobulin M levels remained stable in C/N-15 and C/N-20 groups but were significantly higher than in the C/N-10 group. Additionally, the expression levels of certain immune-related genes increased with higher C/N ratios.
Review
Immunology
Guanghui Qian, Liyan Zhu, Gen Li, Ying Liu, Zimu Zhang, Jian Pan, Haitao Lv
Summary: Viral infections trigger crucial immune responses which need to be balanced carefully to avoid autoimmune diseases. The ubiquitin system, especially DUBs, play a critical role in regulating innate immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Phileno Pinge-Filho
Summary: Blood pathogenic trypanosomatids like Trypanosoma cruzi have specialized systems to export virulence factors into host cells. Extracellular vesicles shed by T. cruzi can enhance infection susceptibility of host cells. The relationship between damage-associated molecular patterns and extracellular vesicles sheds by T. cruzi in the context of Chagas Disease is still unclear.
MEDICAL HYPOTHESES
(2021)
Review
Immunology
Jianya Peng, Hannah G. G. Federman, Christina M. Hernandez, Mark C. C. Siracusa
Summary: Parasitic helminth infections are a global health issue, causing significant morbidity and economic hardships. Host protective responses to helminths involve the initiation of type 2 inflammation and the involvement of various immune cells. Recent studies have also highlighted the importance of neuro-immune interactions in regulating anti-helminth immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Na Zhang, Fei Wang, Gaomeng Zhang, Qi Zhang, Yuhong Liu, Qiao Wang, Mohamed Shafey Elsharkawy, Maiqing Zheng, Jie Wen, Guiping Zhao, Qinghe Li
Summary: Toll-like receptors (TLRs) are important immune sensors involved in host defense. In this study, the researchers discovered that the deubiquitinase USP7 interacts with MyD88 protein, regulating its expression and participating in bacteria-induced inflammation. This finding contributes to our understanding of the regulatory mechanisms in immune signaling.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Mengyao Yu, Yuexinzi Jin, Shichang Zhang, Jian Xu, Jiexin Zhang
Summary: This narrative review focuses on the interaction and molecular mechanisms between Human cytomegalovirus (HCMV) and host immune cells, with a specific emphasis on HCMV-encoded miRNAs. The review highlights the importance of HCMV infection and explores the potential of miRNA-targeted therapies and alternative vaccines.
Review
Biochemistry & Molecular Biology
Nur Azizah A. Rahman, Vinod R. M. T. Balasubramaniam, Wei Boon Yap
Summary: The IL-12 family consists of cytokines that play a crucial role in activating host antiviral immunity and preventing excessive immune reactions. IL-12 and IL-23 stimulate T cell proliferation and effector cytokine release, leading to host defense against virus infections. IL-27 and IL-35 have dual functions in regulating cytokine synthesis, T cell proliferation, and viral antigen presentation to enhance virus clearance. The multitasking nature of the IL-12 family makes it a highly important target for antiviral therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Wei Wu, Yang Qu, Shengqing Yu, Sa Wang, Yuncong Yin, Qinfang Liu, Chunchun Meng, Ying Liao, Zaib Ur Rehman, Lei Tan, Cuiping Song, Xusheng Qiu, Weiwei Liu, Chan Ding, Yingjie Sun
Summary: DDX21 is identified as a key regulator of immune balance, with virus infection and RNA/DNA ligands leading to its cleavage and suppression of the interferon beta signaling pathway. Modulating DDX21 cleavage may impact the innate immune response to viruses.
Article
Cell Biology
Harry J. Hurley, Hannah Dewald, Zachary S. Rothkopf, Sukhwinder Singh, Frank Jenkins, Pratik Deb, Saurav De, Betsy J. Barnes, Patricia Fitzgerald-Bocarsly
Summary: The study indicates that AMP-activated protein kinase is a key driver of metabolic reprogramming in pDCs, with influenza activation leading to increased oxygen consumption and mitochondrial membrane potential, ultimately promoting IFN-alpha production.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Immunology
Samiddha Banerjee, Aruna Pal, Abantika Pal, Subhas Chandra Mandal, Paresh Nath Chatterjee, Jayanta Kumar Chatterjee
Summary: The RIG-I gene plays a crucial role in parasitic immunity in infected sheep, particularly in binding with Haemonchus contortus. Studies suggest that sheep could be a valuable model organism for understanding the role of RIG-I in antiparasitic immunity in humans, based on genetic similarities with other livestock species.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Iwona T. Myszor, Gudmundur Hrafn Gudmundsson
Summary: The innate immune system of the airway epithelium consists of multiple components that work together to protect the host from invading pathogens. Modulating innate immune responses in the airway epithelium to boost host defenses and enhance immune responses is an alternative approach to standard antibiotics. This review discusses the possibilities of such modulation for host-directed therapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
David P. Maison, Youping Deng, Mariana Gerschenson
Summary: The SARS-CoV-2 pandemic and COVID-19 disease have had a global impact, sparking a significant surge in research. To evaluate future approaches, understanding the host immune response and viral antagonism is crucial. This review summarizes current knowledge on SARS-CoV-2, focusing on the viral genome, replication cycle, host immune activation, response, signaling, and antagonism. Efforts should be directed towards current research to develop treatments and prepare for future outbreaks.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Marta Campillo Poveda, Collette Britton, Eileen Devaney, Tom N. Mcneilly, Francois Gerbe, Philippe Jay, Rick M. Maizels
Summary: Tuft cells are chemosensory cells in the intestinal tract that play a crucial role in activating immune responses to parasitic infections. They not only participate in maintaining metabolic and tissue integrity, but also serve as the first sensors of parasite infection. Furthermore, Tuft cells are widely distributed in mucosal tissues and are connected to immune and neuronal cells.
Article
Fisheries
Ana Herrero, Oswaldo Palenzuela, Hamish Rodger, Chris Matthews, Mar Marcos-Lopez, James E. Bron, Mark P. Dagleish, Kim D. Thompson
Summary: The microsporidian D. lepeophtherii is difficult to detect in tissue sections, and this study developed an ISH protocol specific for D. lepeophtherii, which showed higher sensitivity compared to other methods.
JOURNAL OF FISH DISEASES
(2022)
Article
Fisheries
Rosa A. Sueiro, Jesus Lamas, Oswaldo Palenzuela, Paola Gulias, Cristina Diez-Vives, Alba Garcia-Ulloa, Jose M. Leiro
Summary: Scuticociliatosis is a serious disease without effective control measures for flatfish during culture. This study developed a quantitative real-time PCR assay with high sensitivity and precision for monitoring the main pathogenic agents of scuticociliatosis in fish farm water, which could contribute to the establishment of effective prevention and control programs.
Article
Fisheries
M. C. Piazzon, F. Naya-Catala, G. V. Pereira, I. Estensoro, R. Del Pozo, J. A. Calduch-Giner, W. G. Nuez-Ortin, O. Palenzuela, A. Sitja-Bobadilla, J. Dias, L. E. C. Conceicao, J. Perez-Sanchez
Summary: This study evaluated the effects of the NoPAP SANA diet on gilthead sea bream, showing that the diet promotes optimal growth and a healthy condition without affecting susceptibility to intestinal parasites.
Article
Genetics & Heredity
Ahmed Ibrahem Hafez, Beatriz Soriano, Aya Allah Elsayed, Ricardo Futami, Raquel Ceprian, Ricardo Ramos-Ruiz, Genis Martinez, Francisco Jose Roig, Miguel Angel Torres-Font, Fernando Naya-Catala, Josep Alvar Calduch-Giner, Lucia Trilla-Fuertes, Angelo Gamez-Pozo, Vicente Arnau, Jose Maria Sempere-Luna, Jaume Perez-Sanchez, Toni Gabaldon, Carlos Llorens
Summary: The GPRO suite is an ongoing bioinformatic project for the analysis of -omics data. It introduces a client- and server-side solution for comparative transcriptomics and variant analysis. The client-side includes two Java applications, RNASeq and VariantSeq, which manage pipelines and workflows using common command line tools. The server-side, named GPRO Server-Side, hosts all dependencies and requires a Linux operating system, PHP, SQL, Python, bash scripting, and third-party software. The solution offers both desktop and web applications, with step-by-step and pipeline modes for execution. It also features an experimental support system called GENIE, with a chatbot assistant and expert system for troubleshooting and recommendations.
Article
Fisheries
Socorro Toxqui-Rodriguez, Fernando Naya-Catala, Ariadna Sitja-Bobadilla, M. Carla Piazzon, Jaume Perez-Sanchez
Summary: This study compared different sequencing platforms for microbial characterization in fish gut mucosal samples. The results showed that MinION is a reliable and accurate tool for assessing intestinal bacteria communities, with good correlation with Illumina results. However, less abundant but biologically important taxa may be masked compared to Illumina sequencing.
Article
Agriculture, Dairy & Animal Science
Maria Constenla, Oswaldo Palenzuela
Summary: A new parasite species, Endolimax carassius, was identified as the causative agent of systemic granulomatous disease in goldfish. Phylogenetic analyses showed that this goldfish parasite species is closely related to Endolimax piscium, the causative agent of systemic granulomatous disease in Senegalese sole. The discovery of a considerable diversity of Endolimax spp. among fish highlights the importance of characterizing these parasites in order to understand their evolution and pathogenic potential.
Article
Fisheries
Enrique Riera-Ferrer, Raquel Del Pozo, M. Carla Piazzon, Ariadna Sitja-Bobadilla, Itziar Estensoro, Oswaldo Palenzuela
Summary: This study explores the best experimental conditions to set up an in vivo infection model capable of mimicking the sparicotylosis signs observed in farmed diseased fish. The experimental setup for parasite transmission consisted of a recipient fish tank with naive GSB receiving water from two S. chrysophrii-infected donor tanks. The study provides an advancement for studying S. chrysophrii's biology and its interaction with its host, as well as for further researching treatment alternatives and prophylactic measures.
Article
Physiology
Paul G. Holhorea, Fernando Naya-Catala, Alvaro Belenguer, Josep A. Calduch-Giner, Jaume Perez-Sanchez
Summary: This study combines multiple systems to understand the schooling behavior and adaptive features of farmed gilthead sea bream in high stocking density conditions. The results show that high density fish exhibit adaptive behavior, such as changes in feeding behavior and enhanced endogenous swimming activity rhythm, but also experience reduced growth rates and limited oxygen availability.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Genetics & Heredity
Beatriz Soriano, Ahmed Ibrahem Hafez, Fernando Naya-Catala, Federico Moroni, Roxana Andreea Moldovan, Socorro Toxqui-Rodriguez, Maria Carla Piazzon, Vicente Arnau, Carlos Llorens, Jaume Perez-Sanchez
Summary: This paper introduces SAMBA, a computational tool that uses a Bayesian network approach to model the network structure and interactions of fish gut microbiomes in aquaculture systems. SAMBA can infer the influence of farming conditions on microbiome diversity and predict changes under different conditions. It is worth noting that SAMBA can be used for modeling microbiome-host network relationships of any vertebrate organism, including humans, in any system and/or ecosystem.
Article
Immunology
Alberto Ruiz, Ignasi Sanahuja, Karl B. Andree, Dolors Furones, Paul G. Holhorea, Josep A. Calduch-Giner, Jose J. Pastor, Marc Vinas, Jaume Perez-Sanchez, Sofia Morais, Enric Gisbert
Summary: This study investigated the potential of using a combination of pungent spices as a dietary supplement for gilthead seabream. The results showed that the supplement enhanced growth performance, improved lipid metabolism, and reduced fat accumulation in various tissues. It can be used as part of a nutritional strategy to promote a more judicious use of fish oil in fish diets.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
F. Naya-Catala, A. Belenguer, D. Montero, S. Torrecillas, B. Soriano, J. Calduch-Giner, C. Llorens, R. Fontanillas, S. Sarih, M. J. Zamorano, M. Izquierdo, J. Perez-Sanchez
Summary: The study found that the influence of broodstock nutrition on gilthead sea bream with different genetic backgrounds results in distinct hepatic transcriptome and genome-wide DNA methylation patterns, with the magnitude of the impact depending on the genetic background.
Meeting Abstract
Fisheries
Itziar Estensoro, Raquel Del Pozo, Ariadna Sitja-Bobadilla, M. Carla Piazzon
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Meeting Abstract
Fisheries
E. Riera-Ferrer, E. Gimeno, R. Del Pozo, O. Palenzuela, M. C. Piazzon, A. Sitja-Bobadilla, I. Estensoro
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
