Birth of a healthy infant after intracytoplasmic sperm injection using pentoxifylline-activated sperm from a patient with Kartagener's syndrome

Objective: To describe the delivery of a healthy female infant after intracytoplasmic sperm injection (ICSI) using pentoxifylline-activated sperm from a patient with Kartagener's syndrome. Design: Case report. Setting: Private assisted reproductive technology clinic in Japan. Patient(s): A couple with male factor infertility due to Kartagener's syndrome. Intervention(s): Intracytoplasmic sperm injection using ejaculated sperm activated by pentoxifylline. Main Outcome Measure(s): Semen characteristics, sperm ultrastructure, fertilization, pregnancy, and birth after ICSI. Result(s): The fertilization rate was 7 of 12 (58.3%), and the blastocyst formation rate was 4 of 7 (57.1%); all blastocysts were vitrified. After a single blastcyst transfer, a pregnancy ensued and progressed to term; a healthy female infant was delivered. Conclusion(s): With ejaculated sperm, which was activated by pentoxifylline, successful fertilization was accomplished by ICSI; thus, fertilization, vitrification, pregnancy, and delivery are attainable with sperm obtained from men with Kartagener's syndrome. (Fertil Steril (R) 2011; 95: 2431. e9-e11. (C) 2011 by American Society for Reproductive Medicine.)