Journal
FERTILITY AND STERILITY
Volume 95, Issue 7, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2011.03.074
Keywords
Kartagener's syndrome; immotile cilia; pentoxifylline; ICSI; vitrification
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Funding
- Grants-in-Aid for Scientific Research [23659090] Funding Source: KAKEN
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Objective: To describe the delivery of a healthy female infant after intracytoplasmic sperm injection (ICSI) using pentoxifylline-activated sperm from a patient with Kartagener's syndrome. Design: Case report. Setting: Private assisted reproductive technology clinic in Japan. Patient(s): A couple with male factor infertility due to Kartagener's syndrome. Intervention(s): Intracytoplasmic sperm injection using ejaculated sperm activated by pentoxifylline. Main Outcome Measure(s): Semen characteristics, sperm ultrastructure, fertilization, pregnancy, and birth after ICSI. Result(s): The fertilization rate was 7 of 12 (58.3%), and the blastocyst formation rate was 4 of 7 (57.1%); all blastocysts were vitrified. After a single blastcyst transfer, a pregnancy ensued and progressed to term; a healthy female infant was delivered. Conclusion(s): With ejaculated sperm, which was activated by pentoxifylline, successful fertilization was accomplished by ICSI; thus, fertilization, vitrification, pregnancy, and delivery are attainable with sperm obtained from men with Kartagener's syndrome. (Fertil Steril (R) 2011; 95: 2431. e9-e11. (C) 2011 by American Society for Reproductive Medicine.)
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