Article
Obstetrics & Gynecology
Hoon Kim, Soo Jin Han, Yun Soo Hong, Sung Woo Kim, Seung-Yup Ku, Chang Suk Suh, Seok Hyun Kim
Summary: The optimal number of oocytes for maximizing the rate of clinical pregnancy varies depending on the method of pituitary suppression. Too many oocytes may not lead to better clinical outcomes.
REPRODUCTIVE SCIENCES
(2021)
Article
Endocrinology & Metabolism
Mu Lv, Juanjuan Yu, Peiqin Chen, Qimeng Xiao, Liqun Lou, Yifan Luo, Mu Yuan, Yuan Xu, Youji Feng, Mingzhu Bai, Zhenbo Zhang, Linxia Li
Summary: This study compares the efficacy of GnRH-ant protocol and GnRH-a protocol in IVF therapy for patients with severe male infertility factors. The results show that the GnRH-a protocol has a higher live birth rate and ongoing pregnancy rate, especially in single embryo transfer.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, Research & Experimental
Rui Yang, Yichun Guan, Valerie Perrot, Juan Ma, Rong Li
Summary: The study compared the long-acting GnRH agonist follicular protocol and GnRH antagonist protocol in women undergoing IVF, showing that the long-acting GnRH agonist follicular protocol group had higher live birth rate, clinical pregnancy rate, and implantation rate, while the GnRH antagonist protocol group had a lower incidence of OHSS with no significant difference in miscarriage rate.
ADVANCES IN THERAPY
(2021)
Article
Medicine, General & Internal
Michail Papapanou, Kalliopi Syristatidi, Maria Gazouli, Makarios Eleftheriades, Nikolaos Vlahos, Charalampos Siristatidis
Summary: Controlled ovarian hyperstimulation (COH) is crucial for successful in vitro fertilization (IVF). Personalized approaches to study patients' responses to different COH protocols are necessary. The mTOR and Hippo signaling pathways play important roles in follicular homeostasis and oocyte quality.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Bella Martazanova, Nona Mishieva, Valentina Vtorushina, Irina Vedikhina, Lev Levkov, Irina Korneeva, Anastasia Kirillova, Lubov Krechetova, Aydar Abubakirov, Gennady T. Sukhikh
Summary: The study found that the way of ovulation triggering affects the concentrations of VEGFR2 and VEGFA in serum. A low dose of hCG elicits similar concentrations of VEGFA compared to a full dose of hCG, while GnRHa triggering reduces the concentrations of VEGFR2, potentially aiding in the prevention of OHSS.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Chunhui Zhang, Fangrong Wu, Zexuan Wu, Bolan Sun, Cheng Chen, Weiping Qian
Summary: Addition of 150 IU of hCG in the early follicular phase significantly improves the number of oocytes retrieved and usable embryos in unpredictable poor responders undergoing IVF/ICSI treatment.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Genetics & Heredity
Hadas Ganer Herman, Eran Horowitz, Yossi Mizrachi, Jacob Farhi, Arieh Raziel, Ariel Weissman
Summary: This systematic review identified that long-term or recent oral contraceptive use and low or high body mass index may lead to suboptimal response to GnRHa triggering. Low basal serum hormone levels and low LH levels on the day of triggering were associated with suboptimal response. Retriggering with hCG may be considered in patients with suboptimal response.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Medicine, General & Internal
Depeng Zhao, Rui Xie, Xuemei Li
Summary: This study aimed to compare the pregnancy outcomes after fresh embryo transfer in patients with thin endometrium using GnRH antagonist and GnRH agonist regimens. The results showed that in patients with thin endometrium, the rates of clinical pregnancy and live birth were significantly lower in the GnRH antagonist group compared to the GnRH agonist group. Multivariable regression analysis demonstrated that the GnRH agonist regimen was associated with a higher live birth rate compared to the GnRH antagonist protocol.
FRONTIERS IN MEDICINE
(2023)
Article
Endocrinology & Metabolism
Shan Liu, Minghui Liu, Lingxiu Li, Huanhuan Li, Danni Qu, Haiying Ren, Hui Su, Yang Zhang, Yuan Li
Summary: A retrospective cohort study on 110 patients with deep ovarian suppression found that a modified GnRH antagonist protocol based on LH levels during the second ovarian stimulation cycle resulted in significantly better reproductive outcomes compared to continuing with GnRH agonist long protocol. The use of modified protocol led to higher ongoing pregnancy and live birth rates, and lower cancellation rate, suggesting that patients may benefit from adjusting their treatment based on LH levels.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Anat Hershko Klement, Raoul Orvieto, Efrat Esh Broder, Judith Frei, Amy Solnica, Orit Zandman, Hananel Holzer, Jigal Haas
Summary: This study found that LH concentrations post-GnRHa trigger differ based on the antagonist-agonist intervals, but the achieved follicle/mature oocyte ratio was not affected.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Physiology
Yao Lu, Yichao Niu, Yuan Wang, Yaqiong He, Ying Ding, Xinyuan Lu, Bing Xu, Steven R. Lindheim, Yun Sun
Summary: The use of GnRH-ant protocol for ovarian stimulation in IVF cycles after OC pretreatment was associated with significantly lower live birth rate (LBR), while an increase in endometrial thickness on the day of hCG trigger was linked to higher LBR.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Jieru Zhu, Weijie Xing, Tao Li, Hui Lin, Jianping Ou
Summary: The study evaluated the clinical outcomes and maternal-neonatal safety of gonadotropin releasing hormone antagonist (GnRH-ant) and gonadotropin releasing hormone agonist (GnRH-a) protocols. The results showed that GnRH-ant protocol was comparable to GnRH-a protocol in clinical outcomes and obstetric and perinatal outcomes, with a lower risk of ovarian hyperstimulation syndrome (OHSS).
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Li Gu, Xurui Li, Wentao Liu
Summary: In prostate cancer patients, GnRH antagonists have shown a reduced risk of cardiovascular events, cardiovascular death, and myocardial infarctions compared to GnRH agonists. However, there was no significant difference in the incidence of stroke and heart failure. The beneficial effects of GnRH antagonists were more pronounced in patients with preexisting cardiovascular disease.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Bella Martazanova, Nona Mishieva, Irina Vedikhina, Anastasia Kirillova, Irina Korneeva, Tatyana Ivanets, Aydar Abubakirov, Gennady T. Sukhikh
Summary: The use of GnRHa triggering in fresh embryo transfer cycles has limitations due to luteal phase insufficiency. Low-dose hCG supplementation can effectively address this issue and achieve comparable pregnancy rates to full-dose hCG.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Shannon Pretzel, Katherine Kuhn, Lubna Pal, Alex Polotsky, Hugh S. Taylor, Heping Zhang, Jared Robins, Steven L. Young, Nanette Santoro
Summary: Recruitment for an endometriosis clinical trial using an electronic medical record (EMR)-based strategy is feasible, although the overall yield of participants is low. Delays in treatment due to COVID-19 did not appear to overly influence potential recruitment.
REPRODUCTIVE SCIENCES
(2022)
Article
Obstetrics & Gynecology
Laura Emilie Vexo, Sacha Stormlund, Selma Kloeve Landersoe, Henrik Lovendahl Jorgensen, Peter Humaidan, Christina Bergh, Anne Lis Mikkelsen Englund, Anna Klajnbard, Jeanette Wulff Bogstad, Nina la Cour Freiesleben, Anne Zedeler, Lisbeth Praetorius, Anders Nyboe Andersen, Kristine Lossl, Anja Pinborg, Henriette Svarre Nielsen
Summary: Low-grade inflammation, detected by CRP, is associated with the outcome of IVF, including blastocyst quality and pregnancy outcome. Higher baseline CRP concentrations are negatively associated with live birth rate and are associated with pregnancy loss. However, there is no association between CRP concentrations and the number of good-quality blastocysts. More studies are needed to investigate the impact of low-grade inflammation.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Obstetrics & Gynecology
Birgit Alsbjerg, Ulrik Schioler Kesmodel, Peter Humaidan
Summary: What is the optimal serum progesterone cut-off level in patients with endometriosis undergoing hormone replacement therapy frozen embryo transfer (HRT-FET) with intensive progesterone luteal phase support? The study revealed that serum progesterone levels above 118 nmol/l (37.1 ng/ml) resulted in significantly higher live birth rates compared to lower levels, indicating the existence of a threshold for optimal serum progesterone.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Editorial Material
Obstetrics & Gynecology
Peter Humaidan, Juan Antonio Garcia Velasco, Mauro Cozzolino
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
J. Cadenas, L. C. Poulsen, D. Nikiforov, M. L. Grondahl, A. Kumar, K. Bahnu, A. L. M. Englund, J. Malm, G. Marko-Varga, I Pla, A. Sanchez, S. E. Pors, C. Yding Andersen
Summary: This study investigates the substances and signal transduction pathways involved in the regulation of human oocyte maturation downstream to the effects of FSH and LH. The results reveal that human oocyte maturation is a multifactorial process involving several different signal transduction pathways. Various pathways, including those involving CNP, EGF-related peptides, TGF-beta family members, activins/inhibins, FF-MAS, and MDK, are potentially active, while the GDF9 and BMP15 pathways show less pronounced influence.
HUMAN REPRODUCTION
(2023)
Article
Genetics & Heredity
Carlo Alviggi, Salvatore Longobardi, Enrico Papaleo, Daniele Santi, Simona Alfano, Valeria Stella Vanni, Maria Rosaria Campitiello, Pasquale De Rosa, Ida Strina, Ilpo Huhtaniemi, Juha-Pekka Pursiheimo, Thomas D'Hooghe, Peter Humaidan, Alessandro Conforti
Summary: Specific polymorphisms can influence the response to ovarian stimulation in women undergoing assisted reproductive technologies. However, further studies are needed to determine the clinical utility of genotype analysis before ovarian stimulation.
Editorial Material
Endocrinology & Metabolism
Johnny Awwad, Juan Garcia-Velasco, Peter Humaidan
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Obstetrics & Gynecology
J. M. Nielsen, P. Humaidan, M. B. Jensen, B. Alsbjerg
Summary: Bleeding before the eighth week of gestation is common in HRT-FET patients, but does not affect reproductive outcomes. Spontaneously conceived pregnancies have a 20% incidence of bleeding, most of which have normal outcomes.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
B. Alsbjerg, M. B. Jensen, B. B. Povlsen, H. O. Elbaek, R. J. Laursen, U. S. Kesmodel, P. Humaidan
Summary: Rectal administration of progesterone on the day of blastocyst transfer can effectively increase ongoing pregnancy rates in patients with low serum progesterone levels.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Nathalie Soderhamn Bulow, Agnieszka Katarzyna Warzecha, Mette Villads Nielsen, Claus Yding Andersen, Marianne Dreyer Holt, Morten Ronn Petersen, Negjyp Sopa, Anne Zedeler, Anne Lis Englund, Anja Pinborg, Marie Louise Grondahl, Sven Olaf Skouby, Nicholas Stephen Macklon
Summary: LZ co-treatment during ovarian stimulation with gonadotropins for in IVF does not impact follicle recruitment, oocyte number and quality, embryo quality, or live birth rate (LBR).
HUMAN REPRODUCTION
(2023)
Article
Biochemistry & Molecular Biology
Mengxue Zheng, Jesus Cadenas, Susanne Elisabeth Pors, Tasnim Esa, Stine Gry Kristensen, Linn Salto Mamsen, Cristina Subiran Adrados, Claus Yding Andersen
Summary: This study aimed to optimize the culture conditions for murine preantral follicles to improve their growth and survival. The results showed that altering the alginate concentration, adding estradiol, and increasing follicle-stimulating hormone concentration can promote the growth and development of preantral follicles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Stefano Palomba, Flavia Costanzi, Scott M. Nelson, Donatella Caserta, Peter Humaidan
Summary: This study reviewed and analyzed different interventions for preventing and reducing OHSS in IVF patients. The most effective interventions were found to be GnRH-ant co-treatment and GnRH agonist triggering, with moderate evidence. Mild ovarian stimulation and dopaminergic agonists were also effective and safe interventions.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Maria Buhl Borgstrom, Anne Ahrendt Bjerregaard, Sjurdur F. Olsen, Anette Gabrielsen, Peter Humaidan, Ulrik Schioler Kesmodel
Summary: This study aims to investigate the possible association between food intake and semen quality in men, as well as pregnancy and live birth rates in women undergoing intrauterine insemination or assisted reproductive technology treatment. Data will be collected through a web-based questionnaire and medical records, with a total of 4000 participants recruited. The results will be disseminated and published through various channels.
Letter
Obstetrics & Gynecology
Birgit Alsbjerg, Peter Humaidan
HUMAN REPRODUCTION OPEN
(2023)
Article
Obstetrics & Gynecology
Jeanett L. M. Nielsen, Ahmad Majzoub, Sandro Esteves, Peter Humaidan
Summary: In recent years, there has been an increasing interest in identifying subcellular causes of male infertility, with a focus on sperm DNA fragmentation (SDF) research. SDF can occur during spermatogenesis or as sperm transit through the genital tract, negatively impacting male reproductive potential. Studies have found that DNA damage is associated with sperm morphological and functional abnormalities, ultimately affecting natural conception and assisted reproductive technology outcomes.
SEMINARS IN REPRODUCTIVE MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Stefano Palomba, Flavia Costanzi, Scott M. Nelson, Aris Besharat, Donatella Caserta, Peter Humaidan
Summary: The aim of this study was to evaluate and grade interventions for the prevention and reduction of OHSS in IVF patients. The results showed that follitropin delta may reduce the incidence of early OHSS in low-risk IVF patients, while in high-risk patients, inositol pretreatment, low-dose urinary hCG for ovulation triggering, and luteal phase administration of a GnRH antagonist may reduce the risk of OHSS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
